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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR4A1

Z-value: 0.72

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Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
NR4A1
ENSG00000123358.15 nuclear receptor subfamily 4 group A member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR4A1hg19_v2_chr12_+_52445191_524452430.343.2e-07Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_138763734 30.75 ENST00000413199.1
ENST00000502927.2
PRR23C
proline rich 23C
chr11_-_111794446 15.87 ENST00000527950.1
CRYAB
crystallin, alpha B
chr22_+_24891210 14.46 ENST00000382760.2
UPB1
ureidopropionase, beta
chr12_-_16759711 10.53 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_14989186 10.50 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr8_-_120685608 10.00 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr13_-_33112823 8.17 ENST00000504114.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr1_+_236849754 8.12 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr17_+_4855053 7.88 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr4_+_159593271 7.73 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr7_-_37488834 7.46 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr17_+_4854375 7.36 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
ENO3
enolase 3 (beta, muscle)
chr1_+_16062820 6.84 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr15_-_42783303 6.71 ENST00000565380.1
ENST00000564754.1
ZNF106
zinc finger protein 106
chr12_+_109577202 6.38 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chrX_-_43741594 6.23 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chr10_-_75634219 6.19 ENST00000305762.7
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr12_-_95467267 5.98 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr19_+_54926601 5.96 ENST00000301194.4
TTYH1
tweety family member 1
chr4_+_176986978 5.72 ENST00000508596.1
ENST00000393643.2
WDR17
WD repeat domain 17
chr19_+_54926621 5.70 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
TTYH1
tweety family member 1
chr1_+_14075903 5.68 ENST00000343137.4
ENST00000503842.1
ENST00000407521.3
ENST00000505823.1
PRDM2
PR domain containing 2, with ZNF domain
chr1_+_156589051 5.47 ENST00000255039.1
HAPLN2
hyaluronan and proteoglycan link protein 2
chr2_+_234216454 5.41 ENST00000447536.1
ENST00000409110.1
SAG
S-antigen; retina and pineal gland (arrestin)
chr13_-_33112899 5.27 ENST00000267068.3
ENST00000357505.6
ENST00000399396.3
N4BP2L2
NEDD4 binding protein 2-like 2
chr3_+_14989076 5.25 ENST00000413118.1
ENST00000425241.1
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr12_+_6644443 5.21 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr14_-_101295407 5.13 ENST00000596284.1
AL117190.2
AL117190.2
chr12_+_21679220 4.86 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr22_-_51016846 4.86 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr17_-_29624343 4.77 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr7_-_72936608 4.76 ENST00000404251.1
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr14_+_29236269 4.71 ENST00000313071.4
FOXG1
forkhead box G1
chr12_+_32655048 4.62 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr19_-_41256207 4.59 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr2_+_162016827 4.57 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr6_+_30594619 4.43 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr22_-_51017084 4.34 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr13_-_33112956 4.08 ENST00000505213.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr19_+_49713991 4.07 ENST00000597316.1
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr3_+_101443476 4.06 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr20_+_3052264 4.06 ENST00000217386.2
OXT
oxytocin/neurophysin I prepropeptide
chr17_-_7123021 3.86 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr4_-_89744314 3.84 ENST00000508369.1
FAM13A
family with sequence similarity 13, member A
chrX_+_2746818 3.84 ENST00000398806.3
GYG2
glycogenin 2
chr1_+_176432298 3.79 ENST00000367661.3
ENST00000367662.3
PAPPA2
pappalysin 2
chr1_+_104293028 3.75 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr14_-_21567009 3.69 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219
zinc finger protein 219
chr10_-_103815874 3.67 ENST00000370033.4
ENST00000311122.5
C10orf76
chromosome 10 open reading frame 76
chr10_-_17171817 3.64 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr3_-_44519131 3.62 ENST00000425708.2
ENST00000396077.2
ZNF445
zinc finger protein 445
chr20_+_37590942 3.59 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
DHX35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr10_+_12110963 3.57 ENST00000263035.4
ENST00000437298.1
DHTKD1
dehydrogenase E1 and transketolase domain containing 1
chr3_-_133648656 3.56 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr6_-_152958521 3.55 ENST00000367255.5
ENST00000265368.4
ENST00000448038.1
ENST00000341594.5
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_48936272 3.54 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr16_+_21312170 3.51 ENST00000338573.5
ENST00000561968.1
CRYM-AS1
CRYM antisense RNA 1
chr4_-_89744365 3.47 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr10_-_75634260 3.39 ENST00000372765.1
ENST00000351293.3
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr6_-_33771757 3.16 ENST00000507738.1
ENST00000266003.5
ENST00000430124.2
MLN
motilin
chr6_-_152489484 3.11 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr8_+_99956662 3.02 ENST00000523368.1
ENST00000297565.4
ENST00000435298.2
OSR2
odd-skipped related transciption factor 2
chr6_+_69942298 3.02 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr14_-_24711470 2.96 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr1_+_173793777 2.89 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr11_+_116700614 2.88 ENST00000375345.1
APOC3
apolipoprotein C-III
chr7_-_81399329 2.86 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_111743285 2.73 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr11_+_116700600 2.72 ENST00000227667.3
APOC3
apolipoprotein C-III
chr10_-_75634326 2.67 ENST00000322635.3
ENST00000444854.2
ENST00000423381.1
ENST00000322680.3
ENST00000394762.2
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr7_-_81399411 2.62 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_+_3876859 2.47 ENST00000300737.4
STIM1
stromal interaction molecule 1
chr7_+_119913688 2.41 ENST00000331113.4
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr12_+_49687425 2.36 ENST00000257860.4
PRPH
peripherin
chr17_-_66287257 2.36 ENST00000327268.4
SLC16A6
solute carrier family 16, member 6
chr6_+_149068464 2.30 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr7_+_99933730 2.29 ENST00000610247.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr18_+_43753974 2.24 ENST00000282059.6
ENST00000321319.6
C18orf25
chromosome 18 open reading frame 25
chr2_+_162016916 2.22 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr15_-_41120896 2.21 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr5_-_27038683 2.16 ENST00000511822.1
ENST00000231021.4
CDH9
cadherin 9, type 2 (T1-cadherin)
chrX_+_2746850 2.11 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr6_+_118869452 2.09 ENST00000357525.5
PLN
phospholamban
chr3_+_51741072 2.09 ENST00000395052.3
GRM2
glutamate receptor, metabotropic 2
chr7_-_6048702 2.03 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr7_-_81399438 2.01 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr8_+_99956759 1.97 ENST00000522510.1
ENST00000457907.2
OSR2
odd-skipped related transciption factor 2
chr6_+_64346386 1.96 ENST00000509330.1
PHF3
PHD finger protein 3
chr1_-_161102421 1.92 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr18_-_60986613 1.92 ENST00000444484.1
BCL2
B-cell CLL/lymphoma 2
chr3_+_29322437 1.89 ENST00000434693.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr14_+_22386325 1.82 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr17_+_1646130 1.77 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr18_-_60986962 1.67 ENST00000333681.4
BCL2
B-cell CLL/lymphoma 2
chr10_+_101542462 1.58 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr20_-_44485835 1.40 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr6_+_31895467 1.38 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr5_-_74162605 1.38 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
FAM169A
family with sequence similarity 169, member A
chr4_+_100495864 1.37 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr19_-_11639931 1.35 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr7_-_107443652 1.31 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
SLC26A3
solute carrier family 26 (anion exchanger), member 3
chr2_+_162016804 1.27 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr6_+_31895480 1.25 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
C2
CFB
complement component 2
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr4_+_71108300 1.25 ENST00000304954.3
CSN3
casein kappa
chr1_+_50569575 0.99 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr6_+_31895254 0.93 ENST00000299367.5
ENST00000442278.2
C2
complement component 2
chr7_+_120969045 0.92 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr19_-_11639910 0.89 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr1_-_161102367 0.83 ENST00000464113.1
DEDD
death effector domain containing
chr1_+_2398876 0.72 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr11_-_113577052 0.66 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
TMPRSS5
transmembrane protease, serine 5
chr6_+_44126545 0.63 ENST00000532171.1
ENST00000398776.1
ENST00000542245.1
CAPN11
calpain 11
chrX_+_135618258 0.62 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr11_-_113577014 0.57 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
TMPRSS5
transmembrane protease, serine 5
chr18_-_52969844 0.52 ENST00000561831.3
TCF4
transcription factor 4
chr7_-_105517021 0.45 ENST00000318724.4
ENST00000419735.3
ATXN7L1
ataxin 7-like 1
chr12_+_93963590 0.40 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr7_-_6048650 0.38 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr7_-_81399355 0.38 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr8_+_123793633 0.37 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr9_-_75567962 0.29 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr7_-_105516923 0.24 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr4_-_89744457 0.23 ENST00000395002.2
FAM13A
family with sequence similarity 13, member A
chr11_+_120971882 0.20 ENST00000392793.1
TECTA
tectorin alpha
chr4_-_111563076 0.06 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
2.5 17.5 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
2.0 8.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.9 5.6 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
1.8 10.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.7 5.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.6 6.4 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
1.4 4.1 GO:0002125 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
1.3 8.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.2 5.0 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
1.1 5.5 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
1.0 4.1 GO:1903949 positive regulation of cardiac conduction(GO:1903781) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
1.0 7.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.0 2.9 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.9 3.6 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.9 6.2 GO:0010269 response to selenium ion(GO:0010269)
0.9 15.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.8 2.5 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.8 12.7 GO:0006853 carnitine shuttle(GO:0006853)
0.8 14.3 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.7 10.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.7 6.7 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.7 6.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.6 3.9 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.5 1.6 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) response to antineoplastic agent(GO:0097327)
0.5 3.0 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.5 7.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.4 4.4 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.4 11.7 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.4 3.6 GO:0015889 cobalamin transport(GO:0015889)
0.4 1.8 GO:0003072 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.3 15.2 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 4.1 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.3 0.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.3 5.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 2.3 GO:0006477 protein sulfation(GO:0006477)
0.2 1.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 7.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 1.3 GO:0019532 oxalate transport(GO:0019532)
0.2 2.4 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 2.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.2 2.4 GO:0045475 locomotor rhythm(GO:0045475)
0.2 5.4 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 0.3 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 2.1 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 1.4 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.1 3.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 2.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 1.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 4.6 GO:0046847 filopodium assembly(GO:0046847)
0.1 16.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.7 GO:0007595 lactation(GO:0007595)
0.0 3.8 GO:0060349 bone morphogenesis(GO:0060349)
0.0 2.2 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 0.1 GO:0035993 subthalamic nucleus development(GO:0021763) deltoid tuberosity development(GO:0035993) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.0 6.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 2.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.2 GO:0034332 adherens junction organization(GO:0034332)
0.0 2.2 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 3.4 GO:0001505 regulation of neurotransmitter levels(GO:0001505)
0.0 1.9 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.7 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 15.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.3 11.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.0 15.9 GO:0097512 cardiac myofibril(GO:0097512)
0.7 5.2 GO:0097452 GAIT complex(GO:0097452)
0.7 5.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.6 7.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.6 3.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.6 3.0 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.5 6.7 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5 3.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.4 4.4 GO:0097427 microtubule bundle(GO:0097427)
0.4 3.9 GO:0098839 postsynaptic density membrane(GO:0098839)
0.4 2.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.3 2.4 GO:0032389 MutLalpha complex(GO:0032389)
0.3 8.1 GO:0031143 pseudopodium(GO:0031143)
0.3 13.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 7.7 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 1.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 4.1 GO:0034706 sodium channel complex(GO:0034706)
0.2 17.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 5.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 24.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.4 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.3 GO:0097225 sperm midpiece(GO:0097225)
0.1 5.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.4 GO:0043235 receptor complex(GO:0043235)
0.0 6.0 GO:0016605 PML body(GO:0016605)
0.0 4.1 GO:0043195 terminal bouton(GO:0043195)
0.0 5.9 GO:0043202 lysosomal lumen(GO:0043202)
0.0 4.6 GO:0030175 filopodium(GO:0030175)
0.0 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.6 GO:0072562 blood microparticle(GO:0072562)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 15.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.5 10.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.0 8.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
1.9 11.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.8 9.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
1.6 6.4 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.5 5.9 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.4 5.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.3 8.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.3 5.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.3 7.7 GO:0048039 ubiquinone binding(GO:0048039)
1.3 3.9 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
1.2 3.5 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
1.1 5.4 GO:0002046 opsin binding(GO:0002046)
0.9 4.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.9 12.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.8 6.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.7 3.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.6 2.9 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.5 2.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.5 15.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 2.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.4 17.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 3.4 GO:0004969 histamine receptor activity(GO:0004969)
0.3 2.4 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.3 3.6 GO:0031419 cobalamin binding(GO:0031419)
0.3 3.6 GO:0051434 BH3 domain binding(GO:0051434)
0.3 2.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 6.7 GO:0005521 lamin binding(GO:0005521)
0.2 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 5.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 21.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 7.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 14.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 5.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 4.1 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 2.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.6 GO:0001848 complement binding(GO:0001848)
0.1 13.6 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.3 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 3.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 4.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 3.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.4 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 6.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 4.1 GO:0005516 calmodulin binding(GO:0005516)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 15.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.3 3.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 5.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 6.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 7.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 7.9 PID ARF6 PATHWAY Arf6 signaling events
0.1 8.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 6.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.8 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 4.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 3.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 4.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 14.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 19.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.4 20.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 8.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 7.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 9.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 3.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 2.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 8.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 3.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 7.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 3.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 9.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 4.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 6.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 7.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.3 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 3.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 7.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.2 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling