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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PAX1_PAX9

Z-value: 0.53

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37131058_37131139,
hg19_v2_chr14_+_37126765_37126799		0.153.1e-02Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.036.2e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_84824920 14.32 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr18_+_39766626 8.85 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr9_+_33750667 6.47 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3
protease, serine, 3
chr9_+_33750515 6.47 ENST00000361005.5
PRSS3
protease, serine, 3
chr4_+_75230853 6.00 ENST00000244869.2
EREG
epiregulin
chr4_+_123747979 5.59 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr4_+_123747834 5.16 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr8_-_23261589 5.15 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chr1_-_213031418 4.79 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1-AS1
FLVCR1 antisense RNA 1 (head to head)
chr10_-_99393242 4.46 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr10_-_99393208 4.23 ENST00000307450.6
MORN4
MORN repeat containing 4
chr9_+_33795533 4.19 ENST00000379405.3
PRSS3
protease, serine, 3
chr8_-_101965559 3.99 ENST00000353245.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr17_+_15848231 3.57 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr5_-_133747589 2.69 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr7_+_142457315 2.60 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr2_-_175712270 2.48 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr8_-_101965146 2.09 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr6_-_137366163 2.07 ENST00000367748.1
IL20RA
interleukin 20 receptor, alpha
chr7_-_19157248 2.04 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr9_-_21142144 1.93 ENST00000380229.2
IFNW1
interferon, omega 1
chr17_-_39968406 1.93 ENST00000393928.1
LEPREL4
leprecan-like 4
chr9_-_104249400 1.86 ENST00000374848.3
TMEM246
transmembrane protein 246
chr1_-_204165610 1.83 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr8_-_121824374 1.76 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr11_+_6947720 1.58 ENST00000414517.2
ZNF215
zinc finger protein 215
chr17_-_3461092 1.43 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr17_+_39969183 1.43 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr17_-_39968855 1.42 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr3_+_195447738 1.32 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr6_-_132945414 1.32 ENST00000367931.1
ENST00000537809.1
TAAR2
trace amine associated receptor 2
chr2_+_207630081 1.30 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr17_-_7137582 1.25 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr9_-_124991124 1.08 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr9_+_6716478 1.07 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chr19_-_40791211 0.97 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chrX_-_148669116 0.82 ENST00000243314.5
MAGEA9B
melanoma antigen family A, 9B
chr19_-_5838768 0.80 ENST00000527106.1
ENST00000531199.1
ENST00000529165.1
FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr14_+_24540046 0.80 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr13_+_21141270 0.79 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr6_+_74104471 0.75 ENST00000370336.4
DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr11_+_61522844 0.67 ENST00000265460.5
MYRF
myelin regulatory factor
chr13_+_21141208 0.60 ENST00000351808.5
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr20_-_17641097 0.53 ENST00000246043.4
RRBP1
ribosome binding protein 1
chr18_-_47017956 0.52 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr2_-_162931052 0.51 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr18_-_47018769 0.50 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr1_+_213031570 0.49 ENST00000366971.4
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr4_+_619347 0.45 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr12_+_57828521 0.44 ENST00000309668.2
INHBC
inhibin, beta C
chr17_-_33814851 0.42 ENST00000449046.1
ENST00000260908.7
SLFN12L
schlafen family member 12-like
chr7_-_22234381 0.38 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr12_-_101801505 0.34 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr19_-_52148798 0.33 ENST00000534261.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr6_+_3118926 0.30 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr19_-_40791302 0.28 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr11_+_6947647 0.21 ENST00000278319.5
ZNF215
zinc finger protein 215
chr4_+_619386 0.15 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr13_+_98086445 0.10 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr12_+_58138800 0.09 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr22_+_39745930 0.04 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr1_+_26758790 0.02 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
DHDDS
dehydrodolichyl diphosphate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
1.5 10.7 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.9 3.6 GO:0002880 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.8 19.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.7 2.0 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.5 1.4 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.4 1.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.4 6.1 GO:0090168 Golgi reassembly(GO:0090168)
0.4 1.8 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.3 1.3 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.2 1.3 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.2 1.4 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.2 5.2 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.5 GO:0036343 psychomotor behavior(GO:0036343)
0.1 1.1 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.9 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 2.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.8 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.3 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0 0.5 GO:0015886 heme transport(GO:0015886)
0.0 2.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 1.4 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 17.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 5.2 GO:0005604 basement membrane(GO:0005604)
0.0 8.7 GO:0072562 blood microparticle(GO:0072562)
0.0 1.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 20.9 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.5 3.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.5 5.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.4 10.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 1.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 0.8 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.1 1.9 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 6.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 20.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.5 GO:0015232 heme transporter activity(GO:0015232)
0.0 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 6.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 2.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.4 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 10.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 7.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 22.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 3.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 10.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 6.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.2 1.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 6.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.6 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport