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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX1-2_RAX

Z-value: 0.48

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NK1 homeobox 2
RAX
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_56940660-0.305.7e-06Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_34204642 12.29 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr2_+_187371440 9.64 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr7_-_87856280 9.57 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr7_-_87856303 9.31 ENST00000394641.3
SRI
sorcin
chr4_-_25865159 9.02 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr10_+_124914285 6.59 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr4_-_103749179 5.81 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103749205 5.34 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr3_+_23851928 4.42 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chrX_-_77225135 4.36 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr12_+_32832203 4.30 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr10_+_124913930 4.30 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr6_+_30687978 4.24 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr3_+_158519654 4.17 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr1_+_155278539 4.02 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr1_+_155278625 3.77 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr11_-_111741994 3.62 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr2_-_86422095 3.52 ENST00000254636.5
IMMT
inner membrane protein, mitochondrial
chr3_+_183853052 3.24 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr2_-_220264703 3.18 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
DNPEP
aspartyl aminopeptidase
chrX_+_77154935 3.14 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr10_+_124913793 3.07 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr2_+_90077680 2.96 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr4_-_103749313 2.75 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_+_26440700 2.33 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr17_-_27418537 2.33 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr5_-_82969405 2.31 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr19_+_11071546 2.29 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_-_74619152 2.26 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr3_-_105588231 2.22 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr2_+_217524323 2.21 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr4_-_103749105 2.14 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_+_27008865 1.92 ENST00000335756.4
ENST00000233505.8
CENPA
centromere protein A
chr4_-_103748880 1.84 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_112279782 1.83 ENST00000550735.2
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
chr7_+_100770328 1.71 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr3_-_151034734 1.62 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr1_+_43148059 1.60 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr7_-_86849883 1.50 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr11_+_73498898 1.50 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr11_-_3859089 1.41 ENST00000396979.1
RHOG
ras homolog family member G
chr6_+_26402465 1.35 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_26365443 1.32 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr2_-_74618964 1.24 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr1_+_153746683 1.24 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr9_+_125133315 1.16 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_+_114827818 1.06 ENST00000420625.2
PLS3
plastin 3
chr4_-_66536057 1.05 ENST00000273854.3
EPHA5
EPH receptor A5
chr8_-_101571933 1.03 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chr6_-_111927062 1.00 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr7_-_99716952 1.00 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr8_-_101571964 0.88 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr20_-_1447467 0.87 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr15_+_64680003 0.85 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr19_-_3985455 0.82 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chrX_+_19362011 0.79 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr5_-_94890648 0.79 ENST00000513823.1
ENST00000514952.1
ENST00000358746.2
TTC37
tetratricopeptide repeat domain 37
chr3_-_11685345 0.78 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr9_+_125132803 0.77 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_110736659 0.76 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr11_+_5710919 0.76 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr7_-_99717463 0.75 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_+_138145076 0.74 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr20_-_1447547 0.72 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr9_+_34646624 0.72 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr7_-_87342564 0.69 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr4_-_66536196 0.69 ENST00000511294.1
EPHA5
EPH receptor A5
chr22_-_32651326 0.69 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr2_-_89597542 0.66 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr8_-_102803163 0.66 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr19_+_48949030 0.66 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr8_-_42623747 0.65 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr11_-_65625678 0.61 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr22_+_22730353 0.61 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr10_-_114206649 0.61 ENST00000369404.3
ENST00000369405.3
ZDHHC6
zinc finger, DHHC-type containing 6
chr1_+_192605252 0.59 ENST00000391995.2
ENST00000543215.1
RGS13
regulator of G-protein signaling 13
chr1_-_67266939 0.56 ENST00000304526.2
INSL5
insulin-like 5
chr1_+_153747746 0.52 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr16_-_28608364 0.49 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_+_186265399 0.47 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr12_-_12837423 0.47 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr6_+_26402517 0.46 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr12_-_10959892 0.42 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr10_-_105845674 0.42 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr9_+_34646651 0.40 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr7_+_120628731 0.36 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr6_-_82957433 0.32 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_186353756 0.28 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr7_+_50348268 0.26 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_+_201979645 0.23 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr10_-_92681033 0.22 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_62439037 0.22 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr1_-_151804314 0.22 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr12_-_10022735 0.20 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_63376013 0.17 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr6_-_111927449 0.15 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr9_+_135937365 0.13 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr1_-_190446759 0.13 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr16_-_28608424 0.05 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr8_+_107738240 0.05 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr1_+_28261492 0.05 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr2_+_74682150 0.04 ENST00000233331.7
ENST00000431187.1
ENST00000409917.1
ENST00000409493.2
INO80B
INO80 complex subunit B
chr11_-_102651343 0.01 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr19_-_46285736 0.00 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
2.7 18.9 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.6 7.8 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.4 4.3 GO:0090149 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
1.1 4.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.6 1.7 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.6 4.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 2.3 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.4 3.5 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.4 3.2 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.4 1.1 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.4 16.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 14.0 GO:0008608 mitotic spindle assembly checkpoint(GO:0007094) attachment of spindle microtubules to kinetochore(GO:0008608) spindle assembly checkpoint(GO:0071173)
0.3 1.9 GO:0051382 kinetochore assembly(GO:0051382) protein localization to chromosome, centromeric region(GO:0071459)
0.2 1.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 3.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 1.8 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 3.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 3.5 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 3.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.6 GO:2000771 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.1 2.3 GO:0001501 skeletal system development(GO:0001501)
0.1 0.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.8 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 1.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.8 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.7 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.1 1.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.8 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 2.2 GO:0010226 response to lithium ion(GO:0010226)
0.1 1.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 4.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 0.2 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 1.6 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 1.4 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 2.3 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.7 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 3.5 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.8 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.5 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 1.8 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
2.7 18.9 GO:0044326 dendritic spine neck(GO:0044326)
1.1 12.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.6 1.9 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.5 3.5 GO:0061617 MICOS complex(GO:0061617)
0.4 3.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.4 1.6 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.3 4.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 3.5 GO:0005869 dynactin complex(GO:0005869)
0.2 1.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 0.8 GO:0055087 Ski complex(GO:0055087)
0.2 3.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 4.4 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.8 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.8 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 4.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 11.9 GO:0010008 endosome membrane(GO:0010008)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 3.4 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 7.8 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.2 3.6 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.1 4.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.9 12.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.7 4.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.5 18.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 1.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 17.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 4.3 GO:0051400 BH domain binding(GO:0051400)
0.2 4.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 2.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.8 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 1.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 0.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 2.3 GO:0030957 Tat protein binding(GO:0030957)
0.1 3.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.7 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 15.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.5 GO:0070840 dynein complex binding(GO:0070840)
0.1 3.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 1.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 3.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.8 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.7 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 9.6 GO:0045296 cadherin binding(GO:0045296)
0.0 3.6 GO:0003823 antigen binding(GO:0003823)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 17.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 11.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 15.7 PID P73PATHWAY p73 transcription factor network
0.1 1.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.9 PID AURORA A PATHWAY Aurora A signaling
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.6 17.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.5 17.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 7.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 7.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 4.2 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 3.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 3.8 REACTOME TRANSLATION Genes involved in Translation
0.0 1.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport