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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFKB1

Z-value: 1.55

Motif logo

Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
ENSG00000109320.7 nuclear factor kappa B subunit 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v2_chr4_+_103423055_103423112,
hg19_v2_chr4_+_103422471_103422495
0.312.3e-06Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_149792295 62.13 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_+_1067492 34.80 ENST00000586866.1
histocompatibility (minor) HA-1
chr6_+_32605195 34.68 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr19_+_1067144 34.53 ENST00000313093.2
histocompatibility (minor) HA-1
chr19_+_1067271 33.34 ENST00000536472.1
ENST00000590214.1
histocompatibility (minor) HA-1
chr6_+_138188551 32.31 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr1_+_6845384 30.19 ENST00000303635.7
calmodulin binding transcription activator 1
chr22_-_37640277 28.82 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_50776021 28.35 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr19_+_42381173 26.51 ENST00000221972.3
CD79a molecule, immunoglobulin-associated alpha
chr17_+_40440481 25.74 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
signal transducer and activator of transcription 5A
chr6_-_31550192 25.40 ENST00000429299.2
ENST00000446745.2
lymphotoxin beta (TNF superfamily, member 3)
chr22_-_37640456 25.09 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_+_32605134 24.19 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chr16_+_50775971 23.38 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr16_+_50775948 22.22 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
cylindromatosis (turban tumor syndrome)
chr19_+_42381337 22.12 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr15_+_85923797 22.06 ENST00000559362.1
A kinase (PRKA) anchor protein 13
chr15_+_85923856 19.48 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
A kinase (PRKA) anchor protein 13
chr11_-_58345569 19.42 ENST00000528954.1
ENST00000528489.1
leupaxin
chr6_+_29691198 19.27 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr14_-_35873856 19.13 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr6_+_14117872 18.31 ENST00000379153.3
CD83 molecule
chr6_+_29691056 18.17 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
major histocompatibility complex, class I, F
chr2_-_177502659 18.05 ENST00000295549.4
long intergenic non-protein coding RNA 1116
chr3_+_101546827 17.87 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr14_+_73704201 17.81 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
papilin, proteoglycan-like sulfated glycoprotein
chr1_-_202130702 17.53 ENST00000309017.3
ENST00000477554.1
ENST00000492451.1
protein tyrosine phosphatase, non-receptor type 7
chr11_+_128562372 16.59 ENST00000344954.6
Fli-1 proto-oncogene, ETS transcription factor
chr2_+_61108771 16.26 ENST00000394479.3
v-rel avian reticuloendotheliosis viral oncogene homolog
chr19_+_50922187 16.18 ENST00000595883.1
ENST00000597855.1
ENST00000596074.1
ENST00000439922.2
ENST00000594685.1
ENST00000270632.7
Spi-B transcription factor (Spi-1/PU.1 related)
chr12_-_9913489 15.75 ENST00000228434.3
ENST00000536709.1
CD69 molecule
chr4_-_134070250 15.68 ENST00000505289.1
ENST00000509715.1
RP11-9G1.3
chr2_+_61108650 15.49 ENST00000295025.8
v-rel avian reticuloendotheliosis viral oncogene homolog
chr1_-_236030216 14.95 ENST00000389794.3
ENST00000389793.2
lysosomal trafficking regulator
chr6_+_32821924 14.90 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr1_-_202129105 14.61 ENST00000367279.4
protein tyrosine phosphatase, non-receptor type 7
chr19_-_39390440 14.50 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
sirtuin 2
chr17_-_61777090 14.35 ENST00000578061.1
LIM domain containing 2
chr19_-_39390350 14.05 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
sirtuin 2
chr2_+_97202480 13.30 ENST00000357485.3
AT rich interactive domain 5A (MRF1-like)
chr19_+_45504688 13.04 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr14_+_75988851 13.04 ENST00000555504.1
basic leucine zipper transcription factor, ATF-like
chr16_+_28834531 12.67 ENST00000570200.1
ataxin 2-like
chr4_+_103422471 12.65 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr11_+_113930291 12.55 ENST00000335953.4
zinc finger and BTB domain containing 16
chr22_-_39151947 12.39 ENST00000216064.4
Sad1 and UNC84 domain containing 2
chr22_-_39151995 12.11 ENST00000405018.1
ENST00000438058.1
Sad1 and UNC84 domain containing 2
chr1_-_202129704 11.83 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
protein tyrosine phosphatase, non-receptor type 7
chr19_+_2476116 11.62 ENST00000215631.4
ENST00000587345.1
growth arrest and DNA-damage-inducible, beta
chr5_-_127418755 11.44 ENST00000501702.2
ENST00000501173.2
ENST00000514573.1
ENST00000499346.2
ENST00000606251.1
CTC-228N24.3
chr6_+_106534192 11.34 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr1_+_183441500 11.26 ENST00000456731.2
SMG7 nonsense mediated mRNA decay factor
chr19_+_42363917 11.15 ENST00000598742.1
ribosomal protein S19
chr10_+_104154229 11.10 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_-_161168834 11.03 ENST00000367995.3
ENST00000367996.5
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr6_-_32821599 10.98 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_156123359 10.69 ENST00000368284.1
ENST00000368286.2
ENST00000438830.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr14_-_64970494 10.69 ENST00000608382.1
zinc finger and BTB domain containing 25
chr12_+_52445191 10.62 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4, group A, member 1
chr19_+_41222998 10.58 ENST00000263370.2
inositol-trisphosphate 3-kinase C
chr11_+_102188272 10.49 ENST00000532808.1
baculoviral IAP repeat containing 3
chr10_+_30722866 10.38 ENST00000263056.1
mitogen-activated protein kinase kinase kinase 8
chr1_+_156123318 10.33 ENST00000368285.3
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_+_176957619 10.22 ENST00000392539.3
homeobox D13
chr3_-_50605077 9.74 ENST00000426034.1
ENST00000441239.1
chromosome 3 open reading frame 18
chr12_+_100661156 9.73 ENST00000360820.2
SCY1-like 2 (S. cerevisiae)
chr6_+_29910301 9.55 ENST00000376809.5
ENST00000376802.2
major histocompatibility complex, class I, A
chrX_-_73072534 9.49 ENST00000429829.1
X inactive specific transcript (non-protein coding)
chr14_+_61789382 9.45 ENST00000555082.1
protein kinase C, eta
chr4_-_5891918 9.33 ENST00000512574.1
collapsin response mediator protein 1
chr11_+_102188224 9.32 ENST00000263464.3
baculoviral IAP repeat containing 3
chr16_+_3096638 9.24 ENST00000336577.4
matrix metallopeptidase 25
chr1_+_111770278 9.22 ENST00000369748.4
chitinase 3-like 2
chr19_-_54784353 9.21 ENST00000391746.1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr3_+_53195136 9.13 ENST00000394729.2
ENST00000330452.3
protein kinase C, delta
chr14_+_75536280 9.12 ENST00000238686.8
zinc finger, C2HC-type containing 1C
chr19_+_42364460 9.06 ENST00000593863.1
ribosomal protein S19
chr1_+_37940153 9.00 ENST00000373087.6
zinc finger CCCH-type containing 12A
chr19_+_496454 8.97 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
mucosal vascular addressin cell adhesion molecule 1
chr11_-_64570706 8.96 ENST00000294066.2
ENST00000377350.3
mitogen-activated protein kinase kinase kinase kinase 2
chr9_+_82187630 8.92 ENST00000265284.6
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_10857885 8.82 ENST00000254488.2
ENST00000454147.1
solute carrier family 6 (neurotransmitter transporter), member 11
chr6_-_150039249 8.80 ENST00000543571.1
large tumor suppressor kinase 1
chr2_-_157189180 8.80 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
nuclear receptor subfamily 4, group A, member 2
chr17_-_7197881 8.76 ENST00000007699.5
Y box binding protein 2
chr1_+_100818156 8.76 ENST00000336454.3
cell division cycle 14A
chr6_+_292051 8.71 ENST00000344450.5
dual specificity phosphatase 22
chr9_+_82188077 8.71 ENST00000425506.1
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_75536335 8.32 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
zinc finger, C2HC-type containing 1C
chr19_+_51728316 8.29 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr3_-_50605150 8.26 ENST00000357203.3
chromosome 3 open reading frame 18
chr9_+_82187487 8.16 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr9_-_123691047 8.09 ENST00000373887.3
TNF receptor-associated factor 1
chr4_-_74964904 8.05 ENST00000508487.2
chemokine (C-X-C motif) ligand 2
chr17_-_1419878 7.95 ENST00000449479.1
ENST00000477910.1
ENST00000542125.1
ENST00000575172.1
inositol polyphosphate-5-phosphatase K
chr1_+_100818009 7.95 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr2_+_97203082 7.92 ENST00000454558.2
AT rich interactive domain 5A (MRF1-like)
chr11_-_72853091 7.90 ENST00000311172.7
ENST00000409314.1
FCH and double SH3 domains 2
chrX_-_37706661 7.84 ENST00000432389.2
ENST00000378581.3
dynein, light chain, Tctex-type 3
chr1_+_27561104 7.83 ENST00000361771.3
WD and tetratricopeptide repeats 1
chr12_-_54982300 7.82 ENST00000547431.1
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr4_+_185395947 7.81 ENST00000605834.1
RP11-326I11.3
chr12_+_11802753 7.80 ENST00000396373.4
ets variant 6
chr4_-_76944621 7.70 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr6_-_29527702 7.67 ENST00000377050.4
ubiquitin D
chr19_+_42364313 7.66 ENST00000601492.1
ENST00000600467.1
ENST00000221975.2
ribosomal protein S19
chr6_+_135502466 7.65 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr17_+_4634705 7.51 ENST00000575284.1
ENST00000573708.1
ENST00000293777.5
mediator complex subunit 11
chr17_-_1419914 7.48 ENST00000397335.3
ENST00000574561.1
inositol polyphosphate-5-phosphatase K
chr17_-_7123021 7.45 ENST00000399510.2
discs, large homolog 4 (Drosophila)
chr4_-_120550146 7.41 ENST00000354960.3
phosphodiesterase 5A, cGMP-specific
chr11_-_133826852 7.38 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr1_-_161279749 7.30 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
myelin protein zero
chr17_-_1420182 7.29 ENST00000421807.2
inositol polyphosphate-5-phosphatase K
chr19_-_2042065 7.29 ENST00000591588.1
ENST00000591142.1
MAP kinase interacting serine/threonine kinase 2
chr19_+_40697514 7.10 ENST00000253055.3
mitogen-activated protein kinase kinase kinase 10
chr1_+_211432775 6.98 ENST00000419091.2
REST corepressor 3
chr16_+_28835437 6.92 ENST00000568266.1
ataxin 2-like
chr4_-_76928641 6.91 ENST00000264888.5
chemokine (C-X-C motif) ligand 9
chr11_+_118754475 6.90 ENST00000292174.4
chemokine (C-X-C motif) receptor 5
chr19_-_17958832 6.87 ENST00000458235.1
Janus kinase 3
chr5_-_95297534 6.87 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr17_-_1420006 6.86 ENST00000320345.6
ENST00000406424.4
inositol polyphosphate-5-phosphatase K
chr5_-_95297678 6.79 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chr17_-_40333150 6.75 ENST00000264661.3
potassium voltage-gated channel, subfamily H (eag-related), member 4
chrX_+_147582228 6.68 ENST00000342251.3
AF4/FMR2 family, member 2
chr6_-_44233361 6.68 ENST00000275015.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_33160231 6.67 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
collagen, type XI, alpha 2
chr11_+_94706973 6.61 ENST00000536741.1
lysine (K)-specific demethylase 4D
chr16_+_28834303 6.58 ENST00000340394.8
ENST00000325215.6
ENST00000395547.2
ENST00000336783.4
ENST00000382686.4
ENST00000564304.1
ataxin 2-like
chr3_-_194072019 6.57 ENST00000429275.1
ENST00000323830.3
carboxypeptidase N, polypeptide 2
chr6_+_144471643 6.56 ENST00000367568.4
syntaxin 11
chr2_-_206950781 6.47 ENST00000403263.1
INO80 complex subunit D
chr7_+_143013198 6.45 ENST00000343257.2
chloride channel, voltage-sensitive 1
chr15_-_77712477 6.39 ENST00000560626.2
pseudopodium-enriched atypical kinase 1
chr11_+_1860682 6.38 ENST00000381906.1
troponin I type 2 (skeletal, fast)
chr17_-_40333099 6.26 ENST00000607371.1
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr8_+_73449625 6.22 ENST00000523207.1
potassium voltage-gated channel, Shab-related subfamily, member 2
chr19_-_13617247 6.22 ENST00000573710.2
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr1_+_211432593 6.17 ENST00000367006.4
REST corepressor 3
chr1_+_27561007 6.15 ENST00000319394.3
WD and tetratricopeptide repeats 1
chr2_-_100721923 6.13 ENST00000356421.2
AF4/FMR2 family, member 3
chr20_+_44746885 6.03 ENST00000372285.3
CD40 molecule, TNF receptor superfamily member 5
chr1_+_111770232 5.93 ENST00000369744.2
chitinase 3-like 2
chr9_-_136344197 5.89 ENST00000414172.1
ENST00000371897.4
solute carrier family 2 (facilitated glucose transporter), member 6
chr11_-_47399942 5.76 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400078 5.66 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr1_-_57889687 5.59 ENST00000371236.2
ENST00000371230.1
Dab, reelin signal transducer, homolog 1 (Drosophila)
chr11_-_3862206 5.53 ENST00000351018.4
ras homolog family member G
chr12_-_54982420 5.48 ENST00000257905.8
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr12_-_57504069 5.47 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_+_54359854 5.43 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
deiodinase, iodothyronine, type I
chr6_+_31949801 5.43 ENST00000428956.2
ENST00000498271.1
complement component 4A (Rodgers blood group)
chr9_-_115480303 5.34 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INTS3 and NABP interacting protein
chr5_-_135231516 5.34 ENST00000274520.1
interleukin 9
chr6_-_33168391 5.33 ENST00000374685.4
ENST00000413614.2
ENST00000374680.3
retinoid X receptor, beta
chr4_-_76957214 5.27 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr15_-_27018884 5.26 ENST00000299267.4
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr2_-_152955213 5.18 ENST00000427385.1
calcium channel, voltage-dependent, beta 4 subunit
chr11_+_63997750 5.05 ENST00000321685.3
DnaJ (Hsp40) homolog, subfamily C, member 4
chr20_+_44746939 5.04 ENST00000372276.3
CD40 molecule, TNF receptor superfamily member 5
chr6_-_109762344 4.98 ENST00000521072.2
ENST00000424445.2
ENST00000440797.2
peptidylprolyl isomerase (cyclophilin)-like 6
chr5_-_150521192 4.96 ENST00000523714.1
ENST00000521749.1
annexin A6
chr3_+_137483579 4.96 ENST00000306087.1
SRY (sex determining region Y)-box 14
chr10_-_51371321 4.93 ENST00000602930.1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr2_+_208394658 4.89 ENST00000421139.1
cAMP responsive element binding protein 1
chr4_-_120549163 4.82 ENST00000394439.1
ENST00000420633.1
phosphodiesterase 5A, cGMP-specific
chr1_-_16302565 4.79 ENST00000537142.1
ENST00000448462.2
zinc finger and BTB domain containing 17
chr2_-_191885686 4.78 ENST00000432058.1
signal transducer and activator of transcription 1, 91kDa
chr11_+_118307179 4.76 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
lysine (K)-specific methyltransferase 2A
chr4_-_76598326 4.74 ENST00000503660.1
GTPase activating protein (SH3 domain) binding protein 2
chr15_+_89346699 4.72 ENST00000558207.1
aggrecan
chr12_-_54813229 4.71 ENST00000293379.4
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_40324255 4.66 ENST00000593685.1
ENST00000600611.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr19_+_39390320 4.65 ENST00000576510.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_-_2050852 4.58 ENST00000541165.1
ENST00000591601.1
MAP kinase interacting serine/threonine kinase 2
chr5_-_96143602 4.55 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
endoplasmic reticulum aminopeptidase 1
chr5_+_139781445 4.53 ENST00000532219.1
ENST00000394722.3
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr12_+_8185288 4.52 ENST00000162391.3
forkhead box J2
chr3_+_9773409 4.50 ENST00000433861.2
ENST00000424362.1
ENST00000383829.2
ENST00000302054.3
ENST00000420291.1
bromodomain and PHD finger containing, 1
chr14_+_76618242 4.44 ENST00000557542.1
ENST00000557263.1
ENST00000557207.1
ENST00000312858.5
ENST00000261530.7
G patch domain containing 2-like
chr2_-_68694390 4.38 ENST00000377957.3
F-box protein 48
chr1_-_16302608 4.37 ENST00000375743.4
ENST00000375733.2
zinc finger and BTB domain containing 17
chr4_-_185395672 4.33 ENST00000393593.3
interferon regulatory factor 2
chr1_+_154301264 4.31 ENST00000341822.2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr14_+_32798462 4.28 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr17_-_1389228 4.27 ENST00000438665.2
myosin IC
chr2_-_152955537 4.27 ENST00000201943.5
ENST00000539935.1
calcium channel, voltage-dependent, beta 4 subunit
chr10_+_12391481 4.24 ENST00000378847.3
calcium/calmodulin-dependent protein kinase ID
chr19_-_45826125 4.21 ENST00000221476.3
creatine kinase, muscle
chr3_-_49131013 4.14 ENST00000424300.1
glutamine-rich 1
chr2_-_100721178 4.14 ENST00000409236.2
AF4/FMR2 family, member 3
chr14_+_64970662 4.06 ENST00000556965.1
ENST00000554015.1
zinc finger and BTB domain containing 1
chr15_-_71055878 4.05 ENST00000322954.6
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr17_+_63133587 4.05 ENST00000449996.3
ENST00000262406.9
regulator of G-protein signaling 9
chr1_-_146644036 4.03 ENST00000425272.2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr6_+_149068464 4.03 ENST00000367463.4
uronyl-2-sulfotransferase
chr11_+_94706804 4.02 ENST00000335080.5
lysine (K)-specific demethylase 4D
chr19_-_17958771 4.02 ENST00000534444.1
Janus kinase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
24.7 74.0 GO:1990108 protein linear deubiquitination(GO:1990108)
13.8 41.5 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
12.4 62.1 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
11.0 33.1 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
9.5 28.5 GO:2000777 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
7.4 29.6 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
7.0 27.9 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
6.4 25.7 GO:0000255 allantoin metabolic process(GO:0000255)
5.4 59.3 GO:0060263 regulation of respiratory burst(GO:0060263)
5.0 15.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
4.8 47.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
4.3 21.6 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
4.2 25.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
4.1 24.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
4.1 12.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
3.8 19.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
3.8 15.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
3.6 10.9 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
3.5 10.6 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
3.4 23.9 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
3.2 12.7 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
2.9 8.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
2.7 11.0 GO:0046967 cytosol to ER transport(GO:0046967)
2.6 44.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
2.5 7.6 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
2.4 7.3 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
2.4 19.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
2.3 9.2 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
2.3 9.1 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
2.3 2.3 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
2.2 11.1 GO:0033590 response to cobalamin(GO:0033590)
2.2 19.8 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
2.2 8.8 GO:0009386 translational attenuation(GO:0009386)
2.1 10.6 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
2.0 18.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
2.0 26.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
2.0 19.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
1.9 13.0 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.8 7.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.8 8.8 GO:0001826 inner cell mass cell differentiation(GO:0001826)
1.7 5.2 GO:0045062 extrathymic T cell selection(GO:0045062)
1.7 10.2 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.7 6.7 GO:0060023 soft palate development(GO:0060023)
1.7 9.9 GO:0055059 asymmetric neuroblast division(GO:0055059)
1.6 9.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.5 7.7 GO:0070842 aggresome assembly(GO:0070842)
1.5 10.6 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.5 7.4 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.4 9.7 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
1.4 15.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.4 5.5 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
1.3 6.7 GO:0035063 nuclear speck organization(GO:0035063)
1.3 7.8 GO:0007296 vitellogenesis(GO:0007296)
1.3 3.9 GO:0003241 growth involved in heart morphogenesis(GO:0003241) regulation of chromatin silencing at telomere(GO:0031938)
1.3 3.8 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
1.2 7.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
1.2 2.5 GO:0006405 RNA export from nucleus(GO:0006405)
1.2 18.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.2 4.8 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
1.2 4.8 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
1.1 6.7 GO:0072553 terminal button organization(GO:0072553)
1.1 3.3 GO:0070507 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
1.1 3.3 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.0 9.2 GO:0060022 hard palate development(GO:0060022)
1.0 4.1 GO:0002572 pro-T cell differentiation(GO:0002572)
1.0 7.1 GO:0007256 activation of JNKK activity(GO:0007256)
1.0 2.0 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
1.0 4.0 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
1.0 21.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.0 3.8 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.9 5.4 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.9 16.6 GO:0035855 megakaryocyte development(GO:0035855)
0.9 13.1 GO:0042832 defense response to protozoan(GO:0042832)
0.9 3.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.8 2.3 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) leukocyte migration involved in immune response(GO:0002522)
0.8 6.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.8 1.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.7 2.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.7 7.7 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.7 13.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.7 14.5 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.7 8.7 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.7 6.7 GO:0042940 D-amino acid transport(GO:0042940)
0.7 72.2 GO:0031295 T cell costimulation(GO:0031295)
0.6 3.8 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.6 1.9 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.6 11.9 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.6 25.8 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.5 2.7 GO:0030070 insulin processing(GO:0030070)
0.5 30.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.5 45.1 GO:0042100 B cell proliferation(GO:0042100)
0.5 4.2 GO:0006600 creatine metabolic process(GO:0006600)
0.5 4.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.5 8.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.5 8.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.4 4.0 GO:0006477 protein sulfation(GO:0006477)
0.4 2.2 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.4 5.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 17.1 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.4 1.2 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.4 2.0 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.4 1.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.4 1.5 GO:0001714 endodermal cell fate specification(GO:0001714)
0.4 7.8 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.4 11.1 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.4 1.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 9.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.3 6.6 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.3 21.2 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.3 6.1 GO:0006853 carnitine shuttle(GO:0006853)
0.3 2.4 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.3 1.5 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.3 2.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.3 30.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 7.3 GO:0098743 cell aggregation(GO:0098743)
0.3 0.8 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.3 2.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 0.5 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 0.3 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.2 5.4 GO:0006590 thyroid hormone generation(GO:0006590)
0.2 10.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 0.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 5.3 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.2 1.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 5.0 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.2 9.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 9.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 9.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 5.5 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 5.9 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 1.0 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.2 7.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 1.5 GO:0042428 serotonin metabolic process(GO:0042428)
0.2 4.3 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 5.1 GO:0035966 response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.2 6.2 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.2 4.7 GO:0007520 myoblast fusion(GO:0007520)
0.2 13.3 GO:0005977 glycogen metabolic process(GO:0005977)
0.2 3.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 1.6 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.1 5.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 0.5 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 7.4 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.1 2.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 2.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 10.6 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 18.4 GO:0035303 regulation of dephosphorylation(GO:0035303)
0.1 0.8 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.6 GO:0009629 response to gravity(GO:0009629)
0.1 5.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 2.9 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.1 5.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 0.4 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 1.5 GO:0006941 striated muscle contraction(GO:0006941)
0.1 0.9 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.1 1.5 GO:0090003 regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.1 2.5 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 3.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 1.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 4.5 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 1.7 GO:0006833 water transport(GO:0006833)
0.1 6.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 4.7 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.2 GO:1902741 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 6.6 GO:0030449 regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0 4.0 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 2.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.6 GO:0035690 cellular response to drug(GO:0035690)
0.0 1.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 6.5 GO:0006310 DNA recombination(GO:0006310)
0.0 1.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 5.3 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 1.7 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.3 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.8 GO:0071222 cellular response to lipopolysaccharide(GO:0071222)
0.0 1.3 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 3.9 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)
0.0 4.4 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.3 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.3 GO:0097190 apoptotic signaling pathway(GO:0097190)
0.0 1.8 GO:0070268 cornification(GO:0070268)
0.0 1.2 GO:0010977 negative regulation of neuron projection development(GO:0010977)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 62.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
7.4 89.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
6.9 48.6 GO:0019815 B cell receptor complex(GO:0019815)
4.3 47.5 GO:0042612 MHC class I protein complex(GO:0042612)
3.2 28.5 GO:0072687 meiotic spindle(GO:0072687)
2.9 58.9 GO:0042611 MHC protein complex(GO:0042611)
2.6 18.1 GO:0060091 kinocilium(GO:0060091)
1.9 24.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.9 14.9 GO:1990111 spermatoproteasome complex(GO:1990111)
1.9 7.4 GO:0045160 myosin I complex(GO:0045160)
1.8 11.0 GO:0042825 TAP complex(GO:0042825)
1.7 74.0 GO:0097542 ciliary tip(GO:0097542)
1.5 9.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.5 17.8 GO:0015630 microtubule cytoskeleton(GO:0015630)
1.4 11.1 GO:0043196 varicosity(GO:0043196)
1.3 5.3 GO:0070876 SOSS complex(GO:0070876)
1.3 4.0 GO:0005879 axonemal microtubule(GO:0005879)
1.2 4.7 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.1 7.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
1.0 9.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.8 5.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.8 56.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.7 1.5 GO:0005927 muscle tendon junction(GO:0005927)
0.6 3.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.6 7.4 GO:0060077 inhibitory synapse(GO:0060077)
0.6 1.7 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.6 6.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.5 2.7 GO:1990393 3M complex(GO:1990393)
0.5 3.1 GO:0036449 microtubule minus-end(GO:0036449)
0.5 2.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.5 2.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 1.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.5 4.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4 22.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 18.4 GO:0002102 podosome(GO:0002102)
0.4 9.9 GO:0005861 troponin complex(GO:0005861)
0.4 2.0 GO:0071797 LUBAC complex(GO:0071797)
0.4 10.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 27.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 26.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 41.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 33.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 6.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 8.8 GO:0000922 spindle pole(GO:0000922)
0.3 2.6 GO:0042587 glycogen granule(GO:0042587)
0.3 31.6 GO:0032587 ruffle membrane(GO:0032587)
0.2 3.8 GO:0043194 axon initial segment(GO:0043194)
0.2 7.5 GO:0016592 mediator complex(GO:0016592)
0.2 6.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 47.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 5.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 56.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 11.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.2 1.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 9.4 GO:0005911 cell-cell junction(GO:0005911)
0.2 3.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 6.4 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.2 7.7 GO:0016235 aggresome(GO:0016235)
0.2 1.1 GO:0032584 growth cone membrane(GO:0032584)
0.1 6.4 GO:0034707 chloride channel complex(GO:0034707)
0.1 13.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 7.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 4.8 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 6.6 GO:0031201 SNARE complex(GO:0031201)
0.1 11.5 GO:0016363 nuclear matrix(GO:0016363)
0.1 9.2 GO:0035579 specific granule membrane(GO:0035579)
0.1 16.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 5.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 43.5 GO:0016607 nuclear speck(GO:0016607)
0.1 28.2 GO:0000790 nuclear chromatin(GO:0000790)
0.1 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 9.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.3 GO:0001726 ruffle(GO:0001726)
0.1 5.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 10.3 GO:0001650 fibrillar center(GO:0001650)
0.1 23.8 GO:0016604 nuclear body(GO:0016604)
0.1 10.6 GO:0030496 midbody(GO:0030496)
0.1 3.3 GO:0005815 microtubule organizing center(GO:0005815)
0.1 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 5.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 5.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.0 5.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 9.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 24.8 GO:0005730 nucleolus(GO:0005730)
0.0 0.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 6.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 12.1 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 4.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0005604 basement membrane(GO:0005604)
0.0 12.4 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
12.4 62.1 GO:0042289 MHC class II protein binding(GO:0042289)
10.6 106.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
9.5 28.5 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
8.1 48.4 GO:0046979 TAP2 binding(GO:0046979)
4.9 29.6 GO:0042577 lipid phosphatase activity(GO:0042577)
4.5 58.9 GO:0032395 MHC class II receptor activity(GO:0032395)
4.0 19.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
3.7 44.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
3.7 18.6 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
3.0 9.0 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
2.5 7.4 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
2.4 2.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
2.2 13.0 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.8 7.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
1.8 10.6 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.7 13.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.6 4.8 GO:0045322 unmethylated CpG binding(GO:0045322)
1.6 12.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
1.6 6.3 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
1.5 75.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.5 8.8 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
1.4 15.2 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
1.3 5.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
1.2 21.0 GO:0038191 neuropilin binding(GO:0038191)
1.2 9.2 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
1.1 6.7 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
1.0 30.0 GO:0046965 retinoid X receptor binding(GO:0046965)
1.0 19.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.9 18.6 GO:0043495 protein anchor(GO:0043495)
0.9 5.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.9 5.4 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.9 4.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.8 3.3 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.8 27.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.8 3.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.8 3.9 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.8 10.5 GO:0035198 miRNA binding(GO:0035198)
0.7 35.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.7 9.9 GO:0031014 troponin T binding(GO:0031014)
0.7 7.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 9.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.6 1.9 GO:0004915 interleukin-6 receptor activity(GO:0004915) oncostatin-M receptor activity(GO:0004924) interleukin-6 binding(GO:0019981)
0.6 23.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 6.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.6 11.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 6.7 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.6 26.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 3.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 9.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.6 10.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.6 5.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.5 1.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 7.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 3.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.5 4.2 GO:0004111 creatine kinase activity(GO:0004111)
0.5 1.5 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.5 10.6 GO:0031005 filamin binding(GO:0031005)
0.5 14.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 2.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 6.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 13.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.4 1.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 12.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.4 3.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 12.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4 5.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.4 5.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 17.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 1.2 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.4 25.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 2.3 GO:0071837 HMG box domain binding(GO:0071837)
0.4 11.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 1.8 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.3 30.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 7.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 11.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 38.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 19.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 1.9 GO:0043532 angiostatin binding(GO:0043532)
0.3 2.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.3 6.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 0.6 GO:0035877 death effector domain binding(GO:0035877) cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 6.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 3.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 60.6 GO:0019887 protein kinase regulator activity(GO:0019887)
0.2 8.8 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 2.0 GO:0039706 co-receptor binding(GO:0039706)
0.2 18.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 7.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 6.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 5.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 6.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 2.3 GO:0050700 CARD domain binding(GO:0050700)
0.2 2.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 4.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 8.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 12.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.2 3.8 GO:0030506 ankyrin binding(GO:0030506)
0.2 7.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 48.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 6.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.2 GO:0015250 water channel activity(GO:0015250)
0.1 0.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 1.5 GO:0043422 protein kinase B binding(GO:0043422)
0.1 5.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 26.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 7.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 7.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 5.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 22.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.5 GO:0051117 ATPase binding(GO:0051117)
0.1 0.4 GO:0070905 serine binding(GO:0070905)
0.1 2.3 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.1 47.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 2.9 GO:0005518 collagen binding(GO:0005518)
0.1 4.0 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.2 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 14.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.7 GO:0002020 protease binding(GO:0002020)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 6.1 GO:0019900 kinase binding(GO:0019900)
0.0 3.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 138.3 PID CD40 PATHWAY CD40/CD40L signaling
2.2 48.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
1.3 42.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
1.2 50.7 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
1.1 33.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
1.1 52.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
1.0 25.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.7 20.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.7 48.6 PID BCR 5PATHWAY BCR signaling pathway
0.7 19.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.7 23.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.5 17.3 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.5 34.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.5 8.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5 2.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.5 24.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 17.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 29.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 18.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.3 9.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 1.9 PID IL27 PATHWAY IL27-mediated signaling events
0.3 4.7 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.3 7.4 ST GA12 PATHWAY G alpha 12 Pathway
0.2 6.7 NABA COLLAGENS Genes encoding collagen proteins
0.2 7.8 PID REELIN PATHWAY Reelin signaling pathway
0.2 9.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 9.2 PID MYC PATHWAY C-MYC pathway
0.2 10.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 8.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 2.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 23.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.6 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 4.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 26.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.7 PID LKB1 PATHWAY LKB1 signaling events
0.1 16.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.9 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 2.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 5.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.7 PID BMP PATHWAY BMP receptor signaling
0.1 3.8 PID P73PATHWAY p73 transcription factor network
0.1 4.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.7 PID FGF PATHWAY FGF signaling pathway
0.0 2.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 47.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.6 128.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
2.6 58.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.8 37.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.7 19.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
1.3 48.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.2 59.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
1.1 30.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
1.0 18.9 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.9 21.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.7 2.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.7 16.0 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.7 35.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.7 17.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6 18.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.6 10.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.6 65.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.5 12.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.5 23.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.5 8.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.5 10.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 18.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 6.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 8.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 44.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.4 25.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 10.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.4 27.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 12.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 5.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.3 5.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 20.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 16.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 7.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 9.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 6.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 5.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 17.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 1.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 11.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 2.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 5.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 1.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 15.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 9.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 2.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 6.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 11.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 9.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 4.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 2.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.0