ISMARA results: NFIL3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFIL3

Z-value: 1.50

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Transcription factors associated with NFIL3

Gene Symbol	Gene ID	Gene Info
NFIL3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000165030.3	nuclear factor, interleukin 3 regulated

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIL3	hg19_v2_chr9_-_94186131_94186174	-0.18	6.5e-03	Click!

Activity profile of NFIL3 motif

Sorted Z-values of NFIL3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_27468842 Show fit	48.76	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr5_+_150404904 Show fit	27.97	ENST00000521632.1	GPX3 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione peroxidase 3 (plasma)
chr4_-_88450612 Show fit	27.68	ENST00000418378.1 ENST00000282470.6	SPARCL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SPARC-like 1 (hevin)
chr10_-_5046042 Show fit	27.07	ENST00000421196.3 ENST00000455190.1	AKR1C2 Ensembl NCBI GeneCards UniProt NextProt Show fit	aldo-keto reductase family 1, member C2
chr12_-_91573132 Show fit	26.82	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_-_5248294 Show fit	26.64	ENST00000335295.4	HBB Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, beta
chr12_-_91573316 Show fit	25.18	ENST00000393155.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91573249 Show fit	23.96	ENST00000550099.1 ENST00000546391.1 ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr9_+_139871948 Show fit	23.58	ENST00000224167.2 ENST00000457950.1 ENST00000371625.3 ENST00000371623.3	PTGDS Ensembl NCBI GeneCards UniProt NextProt Show fit	prostaglandin D2 synthase 21kDa (brain)
chr8_-_27468945 Show fit	23.38	ENST00000405140.3	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIL3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.7	116.9	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
15.1	90.5	GO:1902998	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
9.9	69.4	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.3	46.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
14.2	42.5	GO:0006982	response to lipid hydroperoxide(GO:0006982)
1.6	36.4	GO:0052695	cellular glucuronidation(GO:0052695)
0.0	29.2	GO:0043547	positive regulation of GTPase activity(GO:0043547)
6.7	26.6	GO:0030185	nitric oxide transport(GO:0030185)
0.9	25.9	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.7	24.3	GO:0008045	motor neuron axon guidance(GO:0008045)

Showing 1 to 10 of 403 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	181.6	GO:0016021	integral component of membrane(GO:0016021)
7.8	109.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
6.5	90.5	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	80.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.4	45.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	34.8	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3	34.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
7.8	31.4	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
1.5	30.6	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
7.6	30.2	GO:0097224	sperm connecting piece(GO:0097224)

Showing 1 to 10 of 167 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	162.0	GO:0050840	extracellular matrix binding(GO:0050840)
4.5	90.5	GO:0051787	misfolded protein binding(GO:0051787)
11.5	69.2	GO:0047115	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
1.3	49.4	GO:0015020	glucuronosyltransferase activity(GO:0015020)
3.9	42.5	GO:0008430	selenium binding(GO:0008430)
0.0	34.1	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
5.6	33.6	GO:0030492	hemoglobin binding(GO:0030492)
0.3	30.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.5	30.2	GO:0032027	myosin light chain binding(GO:0032027)
1.8	29.3	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)

Showing 1 to 10 of 299 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	112.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.7	102.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	91.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	75.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	40.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.5	26.1	PID ATM PATHWAY	ATM pathway
0.3	20.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.8	19.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	18.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	17.0	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 55 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	119.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
4.0	109.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.8	45.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
1.7	45.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	45.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.7	37.2	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
1.4	34.6	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	31.7	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.4	21.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.6	21.0	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway

Showing 1 to 10 of 101 entries

Results for NFIL3

Z-value: 1.50

Motif logo

Transcription factors associated with NFIL3

Activity-expression correlation:

Activity profile of NFIL3 motif

Sorted Z-values of NFIL3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIL3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: