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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU2F1

Z-value: 0.90

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Transcription factors associated with POU2F1

Gene Symbol Gene ID Gene Info
POU2F1
ENSG00000143190.17 POU class 2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F1hg19_v2_chr1_+_167298281_1672983190.136.2e-02Click!

Activity profile of POU2F1 motif

Sorted Z-values of POU2F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90060377 25.11 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr2_-_89459813 23.84 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90108504 22.98 ENST00000390271.2
IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr11_-_58343319 17.46 ENST00000395074.2
LPXN
leupaxin
chr14_-_106642049 15.80 ENST00000390605.2
IGHV1-18
immunoglobulin heavy variable 1-18
chr21_+_10862622 15.68 ENST00000302092.5
ENST00000559480.1
IGHV1OR21-1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr2_+_89890533 15.16 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr14_-_106733624 14.72 ENST00000390610.2
IGHV1-24
immunoglobulin heavy variable 1-24
chr14_-_106539557 14.57 ENST00000390599.2
IGHV1-8
immunoglobulin heavy variable 1-8
chr3_-_121379739 14.00 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_-_89292422 13.12 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr3_-_107777208 12.39 ENST00000398258.3
CD47
CD47 molecule
chr3_-_155524049 12.34 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr2_-_89521942 12.00 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr2_+_89975669 11.43 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr1_-_160681593 11.12 ENST00000368045.3
ENST00000368046.3
CD48
CD48 molecule
chr14_-_107078851 10.85 ENST00000390628.2
IGHV1-58
immunoglobulin heavy variable 1-58
chr2_-_89545079 10.65 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr2_-_88285309 10.51 ENST00000420840.2
RGPD2
RANBP2-like and GRIP domain containing 2
chr15_-_22448819 10.01 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr14_-_106453155 9.81 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr1_+_158801095 9.64 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chr1_-_25291475 9.18 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr15_-_22473353 8.96 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr8_-_117768023 8.27 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr14_-_107283278 8.19 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr2_+_89999259 7.88 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr2_+_90458201 7.78 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr14_+_21249200 7.54 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr6_+_135502408 7.03 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr14_-_106967788 6.89 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr6_+_135502466 6.86 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr14_-_106471723 6.65 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr3_+_133292574 6.45 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chrX_-_135962876 6.18 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr5_-_98262240 6.07 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr2_+_87135076 6.05 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr1_-_146082633 5.62 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
NBPF11
neuroblastoma breakpoint family, member 11
chr15_-_55541227 5.38 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr4_+_68424434 5.34 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr15_+_48623208 5.32 ENST00000559935.1
ENST00000559416.1
DUT
deoxyuridine triphosphatase
chr22_+_23029188 5.10 ENST00000390305.2
IGLV3-25
immunoglobulin lambda variable 3-25
chr10_+_79793518 5.08 ENST00000440692.1
ENST00000435275.1
ENST00000372360.3
ENST00000360830.4
RPS24
ribosomal protein S24
chr11_-_14521379 5.06 ENST00000249923.3
ENST00000529866.1
ENST00000439561.2
ENST00000534771.1
COPB1
coatomer protein complex, subunit beta 1
chr9_-_86593238 4.94 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr4_+_70861647 4.82 ENST00000246895.4
ENST00000381060.2
STATH
statherin
chr12_-_118797475 4.79 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr1_+_146373546 4.77 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr1_+_104293028 4.62 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr15_+_80364901 4.58 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr22_+_23089870 4.46 ENST00000390311.2
IGLV3-16
immunoglobulin lambda variable 3-16
chr2_-_152684977 4.30 ENST00000428992.2
ENST00000295087.8
ARL5A
ADP-ribosylation factor-like 5A
chr1_+_104159999 4.30 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr19_-_9731872 4.20 ENST00000424629.1
ENST00000326044.5
ENST00000354661.4
ENST00000435550.1
ENST00000444611.1
ENST00000421525.1
ZNF561
zinc finger protein 561
chr7_+_64838786 3.96 ENST00000450302.2
ZNF92
zinc finger protein 92
chr9_+_124088860 3.86 ENST00000373806.1
GSN
gelsolin
chr8_-_6837602 3.60 ENST00000382692.2
DEFA1
defensin, alpha 1
chr12_-_91546926 3.57 ENST00000550758.1
DCN
decorin
chr3_-_58200398 3.51 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
DNASE1L3
deoxyribonuclease I-like 3
chr7_+_64838712 3.51 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
ZNF92
zinc finger protein 92
chr1_-_226926864 3.48 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr6_+_135502501 3.46 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_3221358 2.99 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr6_-_152489484 2.99 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_-_63448973 2.96 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr14_-_106791536 2.86 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr1_-_223308098 2.78 ENST00000342210.6
TLR5
toll-like receptor 5
chr20_+_39657454 2.70 ENST00000361337.2
TOP1
topoisomerase (DNA) I
chr11_-_128457446 2.50 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr6_-_132834184 2.50 ENST00000367941.2
ENST00000367937.4
STX7
syntaxin 7
chr2_+_162087577 2.49 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr5_-_176326333 2.49 ENST00000292432.5
HK3
hexokinase 3 (white cell)
chr20_+_36373032 2.48 ENST00000373473.1
CTNNBL1
catenin, beta like 1
chr10_+_13628921 2.45 ENST00000378572.3
PRPF18
pre-mRNA processing factor 18
chr8_+_86121448 2.42 ENST00000520225.1
E2F5
E2F transcription factor 5, p130-binding
chr5_+_67588391 2.41 ENST00000523872.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr18_-_52989217 2.33 ENST00000570287.2
TCF4
transcription factor 4
chr7_+_7606497 2.30 ENST00000340080.4
ENST00000405785.1
ENST00000433635.1
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr21_-_33975547 2.28 ENST00000431599.1
C21orf59
chromosome 21 open reading frame 59
chr19_+_17858547 2.01 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCHO1
FCH domain only 1
chr2_-_74007193 1.85 ENST00000377706.4
ENST00000443070.1
ENST00000272444.3
DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr3_+_149530836 1.80 ENST00000466478.1
ENST00000491086.1
ENST00000467977.1
RNF13
ring finger protein 13
chr1_+_28562617 1.75 ENST00000497986.1
ENST00000335514.5
ENST00000468425.2
ENST00000465645.1
ATPIF1
ATPase inhibitory factor 1
chr8_-_49833978 1.58 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr6_+_26124373 1.55 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr4_-_153274078 1.51 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_-_13621126 1.49 ENST00000600057.1
AL441883.1
Uncharacterized protein
chr3_+_196466710 1.42 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_+_17858509 1.39 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCHO1
FCH domain only 1
chr10_-_116286563 1.39 ENST00000369253.2
ABLIM1
actin binding LIM protein 1
chr17_+_45728427 1.37 ENST00000540627.1
KPNB1
karyopherin (importin) beta 1
chr8_-_93107827 1.33 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_111358372 1.31 ENST00000548438.1
ENST00000228841.8
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr18_+_3252206 1.19 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_161736072 1.12 ENST00000367942.3
ATF6
activating transcription factor 6
chr17_+_75181292 1.09 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr4_+_74301880 0.98 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr1_+_100436065 0.97 ENST00000370153.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr4_-_100356551 0.93 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_-_113594279 0.92 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr15_-_55489097 0.87 ENST00000260443.4
RSL24D1
ribosomal L24 domain containing 1
chr4_-_100356291 0.81 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_+_71205742 0.77 ENST00000360589.3
ANKRD53
ankyrin repeat domain 53
chr9_+_135854091 0.72 ENST00000450530.1
ENST00000534944.1
GFI1B
growth factor independent 1B transcription repressor
chr9_+_12693336 0.72 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr7_-_14026063 0.70 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr16_+_81070792 0.69 ENST00000564241.1
ENST00000565237.1
ATMIN
ATM interactor
chr16_-_18908196 0.60 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr3_-_46249878 0.57 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr17_+_34391625 0.56 ENST00000004921.3
CCL18
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chrX_-_19988382 0.53 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr16_+_33629600 0.53 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr5_-_111092873 0.51 ENST00000509025.1
ENST00000515855.1
NREP
neuronal regeneration related protein
chr3_+_101546827 0.50 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr5_-_111093081 0.47 ENST00000453526.2
ENST00000509427.1
NREP
neuronal regeneration related protein
chr1_+_152975488 0.42 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr8_-_93107696 0.38 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_102615416 0.30 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr4_-_110723194 0.26 ENST00000394635.3
CFI
complement factor I
chr3_+_157154578 0.25 ENST00000295927.3
PTX3
pentraxin 3, long
chr10_-_115904361 0.21 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr18_+_616711 0.18 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr2_+_219524379 0.15 ENST00000443791.1
ENST00000359273.3
ENST00000392109.1
ENST00000392110.2
ENST00000423377.1
ENST00000392111.2
ENST00000412366.1
BCS1L
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr17_+_7387677 0.11 ENST00000322644.6
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr2_+_204571198 0.11 ENST00000374481.3
ENST00000458610.2
ENST00000324106.8
CD28
CD28 molecule
chr2_+_110551851 0.09 ENST00000272454.6
ENST00000430736.1
ENST00000016946.3
ENST00000441344.1
RGPD5
RANBP2-like and GRIP domain containing 5
chr1_+_25598872 0.07 ENST00000328664.4
RHD
Rh blood group, D antigen
chrX_-_130423386 0.06 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr2_-_113191096 0.05 ENST00000496537.1
ENST00000330575.5
ENST00000302558.3
RGPD8
RANBP2-like and GRIP domain containing 8
chr4_-_110723335 0.04 ENST00000394634.2
CFI
complement factor I

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
2.2 17.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
1.8 5.3 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
1.8 5.3 GO:0046081 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
1.2 4.9 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
1.2 3.6 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.1 12.6 GO:0008228 opsonization(GO:0008228)
1.0 143.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.9 2.8 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.9 0.9 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.9 5.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.8 14.0 GO:0045651 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651)
0.8 3.9 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.6 4.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.6 9.6 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.6 1.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.6 16.7 GO:0000042 protein targeting to Golgi(GO:0000042)
0.5 1.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5 1.6 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.5 3.5 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.5 78.6 GO:0002377 immunoglobulin production(GO:0002377)
0.5 9.5 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 4.8 GO:0046541 saliva secretion(GO:0046541)
0.4 2.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.4 6.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.4 1.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.4 1.9 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.4 1.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 1.4 GO:0031291 Ran protein signal transduction(GO:0031291)
0.3 2.5 GO:0030578 PML body organization(GO:0030578)
0.3 1.5 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.3 3.0 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.3 3.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 6.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 2.5 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.3 3.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.2 1.7 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 2.7 GO:0040016 embryonic cleavage(GO:0040016)
0.2 0.9 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 3.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 3.5 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.2 2.5 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.2 4.6 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.2 5.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 1.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 2.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 5.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 3.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 11.1 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.1 4.0 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 7.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.7 GO:0006091 generation of precursor metabolites and energy(GO:0006091)
0.1 0.7 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.3 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 2.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 8.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.6 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 2.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 9.9 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.6 GO:0090026 dendritic cell chemotaxis(GO:0002407) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.7 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 1.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 65.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.2 6.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 8.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.9 2.7 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.6 2.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.5 1.6 GO:0071020 post-spliceosomal complex(GO:0071020)
0.5 5.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 5.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 22.4 GO:0002102 podosome(GO:0002102)
0.3 2.3 GO:0061700 GATOR2 complex(GO:0061700)
0.3 3.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 3.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 2.6 GO:0000974 Prp19 complex(GO:0000974)
0.2 30.3 GO:0072562 blood microparticle(GO:0072562)
0.2 2.0 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 19.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 13.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 12.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 8.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 11.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 10.4 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 2.5 GO:0031201 SNARE complex(GO:0031201)
0.0 56.1 GO:0005615 extracellular space(GO:0005615)
0.0 8.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 13.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0004170 dUTP diphosphatase activity(GO:0004170)
1.6 4.8 GO:0046848 hydroxyapatite binding(GO:0046848)
1.6 17.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 12.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.2 65.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.1 4.3 GO:0016160 amylase activity(GO:0016160)
0.9 5.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.9 162.9 GO:0003823 antigen binding(GO:0003823)
0.6 1.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.6 1.7 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.6 3.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.5 1.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.5 2.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.4 1.7 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.4 2.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 3.9 GO:0045159 myosin II binding(GO:0045159)
0.3 2.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 2.4 GO:0043559 insulin binding(GO:0043559)
0.2 2.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 3.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 5.4 GO:0031489 myosin V binding(GO:0031489)
0.2 1.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 3.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 1.1 GO:0039552 RIG-I binding(GO:0039552)
0.2 2.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 3.0 GO:0008494 translation activator activity(GO:0008494)
0.2 8.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 6.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 5.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.0 GO:0005521 lamin binding(GO:0005521)
0.1 4.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 14.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.3 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 4.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 2.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 5.2 GO:0001047 core promoter binding(GO:0001047)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 6.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 13.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.3 19.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 15.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 5.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 11.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.5 PID MYC PATHWAY C-MYC pathway
0.0 3.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 5.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.4 12.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 1.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 5.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.6 REACTOME DEFENSINS Genes involved in Defensins
0.2 13.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 5.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 11.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 11.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 0.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 5.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction