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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFIA

Z-value: 0.94

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Transcription factors associated with NFIA

Gene Symbol Gene ID Gene Info
NFIA
ENSG00000162599.11 nuclear factor I A

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_29171689 17.84 ENST00000237014.3
TTR
transthyretin
chr16_+_58283814 13.44 ENST00000443128.2
ENST00000219299.4
CCDC113
coiled-coil domain containing 113
chr12_-_15038779 12.64 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr4_-_57547870 12.32 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr14_+_73704201 11.39 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr4_-_57547454 10.91 ENST00000556376.2
HOPX
HOP homeobox
chr14_+_23299088 9.80 ENST00000355151.5
ENST00000397496.3
ENST00000555345.1
ENST00000432849.3
ENST00000553711.1
ENST00000556465.1
ENST00000397505.2
ENST00000557221.1
ENST00000311892.6
ENST00000556840.1
ENST00000555536.1
MRPL52
mitochondrial ribosomal protein L52
chr14_+_75746340 9.48 ENST00000555686.1
ENST00000555672.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr8_-_22089533 9.40 ENST00000321613.3
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr9_+_17135016 8.85 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr14_+_75746781 8.68 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_17134980 8.00 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chr3_+_109128837 7.66 ENST00000497996.1
RP11-702L6.4
RP11-702L6.4
chr19_-_46296011 7.64 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr3_+_45067659 7.41 ENST00000296130.4
CLEC3B
C-type lectin domain family 3, member B
chr14_-_60337684 7.33 ENST00000267484.5
RTN1
reticulon 1
chr22_-_38699003 7.30 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chr4_-_176733897 7.16 ENST00000393658.2
GPM6A
glycoprotein M6A
chr11_-_59383617 7.15 ENST00000263847.1
OSBP
oxysterol binding protein
chr18_+_61144160 7.15 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr4_+_74269956 6.76 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr11_-_5276008 6.65 ENST00000336906.4
HBG2
hemoglobin, gamma G
chr9_+_130911770 6.50 ENST00000372998.1
LCN2
lipocalin 2
chr5_+_40909354 6.43 ENST00000313164.9
C7
complement component 7
chr17_-_1733114 6.36 ENST00000305513.7
SMYD4
SET and MYND domain containing 4
chr1_-_203320617 6.35 ENST00000354955.4
FMOD
fibromodulin
chr9_-_93405352 6.29 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chrX_+_103031758 6.24 ENST00000303958.2
ENST00000361621.2
PLP1
proteolipid protein 1
chr5_-_34043310 6.21 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr9_+_130911723 6.18 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
LCN2
lipocalin 2
chr10_+_5005598 6.03 ENST00000442997.1
AKR1C1
aldo-keto reductase family 1, member C1
chr17_-_4167142 5.97 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr4_-_87028478 5.95 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr16_-_55867146 5.83 ENST00000422046.2
CES1
carboxylesterase 1
chr15_+_81475047 5.80 ENST00000559388.1
IL16
interleukin 16
chr19_+_49258775 5.78 ENST00000593756.1
FGF21
fibroblast growth factor 21
chrX_-_13835147 5.77 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr9_+_117085336 5.76 ENST00000259396.8
ENST00000538816.1
ORM1
orosomucoid 1
chr19_-_40324767 5.75 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr5_+_121647386 5.71 ENST00000542191.1
ENST00000506272.1
ENST00000508681.1
ENST00000509154.2
SNCAIP
synuclein, alpha interacting protein
chr16_+_6533729 5.71 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_-_10251576 5.69 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr11_-_5271122 5.60 ENST00000330597.3
HBG1
hemoglobin, gamma A
chr3_+_101498074 5.57 ENST00000273347.5
ENST00000474165.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr3_-_52860850 5.54 ENST00000441637.2
ITIH4
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr7_-_8302207 5.49 ENST00000407906.1
ICA1
islet cell autoantigen 1, 69kDa
chr2_+_30569506 5.43 ENST00000421976.2
AC109642.1
AC109642.1
chr7_-_8301869 5.37 ENST00000402384.3
ICA1
islet cell autoantigen 1, 69kDa
chr16_-_55866997 5.36 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr1_-_226926864 5.34 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr17_-_8066250 5.34 ENST00000488857.1
ENST00000481878.1
ENST00000316509.6
ENST00000498285.1
VAMP2
RP11-599B13.6
vesicle-associated membrane protein 2 (synaptobrevin 2)
Uncharacterized protein
chr14_+_22964877 5.31 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr1_+_22962948 5.29 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr2_+_241938255 5.28 ENST00000401884.1
ENST00000405547.3
ENST00000310397.8
ENST00000342631.6
SNED1
sushi, nidogen and EGF-like domains 1
chr12_+_113229737 5.20 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr1_+_118148556 5.18 ENST00000369448.3
FAM46C
family with sequence similarity 46, member C
chr7_-_8302164 5.17 ENST00000447326.1
ENST00000406470.2
ICA1
islet cell autoantigen 1, 69kDa
chr6_-_49681235 5.16 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr17_-_10452929 5.16 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr7_+_153749732 5.10 ENST00000377770.3
DPP6
dipeptidyl-peptidase 6
chr9_-_99064429 5.08 ENST00000375263.3
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr12_-_10251603 5.04 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr6_+_26156551 5.02 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr3_-_114343768 5.02 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_208989225 5.00 ENST00000264376.4
CRYGD
crystallin, gamma D
chrX_+_103031421 4.90 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
PLP1
proteolipid protein 1
chr3_-_194072019 4.88 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr12_-_53207842 4.88 ENST00000458244.2
KRT4
keratin 4
chr2_+_189839046 4.87 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr12_+_113229543 4.86 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr12_-_99038732 4.86 ENST00000393042.3
ENST00000420861.1
ENST00000299157.4
ENST00000342502.2
IKBIP
IKBKB interacting protein
chr17_+_34430980 4.83 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr2_-_176866978 4.83 ENST00000392540.2
ENST00000409660.1
ENST00000544803.1
ENST00000272748.4
KIAA1715
KIAA1715
chr2_+_17721230 4.81 ENST00000457525.1
VSNL1
visinin-like 1
chr3_+_111718173 4.75 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_4535155 4.74 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr11_+_126225789 4.71 ENST00000530591.1
ENST00000534083.1
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr12_-_13248562 4.69 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr18_-_5396271 4.64 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr6_+_150920999 4.62 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr16_+_67840986 4.58 ENST00000561639.1
ENST00000567852.1
ENST00000565148.1
ENST00000388833.3
ENST00000561654.1
ENST00000431934.2
TSNAXIP1
translin-associated factor X interacting protein 1
chr12_-_13248705 4.57 ENST00000396310.2
GSG1
germ cell associated 1
chrX_+_122993827 4.52 ENST00000371199.3
XIAP
X-linked inhibitor of apoptosis
chr17_-_10421853 4.48 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chrX_+_69642881 4.45 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
chr9_+_137967366 4.44 ENST00000252854.4
OLFM1
olfactomedin 1
chr14_-_76447494 4.42 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr9_+_37667978 4.41 ENST00000539465.1
FRMPD1
FERM and PDZ domain containing 1
chr13_-_36429763 4.40 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr4_+_113739244 4.37 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr18_+_77155856 4.30 ENST00000253506.5
ENST00000591814.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr9_+_137967268 4.29 ENST00000371799.4
ENST00000277415.11
OLFM1
olfactomedin 1
chr1_+_198608146 4.29 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_13835461 4.26 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr19_-_40440533 4.23 ENST00000221347.6
FCGBP
Fc fragment of IgG binding protein
chr4_+_71263599 4.20 ENST00000399575.2
PROL1
proline rich, lacrimal 1
chr10_-_21463116 4.18 ENST00000417816.2
NEBL
nebulette
chrX_+_122993657 4.13 ENST00000434753.3
ENST00000430625.1
XIAP
X-linked inhibitor of apoptosis
chr1_+_66797687 4.12 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_111150048 4.11 ENST00000485317.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr18_+_61575200 4.10 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr10_-_100995540 4.05 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chr12_+_69864129 4.04 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2
fibroblast growth factor receptor substrate 2
chr8_+_38585704 4.02 ENST00000519416.1
ENST00000520615.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr1_+_180601139 3.99 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr5_+_176853702 3.98 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chr3_+_4535025 3.98 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr11_+_63870660 3.88 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr19_-_12997995 3.86 ENST00000264834.4
KLF1
Kruppel-like factor 1 (erythroid)
chr19_-_40324255 3.84 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr10_-_100995603 3.84 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chr14_-_75079026 3.82 ENST00000261978.4
LTBP2
latent transforming growth factor beta binding protein 2
chr19_+_36249057 3.80 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr11_+_64004888 3.80 ENST00000541681.1
VEGFB
vascular endothelial growth factor B
chr12_-_13248598 3.75 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chrX_-_135849484 3.70 ENST00000370620.1
ENST00000535227.1
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_+_61699766 3.64 ENST00000579585.1
ENST00000584573.1
ENST00000361733.3
ENST00000361357.3
MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr17_+_72270380 3.63 ENST00000582036.1
ENST00000307504.5
DNAI2
dynein, axonemal, intermediate chain 2
chr11_-_128392085 3.63 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr12_+_122064398 3.62 ENST00000330079.7
ORAI1
ORAI calcium release-activated calcium modulator 1
chrX_+_37639264 3.61 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr7_+_94537542 3.56 ENST00000433881.1
PPP1R9A
protein phosphatase 1, regulatory subunit 9A
chr13_+_23755099 3.56 ENST00000537476.1
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr8_-_21988558 3.53 ENST00000312841.8
HR
hair growth associated
chr12_-_13248732 3.52 ENST00000396302.3
GSG1
germ cell associated 1
chr16_-_79634595 3.48 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr4_+_3076388 3.46 ENST00000355072.5
HTT
huntingtin
chr2_+_33701286 3.45 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_+_176853669 3.43 ENST00000355472.5
GRK6
G protein-coupled receptor kinase 6
chrX_+_37639302 3.43 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr16_+_21312170 3.43 ENST00000338573.5
ENST00000561968.1
CRYM-AS1
CRYM antisense RNA 1
chr1_-_120311517 3.42 ENST00000369406.3
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr5_-_55529115 3.42 ENST00000513241.2
ENST00000341048.4
ANKRD55
ankyrin repeat domain 55
chr11_+_47291193 3.39 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MADD
MAP-kinase activating death domain
chr2_-_158345462 3.39 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr17_+_29664830 3.37 ENST00000444181.2
ENST00000417592.2
NF1
neurofibromin 1
chr3_+_121613265 3.36 ENST00000295605.2
SLC15A2
solute carrier family 15 (oligopeptide transporter), member 2
chrX_-_69479654 3.35 ENST00000374519.2
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr12_+_56324756 3.26 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr9_-_104198042 3.26 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr15_+_59499031 3.25 ENST00000307144.4
LDHAL6B
lactate dehydrogenase A-like 6B
chr11_-_35547151 3.21 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr7_-_99381884 3.20 ENST00000336411.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr3_+_111260954 3.19 ENST00000283285.5
CD96
CD96 molecule
chr10_-_82049424 3.19 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chrX_+_122994112 3.14 ENST00000355640.3
XIAP
X-linked inhibitor of apoptosis
chr8_+_124194752 3.12 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr12_+_8995832 3.09 ENST00000541459.1
A2ML1
alpha-2-macroglobulin-like 1
chr7_-_99332719 3.06 ENST00000336374.2
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr3_+_111260856 3.04 ENST00000352690.4
CD96
CD96 molecule
chr13_-_29069232 3.04 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
FLT1
fms-related tyrosine kinase 1
chr14_-_98444386 3.01 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr1_-_21978312 3.00 ENST00000359708.4
ENST00000290101.4
RAP1GAP
RAP1 GTPase activating protein
chr13_+_23755054 2.97 ENST00000218867.3
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr7_-_97619508 2.96 ENST00000257627.4
OCM2
oncomodulin 2
chr19_+_12949251 2.96 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr8_+_133931648 2.96 ENST00000519178.1
ENST00000542445.1
TG
thyroglobulin
chr7_+_147830776 2.95 ENST00000538075.1
CNTNAP2
contactin associated protein-like 2
chr5_+_36608422 2.92 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_39769005 2.90 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr12_+_58138664 2.90 ENST00000257910.3
TSPAN31
tetraspanin 31
chr1_-_111148241 2.87 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr16_-_15474904 2.87 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr1_-_236046872 2.86 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr2_+_87565634 2.85 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr22_+_41763274 2.83 ENST00000406644.3
TEF
thyrotrophic embryonic factor
chr7_-_135433460 2.83 ENST00000415751.1
FAM180A
family with sequence similarity 180, member A
chr1_-_201081579 2.82 ENST00000367338.3
ENST00000362061.3
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr6_-_32784687 2.81 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_+_113970772 2.81 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr2_-_90538397 2.79 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr12_+_56114151 2.79 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr19_+_49259325 2.77 ENST00000222157.3
FGF21
fibroblast growth factor 21
chr9_+_71944241 2.76 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr20_+_42136308 2.74 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr3_+_148508845 2.74 ENST00000491148.1
CPB1
carboxypeptidase B1 (tissue)
chrX_+_22050546 2.73 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr15_+_58702742 2.73 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr5_+_152870106 2.72 ENST00000285900.5
GRIA1
glutamate receptor, ionotropic, AMPA 1
chr17_-_8093471 2.72 ENST00000389017.4
C17orf59
chromosome 17 open reading frame 59
chr2_-_160761179 2.71 ENST00000554112.1
ENST00000553424.1
ENST00000263636.4
ENST00000504764.1
ENST00000505052.1
LY75
LY75-CD302
lymphocyte antigen 75
LY75-CD302 readthrough
chr1_+_209878182 2.70 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr4_+_71226468 2.69 ENST00000226460.4
SMR3A
submaxillary gland androgen regulated protein 3A
chr5_+_161494521 2.66 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr12_+_100897130 2.66 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_-_175712665 2.65 ENST00000263525.2
TNR
tenascin R
chr5_+_67586465 2.65 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_+_36169380 2.63 ENST00000335119.2
CCIN
calicin
chr9_+_27109133 2.62 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr12_+_58138800 2.62 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr12_+_56114189 2.62 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chrX_-_85302531 2.59 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM
choroideremia (Rab escort protein 1)
chr2_+_3705785 2.58 ENST00000252505.3
ALLC
allantoicase
chr5_-_64777733 2.54 ENST00000381055.3
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_+_68592305 2.53 ENST00000234313.7
PLEK
pleckstrin
chr16_+_30383613 2.52 ENST00000568749.1
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr2_-_211036051 2.51 ENST00000418791.1
ENST00000452086.1
ENST00000281772.9
KANSL1L
KAT8 regulatory NSL complex subunit 1-like
chr6_-_30043539 2.46 ENST00000376751.3
ENST00000244360.6
RNF39
ring finger protein 39
chr5_+_140868717 2.46 ENST00000252087.1
PCDHGC5
protocadherin gamma subfamily C, 5
chr11_-_62389621 2.44 ENST00000531383.1
ENST00000265471.5
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
2.5 12.7 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
2.4 7.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.3 18.2 GO:0001661 conditioned taste aversion(GO:0001661)
2.3 6.8 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
2.1 8.6 GO:1904640 response to methionine(GO:1904640)
2.1 6.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
2.1 6.2 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
1.7 7.0 GO:0021633 optic nerve structural organization(GO:0021633)
1.7 8.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.6 4.9 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
1.5 19.6 GO:0070327 thyroid hormone transport(GO:0070327)
1.5 4.5 GO:0044278 cell wall disruption in other organism(GO:0044278)
1.4 7.0 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.3 4.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
1.2 3.5 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
1.1 3.4 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
1.1 6.7 GO:0061370 testosterone biosynthetic process(GO:0061370)
1.1 11.2 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
1.1 8.9 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
1.1 4.4 GO:1905071 ossification involved in bone remodeling(GO:0043932) frontal suture morphogenesis(GO:0060364) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
1.1 5.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.1 3.3 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.1 4.3 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
1.0 23.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
1.0 10.0 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.0 3.0 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
1.0 3.0 GO:0071109 superior temporal gyrus development(GO:0071109)
1.0 8.7 GO:0003190 atrioventricular valve formation(GO:0003190)
1.0 2.9 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.9 5.7 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.9 2.8 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.9 16.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.9 2.8 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.9 3.6 GO:0072402 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.9 5.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.9 2.6 GO:0043605 cellular amide catabolic process(GO:0043605)
0.9 4.3 GO:0048539 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
0.9 11.1 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.8 5.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 12.3 GO:0015671 oxygen transport(GO:0015671)
0.8 3.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.8 2.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.8 5.3 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.8 5.3 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.7 5.9 GO:0007258 JUN phosphorylation(GO:0007258)
0.7 5.8 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.7 2.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.7 4.8 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.7 1.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.7 2.7 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.7 4.6 GO:0071205 protein localization to paranode region of axon(GO:0002175) protein localization to juxtaparanode region of axon(GO:0071205)
0.6 3.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.6 5.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.6 3.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.6 1.8 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.6 6.0 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.6 2.4 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.6 4.0 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6 1.7 GO:0010840 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.5 2.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.5 1.6 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.5 2.7 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.5 2.7 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.5 3.6 GO:0030578 PML body organization(GO:0030578)
0.5 1.0 GO:0008050 female courtship behavior(GO:0008050)
0.5 1.5 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.5 2.0 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.5 2.0 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.5 12.6 GO:0001502 cartilage condensation(GO:0001502)
0.5 3.4 GO:0006857 oligopeptide transport(GO:0006857)
0.5 1.9 GO:0061056 sclerotome development(GO:0061056)
0.5 10.5 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.5 2.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 3.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 2.2 GO:0072021 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
0.4 1.8 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.4 1.3 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.4 5.2 GO:0001778 plasma membrane repair(GO:0001778)
0.4 7.3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.4 2.5 GO:0033625 positive regulation of integrin activation(GO:0033625) protein secretion by platelet(GO:0070560)
0.4 2.9 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 1.7 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.4 2.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 1.6 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.4 2.0 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.4 0.8 GO:0046110 xanthine metabolic process(GO:0046110)
0.4 4.9 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.4 1.9 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.4 1.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.4 3.0 GO:0015705 iodide transport(GO:0015705)
0.4 1.8 GO:0072553 terminal button organization(GO:0072553)
0.3 4.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 3.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 4.5 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.7 GO:0071895 odontoblast differentiation(GO:0071895)
0.3 1.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 3.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 7.2 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.3 3.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 1.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 2.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 1.7 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.3 3.4 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.3 3.7 GO:0051546 keratinocyte migration(GO:0051546)
0.3 3.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.3 1.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.3 2.2 GO:0097106 postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 1.9 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.3 0.8 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.3 6.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 0.5 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.3 1.8 GO:0043587 tongue morphogenesis(GO:0043587)
0.3 2.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 10.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 0.7 GO:1900158 hormone-mediated apoptotic signaling pathway(GO:0008628) positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 0.5 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.2 1.4 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.2 9.6 GO:0007520 myoblast fusion(GO:0007520)
0.2 4.7 GO:0071420 cellular response to histamine(GO:0071420)
0.2 3.5 GO:0006449 regulation of translational termination(GO:0006449)
0.2 0.7 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 1.1 GO:0001555 oocyte growth(GO:0001555)
0.2 8.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.2 1.0 GO:0003344 pericardium morphogenesis(GO:0003344)
0.2 7.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 3.0 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.2 3.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 2.7 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.2 5.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 0.9 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 2.7 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.2 4.7 GO:0097503 sialylation(GO:0097503)
0.2 5.4 GO:0042572 retinol metabolic process(GO:0042572)
0.2 3.0 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.2 5.7 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.2 0.9 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.2 1.1 GO:0001575 globoside metabolic process(GO:0001575)
0.2 3.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 1.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 0.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 2.3 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.2 0.9 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 4.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.1 5.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 4.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 1.3 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 0.6 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.6 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 0.8 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 1.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 5.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 6.7 GO:0010165 response to X-ray(GO:0010165)
0.1 0.6 GO:0009624 response to nematode(GO:0009624)
0.1 1.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 2.4 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1 7.2 GO:0003407 neural retina development(GO:0003407)
0.1 5.3 GO:0010039 response to iron ion(GO:0010039)
0.1 2.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.9 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.6 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 1.5 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 6.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 1.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.5 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 2.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.4 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.7 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 4.8 GO:0006953 acute-phase response(GO:0006953)
0.1 3.9 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 2.4 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 2.0 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 11.3 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 1.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.8 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.1 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 3.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 2.5 GO:0060976 coronary vasculature development(GO:0060976)
0.1 2.1 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 1.5 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 9.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 4.0 GO:0055001 muscle cell development(GO:0055001)
0.1 1.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 2.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.9 GO:0010543 regulation of platelet activation(GO:0010543)
0.1 1.9 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 0.9 GO:0007595 lactation(GO:0007595)
0.1 3.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 5.2 GO:0030449 regulation of complement activation(GO:0030449)
0.0 2.7 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 3.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.9 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.8 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.2 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 1.3 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 2.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 2.0 GO:0030217 T cell differentiation(GO:0030217)
0.0 4.0 GO:0021987 cerebral cortex development(GO:0021987)
0.0 3.7 GO:0070268 cornification(GO:0070268)
0.0 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 1.3 GO:0007140 male meiosis(GO:0007140)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.8 GO:1990138 neuron projection extension(GO:1990138)
0.0 0.7 GO:0010761 fibroblast migration(GO:0010761)
0.0 2.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.1 GO:0048839 inner ear development(GO:0048839)
0.0 1.5 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 1.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 1.6 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 2.3 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 2.2 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 2.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 1.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.4 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 2.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.2 GO:0035976 AP1 complex(GO:0035976)
1.7 5.2 GO:0005826 actomyosin contractile ring(GO:0005826)
1.5 7.4 GO:0001652 granular component(GO:0001652)
1.3 5.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.2 6.0 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
1.1 5.3 GO:0005602 complement component C1 complex(GO:0005602)
1.0 8.7 GO:0005955 calcineurin complex(GO:0005955)
0.9 3.6 GO:0043293 apoptosome(GO:0043293)
0.9 2.7 GO:0072534 perineuronal net(GO:0072534)
0.9 12.3 GO:0005833 hemoglobin complex(GO:0005833)
0.9 2.6 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.8 9.9 GO:0033010 paranodal junction(GO:0033010)
0.8 6.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.8 16.9 GO:0044295 axonal growth cone(GO:0044295)
0.7 3.6 GO:0044308 axonal spine(GO:0044308)
0.7 6.4 GO:0005579 membrane attack complex(GO:0005579)
0.7 4.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.7 2.7 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.6 2.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.6 1.9 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.6 16.7 GO:0034451 centriolar satellite(GO:0034451)
0.6 3.5 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.5 3.6 GO:0044326 dendritic spine neck(GO:0044326)
0.5 3.6 GO:0036157 outer dynein arm(GO:0036157)
0.5 2.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.4 3.4 GO:0014802 terminal cisterna(GO:0014802)
0.4 6.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 2.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 9.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 5.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 5.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.3 1.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 26.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 3.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 3.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.2 GO:0031905 early endosome lumen(GO:0031905)
0.2 6.1 GO:0032982 myosin filament(GO:0032982)
0.2 2.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 20.7 GO:0035580 specific granule lumen(GO:0035580)
0.2 9.3 GO:0031430 M band(GO:0031430)
0.2 1.7 GO:0005587 collagen type IV trimer(GO:0005587)
0.2 1.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.2 4.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.9 GO:0097427 microtubule bundle(GO:0097427)
0.2 3.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 4.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 20.3 GO:0005814 centriole(GO:0005814)
0.2 1.8 GO:0097486 multivesicular body lumen(GO:0097486)
0.2 2.5 GO:0005859 muscle myosin complex(GO:0005859)
0.2 3.9 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 2.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.8 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.9 GO:0030478 actin cap(GO:0030478)
0.1 11.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 3.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 10.5 GO:0043209 myelin sheath(GO:0043209)
0.1 1.6 GO:0036020 endolysosome membrane(GO:0036020)
0.1 2.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 8.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.3 GO:0043194 axon initial segment(GO:0043194)
0.1 5.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 17.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.8 GO:0005581 collagen trimer(GO:0005581)
0.1 2.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.5 GO:0002080 acrosomal membrane(GO:0002080)
0.1 1.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 20.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 4.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.4 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.9 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 4.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.7 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 3.6 GO:0030018 Z disc(GO:0030018)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 7.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 5.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 1.4 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 3.6 GO:0009986 cell surface(GO:0009986)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 1.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.7 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.8 GO:0045121 membrane raft(GO:0045121)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
2.5 7.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
2.2 11.2 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
2.2 8.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
2.0 7.9 GO:0030305 heparanase activity(GO:0030305)
1.9 7.7 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.9 18.9 GO:0070324 thyroid hormone binding(GO:0070324)
1.6 4.9 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
1.5 4.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
1.2 4.7 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
1.1 3.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
1.1 6.7 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
1.1 4.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.0 7.2 GO:0008142 oxysterol binding(GO:0008142)
1.0 5.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.9 12.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.9 11.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.9 10.1 GO:0008430 selenium binding(GO:0008430)
0.9 2.7 GO:0032093 SAM domain binding(GO:0032093)
0.9 2.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.9 5.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.9 2.7 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.8 5.0 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.8 2.4 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.7 3.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 4.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.7 2.0 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.7 5.9 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.6 3.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 1.8 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.6 2.4 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.6 5.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.5 1.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 1.6 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.5 2.1 GO:0016499 orexin receptor activity(GO:0016499)
0.5 2.6 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.5 7.8 GO:0015643 toxic substance binding(GO:0015643)
0.5 5.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.5 3.3 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.5 3.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.5 13.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.4 1.7 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.4 2.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.4 1.7 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.4 4.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.4 7.0 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.4 1.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.4 4.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.3 2.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 4.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 6.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3 15.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 6.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.9 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 5.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.3 1.8 GO:0017018 myosin phosphatase activity(GO:0017018)
0.3 3.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 8.2 GO:0005523 tropomyosin binding(GO:0005523)
0.3 3.5 GO:0034452 dynactin binding(GO:0034452)
0.3 4.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 3.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 3.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.3 5.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.3 3.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 1.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 1.3 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.3 0.8 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 1.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 1.7 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 2.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 1.6 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.2 1.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 24.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 0.9 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.2 1.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 3.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 0.9 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.2 4.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 3.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 2.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 5.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 2.0 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.2 5.4 GO:0005123 death receptor binding(GO:0005123)
0.2 12.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 3.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 0.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 3.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 2.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.6 GO:0004040 amidase activity(GO:0004040)
0.2 5.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 0.8 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.2 3.6 GO:0045503 dynein light chain binding(GO:0045503)
0.2 0.8 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.2 2.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 7.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 7.2 GO:0030507 spectrin binding(GO:0030507)
0.1 1.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 2.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 4.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 4.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.8 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 0.1 GO:0070888 E-box binding(GO:0070888)
0.1 3.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.2 GO:0019864 IgG binding(GO:0019864)
0.1 1.9 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 1.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 5.9 GO:0044325 ion channel binding(GO:0044325)
0.1 12.7 GO:0002020 protease binding(GO:0002020)
0.1 2.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 4.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 9.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 9.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 1.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 3.0 GO:0030546 receptor activator activity(GO:0030546)
0.1 0.8 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 2.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 21.9 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.7 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.4 GO:0005113 patched binding(GO:0005113)
0.1 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 1.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.4 GO:0043236 laminin binding(GO:0043236)
0.1 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 5.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 8.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 8.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 11.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 2.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 3.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 6.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 3.1 GO:0008201 heparin binding(GO:0008201)
0.0 3.7 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 1.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 5.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 1.2 GO:0019213 deacetylase activity(GO:0019213)
0.0 3.0 GO:0017016 Ras GTPase binding(GO:0017016)
0.0 4.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0016248 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 1.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.6 14.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5 5.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.4 11.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4 6.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.3 6.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 23.9 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.3 22.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 7.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 10.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3 13.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 40.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.7 PID RAS PATHWAY Regulation of Ras family activation
0.2 12.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 6.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 11.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 37.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 4.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 8.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 5.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 5.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 3.6 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 1.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.2 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.8 PID ATR PATHWAY ATR signaling pathway
0.1 1.1 PID IL23 PATHWAY IL23-mediated signaling events
0.1 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.9 PID AP1 PATHWAY AP-1 transcription factor network
0.1 1.9 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 2.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 1.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 8.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.8 PID P73PATHWAY p73 transcription factor network
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 24.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.6 10.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.5 7.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.5 5.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 6.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.4 8.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.4 6.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 6.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 3.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 5.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 15.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.3 5.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 4.4 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 5.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 3.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 7.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 4.0 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.2 5.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 4.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 4.1 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 4.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 7.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.7 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 6.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 5.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 6.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 7.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 4.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 0.8 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.5 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.1 1.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 5.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 6.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases