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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-1

Z-value: 0.59

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36989336_369893540.054.6e-01Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_60223225 12.50 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr11_+_60223312 12.31 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr19_+_1065922 11.50 ENST00000539243.2
HMHA1
histocompatibility (minor) HA-1
chr13_-_41240717 8.24 ENST00000379561.5
FOXO1
forkhead box O1
chr1_-_153517473 8.11 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr15_+_89182178 7.64 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_+_25205568 7.49 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205666 7.45 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr1_-_153518270 6.91 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr12_+_25205446 6.77 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr15_+_89181974 6.72 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_+_131157290 6.38 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chrX_+_131157322 6.37 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr1_-_25291475 6.24 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr5_-_171615315 6.19 ENST00000176763.5
STK10
serine/threonine kinase 10
chr15_+_89182156 5.51 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr10_-_98031310 4.73 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr3_-_16524357 4.57 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr17_+_4613918 4.32 ENST00000574954.1
ENST00000346341.2
ENST00000572457.1
ENST00000381488.6
ENST00000412477.3
ENST00000571428.1
ENST00000575877.1
ARRB2
arrestin, beta 2
chr10_-_98031265 4.04 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr19_+_24009879 3.90 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chr11_-_104827425 3.80 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr17_-_76778339 3.78 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr12_-_21810726 3.67 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr12_-_21810765 3.66 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr1_+_24019099 3.49 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr17_+_46048376 3.47 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr19_-_36231437 3.26 ENST00000591748.1
IGFLR1
IGF-like family receptor 1
chr6_+_31554779 3.01 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr16_-_67190152 2.88 ENST00000486556.1
TRADD
TNFRSF1A-associated via death domain
chr1_-_38397384 2.67 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr15_-_44955842 2.67 ENST00000427534.2
ENST00000559193.1
ENST00000261866.7
ENST00000535302.2
ENST00000558319.1
SPG11
spastic paraplegia 11 (autosomal recessive)
chr8_-_16859690 2.62 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr1_+_15736359 2.54 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr6_-_26056695 2.30 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr19_-_46234119 2.30 ENST00000317683.3
FBXO46
F-box protein 46
chr5_+_134094461 2.25 ENST00000452510.2
ENST00000354283.4
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr16_+_1359138 2.21 ENST00000325437.5
UBE2I
ubiquitin-conjugating enzyme E2I
chr11_+_35160709 2.20 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44
CD44 molecule (Indian blood group)
chrX_-_70474499 2.20 ENST00000353904.2
ZMYM3
zinc finger, MYM-type 3
chr8_-_144679296 2.18 ENST00000317198.6
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr6_-_137113604 2.18 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr12_+_121837905 2.03 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34
ring finger protein 34, E3 ubiquitin protein ligase
chr14_-_58893832 1.99 ENST00000556007.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr15_+_40453204 1.99 ENST00000287598.6
ENST00000412359.3
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
chr12_-_54694758 1.98 ENST00000553070.1
NFE2
nuclear factor, erythroid 2
chr16_-_28222797 1.92 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chr8_-_28747424 1.91 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chr3_-_52029830 1.87 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
RPL29
ribosomal protein L29
chr15_-_44116873 1.74 ENST00000267812.3
MFAP1
microfibrillar-associated protein 1
chr16_+_71929397 1.66 ENST00000537613.1
ENST00000424485.2
ENST00000606369.1
ENST00000329908.8
ENST00000538850.1
ENST00000541918.1
ENST00000534994.1
ENST00000378798.5
ENST00000539186.1
IST1
increased sodium tolerance 1 homolog (yeast)
chr19_-_10679644 1.53 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr3_-_52029958 1.50 ENST00000294189.6
RPL29
ribosomal protein L29
chr1_-_92952433 1.49 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr18_-_24283586 1.48 ENST00000579458.1
U3
Small nucleolar RNA U3
chr3_+_4535025 1.48 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr11_+_105948216 1.45 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr16_-_58663720 1.43 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr2_+_99797542 1.43 ENST00000338148.3
ENST00000512183.2
MRPL30
C2orf15
mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr12_-_719573 1.36 ENST00000397265.3
NINJ2
ninjurin 2
chr3_+_23847432 1.36 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr11_-_62313090 1.35 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr1_-_175712665 1.35 ENST00000263525.2
TNR
tenascin R
chrX_-_70473957 1.34 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3
zinc finger, MYM-type 3
chr10_+_111967345 1.31 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr15_+_57511609 1.30 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr4_+_144354644 1.30 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr22_+_24891210 1.28 ENST00000382760.2
UPB1
ureidopropionase, beta
chr6_-_55739542 1.23 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr14_+_74353320 1.22 ENST00000540593.1
ENST00000555730.1
ZNF410
zinc finger protein 410
chr17_-_42466864 1.17 ENST00000353281.4
ENST00000262407.5
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr6_-_27841289 1.17 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr16_-_28223166 1.13 ENST00000304658.5
XPO6
exportin 6
chr1_+_32930647 1.09 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chrX_-_110655306 1.08 ENST00000371993.2
DCX
doublecortin
chr15_+_77287426 1.07 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr1_+_206643787 0.90 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr21_+_45432174 0.89 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr19_+_48958766 0.87 ENST00000342291.2
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr12_+_41582103 0.79 ENST00000402685.2
PDZRN4
PDZ domain containing ring finger 4
chr18_+_42260861 0.73 ENST00000282030.5
SETBP1
SET binding protein 1
chr12_+_60058458 0.73 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr11_-_65325430 0.69 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr6_+_42883727 0.69 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr22_-_30968813 0.68 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_-_11685345 0.65 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr17_-_47492164 0.62 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr1_-_160232197 0.60 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr15_-_66790146 0.59 ENST00000316634.5
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr1_-_153538011 0.59 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr11_+_66512303 0.58 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr6_-_55740352 0.53 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr8_+_94752349 0.53 ENST00000391680.1
RBM12B-AS1
RBM12B antisense RNA 1
chr19_-_51336443 0.53 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr17_+_76210367 0.52 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chr11_+_66512089 0.51 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr10_+_102222798 0.50 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr2_-_157189180 0.49 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chrX_-_32173579 0.48 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr2_+_136289030 0.46 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr2_+_119699742 0.45 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr17_-_47492236 0.43 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr20_-_22565101 0.42 ENST00000419308.2
FOXA2
forkhead box A2
chrX_-_134478012 0.42 ENST00000370766.3
ZNF75D
zinc finger protein 75D
chr12_+_50478977 0.42 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr4_-_54930790 0.41 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr9_-_128246769 0.41 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr2_-_31360887 0.40 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr8_+_22019168 0.40 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr22_-_30925150 0.39 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr12_+_121416489 0.36 ENST00000541395.1
ENST00000544413.1
HNF1A
HNF1 homeobox A
chr18_-_58040000 0.36 ENST00000299766.3
MC4R
melanocortin 4 receptor
chrX_+_153170189 0.36 ENST00000358927.2
AVPR2
arginine vasopressin receptor 2
chr1_-_153538292 0.33 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr7_-_27224842 0.31 ENST00000517402.1
HOXA11
homeobox A11
chr4_+_55524085 0.30 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr7_-_27224795 0.28 ENST00000006015.3
HOXA11
homeobox A11
chr14_+_81421921 0.27 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr19_+_55014085 0.27 ENST00000351841.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr1_+_55464600 0.27 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr17_+_59529743 0.26 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr2_+_119699864 0.24 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr12_-_67197760 0.24 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr1_+_206643806 0.19 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr10_-_81320151 0.19 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2
surfactant protein A2
chrX_+_78003204 0.16 ENST00000435339.3
ENST00000514744.1
LPAR4
lysophosphatidic acid receptor 4
chr17_+_76210267 0.13 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5
baculoviral IAP repeat containing 5
chr6_+_31674639 0.13 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr20_-_36793663 0.11 ENST00000536701.1
ENST00000536724.1
TGM2
transglutaminase 2
chr2_+_101591314 0.09 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr19_+_751122 0.08 ENST00000215582.6
MISP
mitotic spindle positioning
chr5_-_58571935 0.07 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_137548997 0.05 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
CDC23
cell division cycle 23
chr9_+_33290491 0.01 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr15_+_69452959 0.00 ENST00000261858.2
GLCE
glucuronic acid epimerase

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.7 10.3 GO:0070417 cellular response to cold(GO:0070417)
0.9 3.5 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.9 4.3 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.7 2.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.7 4.6 GO:0032596 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.6 1.8 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.5 1.5 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.5 2.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.5 7.3 GO:0006089 lactate metabolic process(GO:0006089)
0.4 2.6 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.4 3.5 GO:0071569 protein ufmylation(GO:0071569)
0.4 1.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 3.8 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.3 2.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.3 2.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 2.9 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 2.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 24.4 GO:0042100 B cell proliferation(GO:0042100)
0.2 1.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.2 1.7 GO:0009838 abscission(GO:0009838)
0.2 1.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 1.0 GO:2000323 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.2 22.6 GO:0006903 vesicle targeting(GO:0006903)
0.2 1.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 0.5 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 2.2 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.2 1.5 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.3 GO:0070662 mast cell proliferation(GO:0070662)
0.1 2.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 1.4 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.4 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 6.2 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.1 0.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 3.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.4 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.1 2.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.9 GO:0016180 snRNA processing(GO:0016180)
0.1 2.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.7 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 8.8 GO:0030183 B cell differentiation(GO:0030183)
0.1 2.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.7 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 13.0 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 0.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 0.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.4 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 3.4 GO:0007566 embryo implantation(GO:0007566)
0.1 1.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 3.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.3 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 1.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 3.6 GO:0006414 translational elongation(GO:0006414)
0.0 1.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.9 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.5 2.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.5 2.0 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.3 22.1 GO:0015030 Cajal body(GO:0015030)
0.3 2.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 21.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 1.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 2.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 1.9 GO:0032039 integrator complex(GO:0032039)
0.2 1.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 2.9 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 1.7 GO:0090543 Flemming body(GO:0090543)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 24.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.2 GO:0000795 synaptonemal complex(GO:0000795)
0.1 6.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 4.4 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 4.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 12.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 3.1 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0042599 lamellar body(GO:0042599)
0.0 4.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.9 GO:0008859 exoribonuclease II activity(GO:0008859)
1.4 4.3 GO:0031859 platelet activating factor receptor binding(GO:0031859)
1.0 7.3 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.8 24.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.6 2.2 GO:0043398 HLH domain binding(GO:0043398)
0.5 8.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4 8.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 1.1 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.3 3.5 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3 1.2 GO:0070051 fibrinogen binding(GO:0070051)
0.3 3.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 8.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 3.8 GO:0050700 CARD domain binding(GO:0050700)
0.3 1.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.3 1.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 1.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 2.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 2.9 GO:0070513 death domain binding(GO:0070513)
0.1 1.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.7 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 3.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 4.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 1.7 GO:0050699 WW domain binding(GO:0050699)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 2.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 2.0 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 2.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 2.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 7.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 12.8 PID LKB1 PATHWAY LKB1 signaling events
0.2 10.8 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 4.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 2.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 2.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 3.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 8.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 7.3 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 8.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 19.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.6 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 3.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 8.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 6.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 3.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 6.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.2 REACTOME TRANSLATION Genes involved in Translation
0.0 0.9 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins