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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFATC1

Z-value: 0.84

Motif logo

Transcription factors associated with NFATC1

Gene Symbol Gene ID Gene Info
ENSG00000131196.13 nuclear factor of activated T cells 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v2_chr18_+_77155942_771559510.091.8e-01Click!

Activity profile of NFATC1 motif

Sorted Z-values of NFATC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153517473 26.54 ENST00000368715.1
S100 calcium binding protein A4
chr14_-_92413353 11.81 ENST00000556154.1
fibulin 5
chr6_-_32920794 10.06 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_+_32407619 9.92 ENST00000395388.2
ENST00000374982.5
major histocompatibility complex, class II, DR alpha
chr2_-_161349909 9.19 ENST00000392753.3
RNA binding motif, single stranded interacting protein 1
chr3_+_152017360 9.01 ENST00000485910.1
ENST00000463374.1
muscleblind-like splicing regulator 1
chr4_-_71532339 8.88 ENST00000254801.4
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_189839046 8.84 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr3_+_151986709 8.77 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr1_-_226926864 8.36 ENST00000429204.1
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr22_+_38071615 8.24 ENST00000215909.5
lectin, galactoside-binding, soluble, 1
chr5_+_135394840 8.23 ENST00000503087.1
transforming growth factor, beta-induced, 68kDa
chr3_+_69134080 8.07 ENST00000273258.3
ADP-ribosylation-like factor 6 interacting protein 5
chr5_+_49962495 7.77 ENST00000515175.1
poly (ADP-ribose) polymerase family, member 8
chr3_+_69134124 7.19 ENST00000478935.1
ADP-ribosylation-like factor 6 interacting protein 5
chr1_+_86046433 7.03 ENST00000451137.2
cysteine-rich, angiogenic inducer, 61
chr10_-_121296045 6.92 ENST00000392865.1
regulator of G-protein signaling 10
chr12_-_91573249 6.87 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
decorin
chr14_-_35873856 6.70 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr5_+_118690466 6.68 ENST00000503646.1
tumor necrosis factor, alpha-induced protein 8
chr1_+_209941942 6.56 ENST00000487271.1
ENST00000477431.1
TRAF3 interacting protein 3
chr1_-_111743285 6.49 ENST00000357640.4
DENN/MADD domain containing 2D
chr9_-_35691017 6.18 ENST00000378292.3
tropomyosin 2 (beta)
chr14_-_92413727 6.12 ENST00000267620.10
fibulin 5
chr11_+_18417813 5.18 ENST00000540430.1
ENST00000379412.5
lactate dehydrogenase A
chr17_-_29648761 5.01 ENST00000247270.3
ENST00000462804.2
ecotropic viral integration site 2A
chr10_+_11206925 4.98 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr4_-_83765613 4.89 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr1_-_150780757 4.87 ENST00000271651.3
cathepsin K
chr12_-_91573316 4.85 ENST00000393155.1
decorin
chr12_-_91573132 4.79 ENST00000550563.1
ENST00000546370.1
decorin
chr3_+_69812877 4.69 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chr14_-_89883412 4.49 ENST00000557258.1
forkhead box N3
chr3_-_107777208 4.42 ENST00000398258.3
CD47 molecule
chr17_-_39743139 4.40 ENST00000167586.6
keratin 14
chr12_-_50616122 4.15 ENST00000552823.1
ENST00000552909.1
LIM domain and actin binding 1
chr9_+_124062071 4.10 ENST00000373818.4
gelsolin
chr7_-_22862406 4.06 ENST00000372879.4
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr10_+_22610124 4.05 ENST00000376663.3
BMI1 polycomb ring finger oncogene
chr12_+_50144381 4.05 ENST00000552370.1
transmembrane BAX inhibitor motif containing 6
chr6_-_134495992 4.03 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
serum/glucocorticoid regulated kinase 1
chr12_-_50616382 4.02 ENST00000552783.1
LIM domain and actin binding 1
chr8_-_134072593 3.98 ENST00000427060.2
Src-like-adaptor
chr1_+_79115503 3.95 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr10_+_104535994 3.84 ENST00000369889.4
WW domain binding protein 1-like
chr3_+_133293278 3.80 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3 homolog (mouse)
chr10_-_27149851 3.64 ENST00000376142.2
ENST00000359188.4
ENST00000376139.2
ENST00000376160.1
abl-interactor 1
chr1_+_167298281 3.63 ENST00000367862.5
POU class 2 homeobox 1
chr12_-_56352368 3.61 ENST00000549404.1
premelanosome protein
chr10_-_27149904 3.58 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr10_-_27149792 3.47 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr4_-_104021009 3.46 ENST00000509245.1
ENST00000296424.4
3-hydroxybutyrate dehydrogenase, type 2
chr5_+_33441053 3.21 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
threonyl-tRNA synthetase
chr4_+_154387480 3.17 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
chr5_+_33440802 3.13 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
threonyl-tRNA synthetase
chr12_-_52887034 3.12 ENST00000330722.6
keratin 6A
chr6_-_11232891 3.12 ENST00000379433.5
ENST00000379446.5
neural precursor cell expressed, developmentally down-regulated 9
chr13_-_76056250 3.10 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1 domain family, member 4
chr17_+_27047570 3.09 ENST00000472628.1
ENST00000578181.1
ribosomal protein L23a
chr1_-_94703118 3.06 ENST00000260526.6
ENST00000370217.3
Rho GTPase activating protein 29
chrX_+_102611373 3.04 ENST00000372661.3
ENST00000372656.3
WW domain binding protein 5
chr10_-_27443294 3.04 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1-like 1 ATPase
chr22_-_43355858 3.01 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
protein kinase C and casein kinase substrate in neurons 2
chr10_-_27443155 2.95 ENST00000427324.1
ENST00000326799.3
YME1-like 1 ATPase
chr9_-_14314518 2.92 ENST00000397581.2
nuclear factor I/B
chr7_-_29186008 2.90 ENST00000396276.3
ENST00000265394.5
carboxypeptidase, vitellogenic-like
chr3_-_141747439 2.87 ENST00000467667.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_186649543 2.85 ENST00000367468.5
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_63921351 2.85 ENST00000370659.1
FK506 binding protein 1C
chr13_+_37581115 2.82 ENST00000481013.1
exosome component 8
chr10_-_105212141 2.81 ENST00000369788.3
calcium homeostasis modulator 2
chr17_-_39677971 2.80 ENST00000393976.2
keratin 15
chr14_+_21538517 2.75 ENST00000298693.3
Rho guanine nucleotide exchange factor (GEF) 40
chr8_+_128748466 2.69 ENST00000524013.1
ENST00000520751.1
v-myc avian myelocytomatosis viral oncogene homolog
chr12_+_96588143 2.68 ENST00000228741.3
ENST00000547249.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_+_86668464 2.62 ENST00000409064.1
lysine (K)-specific demethylase 3A
chr5_-_39203093 2.61 ENST00000515010.1
FYN binding protein
chr19_+_10197463 2.59 ENST00000590378.1
ENST00000397881.3
chromosome 19 open reading frame 66
chr1_+_948803 2.56 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr10_-_105212059 2.54 ENST00000260743.5
calcium homeostasis modulator 2
chr2_+_75061108 2.54 ENST00000290573.2
hexokinase 2
chr7_+_79998864 2.47 ENST00000435819.1
CD36 molecule (thrombospondin receptor)
chr17_-_35969409 2.46 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
synergin, gamma
chr13_-_99174252 2.45 ENST00000376547.3
serine/threonine kinase 24
chr9_-_14314566 2.42 ENST00000397579.2
nuclear factor I/B
chr17_+_27046988 2.42 ENST00000496182.1
ribosomal protein L23a
chr3_-_158390282 2.39 ENST00000264265.3
latexin
chr6_+_15246501 2.35 ENST00000341776.2
jumonji, AT rich interactive domain 2
chr5_-_179050066 2.35 ENST00000329433.6
ENST00000510411.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_-_145278475 2.33 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr1_+_162602244 2.32 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr17_-_39780819 2.30 ENST00000311208.8
keratin 17
chr17_-_34207295 2.25 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr12_+_104359614 2.14 ENST00000266775.9
ENST00000544861.1
thymine-DNA glycosylase
chr10_-_65028938 2.13 ENST00000402544.1
jumonji domain containing 1C
chr12_+_104359641 2.10 ENST00000537100.1
thymine-DNA glycosylase
chr11_+_11863500 2.09 ENST00000527733.1
ENST00000539466.1
ubiquitin specific peptidase 47
chr12_-_123756781 2.05 ENST00000544658.1
cyclin-dependent kinase 2 associated protein 1
chr12_-_7656357 1.98 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163 molecule
chr5_+_49963239 1.97 ENST00000505554.1
poly (ADP-ribose) polymerase family, member 8
chr1_+_82266053 1.96 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr1_-_103574024 1.96 ENST00000512756.1
ENST00000370096.3
ENST00000358392.2
ENST00000353414.4
collagen, type XI, alpha 1
chr5_+_139781393 1.95 ENST00000360839.2
ENST00000297183.6
ENST00000421134.1
ENST00000394723.3
ENST00000511151.1
ankyrin repeat and KH domain containing 1
chr3_-_182817367 1.94 ENST00000265594.4
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr11_-_102668879 1.92 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr11_+_11863579 1.91 ENST00000399455.2
ubiquitin specific peptidase 47
chr8_+_70404996 1.90 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr4_-_16085340 1.89 ENST00000508167.1
prominin 1
chr1_+_155178481 1.88 ENST00000368376.3
metaxin 1
chrX_-_129244655 1.87 ENST00000335997.7
E74-like factor 4 (ets domain transcription factor)
chr5_+_32788945 1.87 ENST00000326958.1
AC026703.1
chr10_-_65028817 1.87 ENST00000542921.1
jumonji domain containing 1C
chr11_+_92085707 1.85 ENST00000525166.1
FAT atypical cadherin 3
chr11_-_122930121 1.84 ENST00000524552.1
heat shock 70kDa protein 8
chr3_-_36986534 1.82 ENST00000429976.2
ENST00000301807.6
tetratricopeptide repeat and ankyrin repeat containing 1
chr3_+_88188254 1.82 ENST00000309495.5
zinc finger protein 654
chr6_+_42584847 1.81 ENST00000372883.3
ubiquitin protein ligase E3 component n-recognin 2
chr4_-_38806404 1.80 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
toll-like receptor 1
chr17_+_32582293 1.80 ENST00000580907.1
ENST00000225831.4
chemokine (C-C motif) ligand 2
chr12_+_26348582 1.80 ENST00000535504.1
sarcospan
chr16_+_1583567 1.80 ENST00000566264.1
transmembrane protein 204
chr3_-_111314230 1.80 ENST00000317012.4
zinc finger, BED-type containing 2
chrX_+_152760397 1.77 ENST00000331595.4
ENST00000431891.1
biglycan
chr11_+_65190245 1.76 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr18_+_77155942 1.76 ENST00000397790.2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr5_+_49962772 1.72 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
poly (ADP-ribose) polymerase family, member 8
chr11_-_46142948 1.71 ENST00000257821.4
PHD finger protein 21A
chr12_-_123756687 1.70 ENST00000261692.2
cyclin-dependent kinase 2 associated protein 1
chr2_-_97535708 1.67 ENST00000305476.5
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr4_-_16085314 1.66 ENST00000510224.1
prominin 1
chr2_-_211179883 1.63 ENST00000352451.3
myosin, light chain 1, alkali; skeletal, fast
chr3_-_149375783 1.62 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr3_-_136471204 1.62 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
stromal antigen 1
chr19_+_56152262 1.61 ENST00000325333.5
ENST00000590190.1
zinc finger protein 580
chr8_-_95274536 1.61 ENST00000297596.2
ENST00000396194.2
GTP binding protein overexpressed in skeletal muscle
chr15_+_23255242 1.57 ENST00000450802.3
golgin A8 family, member I
chr14_-_35591433 1.56 ENST00000261475.5
ENST00000555644.1
protein phosphatase 2, regulatory subunit B'', gamma
chr2_-_211168332 1.54 ENST00000341685.4
myosin, light chain 1, alkali; skeletal, fast
chr10_+_124913793 1.51 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3 mitotic checkpoint protein
chr7_+_139529040 1.50 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr15_-_90222642 1.50 ENST00000430628.2
perilipin 1
chr2_+_1417228 1.48 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
thyroid peroxidase
chr5_+_135496675 1.46 ENST00000507637.1
SMAD family member 5
chr15_-_90222610 1.44 ENST00000300055.5
perilipin 1
chr18_-_53089723 1.44 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr8_+_57124245 1.44 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
coiled-coil-helix-coiled-coil-helix domain containing 7
chr1_+_158323486 1.37 ENST00000444681.2
ENST00000368167.3
CD1e molecule
chr4_-_178363581 1.35 ENST00000264595.2
aspartylglucosaminidase
chr3_-_141747459 1.34 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_100356291 1.34 ENST00000476959.1
ENST00000482593.1
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_+_139781445 1.33 ENST00000532219.1
ENST00000394722.3
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr22_+_40573921 1.27 ENST00000454349.2
ENST00000335727.9
trinucleotide repeat containing 6B
chr4_-_41750922 1.26 ENST00000226382.2
paired-like homeobox 2b
chr8_+_95653373 1.26 ENST00000358397.5
epithelial splicing regulatory protein 1
chr12_+_98987369 1.24 ENST00000401722.3
ENST00000188376.5
ENST00000228318.3
ENST00000551917.1
ENST00000548046.1
ENST00000552981.1
ENST00000551265.1
ENST00000550695.1
ENST00000547534.1
ENST00000549338.1
ENST00000548847.1
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr8_+_95653302 1.23 ENST00000423620.2
ENST00000433389.2
epithelial splicing regulatory protein 1
chr2_+_204732666 1.17 ENST00000295854.6
ENST00000472206.1
cytotoxic T-lymphocyte-associated protein 4
chr7_-_151217166 1.15 ENST00000496004.1
Ras homolog enriched in brain
chr8_+_95653427 1.13 ENST00000454170.2
epithelial splicing regulatory protein 1
chr6_-_119670919 1.13 ENST00000368468.3
mannosidase, alpha, class 1A, member 1
chr11_+_128563652 1.13 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr3_-_79068594 1.12 ENST00000436010.2
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_+_9431324 1.10 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr1_+_158323634 1.09 ENST00000452291.2
ENST00000368165.3
ENST00000368166.3
ENST00000368163.3
ENST00000368164.3
CD1e molecule
chr11_-_110167352 1.08 ENST00000533991.1
ENST00000528498.1
ENST00000405097.1
ENST00000528900.1
ENST00000530301.1
ENST00000343115.4
radixin
chr17_+_27047244 1.08 ENST00000394938.4
ENST00000394935.3
ENST00000355731.4
ribosomal protein L23a
chr19_-_2427863 1.08 ENST00000215570.3
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr9_-_16870704 1.07 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
basonuclin 2
chr14_+_81421921 1.07 ENST00000554263.1
ENST00000554435.1
thyroid stimulating hormone receptor
chr1_-_155880672 1.06 ENST00000609492.1
ENST00000368322.3
Ras-like without CAAX 1
chr1_-_154164534 1.05 ENST00000271850.7
ENST00000368530.2
tropomyosin 3
chr22_+_24407847 1.04 ENST00000445422.1
ENST00000398319.2
calcineurin binding protein 1
chr6_+_129204337 1.03 ENST00000421865.2
laminin, alpha 2
chr9_-_20622478 1.02 ENST00000355930.6
ENST00000380338.4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr9_-_132597529 1.01 ENST00000372447.3
chromosome 9 open reading frame 78
chr22_+_24407642 1.00 ENST00000454754.1
ENST00000263119.5
calcineurin binding protein 1
chr19_+_10216899 0.98 ENST00000428358.1
ENST00000393796.4
ENST00000253107.7
ENST00000556468.1
ENST00000393793.1
PPAN-P2RY11 readthrough
peter pan homolog (Drosophila)
chr22_+_24407776 0.98 ENST00000405822.2
calcineurin binding protein 1
chr14_-_107013465 0.98 ENST00000390625.2
immunoglobulin heavy variable 3-49
chr1_-_77685084 0.98 ENST00000370812.3
ENST00000359130.1
ENST00000445065.1
ENST00000370813.5
phosphatidylinositol glycan anchor biosynthesis, class K
chr3_+_46395219 0.97 ENST00000445132.2
ENST00000292301.4
chemokine (C-C motif) receptor 2
chr11_-_122929699 0.96 ENST00000526686.1
heat shock 70kDa protein 8
chr3_+_63897605 0.94 ENST00000487717.1
ataxin 7
chr5_+_7869217 0.94 ENST00000264668.2
ENST00000514220.1
ENST00000341013.6
ENST00000440940.2
ENST00000502550.1
ENST00000506877.1
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr5_-_111093759 0.93 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
neuronal regeneration related protein
chr1_+_162760513 0.92 ENST00000367915.1
ENST00000367917.3
ENST00000254521.3
ENST00000367913.1
hydroxysteroid (17-beta) dehydrogenase 7
chr9_+_100818976 0.92 ENST00000210444.5
N-acetylneuraminic acid synthase
chr1_+_203734296 0.92 ENST00000442561.2
ENST00000367217.5
lymphocyte transmembrane adaptor 1
chr5_-_7869108 0.92 ENST00000264669.5
ENST00000507572.1
ENST00000504695.1
FAST kinase domains 3
chr1_+_155179012 0.91 ENST00000609421.1
metaxin 1
chr14_+_81421861 0.91 ENST00000298171.2
thyroid stimulating hormone receptor
chr1_+_155178518 0.90 ENST00000316721.4
metaxin 1
chr9_-_36276966 0.88 ENST00000543356.2
ENST00000396594.3
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr18_-_53257027 0.85 ENST00000568740.1
ENST00000564403.2
ENST00000537578.1
transcription factor 4
chr1_-_27226928 0.84 ENST00000361720.5
G patch domain containing 3
chr1_-_203320617 0.84 ENST00000354955.4
fibromodulin
chr12_-_10605929 0.83 ENST00000347831.5
ENST00000359151.3
killer cell lectin-like receptor subfamily C, member 1
chr14_-_30396802 0.81 ENST00000415220.2
protein kinase D1
chr17_-_49124230 0.81 ENST00000510283.1
ENST00000510855.1
sperm associated antigen 9
chr8_+_86121448 0.80 ENST00000520225.1
E2F transcription factor 5, p130-binding

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 20.0 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
2.1 6.3 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
2.1 8.2 GO:0002317 plasma cell differentiation(GO:0002317)
1.7 13.3 GO:0002036 regulation of L-glutamate transport(GO:0002036)
1.5 17.9 GO:0048251 elastic fiber assembly(GO:0048251)
1.4 16.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.2 8.4 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
1.1 6.7 GO:0070417 cellular response to cold(GO:0070417) nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.1 8.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.1 4.2 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
1.0 3.1 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
1.0 6.0 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
1.0 4.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.9 2.8 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.9 3.5 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.9 2.6 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.8 4.1 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.8 7.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.8 5.3 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 4.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.7 2.8 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.7 2.8 GO:0072683 T cell extravasation(GO:0072683)
0.7 4.0 GO:0060702 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.7 2.6 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.7 2.0 GO:0035989 tendon development(GO:0035989)
0.6 1.8 GO:0042495 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.6 2.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.6 4.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.6 2.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 2.8 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.5 1.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5 11.8 GO:0035855 megakaryocyte development(GO:0035855)
0.5 1.9 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.4 2.7 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.4 1.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.4 5.2 GO:0006089 lactate metabolic process(GO:0006089)
0.4 2.5 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.4 5.1 GO:0007379 segment specification(GO:0007379)
0.4 1.3 GO:0003358 noradrenergic neuron development(GO:0003358)
0.4 7.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.4 1.1 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.4 2.6 GO:0006552 leucine catabolic process(GO:0006552)
0.4 4.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.4 2.5 GO:0071726 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) blood microparticle formation(GO:0072564) positive regulation of NLRP3 inflammasome complex assembly(GO:1900227) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.3 4.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.3 2.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.3 1.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.3 1.8 GO:0071233 cellular response to leucine(GO:0071233)
0.3 3.0 GO:0070836 caveola assembly(GO:0070836)
0.3 3.5 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.3 0.8 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.3 4.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 0.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 4.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.3 0.8 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.3 0.8 GO:0071109 superior temporal gyrus development(GO:0071109)
0.3 3.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.2 1.5 GO:0001880 Mullerian duct regression(GO:0001880)
0.2 4.5 GO:0008228 opsonization(GO:0008228)
0.2 0.4 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.2 1.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 4.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 0.6 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 7.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 1.6 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.2 2.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 2.3 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 0.5 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 0.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 2.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 0.9 GO:0043418 homocysteine catabolic process(GO:0043418)
0.2 23.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.6 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 8.0 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 3.6 GO:0032438 melanosome organization(GO:0032438)
0.1 5.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.0 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.8 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.6 GO:0070295 renal water absorption(GO:0070295)
0.1 10.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 1.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 19.2 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 2.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.7 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 0.3 GO:0043132 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132)
0.1 0.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.0 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 2.4 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.7 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 4.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.3 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 2.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.8 GO:0001866 NK T cell proliferation(GO:0001866)
0.1 1.0 GO:0043586 tongue development(GO:0043586)
0.1 1.8 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.1 3.4 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 2.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 1.2 GO:0035435 phosphate ion transport(GO:0006817) phosphate ion transmembrane transport(GO:0035435)
0.1 0.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 3.0 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.1 1.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 0.9 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 2.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 1.9 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 0.5 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.0 4.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 1.1 GO:0070997 neuron death(GO:0070997)
0.0 0.9 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.0 3.2 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.2 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 2.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 3.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 7.3 GO:0006260 DNA replication(GO:0006260)
0.0 1.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 2.4 GO:0031424 keratinization(GO:0031424)
0.0 1.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.7 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.0 GO:0035711 T-helper 1 cell activation(GO:0035711)
0.0 0.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.9 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.3 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 17.9 GO:0071953 elastic fiber(GO:0071953)
1.2 16.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.0 20.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.9 10.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.8 10.7 GO:0031209 SCAR complex(GO:0031209)
0.7 4.9 GO:0036021 endolysosome lumen(GO:0036021)
0.6 1.8 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.6 4.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.6 6.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 2.6 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.5 1.5 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.4 2.8 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.4 6.6 GO:0031932 TORC2 complex(GO:0031932)
0.4 7.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 2.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 1.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 4.1 GO:0035102 PRC1 complex(GO:0035102)
0.3 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 2.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 16.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 3.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 4.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 3.0 GO:0030478 actin cap(GO:0030478)
0.2 3.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 1.1 GO:0051286 cell tip(GO:0051286)
0.1 1.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 5.2 GO:0045095 keratin filament(GO:0045095)
0.1 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 8.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 2.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.8 GO:0005912 adherens junction(GO:0005912)
0.1 3.2 GO:0005859 muscle myosin complex(GO:0005859)
0.1 2.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 7.8 GO:0005604 basement membrane(GO:0005604)
0.1 0.8 GO:0030877 beta-catenin destruction complex(GO:0030877) Wnt signalosome(GO:1990909)
0.1 1.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0035976 AP1 complex(GO:0035976)
0.1 1.4 GO:0071141 SMAD protein complex(GO:0071141)
0.1 2.9 GO:0016235 aggresome(GO:0016235)
0.0 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 7.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.6 GO:0005901 caveola(GO:0005901)
0.0 4.9 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.9 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.8 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.1 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0032982 myosin filament(GO:0032982)
0.0 3.6 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 8.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.6 GO:0016605 PML body(GO:0016605)
0.0 4.0 GO:0043679 axon terminus(GO:0043679)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 17.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 13.6 GO:0016604 nuclear body(GO:0016604)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.4 GO:0043235 receptor complex(GO:0043235)
0.0 0.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.9 GO:0005795 Golgi stack(GO:0005795)
0.0 2.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.8 GO:0001069 regulatory region RNA binding(GO:0001069)
2.7 8.2 GO:0048030 disaccharide binding(GO:0048030)
2.1 6.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
1.4 4.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
1.4 8.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.3 26.5 GO:0050786 RAGE receptor binding(GO:0050786)
1.2 3.5 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
1.0 4.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.9 2.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.9 12.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.8 4.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.7 6.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.7 5.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.7 4.4 GO:1990254 keratin filament binding(GO:1990254)
0.7 2.8 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.7 6.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.7 4.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.6 8.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.6 1.8 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.5 2.6 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.5 1.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.5 1.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 5.6 GO:0001968 fibronectin binding(GO:0001968)
0.5 2.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 12.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.4 12.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 31.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 2.6 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.4 11.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 4.1 GO:0015266 protein channel activity(GO:0015266)
0.4 1.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.4 1.8 GO:0070728 leucine binding(GO:0070728)
0.3 6.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 4.1 GO:0045159 myosin II binding(GO:0045159)
0.3 1.3 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.3 1.0 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.3 2.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 0.9 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 3.1 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.3 2.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.2 1.5 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 6.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 2.6 GO:0031386 protein tag(GO:0031386)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.6 GO:0042806 fucose binding(GO:0042806)
0.2 8.2 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.6 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 7.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 2.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 2.4 GO:0032452 histone demethylase activity(GO:0032452)
0.2 4.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 0.8 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.2 0.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.2 3.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.0 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 3.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 2.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 6.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 18.1 GO:0005178 integrin binding(GO:0005178)
0.1 10.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 6.4 GO:0070888 E-box binding(GO:0070888)
0.1 0.3 GO:0051185 FAD transmembrane transporter activity(GO:0015230) coenzyme transporter activity(GO:0051185)
0.1 4.3 GO:0042805 actinin binding(GO:0042805)
0.1 1.4 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151) transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 6.7 GO:0019843 rRNA binding(GO:0019843)
0.1 4.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 9.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 2.8 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 3.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 4.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.8 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0 0.2 GO:0033265 choline binding(GO:0033265)
0.0 0.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 1.7 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 3.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.3 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.0 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.6 GO:0019003 GDP binding(GO:0019003)
0.0 1.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.6 GO:0008289 lipid binding(GO:0008289)
0.0 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 1.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 3.3 GO:0004888 transmembrane signaling receptor activity(GO:0004888)
0.0 1.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 2.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.0 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.0 0.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.4 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.3 15.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 22.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 8.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 18.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 11.3 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 10.5 NABA COLLAGENS Genes encoding collagen proteins
0.2 9.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 6.7 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 7.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 1.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 10.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 4.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 15.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 21.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 5.0 PID E2F PATHWAY E2F transcription factor network
0.0 3.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 4.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 3.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 4.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 2.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID ATM PATHWAY ATM pathway
0.0 1.5 PID P73PATHWAY p73 transcription factor network
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 18.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.4 6.7 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.3 4.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 2.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 2.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 4.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 1.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.2 5.2 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 6.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 1.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 10.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 8.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 8.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 11.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 4.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 5.8 REACTOME RNA POL III TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 2.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 4.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 10.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 2.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 6.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 4.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins