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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-8

Z-value: 0.71

Motif logo

Transcription factors associated with NKX2-8

Gene Symbol Gene ID Gene Info
ENSG00000136327.6 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_37051831-0.283.3e-05Click!

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_107049312 8.59 ENST00000390627.2
immunoglobulin heavy variable 3-53
chr14_-_106573756 7.98 ENST00000390601.2
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr14_-_107131560 7.71 ENST00000390632.2
immunoglobulin heavy variable 3-66
chr14_-_106994333 6.88 ENST00000390624.2
immunoglobulin heavy variable 3-48
chr14_-_106963409 6.82 ENST00000390621.2
immunoglobulin heavy variable 1-45
chr3_-_58613323 6.38 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr14_-_106552755 6.25 ENST00000390600.2
immunoglobulin heavy variable 3-9
chr14_-_106586656 6.07 ENST00000390602.2
immunoglobulin heavy variable 3-13
chr14_-_106692191 5.81 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr14_-_107219365 5.79 ENST00000424969.2
immunoglobulin heavy variable 3-74
chr15_-_20170354 5.30 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr14_-_106845789 5.02 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr14_-_106518922 4.83 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr2_-_55277436 4.76 ENST00000354474.6
reticulon 4
chr16_-_33647696 4.73 ENST00000558425.1
ENST00000569103.2
Uncharacterized protein
chr2_-_55277512 4.65 ENST00000402434.2
reticulon 4
chr8_-_81083341 4.51 ENST00000519303.2
tumor protein D52
chr12_+_25205568 4.47 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr15_-_77363441 4.40 ENST00000346495.2
ENST00000424443.3
ENST00000561277.1
tetraspanin 3
chr2_-_55277692 4.39 ENST00000394611.2
reticulon 4
chr2_-_55277654 4.35 ENST00000337526.6
ENST00000317610.7
ENST00000357732.4
reticulon 4
chr5_-_78808617 4.29 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
homer homolog 1 (Drosophila)
chr15_-_77363375 4.21 ENST00000559494.1
tetraspanin 3
chr15_-_77363513 4.14 ENST00000267970.4
tetraspanin 3
chr12_-_21810726 3.86 ENST00000396076.1
lactate dehydrogenase B
chr12_-_21810765 3.85 ENST00000450584.1
ENST00000350669.1
lactate dehydrogenase B
chr16_+_32063311 3.83 ENST00000426099.1
AC142381.1
chr16_+_32077386 3.83 ENST00000354689.6
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr5_-_176056974 3.81 ENST00000510387.1
ENST00000506696.1
synuclein, beta
chr3_+_111717600 3.47 ENST00000273368.4
transgelin 3
chr2_+_136289030 3.35 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3H domain containing 1
chr3_-_16524357 3.33 ENST00000432519.1
raftlin, lipid raft linker 1
chr12_+_25205666 3.31 ENST00000547044.1
lymphoid-restricted membrane protein
chr16_+_33020496 3.22 ENST00000565407.2
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr6_-_32731299 3.09 ENST00000435145.2
ENST00000437316.2
major histocompatibility complex, class II, DQ beta 2
chr3_+_111717511 3.03 ENST00000478951.1
ENST00000393917.2
transgelin 3
chr2_-_132249955 2.96 ENST00000309451.6
mitotic spindle organizing protein 2A
chr14_-_106791536 2.80 ENST00000390613.2
immunoglobulin heavy variable 3-30
chr16_+_88872176 2.61 ENST00000569140.1
chromatin licensing and DNA replication factor 1
chr16_+_33006369 2.52 ENST00000425181.3
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr16_+_33629600 2.23 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr12_+_25205446 2.22 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr15_+_51973680 2.14 ENST00000542355.2
secretogranin III
chr6_+_32146131 2.09 ENST00000375094.3
ring finger protein 5, E3 ubiquitin protein ligase
chr12_+_13349650 2.09 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
epithelial membrane protein 1
chr10_+_118305435 2.04 ENST00000369221.2
pancreatic lipase
chr12_+_51442101 1.99 ENST00000550929.1
ENST00000262055.4
ENST00000550442.1
ENST00000549340.1
ENST00000548209.1
ENST00000548251.1
ENST00000550814.1
ENST00000547660.1
ENST00000380123.2
ENST00000548401.1
ENST00000418425.2
ENST00000547008.1
ENST00000552739.1
LETM1 domain containing 1
chr3_-_53290016 1.99 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
transketolase
chr15_+_51973550 1.98 ENST00000220478.3
secretogranin III
chr2_+_101591314 1.98 ENST00000450763.1
neuronal PAS domain protein 2
chr11_-_77348796 1.98 ENST00000263309.3
ENST00000525064.1
chloride channel, nucleotide-sensitive, 1A
chrX_+_77154935 1.94 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chr14_-_106622419 1.93 ENST00000390604.2
immunoglobulin heavy variable 3-16 (non-functional)
chr7_+_99816859 1.92 ENST00000317271.2
poliovirus receptor related immunoglobulin domain containing
chr7_+_30634297 1.90 ENST00000389266.3
glycyl-tRNA synthetase
chr2_+_79252804 1.87 ENST00000393897.2
regenerating islet-derived 3 gamma
chr2_+_79252822 1.87 ENST00000272324.5
regenerating islet-derived 3 gamma
chr6_-_32731243 1.84 ENST00000427449.1
ENST00000411527.1
major histocompatibility complex, class II, DQ beta 2
chr19_+_34856141 1.83 ENST00000586425.1
glucose-6-phosphate isomerase
chr2_+_79252834 1.79 ENST00000409471.1
regenerating islet-derived 3 gamma
chr11_-_77348821 1.63 ENST00000528364.1
ENST00000532069.1
ENST00000525428.1
chloride channel, nucleotide-sensitive, 1A
chr7_-_766879 1.61 ENST00000537384.1
ENST00000417852.1
protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_-_75248954 1.59 ENST00000499788.2
ribonuclease P/MRP 25kDa subunit
chr2_-_207024233 1.58 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr1_+_179050512 1.57 ENST00000367627.3
torsin family 3, member A
chr1_+_158223923 1.57 ENST00000289429.5
CD1a molecule
chr6_+_69942298 1.53 ENST00000238918.8
brain-specific angiogenesis inhibitor 3
chr16_+_22501658 1.47 ENST00000415833.2
nuclear pore complex interacting protein family, member B5
chr11_-_72353451 1.46 ENST00000376450.3
phosphodiesterase 2A, cGMP-stimulated
chr13_-_46964177 1.35 ENST00000389908.3
KIAA0226-like
chr14_-_58894223 1.33 ENST00000555593.1
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr13_-_23949671 1.32 ENST00000402364.1
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr17_+_76210267 1.28 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
baculoviral IAP repeat containing 5
chr15_+_93749295 1.25 ENST00000599897.1
AC112693.2
chr1_-_95007193 1.23 ENST00000370207.4
ENST00000334047.7
coagulation factor III (thromboplastin, tissue factor)
chr1_-_27998689 1.21 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
interferon, alpha-inducible protein 6
chr22_-_50523760 1.14 ENST00000395876.2
megalencephalic leukoencephalopathy with subcortical cysts 1
chr15_+_40453204 1.14 ENST00000287598.6
ENST00000412359.3
BUB1 mitotic checkpoint serine/threonine kinase B
chr3_-_47950745 1.11 ENST00000429422.1
microtubule-associated protein 4
chr17_-_46178527 1.09 ENST00000393408.3
chromobox homolog 1
chr16_-_30441293 1.06 ENST00000565758.1
ENST00000567983.1
ENST00000319285.4
dCTP pyrophosphatase 1
chr14_-_24732403 1.06 ENST00000206765.6
transglutaminase 1
chr5_+_92919043 1.01 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr17_-_62502399 1.00 ENST00000450599.2
ENST00000585060.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr17_-_62502639 1.00 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr1_+_152957707 0.99 ENST00000368762.1
small proline-rich protein 1A
chr7_-_137686791 0.98 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
cAMP responsive element binding protein 3-like 2
chr3_-_114343039 0.97 ENST00000481632.1
zinc finger and BTB domain containing 20
chr2_+_207024306 0.97 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
eukaryotic translation elongation factor 1 beta 2
chr1_-_67266939 0.95 ENST00000304526.2
insulin-like 5
chr11_-_10828892 0.95 ENST00000525681.1
eukaryotic translation initiation factor 4 gamma, 2
chr1_+_55464600 0.91 ENST00000371265.4
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr14_+_24540046 0.90 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
copine VI (neuronal)
chr3_-_114790179 0.89 ENST00000462705.1
zinc finger and BTB domain containing 20
chr16_-_18468926 0.82 ENST00000545114.1
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr8_-_141810634 0.81 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
protein tyrosine kinase 2
chr15_-_35047166 0.78 ENST00000290374.4
gap junction protein, delta 2, 36kDa
chr1_-_68698222 0.75 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr3_+_4535025 0.74 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
inositol 1,4,5-trisphosphate receptor, type 1
chr5_-_95158644 0.72 ENST00000237858.6
glutaredoxin (thioltransferase)
chrX_-_64196376 0.71 ENST00000447788.2
zinc finger, C4H2 domain containing
chr15_+_45422178 0.70 ENST00000389037.3
ENST00000558322.1
dual oxidase 1
chr11_-_114466477 0.70 ENST00000375478.3
neurexophilin and PC-esterase domain family, member 4
chr17_-_202579 0.67 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
rabphilin 3A-like (without C2 domains)
