ISMARA results: NFKB1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFKB1

Z-value: 1.55

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Transcription factors associated with NFKB1

Gene Symbol	Gene ID	Gene Info
NFKB1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000109320.7	nuclear factor kappa B subunit 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB1	hg19_v2_chr4_+_103423055_103423112, hg19_v2_chr4_+_103422471_103422495	0.31	2.3e-06	Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_149792295 Show fit	62.13	ENST00000518797.1 ENST00000524315.1 ENST00000009530.7 ENST00000377795.3	CD74 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_+_1067492 Show fit	34.80	ENST00000586866.1	HMHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	histocompatibility (minor) HA-1
chr6_+_32605195 Show fit	34.68	ENST00000374949.2	HLA-DQA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ alpha 1
chr19_+_1067144 Show fit	34.53	ENST00000313093.2	HMHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	histocompatibility (minor) HA-1
chr19_+_1067271 Show fit	33.34	ENST00000536472.1 ENST00000590214.1	HMHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	histocompatibility (minor) HA-1
chr6_+_138188551 Show fit	32.31	ENST00000237289.4 ENST00000433680.1	TNFAIP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 3
chr1_+_6845384 Show fit	30.19	ENST00000303635.7	CAMTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin binding transcription activator 1
chr22_-_37640277 Show fit	28.82	ENST00000401529.3 ENST00000249071.6	RAC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_50776021 Show fit	28.35	ENST00000566679.2 ENST00000564634.1 ENST00000398568.2	CYLD Ensembl NCBI GeneCards UniProt NextProt Show fit	cylindromatosis (turban tumor syndrome)
chr19_+_42381173 Show fit	26.51	ENST00000221972.3	CD79A Ensembl NCBI GeneCards UniProt NextProt Show fit	CD79a molecule, immunoglobulin-associated alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
24.7	74.0	GO:1990108	protein linear deubiquitination(GO:1990108)
0.7	72.2	GO:0031295	T cell costimulation(GO:0031295)
12.4	62.1	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
5.4	59.3	GO:0060263	regulation of respiratory burst(GO:0060263)
4.8	47.5	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.5	45.1	GO:0042100	B cell proliferation(GO:0042100)
2.6	44.8	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
13.8	41.5	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
11.0	33.1	GO:0090291	negative regulation of osteoclast proliferation(GO:0090291)
0.3	30.8	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)

Showing 1 to 10 of 185 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.4	89.3	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
1.7	74.0	GO:0097542	ciliary tip(GO:0097542)
8.9	62.1	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
2.9	58.9	GO:0042611	MHC protein complex(GO:0042611)
0.2	56.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.8	56.6	GO:0030670	phagocytic vesicle membrane(GO:0030670)
6.9	48.6	GO:0019815	B cell receptor complex(GO:0019815)
0.2	47.9	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
4.3	47.5	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	43.5	GO:0016607	nuclear speck(GO:0016607)

Showing 1 to 10 of 99 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.6	106.3	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
1.5	75.7	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
12.4	62.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.2	60.6	GO:0019887	protein kinase regulator activity(GO:0019887)
4.5	58.9	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	48.5	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
8.1	48.4	GO:0046979	TAP2 binding(GO:0046979)
0.1	47.5	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
3.7	44.9	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.3	38.1	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 132 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	138.3	PID CD40 PATHWAY	CD40/CD40L signaling
1.1	52.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.2	50.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.7	48.6	PID BCR 5PATHWAY	BCR signaling pathway
2.2	48.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
1.3	42.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.5	34.5	PID IL12 2PATHWAY	IL12-mediated signaling events
1.1	33.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.4	29.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	26.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	128.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.6	65.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.2	59.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
2.6	58.9	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.3	48.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
4.8	47.5	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.4	44.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.8	37.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.7	35.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
1.1	30.9	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane

Showing 1 to 10 of 70 entries

Results for NFKB1

Z-value: 1.55

Motif logo

Transcription factors associated with NFKB1

Activity-expression correlation:

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: