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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PKNOX1_TGIF2

Z-value: 0.85

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Transcription factors associated with PKNOX1_TGIF2

Gene Symbol Gene ID Gene Info
ENSG00000160199.10 PBX/knotted 1 homeobox 1
ENSG00000118707.5 TGFB induced factor homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TGIF2hg19_v2_chr20_+_35202909_352030750.452.0e-12Click!
PKNOX1hg19_v2_chr21_+_44394620_44394737-0.194.2e-03Click!

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_11666649 19.59 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chr7_-_148580563 16.90 ENST00000476773.1
enhancer of zeste homolog 2 (Drosophila)
chr19_+_49496705 15.12 ENST00000595090.1
RuvB-like AAA ATPase 2
chr1_-_32384693 14.54 ENST00000602683.1
ENST00000470404.1
protein tyrosine phosphatase type IVA, member 2
chr1_-_63988846 13.92 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
integrin beta 3 binding protein (beta3-endonexin)
chr18_-_54318353 13.77 ENST00000590954.1
ENST00000540155.1
thioredoxin-like 1
chr6_+_111195973 13.05 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
adenosylmethionine decarboxylase 1
chr3_+_52719936 11.63 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr19_+_49496782 11.24 ENST00000601968.1
ENST00000596837.1
RuvB-like AAA ATPase 2
chr22_-_50219548 10.91 ENST00000404034.1
bromodomain containing 1
chr1_+_207262881 10.41 ENST00000451804.2
complement component 4 binding protein, beta
chr1_-_51425902 10.41 ENST00000396153.2
Fas (TNFRSF6) associated factor 1
chr18_+_3449695 9.94 ENST00000343820.5
TGFB-induced factor homeobox 1
chr20_-_33872518 9.73 ENST00000374436.3
eukaryotic translation initiation factor 6
chr20_-_33872548 9.56 ENST00000374443.3
eukaryotic translation initiation factor 6
chr12_-_121019165 9.50 ENST00000341039.2
ENST00000357500.4
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr17_-_29151794 9.09 ENST00000324238.6
cytokine receptor-like factor 3
chr2_+_85804614 9.08 ENST00000263864.5
ENST00000409760.1
vesicle-associated membrane protein 8
chr1_+_181057638 9.06 ENST00000367577.4
immediate early response 5
chr11_-_107729887 8.78 ENST00000525815.1
solute carrier family 35, member F2
chr19_+_49497121 8.67 ENST00000413176.2
RuvB-like AAA ATPase 2
chr12_+_69004619 8.57 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B, member of RAS oncogene family
chr16_-_30457048 8.53 ENST00000500504.2
ENST00000542752.1
selenophosphate synthetase 2
chr2_-_61765315 8.35 ENST00000406957.1
ENST00000401558.2
exportin 1 (CRM1 homolog, yeast)
chr19_-_13044494 8.10 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
phenylalanyl-tRNA synthetase, alpha subunit
chr3_-_33481835 8.02 ENST00000283629.3
upstream binding protein 1 (LBP-1a)
chr9_-_132805430 8.01 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
formin binding protein 1
chr18_-_54305658 7.84 ENST00000586262.1
ENST00000217515.6
thioredoxin-like 1
chr18_+_3449821 7.44 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGFB-induced factor homeobox 1
chr1_+_207262540 7.17 ENST00000452902.2
complement component 4 binding protein, beta
chr9_-_130635741 7.07 ENST00000223836.10
adenylate kinase 1
chr1_-_225615599 7.06 ENST00000421383.1
ENST00000272163.4
lamin B receptor
chr1_+_207262578 6.97 ENST00000243611.5
ENST00000367076.3
complement component 4 binding protein, beta
chr22_-_37640277 6.61 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr13_-_46716969 6.48 ENST00000435666.2
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_74701062 6.27 ENST00000326637.3
TNNI3 interacting kinase
chr17_-_30228678 6.20 ENST00000261708.4
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr1_+_207262627 6.17 ENST00000391923.1
complement component 4 binding protein, beta
chr17_-_79827808 6.11 ENST00000580685.1
Rho GDP dissociation inhibitor (GDI) alpha
chr1_-_70671216 5.97 ENST00000370952.3
leucine rich repeat containing 40
chr12_+_72148614 5.86 ENST00000261263.3
RAB21, member RAS oncogene family
chr1_+_207262170 5.86 ENST00000367078.3
complement component 4 binding protein, beta
chr2_+_219081817 5.66 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
actin related protein 2/3 complex, subunit 2, 34kDa
chr4_-_100871506 5.55 ENST00000296417.5
H2A histone family, member Z
chr6_-_32140886 5.51 ENST00000395496.1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr5_+_43603229 5.34 ENST00000344920.4
ENST00000512996.2
nicotinamide nucleotide transhydrogenase
chr16_-_3030407 5.21 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
protein kinase, membrane associated tyrosine/threonine 1
chr9_-_123605177 5.20 ENST00000373904.5
ENST00000210313.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr3_+_52828805 5.19 ENST00000416872.2
ENST00000449956.2
inter-alpha-trypsin inhibitor heavy chain 3
chr7_-_104909435 5.01 ENST00000357311.3
SRSF protein kinase 2
chr11_-_46867780 4.91 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
cytoskeleton associated protein 5
chr22_-_37640456 4.90 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr3_-_3221358 4.87 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
cereblon
chr4_-_105416039 4.80 ENST00000394767.2
CXXC finger protein 4
chr15_-_61521495 4.60 ENST00000335670.6
RAR-related orphan receptor A
chr6_+_138188551 4.45 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr5_-_169725231 4.45 ENST00000046794.5
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_+_70661014 4.42 ENST00000373585.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr9_-_33447584 4.37 ENST00000297991.4
aquaporin 3 (Gill blood group)
chr5_-_179051579 4.29 ENST00000505811.1
ENST00000515714.1
ENST00000513225.1
ENST00000503664.1
ENST00000356731.5
ENST00000523137.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr17_+_76374714 4.23 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
phosphatidylglycerophosphate synthase 1
chr12_+_122326662 4.16 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr18_+_3451584 4.16 ENST00000551541.1
TGFB-induced factor homeobox 1
chr1_+_24286287 4.02 ENST00000334351.7
ENST00000374468.1
proline-rich nuclear receptor coactivator 2
chr20_+_60878005 4.02 ENST00000253003.2
adhesion regulating molecule 1
chr1_+_28844648 4.01 ENST00000373832.1
ENST00000373831.3
regulator of chromosome condensation 1
chr2_+_198380289 3.95 ENST00000233892.4
ENST00000409916.1
MOB family member 4, phocein
chr17_+_8191815 3.87 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RAN guanine nucleotide release factor
chr5_-_180666570 3.82 ENST00000509535.1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr12_-_31479045 3.81 ENST00000539409.1
ENST00000395766.1
family with sequence similarity 60, member A
chr21_-_34185944 3.67 ENST00000479548.1
chromosome 21 open reading frame 62
chr12_+_10658489 3.64 ENST00000538173.1
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr6_-_101329191 3.61 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
activating signal cointegrator 1 complex subunit 3
chr8_-_117768023 3.47 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chr11_+_74660278 3.47 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr7_+_76139741 3.44 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
uroplakin 3B
chr3_+_111260954 3.40 ENST00000283285.5
CD96 molecule
chr3_-_52569023 3.34 ENST00000307076.4
5'-nucleotidase domain containing 2
chr10_-_73848531 3.30 ENST00000373109.2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr2_+_191208196 3.12 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
inositol polyphosphate-1-phosphatase
chr13_-_41837620 3.09 ENST00000379477.1
ENST00000452359.1
ENST00000379480.4
ENST00000430347.2
mitochondrial translational release factor 1
chr11_-_111741994 3.08 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr6_+_31674639 2.98 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr1_+_109756523 2.97 ENST00000234677.2
ENST00000369923.4
seryl-tRNA synthetase
chr10_+_51565188 2.93 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
nuclear receptor coactivator 4
chr4_-_46391805 2.90 ENST00000540012.1
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr16_+_30212378 2.88 ENST00000569485.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_9938562 2.88 ENST00000586895.1
ENST00000358666.3
ENST00000590068.1
ENST00000593087.1
ubiquitin-like 5
chr1_+_32479430 2.85 ENST00000327300.7
ENST00000492989.1
KH domain containing, RNA binding, signal transduction associated 1
chr16_+_50776021 2.82 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr6_-_131949200 2.78 ENST00000539158.1
ENST00000368058.1
mediator complex subunit 23
chr2_+_99953816 2.74 ENST00000289371.6
eukaryotic translation initiation factor 5B
chr2_+_10560147 2.65 ENST00000422133.1
hippocalcin-like 1
chrX_-_153775426 2.63 ENST00000393562.2
glucose-6-phosphate dehydrogenase
chr19_-_50083803 2.63 ENST00000391853.3
ENST00000339093.3
nitric oxide synthase interacting protein
chr2_+_233925064 2.59 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr19_-_50083822 2.58 ENST00000596358.1
nitric oxide synthase interacting protein
chr15_+_68346501 2.57 ENST00000249636.6
protein inhibitor of activated STAT, 1
chr6_+_150070831 2.53 ENST00000367380.5
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr6_-_24911195 2.52 ENST00000259698.4
family with sequence similarity 65, member B
chr2_+_223725652 2.43 ENST00000357430.3
ENST00000392066.3
acyl-CoA synthetase long-chain family member 3
chr1_-_145715565 2.38 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160 molecule
chr8_-_141774467 2.33 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr3_+_183892635 2.32 ENST00000427072.1
ENST00000411763.2
ENST00000292807.5
ENST00000448139.1
ENST00000455925.1
adaptor-related protein complex 2, mu 1 subunit
chr6_+_150070857 2.31 ENST00000544496.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr20_-_36156293 2.31 ENST00000373537.2
ENST00000414542.2
bladder cancer associated protein
chr20_-_36156125 2.30 ENST00000397135.1
ENST00000397137.1
bladder cancer associated protein
chr10_-_16859442 2.30 ENST00000602389.1
ENST00000345264.5
Ras suppressor protein 1
chr18_+_3451646 2.28 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGFB-induced factor homeobox 1
chr2_-_203103281 2.26 ENST00000392244.3
ENST00000409181.1
ENST00000409712.1
ENST00000409498.2
ENST00000409368.1
ENST00000392245.1
ENST00000392246.2
small ubiquitin-like modifier 1
chr1_-_33502441 2.16 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
adenylate kinase 2
chr14_-_105635090 2.13 ENST00000331782.3
ENST00000347004.2
jagged 2
chr2_+_234668894 2.12 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr14_-_94856987 2.12 ENST00000449399.3
ENST00000404814.4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_62654155 2.09 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
ubiquitin specific peptidase 15
chr12_+_95867727 2.04 ENST00000323666.5
ENST00000546753.1
methionyl aminopeptidase 2
chr17_+_38296576 2.02 ENST00000264645.7
cancer susceptibility candidate 3
chr1_-_35658736 2.00 ENST00000357214.5
splicing factor proline/glutamine-rich
chr19_-_12512062 1.96 ENST00000595766.1
ENST00000430385.3
zinc finger protein 799
chr5_-_52405564 1.94 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
molybdenum cofactor synthesis 2
chr22_-_30234218 1.93 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
activating signal cointegrator 1 complex subunit 2
chr3_+_111260856 1.89 ENST00000352690.4
CD96 molecule
chr10_-_73848764 1.88 ENST00000317376.4
ENST00000412663.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_-_100459639 1.84 ENST00000375128.4
xeroderma pigmentosum, complementation group A
chr3_+_38017264 1.82 ENST00000436654.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr16_+_16484691 1.81 ENST00000344087.4
nuclear pore complex interacting protein family, member A7
chr17_-_64225508 1.81 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr19_+_49375649 1.74 ENST00000200453.5
protein phosphatase 1, regulatory subunit 15A
chr1_-_33502528 1.73 ENST00000354858.6
adenylate kinase 2
chr14_-_94856951 1.70 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_-_175443484 1.67 ENST00000514584.1
ENST00000542498.1
ENST00000296521.7
ENST00000422112.2
ENST00000504433.1
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr12_-_30887948 1.62 ENST00000433722.2
caprin family member 2
chrX_+_135730297 1.61 ENST00000370629.2
CD40 ligand
chr14_-_94857004 1.60 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_-_39322299 1.55 ENST00000601094.1
ENST00000595567.1
ENST00000602115.1
ENST00000601778.1
ENST00000597205.1
ENST00000595470.1
enoyl CoA hydratase 1, peroxisomal
chr13_+_73302047 1.54 ENST00000377814.2
ENST00000377815.3
ENST00000390667.5
bora, aurora kinase A activator
chr12_-_112847354 1.54 ENST00000550566.2
ENST00000553213.2
ENST00000424576.2
ENST00000202773.9
ribosomal protein L6
chr3_-_49823941 1.47 ENST00000321599.4
ENST00000395238.1
ENST00000468463.1
ENST00000460540.1
inositol hexakisphosphate kinase 1
chr14_-_21994525 1.47 ENST00000538754.1
spalt-like transcription factor 2
chr6_-_131949305 1.44 ENST00000368053.4
ENST00000354577.4
ENST00000403834.3
ENST00000540546.1
ENST00000368068.3
ENST00000368060.3
mediator complex subunit 23
chr2_-_225811747 1.42 ENST00000409592.3
dedicator of cytokinesis 10
chr2_-_37068530 1.41 ENST00000593798.1
Uncharacterized protein
chr6_-_86099898 1.36 ENST00000455071.1
RP11-30P6.6
chr14_-_100842588 1.34 ENST00000556645.1
ENST00000556209.1
ENST00000556504.1
ENST00000556435.1
ENST00000554772.1
ENST00000553581.1
ENST00000553769.2
ENST00000554605.1
ENST00000557722.1
ENST00000553413.1
ENST00000553524.1
ENST00000358655.4
tryptophanyl-tRNA synthetase
chr2_-_24149977 1.31 ENST00000238789.5
ATPase family, AAA domain containing 2B
chr16_+_27413483 1.31 ENST00000337929.3
ENST00000564089.1
interleukin 21 receptor
chr15_+_49170083 1.27 ENST00000530028.2
EP300 interacting inhibitor of differentiation 1
chr22_-_50946113 1.23 ENST00000216080.5
ENST00000474879.2
ENST00000380796.3
lipase maturation factor 2
chr7_+_99971068 1.23 ENST00000198536.2
ENST00000453419.1
paired immunoglobin-like type 2 receptor alpha
chrX_+_148622513 1.22 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
chromosome X open reading frame 40A
chr7_-_156803329 1.20 ENST00000252971.6
motor neuron and pancreas homeobox 1
chr4_+_110736659 1.19 ENST00000394631.3
ENST00000226796.6
GAR1 ribonucleoprotein
chr21_+_30502806 1.19 ENST00000399928.1
ENST00000399926.1
MAP3K7 C-terminal like
chr12_-_57522813 1.12 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_246729544 1.10 ENST00000544618.1
ENST00000366514.4
transcription factor B2, mitochondrial
chr6_-_31651817 1.09 ENST00000375863.3
ENST00000375860.2
lymphocyte antigen 6 complex, locus G5C
chr11_-_842509 1.07 ENST00000322028.4
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr4_+_74347400 1.07 ENST00000226355.3
afamin
chr15_-_37391614 1.06 ENST00000219869.9
Meis homeobox 2
chrX_+_135730373 1.06 ENST00000370628.2
CD40 ligand
chr1_+_154966058 1.06 ENST00000392487.1
lens epithelial protein
chr1_+_2036149 1.04 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
protein kinase C, zeta
chr16_+_31044812 1.03 ENST00000313843.3
syntaxin 4
chr15_-_43785303 1.01 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
tumor protein p53 binding protein 1
chr11_-_64052111 1.01 ENST00000394532.3
ENST00000394531.3
ENST00000309032.3
BCL2-associated agonist of cell death
chr9_+_34652164 1.01 ENST00000441545.2
ENST00000553620.1
interleukin 11 receptor, alpha
chr16_-_57831676 0.99 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
kinesin family member C3
chr12_+_104458235 0.96 ENST00000229330.4
host cell factor C2
chr15_+_49913175 0.94 ENST00000403028.3
DTW domain containing 1
chr3_+_63897605 0.94 ENST00000487717.1
ataxin 7
chr16_-_20817753 0.93 ENST00000389345.5
ENST00000300005.3
ENST00000357967.4
ENST00000569729.1
ERI1 exoribonuclease family member 2
chr16_-_31076332 0.92 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
zinc finger protein 668
chr3_+_45636219 0.91 ENST00000273317.4
LIM domains containing 1
chr11_-_2924720 0.91 ENST00000455942.2
solute carrier family 22 (organic cation transporter), member 18 antisense
chr2_-_86790593 0.89 ENST00000263856.4
ENST00000409225.2
charged multivesicular body protein 3
chr17_-_35969409 0.87 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
synergin, gamma
chr12_+_59989918 0.84 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr17_+_39411636 0.83 ENST00000394008.1
keratin associated protein 9-9
chr2_-_183106641 0.82 ENST00000346717.4
phosphodiesterase 1A, calmodulin-dependent
chr15_+_49913201 0.82 ENST00000329873.5
ENST00000558653.1
ENST00000559164.1
ENST00000560632.1
ENST00000559405.1
ENST00000251250.6
DTW domain containing 1
chr6_-_35656685 0.82 ENST00000539068.1
ENST00000540787.1
FK506 binding protein 5
chr21_-_34144157 0.82 ENST00000331923.4
PAX3 and PAX7 binding protein 1
chr17_+_68071389 0.82 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_+_4699244 0.81 ENST00000540757.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr2_-_203103185 0.80 ENST00000409205.1
small ubiquitin-like modifier 1
chr1_+_171217677 0.79 ENST00000402921.2
flavin containing monooxygenase 1
chr5_-_58882219 0.76 ENST00000505453.1
ENST00000360047.5
phosphodiesterase 4D, cAMP-specific
chr16_+_4896659 0.76 ENST00000592120.1
ubinuclein 1
chr19_-_39322497 0.75 ENST00000221418.4
enoyl CoA hydratase 1, peroxisomal
chr19_-_51537982 0.74 ENST00000525263.1
kallikrein-related peptidase 12
chr19_-_51538148 0.74 ENST00000319590.4
ENST00000250351.4
kallikrein-related peptidase 12
chr4_+_57774042 0.73 ENST00000309042.7
RE1-silencing transcription factor
chr5_+_71014990 0.71 ENST00000296777.4
CART prepropeptide
chr1_+_161736072 0.70 ENST00000367942.3
activating transcription factor 6
chr2_+_234959323 0.69 ENST00000373368.1
ENST00000168148.3
secreted phosphoprotein 2, 24kDa
chr1_-_22469459 0.69 ENST00000290167.6
wingless-type MMTV integration site family, member 4
chr7_+_76139833 0.69 ENST00000257632.5
uroplakin 3B
chr10_-_11574274 0.65 ENST00000277575.5
USP6 N-terminal like
chr14_-_106573756 0.65 ENST00000390601.2
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr7_+_99971129 0.63 ENST00000394000.2
ENST00000350573.2
paired immunoglobin-like type 2 receptor alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 35.0 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
5.6 16.9 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
4.8 19.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
4.4 13.1 GO:0006597 spermine biosynthetic process(GO:0006597)
4.1 36.6 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
3.9 19.6 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
3.0 9.1 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
2.9 11.5 GO:0016259 selenocysteine metabolic process(GO:0016259)
2.0 8.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.9 9.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
1.8 5.3 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
1.6 8.0 GO:0006740 NADPH regeneration(GO:0006740)
1.5 4.5 GO:0034146 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.3 3.9 GO:0006172 ADP biosynthetic process(GO:0006172)
1.2 8.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
1.1 4.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.0 11.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.0 5.0 GO:0035063 nuclear speck organization(GO:0035063)
1.0 3.9 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
1.0 9.5 GO:0009249 protein lipoylation(GO:0009249)
0.9 14.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.9 2.8 GO:1990108 protein linear deubiquitination(GO:1990108)
0.9 4.4 GO:0070295 renal water absorption(GO:0070295)
0.9 2.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.8 2.4 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.8 4.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.8 5.5 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.7 2.8 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.7 10.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.6 3.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.6 5.9 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.6 1.7 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.5 4.8 GO:0030091 protein repair(GO:0030091)
0.5 2.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 4.0 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.5 4.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 13.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 2.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.4 2.9 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.4 4.9 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.4 6.5 GO:0051639 actin filament network formation(GO:0051639)
0.4 5.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.4 5.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.4 4.0 GO:0043248 proteasome assembly(GO:0043248)
0.3 1.0 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.3 2.0 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 8.6 GO:0030033 microvillus assembly(GO:0030033)
0.3 6.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.3 4.6 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.3 2.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.3 1.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.3 1.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.3 1.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 2.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.3 1.0 GO:0052042 induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of type B pancreatic cell development(GO:2000078)
0.3 21.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 5.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.7 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.2 1.9 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 1.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 0.7 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.2 3.1 GO:0006449 regulation of translational termination(GO:0006449)
0.2 10.9 GO:0051602 response to electrical stimulus(GO:0051602)
0.2 3.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 7.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.2 2.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 3.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 1.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 2.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.2 1.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.2 3.5 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.8 GO:0051918 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) negative regulation of fibrinolysis(GO:0051918)
0.2 4.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.2 6.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.3 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.1 2.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.7 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 1.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.5 GO:0060694 regulation of cholesterol transporter activity(GO:0060694) response to metformin(GO:1901558) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 1.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 4.6 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 1.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.5 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 5.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.9 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 5.1 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 9.1 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 13.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.2 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 0.8 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.3 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.4 GO:0070253 somatostatin secretion(GO:0070253)
0.1 4.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 9.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 10.7 GO:0002576 platelet degranulation(GO:0002576)
0.1 0.7 GO:1903358 regulation of Golgi organization(GO:1903358)
0.1 4.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.4 GO:0050663 cytokine secretion(GO:0050663)
0.1 4.6 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 2.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.8 GO:0018212 peptidyl-tyrosine phosphorylation(GO:0018108) peptidyl-tyrosine modification(GO:0018212)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 1.1 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 2.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0035701 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986) hematopoietic stem cell migration(GO:0035701)
0.0 2.6 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 3.7 GO:0019079 viral genome replication(GO:0019079)
0.0 3.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 3.7 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 1.3 GO:0008542 visual learning(GO:0008542)
0.0 0.7 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 1.3 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0030101 natural killer cell activation(GO:0030101)
0.0 2.2 GO:0031424 keratinization(GO:0031424)
0.0 3.8 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.9 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 35.0 GO:0097255 R2TP complex(GO:0097255)
1.9 5.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.4 9.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.2 6.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.1 16.9 GO:0045120 pronucleus(GO:0045120)
1.1 10.9 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.9 5.5 GO:0001740 Barr body(GO:0001740)
0.9 4.4 GO:0036398 TCR signalosome(GO:0036398)
0.8 3.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.7 10.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 5.9 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.7 8.3 GO:0005642 annulate lamellae(GO:0005642)
0.6 1.9 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.6 19.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.5 3.5 GO:0005787 signal peptidase complex(GO:0005787)
0.5 9.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.4 4.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.4 4.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.4 3.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.4 36.6 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.3 6.5 GO:0001891 phagocytic cup(GO:0001891)
0.3 6.6 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 21.6 GO:0000502 proteasome complex(GO:0000502)
0.3 4.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.3 9.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.8 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 2.0 GO:0042382 paraspeckles(GO:0042382)
0.2 17.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 2.6 GO:0044754 autolysosome(GO:0044754)
0.2 1.2 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.2 19.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 3.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.0 GO:0045179 apical cortex(GO:0045179)
0.1 1.0 GO:0000322 storage vacuole(GO:0000322)
0.1 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 2.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 8.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 2.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 2.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.1 3.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.9 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 5.3 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 2.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.7 GO:0005912 adherens junction(GO:0005912) anchoring junction(GO:0070161)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.0 3.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 4.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.7 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 7.4 GO:0005938 cell cortex(GO:0005938)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 17.4 GO:0005730 nucleolus(GO:0005730)
0.0 2.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 13.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.7 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 35.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
4.9 19.6 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
3.9 19.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
3.6 14.5 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
3.1 3.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
3.1 21.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
2.8 8.5 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
2.4 7.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
2.0 8.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.9 16.9 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6 4.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
1.1 7.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.1 4.4 GO:0015254 glycerol channel activity(GO:0015254)
1.0 3.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.0 3.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.9 11.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.9 2.7 GO:0005174 CD40 receptor binding(GO:0005174)
0.9 2.6 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.9 2.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.8 9.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.8 23.8 GO:0070410 co-SMAD binding(GO:0070410)
0.8 8.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.7 7.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.6 1.9 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.6 6.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 9.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.6 4.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.6 6.3 GO:0031013 troponin I binding(GO:0031013)
0.5 3.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.5 3.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.5 2.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.5 5.9 GO:0031386 protein tag(GO:0031386)
0.5 2.9 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.5 3.6 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.4 4.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.4 4.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 1.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 11.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 3.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 7.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 10.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 1.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.3 1.1 GO:0008431 vitamin E binding(GO:0008431)
0.3 7.4 GO:0030515 snoRNA binding(GO:0030515)
0.3 1.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.3 5.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 1.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.2 13.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 1.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.8 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 5.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.6 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 2.4 GO:0032393 MHC class I receptor activity(GO:0032393)
0.2 4.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 14.0 GO:0019003 GDP binding(GO:0019003)
0.1 5.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 9.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.1 GO:0005112 Notch binding(GO:0005112)
0.1 2.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.3 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 9.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.9 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 1.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 2.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 4.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 3.7 GO:0051287 NAD binding(GO:0051287)
0.0 11.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 9.2 GO:0042393 histone binding(GO:0042393)
0.0 2.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 11.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 10.4 GO:0051015 actin filament binding(GO:0051015)
0.0 11.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.7 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.6 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 3.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.9 GO:0004527 exonuclease activity(GO:0004527)
0.0 2.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 4.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 1.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 2.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0008233 peptidase activity(GO:0008233)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 35.0 PID MYC PATHWAY C-MYC pathway
0.7 10.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.5 42.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 14.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 26.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 4.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 7.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 7.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 3.7 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 6.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.9 PID AURORA A PATHWAY Aurora A signaling
0.1 3.8 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 11.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 6.7 PID CDC42 PATHWAY CDC42 signaling events
0.1 2.3 PID ARF 3PATHWAY Arf1 pathway
0.1 2.7 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 4.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 4.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.0 PID ATM PATHWAY ATM pathway
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.1 PID P73PATHWAY p73 transcription factor network
0.0 1.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 34.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.9 35.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.9 26.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.5 23.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 2.1 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.5 13.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 11.1 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.5 13.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 10.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 12.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 11.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 4.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 5.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.2 5.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 9.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 9.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 7.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 5.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 2.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 4.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 5.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 9.4 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 3.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 10.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 4.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 4.5 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.1 7.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 5.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 6.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 3.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.7 REACTOME TRANSLATION Genes involved in Translation
0.0 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 4.0 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 4.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 3.6 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12