chrX_-_64196351 0.65 ENST00000374839.3
zinc finger, C4H2 domain containing
chrX_-_64196307 0.65 ENST00000545618.1
zinc finger, C4H2 domain containing
chr12_-_11548496 0.65 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr3_-_116163830 0.64 ENST00000333617.4
limbic system-associated membrane protein
chrX_-_110039286 0.61 ENST00000434224.1
chordin-like 1
chr6_-_132272504 0.61 ENST00000367976.3
connective tissue growth factor
chr16_+_58426296 0.61 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS complex subunit 3 (Psf3 homolog)
chr6_-_31830655 0.61 ENST00000375631.4
sialidase 1 (lysosomal sialidase)
chr8_+_27182862 0.60 ENST00000521164.1
ENST00000346049.5
protein tyrosine kinase 2 beta
chr20_-_44485835 0.59 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
acyl-CoA thioesterase 8
chr14_-_24732368 0.56 ENST00000544573.1
transglutaminase 1
chr10_+_71078595 0.55 ENST00000359426.6
hexokinase 1
chr17_+_76210367 0.54 ENST00000592734.1
ENST00000587746.1
baculoviral IAP repeat containing 5
chr8_+_104310661 0.54 ENST00000522566.1
frizzled family receptor 6
chr1_+_42922173 0.50 ENST00000455780.1
ENST00000372560.3
ENST00000372561.3
ENST00000372556.3
phosphopantothenoylcysteine synthetase
chr7_+_135242652 0.49 ENST00000285968.6
ENST00000440390.2
nucleoporin 205kDa
chr12_+_121837905 0.47 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
ring finger protein 34, E3 ubiquitin protein ligase
chr1_-_115292591 0.46 ENST00000438362.2
cold shock domain containing E1, RNA-binding
chr8_+_67341239 0.44 ENST00000320270.2
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr21_-_35899113 0.42 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
regulator of calcineurin 1
chr2_-_207023918 0.39 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr19_+_36486078 0.37 ENST00000378887.2
succinate dehydrogenase complex assembly factor 1
chrX_-_48858667 0.35 ENST00000376423.4
ENST00000376441.1
GRIP1 associated protein 1
chr1_+_32671236 0.35 ENST00000537469.1
ENST00000291358.6
IQ motif containing C
chr19_-_38720354 0.35 ENST00000416611.1
D4, zinc and double PHD fingers family 1
chr3_-_8811288 0.34 ENST00000316793.3
ENST00000431493.1
oxytocin receptor
chr14_-_58894332 0.33 ENST00000395159.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr17_+_73472575 0.30 ENST00000375248.5
KIAA0195
chr1_-_104238912 0.29 ENST00000330330.5
amylase, alpha 1B (salivary)
chr2_-_207024134 0.29 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr1_+_224301787 0.27 ENST00000366862.5
ENST00000424254.2
F-box protein 28
chrX_+_48681768 0.27 ENST00000430858.1
histone deacetylase 6
chr8_+_24241789 0.26 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr16_-_3767551 0.25 ENST00000246957.5
TNF receptor-associated protein 1
chr3_+_173302222 0.25 ENST00000361589.4
neuroligin 1
chr13_-_46756351 0.25 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_8807419 0.25 ENST00000565016.1
ENST00000567812.1
4-aminobutyrate aminotransferase
chr20_-_48530230 0.24 ENST00000422556.1
spermatogenesis associated 2
chr1_-_94147385 0.24 ENST00000260502.6
breast cancer anti-estrogen resistance 3
chr1_+_12040238 0.23 ENST00000444836.1
ENST00000235329.5
mitofusin 2
chr5_+_43602750 0.22 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
nicotinamide nucleotide transhydrogenase
chr8_+_23430157 0.22 ENST00000399967.3
FP15737
chrX_+_123094369 0.21 ENST00000455404.1
ENST00000218089.9
stromal antigen 2
chr11_-_107590383 0.21 ENST00000525934.1
ENST00000531293.1
sarcolipin
chr16_-_3767506 0.21 ENST00000538171.1
TNF receptor-associated protein 1
chr14_-_107199464 0.20 ENST00000433072.2
immunoglobulin heavy variable 3-72
chr16_-_66952779 0.16 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
cadherin 16, KSP-cadherin
chr19_-_18391708 0.15 ENST00000600972.1
jun D proto-oncogene
chr6_+_125524785 0.15 ENST00000392482.2
tumor protein D52-like 1
chr12_+_66218598 0.15 ENST00000541363.1
high mobility group AT-hook 2
chr6_+_143772060 0.15 ENST00000367591.4
peroxisomal biogenesis factor 3
chr22_+_38609538 0.14 ENST00000407965.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr6_-_32145861 0.13 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr1_+_151512775 0.13 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
tuftelin 1
chr4_-_110723134 0.13 ENST00000510800.1
ENST00000512148.1
complement factor I
chr10_+_115674530 0.13 ENST00000451472.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr4_-_153601136 0.13 ENST00000504064.1
ENST00000304385.3
transmembrane protein 154
chr12_+_121416489 0.12 ENST00000541395.1
ENST00000544413.1
HNF1 homeobox A
chr16_-_66952742 0.12 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
cadherin 16, KSP-cadherin
chr10_-_15762124 0.12 ENST00000378076.3
integrin, alpha 8
chr12_-_371994 0.11 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
solute carrier family 6 (neurotransmitter transporter), member 13
chr10_-_118032979 0.11 ENST00000355422.6
GDNF family receptor alpha 1
chr1_+_16348525 0.10 ENST00000331433.4
chloride channel, voltage-sensitive Ka
chr14_-_36990354 0.10 ENST00000518149.1
NK2 homeobox 1
chr3_-_114343768 0.08 ENST00000393785.2
zinc finger and BTB domain containing 20
chr10_-_118032697 0.06 ENST00000439649.3
GDNF family receptor alpha 1
chr2_+_119699742 0.05 ENST00000327097.4
macrophage receptor with collagenous structure
chr4_+_144303093 0.05 ENST00000505913.1
GRB2-associated binding protein 1
chr20_+_47835884 0.05 ENST00000371764.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr7_+_112063192 0.04 ENST00000005558.4
interferon-related developmental regulator 1
chr7_-_86974767 0.03 ENST00000610086.1
TP53 target 1 (non-protein coding)
chrX_-_110654147 0.03 ENST00000358070.4
doublecortin
chr2_-_152118352 0.03 ENST00000331426.5
RNA binding motif protein 43
chr19_-_44259053 0.02 ENST00000601170.1
SMG9 nonsense mediated mRNA decay factor
chrX_-_53461288 0.02 ENST00000375298.4
ENST00000375304.5
hydroxysteroid (17-beta) dehydrogenase 10
chr19_-_44259136 0.02 ENST00000270066.6
SMG9 nonsense mediated mRNA decay factor
chr5_+_149737202 0.01 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
Treacher Collins-Franceschetti syndrome 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 18.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.8 5.5 GO:0044278 cell wall disruption in other organism(GO:0044278)
1.4 4.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.9 2.6 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.7 49.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.7 2.0 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 1.8 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.5 1.6 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.5 7.7 GO:0006089 lactate metabolic process(GO:0006089)
0.5 1.5 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.5 3.3 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.5 1.9 GO:0015966 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.4 43.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 1.2 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.3 1.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 0.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 0.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.2 1.1 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.2 0.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 1.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 1.1 GO:0051012 microtubule sliding(GO:0051012)
0.2 0.7 GO:0042335 cuticle development(GO:0042335)
0.2 0.5 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.2 0.6 GO:0048749 compound eye development(GO:0048749)
0.2 0.6 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 2.0 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 2.0 GO:1903800 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 2.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.6 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 3.6 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 1.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.5 GO:0009386 translational attenuation(GO:0009386)
0.1 2.0 GO:0051775 response to redox state(GO:0051775)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.1 1.8 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 1.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.8 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.3 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.1 1.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.3 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 1.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 9.6 GO:0006903 vesicle targeting(GO:0006903)
0.1 1.1 GO:0072584 caveolin-mediated endocytosis(GO:0072584)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 4.1 GO:0042417 dopamine metabolic process(GO:0042417)
0.1 1.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.4 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) protein localization to nucleolus(GO:1902570)
0.1 0.6 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 1.8 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.6 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.7 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.0 1.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 4.9 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.6 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.5 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 1.0 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.9 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.6 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639) positive regulation of podosome assembly(GO:0071803)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.0 GO:0007518 myoblast fate determination(GO:0007518)
0.0 5.5 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 49.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.9 18.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.5 2.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.5 3.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.4 1.7 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.3 3.0 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.2 4.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.1 GO:0001940 male pronucleus(GO:0001940)
0.2 2.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.2 1.3 GO:0070852 cell body fiber(GO:0070852)
0.1 9.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.7 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.1 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 1.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.1 0.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 17.2 GO:0043209 myelin sheath(GO:0043209)
0.1 0.2 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 2.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 4.0 GO:0016234 inclusion body(GO:0016234)
0.0 2.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 4.8 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 5.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 4.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0030424 axon(GO:0030424)
0.0 2.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.7 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.9 49.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.7 2.0 GO:0004802 transketolase activity(GO:0004802)
0.6 1.8 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.5 5.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.4 4.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 3.8 GO:1903136 cuprous ion binding(GO:1903136)
0.3 1.5 GO:0030911 TPR domain binding(GO:0030911)
0.3 4.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.3 45.0 GO:0003823 antigen binding(GO:0003823)
0.2 1.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 2.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 1.1 GO:0035500 MH2 domain binding(GO:0035500)
0.2 0.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 1.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 0.6 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 1.1 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.9 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 2.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 1.6 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.6 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 1.3 GO:0070628 proteasome binding(GO:0070628)
0.1 0.4 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.2 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.8 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 2.0 GO:0043022 ribosome binding(GO:0043022)
0.0 2.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 16.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.4 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 3.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 6.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 6.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 3.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.8 PID AURORA A PATHWAY Aurora A signaling
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.6 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 2.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 18.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 4.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 4.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.2 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 2.0 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 3.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis