ISMARA results: NR5A2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR5A2

Z-value: 1.53

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Transcription factors associated with NR5A2

Gene Symbol	Gene ID	Gene Info
NR5A2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000116833.9	nuclear receptor subfamily 5 group A member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR5A2	hg19_v2_chr1_+_199996702_199996732	0.32	2.0e-06	Click!

Activity profile of NR5A2 motif

Sorted Z-values of NR5A2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_21491477 Show fit	65.98	ENST00000298684.5 ENST00000557169.1 ENST00000553563.1	NDRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 2
chr14_-_21492251 Show fit	58.22	ENST00000554398.1	NDRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 2
chr14_-_21492113 Show fit	57.00	ENST00000554094.1	NDRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 2
chr16_+_56623433 Show fit	36.02	ENST00000570176.1	MT3 Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 3
chrX_+_103031421 Show fit	35.60	ENST00000433491.1 ENST00000418604.1 ENST00000443502.1	PLP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteolipid protein 1
chr8_-_110704014 Show fit	35.09	ENST00000529190.1 ENST00000422135.1 ENST00000419099.1	SYBU Ensembl NCBI GeneCards UniProt NextProt Show fit	syntabulin (syntaxin-interacting)
chrX_+_103031758 Show fit	34.81	ENST00000303958.2 ENST00000361621.2	PLP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteolipid protein 1
chr2_+_220491973 Show fit	28.49	ENST00000358055.3	SLC4A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 4 (anion exchanger), member 3
chr16_+_226658 Show fit	28.47	ENST00000320868.5 ENST00000397797.1	HBA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, alpha 1
chr14_-_21490958 Show fit	26.64	ENST00000554104.1	NDRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.3	228.6	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1	102.6	GO:0043547	positive regulation of GTPase activity(GO:0043547)
1.5	78.3	GO:0015701	bicarbonate transport(GO:0015701)
4.1	69.5	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
8.3	41.6	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.2	39.3	GO:0070588	calcium ion transmembrane transport(GO:0070588)
1.9	36.8	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
12.0	36.0	GO:2000296	cadmium ion homeostasis(GO:0055073) negative regulation of hydrogen peroxide catabolic process(GO:2000296)
3.1	34.6	GO:0006600	creatine metabolic process(GO:0006600)
1.8	31.6	GO:0007021	tubulin complex assembly(GO:0007021)

Showing 1 to 10 of 292 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	219.3	GO:0030426	growth cone(GO:0030426)
0.1	96.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	59.1	GO:0016021	integral component of membrane(GO:0016021)
3.0	51.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
3.8	49.9	GO:0097433	dense body(GO:0097433)
1.0	44.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
2.6	41.7	GO:0097512	cardiac myofibril(GO:0097512)
3.0	41.6	GO:0097227	sperm annulus(GO:0097227)
0.5	39.8	GO:0043195	terminal bouton(GO:0043195)
0.2	39.4	GO:0043209	myelin sheath(GO:0043209)

Showing 1 to 10 of 126 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	77.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
2.5	76.2	GO:0017075	syntaxin-1 binding(GO:0017075)
5.9	70.4	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.3	69.7	GO:0000287	magnesium ion binding(GO:0000287)
0.7	46.2	GO:0043621	protein self-association(GO:0043621)
1.5	44.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
1.4	41.0	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.6	36.8	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.3	36.3	GO:0035591	signaling adaptor activity(GO:0035591)
2.7	35.6	GO:0046870	cadmium ion binding(GO:0046870)

Showing 1 to 10 of 230 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	190.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
2.0	71.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.9	37.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.6	33.9	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.4	19.0	PID RAS PATHWAY	Regulation of Ras family activation
0.4	15.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.9	15.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	14.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	14.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.4	14.0	PID NETRIN PATHWAY	Netrin-mediated signaling events

Showing 1 to 10 of 63 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	47.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.6	44.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	34.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	32.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.6	31.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	29.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
1.6	27.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.4	24.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
1.0	20.7	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	16.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation

Showing 1 to 10 of 95 entries

Results for NR5A2

Z-value: 1.53

Motif logo

Transcription factors associated with NR5A2

Activity-expression correlation:

Activity profile of NR5A2 motif

Sorted Z-values of NR5A2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: