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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX6-3

Z-value: 0.27

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_125132803 3.58 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_141747950 3.30 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_+_125133315 1.92 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_90769422 1.88 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr4_+_80584903 1.83 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr3_-_141719195 1.70 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr13_+_53602894 1.52 ENST00000219022.2
OLFM4
olfactomedin 4
chr7_-_25268104 1.40 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr11_-_13517565 1.35 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr14_-_51027838 1.29 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chrX_+_107288239 1.02 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_43515467 0.92 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chrX_+_107288197 0.82 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr19_+_50016610 0.76 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_+_93443419 0.75 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr17_-_10372875 0.73 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr17_-_64225508 0.62 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_+_138340067 0.61 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr4_-_123542224 0.60 ENST00000264497.3
IL21
interleukin 21
chr5_-_142780280 0.58 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_4402659 0.53 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr3_+_138340049 0.48 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr7_+_138145076 0.41 ENST00000343526.4
TRIM24
tripartite motif containing 24
chrX_-_130423200 0.37 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr8_+_77593448 0.37 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr8_+_77593474 0.34 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr6_+_114178512 0.31 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr5_-_58295712 0.26 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_-_67517716 0.23 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr2_+_234826016 0.23 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr20_+_30697298 0.23 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr3_+_121902511 0.22 ENST00000490131.1
CASR
calcium-sensing receptor
chrX_+_47696275 0.22 ENST00000376954.1
ENST00000338637.7
ZNF81
zinc finger protein 81
chr5_-_139726181 0.21 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr1_-_151431647 0.21 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr12_-_52761262 0.18 ENST00000257901.3
KRT85
keratin 85
chr20_-_33735070 0.15 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr1_-_151431909 0.10 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr11_+_22689648 0.07 ENST00000278187.3
GAS2
growth arrest-specific 2
chrX_-_110655306 0.05 ENST00000371993.2
DCX
doublecortin
chr14_+_88851874 0.03 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.3 5.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.5 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 1.4 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 5.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.8 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 1.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.6 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.6 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 5.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.7 GO:0032982 myosin filament(GO:0032982)
0.0 5.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.3 GO:0043073 germ cell nucleus(GO:0043073)
0.0 1.5 GO:1904724 specific granule lumen(GO:0035580) tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 0.8 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.4 GO:0034711 inhibin binding(GO:0034711)
0.0 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.0 PID E2F PATHWAY E2F transcription factor network
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants