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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for OVOL1
Z-value: 0.27
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Transcription factors associated with OVOL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OVOL1 | hg19_v2_chr11_+_65554493_65554546 | 0.20 | 3.0e-03 | Click! |
Top targets:  
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_84419101 Show fit | 5.34 |
ENST00000520302.1
ENST00000520213.1 ENST00000439399.2 ENST00000428679.2 ENST00000437520.1 |
synaptosomal-associated protein, 91kDa |
|
| chr10_-_73848086 Show fit | 3.44 |
ENST00000536168.1
|
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
|
| chr10_-_21786179 Show fit | 3.39 |
ENST00000377113.5
|
cancer susceptibility candidate 10 |
|
| chr10_-_73848764 Show fit | 3.24 |
ENST00000317376.4
ENST00000412663.1 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
|
| chr5_+_140739537 Show fit | 3.16 |
ENST00000522605.1
|
protocadherin gamma subfamily B, 2 |
|
| chr10_-_73848531 Show fit | 2.86 |
ENST00000373109.2
|
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
|
| chr5_-_16509101 Show fit | 2.46 |
ENST00000399793.2
|
family with sequence similarity 134, member B |
|
| chr5_+_140261703 Show fit | 1.88 |
ENST00000409494.1
ENST00000289272.2 |
protocadherin alpha 13 |
|
| chr1_+_174846570 Show fit | 1.45 |
ENST00000392064.2
|
RAB GTPase activating protein 1-like |
|
| chr3_-_165555200 Show fit | 1.18 |
ENST00000479451.1
ENST00000540653.1 ENST00000488954.1 ENST00000264381.3 |
butyrylcholinesterase |
Network of associatons between targets according to the STRING database.
First level regulatory network of OVOL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.2 | 5.3 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 5.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 1.4 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.4 | 1.2 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 0.8 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 0.8 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.6 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.2 | GO:0090240 | follicle-stimulating hormone signaling pathway(GO:0042699) positive regulation of histone H4 acetylation(GO:0090240) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 5.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.8 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 5.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.3 | 2.4 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 1.2 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.2 | 0.8 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.0 | 0.8 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 0.2 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.8 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |