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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NFKB2
Z-value: 1.11
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Transcription factors associated with NFKB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104155450_104155479 | 0.53 | 7.4e-17 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_37640277 Show fit | 28.30 |
ENST00000401529.3
ENST00000249071.6 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
|
| chr1_-_27961720 Show fit | 24.30 |
ENST00000545953.1
ENST00000374005.3 |
feline Gardner-Rasheed sarcoma viral oncogene homolog |
|
| chr6_+_32605195 Show fit | 21.69 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr14_+_24605389 Show fit | 20.54 |
ENST00000382708.3
ENST00000561435.1 |
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
|
| chr22_-_37640456 Show fit | 19.73 |
ENST00000405484.1
ENST00000441619.1 ENST00000406508.1 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
|
| chr14_-_24615805 Show fit | 17.47 |
ENST00000560410.1
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
|
| chr19_-_41859814 Show fit | 17.45 |
ENST00000221930.5
|
transforming growth factor, beta 1 |
|
| chr19_-_10450328 Show fit | 17.39 |
ENST00000160262.5
|
intercellular adhesion molecule 3 |
|
| chr14_+_24605361 Show fit | 16.46 |
ENST00000206451.6
ENST00000559123.1 |
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
|
| chr19_+_48824711 Show fit | 16.29 |
ENST00000599704.1
|
epithelial membrane protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 93.5 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 4.4 | 48.0 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.3 | 47.9 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.3 | 37.3 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.4 | 26.3 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 1.3 | 24.3 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 2.9 | 22.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 20.4 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 6.1 | 18.3 | GO:1905154 | negative regulation of eosinophil activation(GO:1902567) negative regulation of membrane invagination(GO:1905154) negative regulation of eosinophil migration(GO:2000417) |
| 1.2 | 17.6 | GO:0097264 | self proteolysis(GO:0097264) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.0 | 72.3 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.6 | 48.3 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.4 | 38.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.7 | 36.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 26.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 25.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 23.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 23.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 23.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 22.8 | GO:0034774 | secretory granule lumen(GO:0034774) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 72.3 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.4 | 66.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 41.8 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 2.6 | 36.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 29.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 6.1 | 24.3 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 3.8 | 22.9 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.6 | 22.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 2.1 | 21.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 21.1 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 73.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.5 | 41.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.5 | 40.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.4 | 25.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.7 | 25.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.6 | 24.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.8 | 23.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.3 | 19.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.3 | 17.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 12.7 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 72.3 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 1.2 | 63.5 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 1.6 | 36.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.3 | 35.0 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.7 | 33.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 27.7 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.7 | 24.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.8 | 21.2 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.2 | 17.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.7 | 16.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |