ISMARA results: PBX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PBX1

Z-value: 0.85

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Transcription factors associated with PBX1

Gene Symbol	Gene ID	Gene Info
PBX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185630.14	PBX homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PBX1	hg19_v2_chr1_+_164529004_164529060	-0.13	5.9e-02	Click!

Activity profile of PBX1 motif

Sorted Z-values of PBX1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_140135665 Show fit	23.24	ENST00000340384.4	TUBB4B Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, beta 4B class IVb
chr4_+_83956237 Show fit	14.04	ENST00000264389.2	COPS4 Ensembl NCBI GeneCards UniProt NextProt Show fit	COP9 signalosome subunit 4
chr4_+_83956312 Show fit	14.00	ENST00000509317.1 ENST00000503682.1 ENST00000511653.1	COPS4 Ensembl NCBI GeneCards UniProt NextProt Show fit	COP9 signalosome subunit 4
chr18_+_29171689 Show fit	12.57	ENST00000237014.3	TTR Ensembl NCBI GeneCards UniProt NextProt Show fit	transthyretin
chr8_+_98788003 Show fit	11.57	ENST00000521545.2	LAPTM4B Ensembl NCBI GeneCards UniProt NextProt Show fit	lysosomal protein transmembrane 4 beta
chr10_-_101190202 Show fit	8.94	ENST00000543866.1 ENST00000370508.5	GOT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamic-oxaloacetic transaminase 1, soluble
chr3_+_159557637 Show fit	8.26	ENST00000445224.2	SCHIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	schwannomin interacting protein 1
chr4_+_69962185 Show fit	8.00	ENST00000305231.7	UGT2B7 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide B7
chr16_+_15596123 Show fit	7.99	ENST00000452191.2	C16orf45 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 16 open reading frame 45
chr4_+_69962212 Show fit	7.66	ENST00000508661.1	UGT2B7 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide B7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	28.0	GO:0000338	protein deneddylation(GO:0000338)
0.3	22.1	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.8	17.9	GO:0052695	cellular glucuronidation(GO:0052695)
0.5	13.8	GO:0070987	error-free translesion synthesis(GO:0070987)
1.3	13.3	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.0	12.6	GO:0070327	thyroid hormone transport(GO:0070327)
4.1	12.4	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.3	12.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.8	11.7	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
1.0	10.3	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)

Showing 1 to 10 of 105 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	31.4	GO:0035578	azurophil granule lumen(GO:0035578)
0.5	28.4	GO:0008180	COP9 signalosome(GO:0008180)
0.1	14.9	GO:0043679	axon terminus(GO:0043679)
0.0	14.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.9	13.8	GO:0005662	DNA replication factor A complex(GO:0005662)
0.2	13.3	GO:0000118	histone deacetylase complex(GO:0000118)
2.5	12.4	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	12.1	GO:0005938	cell cortex(GO:0005938)
0.0	10.4	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
2.6	10.3	GO:0070985	TFIIK complex(GO:0070985)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	28.0	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.7	24.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.7	23.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.6	12.7	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
1.3	12.6	GO:0070324	thyroid hormone binding(GO:0070324)
2.5	12.4	GO:0030348	syntaxin-3 binding(GO:0030348)
0.0	12.4	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.1	12.3	GO:0005499	vitamin D binding(GO:0005499)
0.8	12.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.4	10.3	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Showing 1 to 10 of 87 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.4	PID ATR PATHWAY	ATR signaling pathway
0.2	14.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	12.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	10.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	10.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	7.0	PID AURORA B PATHWAY	Aurora B signaling
0.1	6.7	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.1	6.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	5.1	PID MYC PATHWAY	C-MYC pathway
0.1	4.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	23.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.9	23.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.7	17.4	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
1.1	13.8	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.7	12.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.2	11.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.4	10.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.5	7.8	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	7.3	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	6.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones

Showing 1 to 10 of 35 entries

Results for PBX1

Z-value: 0.85

Motif logo

Transcription factors associated with PBX1

Activity-expression correlation:

Activity profile of PBX1 motif

Sorted Z-values of PBX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: