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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU5F1_POU2F3

Z-value: 3.15

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Transcription factors associated with POU5F1_POU2F3

Gene Symbol Gene ID Gene Info
ENSG00000204531.11 POU class 5 homeobox 1
ENSG00000137709.5 POU class 2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F3hg19_v2_chr11_+_120107344_1201073510.305.3e-06Click!
POU5F1hg19_v2_chr6_-_31138439_311384750.203.0e-03Click!

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90060377 91.79 ENST00000436451.2
immunoglobulin kappa variable 6D-21 (non-functional)
chr2_+_90248739 83.44 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr2_+_90139056 83.06 ENST00000492446.1
immunoglobulin kappa variable 1D-16
chr2_-_89399845 82.87 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr2_+_90108504 78.23 ENST00000390271.2
immunoglobulin kappa variable 6D-41 (non-functional)
chr2_+_90077680 75.77 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr14_-_107049312 72.79 ENST00000390627.2
immunoglobulin heavy variable 3-53
chr2_+_89998789 69.92 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr2_-_89340242 66.20 ENST00000480492.1
immunoglobulin kappa variable 1-12
chr2_+_90121477 64.87 ENST00000483379.1
immunoglobulin kappa variable 1D-17
chr22_+_22786288 63.97 ENST00000390301.2
immunoglobulin lambda variable 1-36
chr2_-_89521942 62.30 ENST00000482769.1
immunoglobulin kappa variable 2-28
chr22_+_23077065 61.74 ENST00000390310.2
immunoglobulin lambda variable 2-18
chr2_+_89975669 61.04 ENST00000474213.1
immunoglobulin kappa variable 2D-30
chr2_-_89442621 59.35 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr14_-_107078851 58.55 ENST00000390628.2
immunoglobulin heavy variable 1-58
chr21_+_10862622 58.42 ENST00000302092.5
ENST00000559480.1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr16_+_33605231 56.84 ENST00000570121.2
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr2_+_90198535 56.54 ENST00000390276.2
immunoglobulin kappa variable 1D-12
chr2_-_89597542 55.48 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr14_-_106539557 55.36 ENST00000390599.2
immunoglobulin heavy variable 1-8
chr2_-_89266286 54.90 ENST00000464162.1
immunoglobulin kappa variable 1-6
chr2_+_89923550 54.78 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr14_-_107083690 54.15 ENST00000455737.1
ENST00000390629.2
immunoglobulin heavy variable 4-59
chr14_-_107095662 52.77 ENST00000390630.2
immunoglobulin heavy variable 4-61
chr2_-_89545079 52.62 ENST00000468494.1
immunoglobulin kappa variable 2-30
chr22_+_23134974 52.13 ENST00000390314.2
immunoglobulin lambda variable 2-11
chr22_+_22707260 51.50 ENST00000390293.1
immunoglobulin lambda variable 5-48 (non-functional)
chr2_-_89459813 50.92 ENST00000390256.2
immunoglobulin kappa variable 6-21 (non-functional)
chr16_+_32077386 50.48 ENST00000354689.6
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr14_-_107170409 49.99 ENST00000390633.2
immunoglobulin heavy variable 1-69
chr22_+_22712087 49.92 ENST00000390294.2
immunoglobulin lambda variable 1-47
chr14_-_106552755 49.83 ENST00000390600.2
immunoglobulin heavy variable 3-9
chr2_+_90192768 49.80 ENST00000390275.2
immunoglobulin kappa variable 1D-13
chr2_-_89417335 48.69 ENST00000490686.1
immunoglobulin kappa variable 1-17
chr16_+_33020496 47.78 ENST00000565407.2
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr14_-_106573756 47.13 ENST00000390601.2
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr14_-_107114267 47.09 ENST00000454421.2
immunoglobulin heavy variable 3-64
chr2_+_90153696 46.89 ENST00000417279.2
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_+_89890533 45.74 ENST00000429992.2
immunoglobulin kappa variable 2D-40
chr22_+_23063100 45.11 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr22_+_22735135 44.81 ENST00000390297.2
immunoglobulin lambda variable 1-44
chr15_-_22473353 44.00 ENST00000557788.2
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr22_+_23154239 43.64 ENST00000390315.2
immunoglobulin lambda variable 3-10
chr22_+_23089870 43.36 ENST00000390311.2
immunoglobulin lambda variable 3-16
chr14_-_106733624 43.34 ENST00000390610.2
immunoglobulin heavy variable 1-24
chr4_-_71532339 42.31 ENST00000254801.4
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_89952792 42.01 ENST00000390265.2
immunoglobulin kappa variable 1D-33
chr2_-_89619904 41.51 ENST00000498574.1
immunoglobulin kappa variable 1-39 (gene/pseudogene)
chr14_-_106830057 40.28 ENST00000390616.2
immunoglobulin heavy variable 4-34
chr16_-_33647696 40.25 ENST00000558425.1
ENST00000569103.2
Uncharacterized protein
chr5_-_172198190 39.05 ENST00000239223.3
dual specificity phosphatase 1
chr16_+_32063311 38.34 ENST00000426099.1
AC142381.1
chr22_+_23165153 38.04 ENST00000390317.2
immunoglobulin lambda variable 2-8
chr2_+_68962014 37.99 ENST00000467265.1
Rho GTPase activating protein 25
chr16_+_23847267 37.64 ENST00000321728.7
protein kinase C, beta
chr14_-_106926724 37.44 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr22_+_23101182 37.41 ENST00000390312.2
immunoglobulin lambda variable 2-14
chr2_+_87565634 37.36 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr22_+_23040274 37.24 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr10_-_98031265 37.19 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr2_-_90538397 37.10 ENST00000443397.3
Uncharacterized protein
chr2_+_89901292 36.74 ENST00000448155.2
immunoglobulin kappa variable 1D-39
chr10_-_98031310 36.59 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr14_-_106963409 35.74 ENST00000390621.2
immunoglobulin heavy variable 1-45
chr2_+_90273679 35.55 ENST00000423080.2
immunoglobulin kappa variable 3D-7
chr14_-_106845789 35.55 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr18_-_52989217 34.84 ENST00000570287.2
transcription factor 4
chr14_-_106878083 34.79 ENST00000390619.2
immunoglobulin heavy variable 4-39
chr2_-_89278535 34.52 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr2_+_89184868 33.76 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr2_-_89327228 33.68 ENST00000483158.1
immunoglobulin kappa variable 3-11
chr16_+_23847339 33.54 ENST00000303531.7
protein kinase C, beta
chr2_+_114163945 33.46 ENST00000453673.3
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr19_-_1021113 33.44 ENST00000333175.5
ENST00000356663.3
transmembrane protein 259
chr14_-_106478603 33.30 ENST00000390596.2
immunoglobulin heavy variable 4-4
chr2_-_89568263 32.56 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr2_+_89986318 31.69 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr2_+_90458201 31.66 ENST00000603238.1
Uncharacterized protein
chrX_-_106960285 31.36 ENST00000503515.1
ENST00000372397.2
TSC22 domain family, member 3
chr2_-_89385283 31.14 ENST00000390252.2
immunoglobulin kappa variable 3-15
chr2_+_90211643 31.02 ENST00000390277.2
immunoglobulin kappa variable 3D-11
chr16_+_33006369 30.78 ENST00000425181.3
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr6_-_32557610 30.62 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr6_+_32407619 30.02 ENST00000395388.2
ENST00000374982.5
major histocompatibility complex, class II, DR alpha
chr7_-_100183742 29.78 ENST00000310300.6
leucine-rich repeats and calponin homology (CH) domain containing 4
chr12_-_91574142 29.69 ENST00000547937.1
decorin
chr22_+_22764088 28.75 ENST00000390299.2
immunoglobulin lambda variable 1-40
chr1_-_153363452 28.46 ENST00000368732.1
ENST00000368733.3
S100 calcium binding protein A8
chr3_+_186648307 28.13 ENST00000457772.2
ENST00000455441.1
ENST00000427315.1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr22_+_22930626 27.81 ENST00000390302.2
immunoglobulin lambda variable 2-33 (non-functional)
chr6_-_32784687 27.79 ENST00000447394.1
ENST00000438763.2
major histocompatibility complex, class II, DO beta
chr3_+_186648274 27.27 ENST00000169298.3
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr22_+_23046750 27.23 ENST00000390307.2
immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr2_-_89513402 26.93 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr14_-_106994333 26.76 ENST00000390624.2
immunoglobulin heavy variable 3-48
chr2_-_89247338 26.37 ENST00000496168.1
immunoglobulin kappa variable 1-5
chr1_-_149858227 26.31 ENST00000369155.2
histone cluster 2, H2be
chr14_-_106610852 25.90 ENST00000390603.2
immunoglobulin heavy variable 3-15
chr7_+_26438187 25.62 ENST00000439120.1
ENST00000430548.1
ENST00000421862.1
ENST00000449537.1
ENST00000420774.1
ENST00000418758.2
AC004540.5
chr18_-_52989525 25.47 ENST00000457482.3
transcription factor 4
chr14_-_106692191 25.39 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr14_-_106816253 25.13 ENST00000390615.2
immunoglobulin heavy variable 3-33
chr17_-_62009621 25.09 ENST00000349817.2
ENST00000392795.3
CD79b molecule, immunoglobulin-associated beta
chr12_-_91573132 25.02 ENST00000550563.1
ENST00000546370.1
decorin
chr19_+_35820064 24.95 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22 molecule
chr14_-_106866934 24.87 ENST00000390618.2
immunoglobulin heavy variable 3-38 (non-functional)
chr22_+_23029188 24.80 ENST00000390305.2
immunoglobulin lambda variable 3-25
chr17_-_62009702 24.77 ENST00000006750.3
CD79b molecule, immunoglobulin-associated beta
chr15_-_20193370 24.52 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr18_-_53089723 24.06 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr14_-_107283278 23.89 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr22_-_24096562 23.66 ENST00000398465.3
pre-B lymphocyte 3
chr14_-_107131560 23.30 ENST00000390632.2
immunoglobulin heavy variable 3-66
chr3_+_49507674 22.71 ENST00000431960.1
ENST00000452317.1
ENST00000435508.2
ENST00000452060.1
ENST00000428779.1
ENST00000419218.1
ENST00000430636.1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr19_-_39108568 22.18 ENST00000586296.1
mitogen-activated protein kinase kinase kinase kinase 1
chr15_-_22448819 21.91 ENST00000604066.1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr7_-_130080818 20.88 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
centrosomal protein 41kDa
chr14_-_107219365 20.86 ENST00000424969.2
immunoglobulin heavy variable 3-74
chr10_-_105452917 20.82 ENST00000427662.2
SH3 and PX domains 2A
chr1_-_153029980 20.26 ENST00000392653.2
small proline-rich protein 2A
chr18_-_53255766 20.24 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
transcription factor 4
chr8_-_134115118 20.16 ENST00000395352.3
ENST00000338087.5
Src-like-adaptor
chr7_-_37024665 20.03 ENST00000396040.2
engulfment and cell motility 1
chr17_-_47841485 19.90 ENST00000506156.1
ENST00000240364.2
family with sequence similarity 117, member A
chr18_-_53257027 19.74 ENST00000568740.1
ENST00000564403.2
ENST00000537578.1
transcription factor 4
chr9_-_35618364 19.33 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72 molecule
chr19_-_39108552 19.27 ENST00000591517.1
mitogen-activated protein kinase kinase kinase kinase 1
chr1_-_31230650 19.20 ENST00000294507.3
lysosomal protein transmembrane 5
chr16_+_33629600 18.82 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr8_+_56792355 18.81 ENST00000519728.1
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_-_153013588 18.63 ENST00000360379.3
small proline-rich protein 2D
chr22_-_24096630 18.59 ENST00000248948.3
pre-B lymphocyte 3
chr16_+_90089008 18.37 ENST00000268699.4
growth arrest-specific 8
chr6_+_37137939 18.19 ENST00000373509.5
pim-1 oncogene
chr1_-_153044083 18.04 ENST00000341611.2
small proline-rich protein 2B
chr12_-_91576561 17.99 ENST00000547568.2
ENST00000552962.1
decorin
chr19_+_19144384 17.71 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
armadillo repeat containing 6
chr12_-_91576429 17.49 ENST00000552145.1
ENST00000546745.1
decorin
chr8_+_56792377 17.44 ENST00000520220.2
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr15_-_20170354 17.22 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr12_-_123201337 17.12 ENST00000528880.2
hydroxycarboxylic acid receptor 3
chr14_-_106453155 17.00 ENST00000390594.2
immunoglobulin heavy variable 1-2
chr1_+_156119798 16.75 ENST00000355014.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_134070250 16.52 ENST00000505289.1
ENST00000509715.1
RP11-9G1.3
chr19_+_13858593 16.30 ENST00000221554.8
coiled-coil domain containing 130
chr9_-_127533582 16.24 ENST00000416460.2
nuclear receptor subfamily 6, group A, member 1
chr22_+_22936998 16.08 ENST00000390303.2
immunoglobulin lambda variable 3-32 (non-functional)
chr6_-_159421198 16.04 ENST00000252655.1
ENST00000297262.3
ENST00000367069.2
radial spoke 3 homolog (Chlamydomonas)
chr12_-_7245125 16.04 ENST00000542285.1
ENST00000540610.1
complement component 1, r subcomponent
chr14_-_106805716 16.00 ENST00000438142.2
immunoglobulin heavy variable 4-31
chr7_+_100183927 15.83 ENST00000241071.6
ENST00000360609.2
F-box protein 24
chr12_+_25205568 15.61 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr9_+_136325089 15.61 ENST00000291722.7
ENST00000316948.4
ENST00000540581.1
calcium channel flower domain containing 1
chr12_+_25205666 15.42 ENST00000547044.1
lymphoid-restricted membrane protein
chr19_-_4723761 15.26 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
dipeptidyl-peptidase 9
chr12_+_25205446 15.15 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr12_-_16761007 15.07 ENST00000354662.1
ENST00000441439.2
LIM domain only 3 (rhombotin-like 2)
chr12_-_6772303 14.65 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
inhibitor of growth family, member 4
chr19_-_39108643 14.60 ENST00000396857.2
mitogen-activated protein kinase kinase kinase kinase 1
chr14_-_106586656 14.60 ENST00000390602.2
immunoglobulin heavy variable 3-13
chr13_-_99959641 14.33 ENST00000376414.4
G protein-coupled receptor 183
chr18_+_74240610 14.32 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr7_-_37488834 14.20 ENST00000310758.4
engulfment and cell motility 1
chr22_+_42229100 14.18 ENST00000361204.4
sterol regulatory element binding transcription factor 2
chr12_-_91576750 14.16 ENST00000228329.5
ENST00000303320.3
ENST00000052754.5
decorin
chr22_+_22550113 14.16 ENST00000390285.3
immunoglobulin lambda variable 6-57
chrX_-_48776292 14.14 ENST00000376509.4
pim-2 oncogene
chr18_+_42260861 14.07 ENST00000282030.5
SET binding protein 1
chr5_+_49961727 13.91 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
poly (ADP-ribose) polymerase family, member 8
chr12_+_124997766 13.83 ENST00000543970.1
RP11-83B20.1
chr14_-_106622419 13.78 ENST00000390604.2
immunoglobulin heavy variable 3-16 (non-functional)
chr14_-_106518922 13.38 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr6_-_24877490 13.05 ENST00000540914.1
ENST00000378023.4
family with sequence similarity 65, member B
chr5_-_175964366 13.03 ENST00000274811.4
ring finger protein 44
chr1_+_152975488 13.00 ENST00000542696.1
small proline-rich protein 3
chr14_-_106725723 12.96 ENST00000390609.2
immunoglobulin heavy variable 3-23
chr17_+_14204389 12.90 ENST00000360954.2
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr2_-_99224915 12.77 ENST00000328709.3
ENST00000409997.1
cytochrome c oxidase assembly factor 5
chr1_+_104198377 12.75 ENST00000370083.4
amylase, alpha 1A (salivary)
chr4_-_46911223 12.74 ENST00000396533.1
cytochrome c oxidase subunit VIIb2
chr19_-_19144243 12.65 ENST00000594445.1
ENST00000452918.2
ENST00000600377.1
ENST00000337018.6
SURP and G patch domain containing 2
chr9_-_34691201 12.59 ENST00000378800.3
ENST00000311925.2
chemokine (C-C motif) ligand 19
chr1_+_192778161 12.56 ENST00000235382.5
regulator of G-protein signaling 2, 24kDa
chr4_-_46911248 12.50 ENST00000355591.3
ENST00000505102.1
cytochrome c oxidase subunit VIIb2
chr16_-_79634595 12.46 ENST00000326043.4
ENST00000393350.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr13_-_99910673 12.46 ENST00000397473.2
ENST00000397470.2
G protein-coupled receptor 18
chr17_-_41465674 12.44 ENST00000592135.1
ENST00000587874.1
ENST00000588654.1
ENST00000592094.1
long intergenic non-protein coding RNA 910
chr11_-_64511575 12.41 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr14_-_106967788 12.30 ENST00000390622.2
immunoglobulin heavy variable 1-46
chr6_-_52628271 12.16 ENST00000493422.1
glutathione S-transferase alpha 2
chr2_+_90259593 12.10 ENST00000471857.1
immunoglobulin kappa variable 1D-8
chr19_-_12267524 12.08 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
zinc finger protein 625
chr12_-_11422630 12.08 ENST00000381842.3
ENST00000538488.1
proline-rich protein BstNI subfamily 3
chr11_-_62369291 11.99 ENST00000278823.2
metastasis associated 1 family, member 2
chr1_+_32666188 11.88 ENST00000421922.2
coiled-coil domain containing 28B
chr5_+_66254698 11.86 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
microtubule associated serine/threonine kinase family member 4
chr22_-_43010928 11.83 ENST00000348657.2
ENST00000252115.5
polymerase (DNA-directed), delta interacting protein 3
chr11_-_2906979 11.80 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr2_+_68592305 11.76 ENST00000234313.7
pleckstrin

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
17.9 2692.4 GO:0006958 complement activation, classical pathway(GO:0006958)
12.1 60.6 GO:0002399 MHC class II protein complex assembly(GO:0002399)
12.1 36.3 GO:0070668 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
10.4 124.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
9.3 27.8 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
7.0 21.1 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
6.5 1120.7 GO:0002377 immunoglobulin production(GO:0002377)
5.2 20.8 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
4.8 14.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
4.8 23.9 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
4.2 12.6 GO:2000547 dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
4.0 8.0 GO:0002436 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
4.0 11.9 GO:0045925 positive regulation of female receptivity(GO:0045925)
3.9 31.4 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
3.8 15.4 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
3.7 14.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
3.6 14.3 GO:0036269 swimming behavior(GO:0036269)
3.6 7.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
3.6 17.8 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
3.5 14.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
3.5 20.9 GO:0018095 protein polyglutamylation(GO:0018095)
3.5 17.3 GO:0016476 regulation of embryonic cell shape(GO:0016476)
3.4 13.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
3.3 16.6 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
3.3 13.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
3.3 9.8 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
3.2 42.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
3.2 6.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
3.1 6.1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
3.1 9.2 GO:0072709 cellular response to sorbitol(GO:0072709)
2.7 8.2 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
2.7 18.9 GO:0033029 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029)
2.7 5.4 GO:0010958 regulation of amino acid import(GO:0010958)
2.7 8.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
2.6 18.4 GO:0060294 cilium movement involved in cell motility(GO:0060294)
2.5 15.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.4 39.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
2.4 9.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
2.4 9.6 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
2.4 4.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.4 9.6 GO:0014807 regulation of somitogenesis(GO:0014807)
2.3 9.3 GO:0072423 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
2.3 6.9 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
2.3 6.9 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
2.3 6.9 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
2.1 12.6 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
2.1 12.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
2.0 12.3 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
2.0 8.2 GO:0010165 response to X-ray(GO:0010165)
2.0 28.5 GO:0002544 chronic inflammatory response(GO:0002544)
2.0 16.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
2.0 4.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
2.0 46.0 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
2.0 16.0 GO:0009615 response to virus(GO:0009615)
2.0 5.9 GO:0021571 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
2.0 11.8 GO:0033625 positive regulation of integrin activation(GO:0033625) protein secretion by platelet(GO:0070560)
1.9 13.6 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
1.9 7.7 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
1.9 5.8 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
1.9 7.7 GO:0003219 cardiac right ventricle formation(GO:0003219)
1.8 12.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.8 9.2 GO:0030070 insulin processing(GO:0030070)
1.8 5.5 GO:0071934 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
1.8 1.8 GO:0060067 cervix development(GO:0060067)
1.8 33.6 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
1.7 18.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
1.6 13.0 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
1.6 4.9 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
1.6 6.4 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.6 4.8 GO:0097254 renal tubular secretion(GO:0097254)
1.6 7.9 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.6 3.2 GO:0008050 female courtship behavior(GO:0008050)
1.6 9.3 GO:0001714 endodermal cell fate specification(GO:0001714)
1.5 7.7 GO:0070842 aggresome assembly(GO:0070842)
1.5 56.3 GO:0007257 activation of JUN kinase activity(GO:0007257)
1.5 10.6 GO:0032596 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
1.5 1.5 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
1.5 13.3 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.5 10.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
1.5 8.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.4 5.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
1.4 4.3 GO:0048852 hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852)
1.4 5.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.4 5.5 GO:0035701 hematopoietic stem cell migration(GO:0035701)
1.3 2.7 GO:2000366 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
1.3 6.6 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
1.3 15.8 GO:0048251 elastic fiber assembly(GO:0048251)
1.3 6.6 GO:1903960 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960)
1.3 10.4 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
1.3 64.9 GO:0018149 peptide cross-linking(GO:0018149)
1.3 3.8 GO:0060595 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
1.3 5.1 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
1.3 3.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.2 8.6 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
1.2 11.9 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
1.2 3.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.2 20.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
1.1 3.4 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.1 13.1 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
1.1 8.6 GO:0070995 NADPH oxidation(GO:0070995)
1.1 6.4 GO:0035799 ureter maturation(GO:0035799)
1.1 5.3 GO:0016045 detection of bacterium(GO:0016045)
1.0 4.1 GO:0036343 psychomotor behavior(GO:0036343)
1.0 7.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.0 9.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
1.0 3.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
1.0 4.9 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
1.0 5.9 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.0 3.9 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
1.0 2.9 GO:0061386 closure of optic fissure(GO:0061386)
1.0 3.8 GO:0030223 neutrophil differentiation(GO:0030223)
0.9 2.8 GO:0006014 D-ribose metabolic process(GO:0006014)
0.9 6.6 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.9 3.7 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.9 2.8 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.9 10.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.9 54.6 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.9 5.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.9 5.3 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.9 7.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.9 5.2 GO:0006196 AMP catabolic process(GO:0006196)
0.9 8.6 GO:0001865 NK T cell differentiation(GO:0001865)
0.9 8.6 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.9 3.4 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.9 10.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.9 5.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.8 0.8 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.8 6.6 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.8 6.5 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.8 34.2 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.8 2.4 GO:0009447 putrescine catabolic process(GO:0009447)
0.8 3.8 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.8 4.5 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.7 11.5 GO:0031033 myosin filament organization(GO:0031033)
0.7 6.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.7 7.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.7 8.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.7 7.5 GO:0006554 lysine catabolic process(GO:0006554)
0.7 3.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.7 9.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.7 5.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.6 2.6 GO:0000023 maltose metabolic process(GO:0000023)
0.6 3.2 GO:0090131 mesenchyme migration(GO:0090131)
0.6 4.4 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6 2.5 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.6 1.9 GO:0015871 choline transport(GO:0015871)
0.6 1.9 GO:1903027 regulation of opsonization(GO:1903027)
0.6 11.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.6 6.8 GO:0048263 determination of dorsal identity(GO:0048263)
0.6 9.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.6 6.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.6 4.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.6 57.6 GO:0030183 B cell differentiation(GO:0030183)
0.6 4.7 GO:0003190 atrioventricular valve formation(GO:0003190)
0.6 5.8 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.6 2.9 GO:0021759 globus pallidus development(GO:0021759)
0.6 2.9 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.6 4.6 GO:0006689 ganglioside catabolic process(GO:0006689)
0.6 6.8 GO:0044146 negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.6 4.5 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.6 7.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.6 3.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.6 5.0 GO:0008343 adult feeding behavior(GO:0008343)
0.5 2.7 GO:0006067 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.5 2.2 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 12.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.5 2.1 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.5 1.6 GO:0060168 regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.5 3.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.5 5.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.5 4.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.5 9.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 2.0 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.5 16.9 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.5 11.8 GO:0035455 response to interferon-alpha(GO:0035455)
0.5 9.8 GO:0036035 osteoclast development(GO:0036035)
0.5 8.7 GO:0051607 defense response to virus(GO:0051607)
0.5 3.9 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 1.4 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.5 2.8 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.5 2.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.5 1.9 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.5 1.4 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.5 4.6 GO:0046834 lipid phosphorylation(GO:0046834)
0.5 5.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 1.8 GO:0015942 folic acid-containing compound catabolic process(GO:0009397) formate metabolic process(GO:0015942) pteridine-containing compound catabolic process(GO:0042560)
0.4 2.2 GO:0030035 microspike assembly(GO:0030035)
0.4 8.2 GO:0021542 dentate gyrus development(GO:0021542)
0.4 1.3 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.4 1.7 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.4 3.0 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.4 9.6 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.4 6.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.4 8.3 GO:2000811 negative regulation of anoikis(GO:2000811)
0.4 4.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 11.2 GO:0050832 defense response to fungus(GO:0050832)
0.4 1.6 GO:0042220 response to cocaine(GO:0042220)
0.4 8.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.4 3.9 GO:0072672 neutrophil extravasation(GO:0072672)
0.4 27.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.4 1.2 GO:0048539 bone marrow development(GO:0048539)
0.4 1.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 11.7 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.4 1.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.4 4.8 GO:0005513 detection of calcium ion(GO:0005513)
0.4 15.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.4 6.9 GO:0046135 pyrimidine nucleoside catabolic process(GO:0046135)
0.4 2.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 3.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 6.4 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.4 2.1 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 1.4 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.3 4.8 GO:0021516 dorsal spinal cord development(GO:0021516)
0.3 2.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.3 1.7 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 2.9 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.3 8.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.3 1.0 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.3 4.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 2.2 GO:0034765 regulation of ion transmembrane transport(GO:0034765)
0.3 2.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.3 12.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 3.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 4.0 GO:0098751 bone cell development(GO:0098751)
0.3 9.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 10.9 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.3 2.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.3 74.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.3 15.4 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.3 3.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.3 2.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.3 16.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 3.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.3 10.8 GO:0033344 cholesterol efflux(GO:0033344)
0.3 4.9 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.3 2.7 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.3 1.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.3 3.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.3 5.5 GO:0030225 macrophage differentiation(GO:0030225)
0.3 8.4 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.3 1.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 3.6 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.3 1.8 GO:0015870 acetylcholine transport(GO:0015870)
0.3 3.3 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.3 5.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 2.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 5.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 1.3 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.2 1.2 GO:0032364 oxygen homeostasis(GO:0032364)
0.2 1.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 5.0 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.2 8.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 1.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 1.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 8.2 GO:0019228 neuronal action potential(GO:0019228)
0.2 2.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 0.7 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.2 1.5 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.2 2.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.2 4.2 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 4.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 30.8 GO:0006906 vesicle fusion(GO:0006906)
0.2 1.6 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 4.6 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.2 14.0 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.2 2.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 3.0 GO:0001709 cell fate determination(GO:0001709)
0.2 3.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 35.5 GO:0002250 adaptive immune response(GO:0002250)
0.2 0.6 GO:2000342 negative regulation of interleukin-8 biosynthetic process(GO:0045415) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.2 6.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 2.0 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 8.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.2 2.2 GO:0042306 regulation of protein import into nucleus(GO:0042306) regulation of protein import(GO:1904589)
0.2 7.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 3.9 GO:0045576 mast cell activation(GO:0045576)
0.2 6.8 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 1.5 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 3.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 1.9 GO:0060037 pharyngeal system development(GO:0060037)
0.2 0.3 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 4.5 GO:0042417 dopamine metabolic process(GO:0042417)
0.1 0.6 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 2.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 3.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.0 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.1 1.7 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.1 0.7 GO:0048665 neuron fate specification(GO:0048665)
0.1 5.1 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 0.4 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 1.2 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 3.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 3.4 GO:0007409 axonogenesis(GO:0007409)
0.1 6.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 3.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 8.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 1.2 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 4.5 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 8.7 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.2 GO:0001756 somitogenesis(GO:0001756)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 2.5 GO:0033198 response to ATP(GO:0033198)
0.1 1.6 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.7 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.4 GO:0009629 response to gravity(GO:0009629)
0.1 0.5 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 3.2 GO:0010107 potassium ion import(GO:0010107)
0.1 0.9 GO:0006702 androgen biosynthetic process(GO:0006702)
0.1 3.1 GO:0060711 labyrinthine layer development(GO:0060711)
0.1 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 6.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 6.3 GO:0007631 feeding behavior(GO:0007631)
0.1 1.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 10.7 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 7.8 GO:0034332 adherens junction organization(GO:0034332)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.8 GO:0044253 positive regulation of collagen metabolic process(GO:0010714) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.1 1.0 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 4.0 GO:0006968 cellular defense response(GO:0006968)
0.1 0.9 GO:0021549 cerebellum development(GO:0021549) metencephalon development(GO:0022037)
0.1 2.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 2.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.5 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 1.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.4 GO:0003407 neural retina development(GO:0003407)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 1.4 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 5.2 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 1.2 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.5 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0086097 renin-angiotensin regulation of aldosterone production(GO:0002018) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.5 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 1.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.1 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 1.0 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0014874 response to muscle inactivity(GO:0014870) response to stimulus involved in regulation of muscle adaptation(GO:0014874) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 1.8 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:0002507 tolerance induction(GO:0002507)
0.0 0.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.6 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 0.0 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
19.8 59.4 GO:0071745 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
16.8 790.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
8.9 124.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
7.3 36.3 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
7.1 49.9 GO:0019815 B cell receptor complex(GO:0019815)
4.2 88.4 GO:0042613 MHC class II protein complex(GO:0042613)
3.5 14.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
3.4 13.6 GO:0031088 platelet dense granule membrane(GO:0031088)
3.2 16.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
2.9 529.1 GO:0072562 blood microparticle(GO:0072562)
2.9 34.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
2.5 17.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
2.3 9.3 GO:0043293 apoptosome(GO:0043293)
2.3 11.6 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
2.3 6.9 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
2.2 11.1 GO:0005579 membrane attack complex(GO:0005579)
2.2 8.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
2.1 8.6 GO:1990031 pinceau fiber(GO:1990031)
1.8 9.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
1.8 15.8 GO:0071953 elastic fiber(GO:0071953)
1.7 17.3 GO:0070938 contractile ring(GO:0070938)
1.6 9.8 GO:0005577 fibrinogen complex(GO:0005577)
1.6 27.2 GO:0045277 respiratory chain complex IV(GO:0045277)
1.4 7.0 GO:0044308 axonal spine(GO:0044308)
1.4 9.7 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
1.3 8.1 GO:0032009 early phagosome(GO:0032009)
1.3 4.0 GO:0036398 TCR signalosome(GO:0036398)
1.2 6.2 GO:0045298 tubulin complex(GO:0045298)
1.2 65.0 GO:0001533 cornified envelope(GO:0001533)
1.2 7.3 GO:0000322 storage vacuole(GO:0000322)
1.2 3.6 GO:0032437 cuticular plate(GO:0032437)
1.1 8.5 GO:0036157 outer dynein arm(GO:0036157)
1.0 5.2 GO:0071546 pi-body(GO:0071546)
0.9 1451.5 GO:0005615 extracellular space(GO:0005615)
0.8 77.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.8 5.0 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.8 9.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.8 11.8 GO:0000346 transcription export complex(GO:0000346)
0.8 2.3 GO:0097447 dendritic tree(GO:0097447)
0.8 10.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.7 2.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.7 5.5 GO:0035976 AP1 complex(GO:0035976)
0.7 2.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.7 39.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.6 22.9 GO:0016592 mediator complex(GO:0016592)
0.6 3.0 GO:0089701 U2AF(GO:0089701)
0.6 3.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.6 8.0 GO:0005687 U4 snRNP(GO:0005687)
0.6 9.1 GO:0097512 cardiac myofibril(GO:0097512)
0.6 3.4 GO:1990037 Lewy body core(GO:1990037)
0.6 7.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 15.6 GO:0001726 ruffle(GO:0001726)
0.5 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.5 30.5 GO:0030427 site of polarized growth(GO:0030427)
0.5 8.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.5 9.1 GO:0044295 axonal growth cone(GO:0044295)
0.5 23.5 GO:0048786 presynaptic active zone(GO:0048786)
0.5 5.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.4 35.1 GO:0036064 ciliary basal body(GO:0036064)
0.4 23.4 GO:0031901 early endosome membrane(GO:0031901)
0.4 6.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 11.1 GO:0034451 centriolar satellite(GO:0034451)
0.4 11.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 13.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 5.1 GO:0046930 pore complex(GO:0046930)
0.3 1.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 11.2 GO:0005859 muscle myosin complex(GO:0005859)
0.3 38.7 GO:0016605 PML body(GO:0016605)
0.3 22.9 GO:0042734 presynaptic membrane(GO:0042734)
0.3 6.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 4.5 GO:0036020 endolysosome membrane(GO:0036020)
0.3 11.6 GO:0008305 integrin complex(GO:0008305)
0.3 2.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.3 14.2 GO:0005796 Golgi lumen(GO:0005796)
0.3 3.3 GO:0030673 axolemma(GO:0030673)
0.3 6.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 14.2 GO:0043195 terminal bouton(GO:0043195)
0.3 6.5 GO:0042629 mast cell granule(GO:0042629)
0.3 3.3 GO:0000815 ESCRT III complex(GO:0000815)
0.3 2.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 16.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 2.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 48.1 GO:0032993 protein-DNA complex(GO:0032993)
0.2 0.5 GO:0005916 fascia adherens(GO:0005916)
0.2 9.4 GO:0016235 aggresome(GO:0016235)
0.2 6.4 GO:1904115 axon cytoplasm(GO:1904115)
0.2 3.6 GO:0031932 TORC2 complex(GO:0031932)
0.2 1.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 6.1 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.2 5.4 GO:0035580 specific granule lumen(GO:0035580)
0.2 2.2 GO:0043194 axon initial segment(GO:0043194)
0.2 1.4 GO:0042382 paraspeckles(GO:0042382)
0.2 4.6 GO:0031904 endosome lumen(GO:0031904)
0.2 1.2 GO:0097361 CIA complex(GO:0097361)
0.2 1.6 GO:0016013 syntrophin complex(GO:0016013)
0.2 17.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.5 GO:0043204 perikaryon(GO:0043204)
0.2 7.7 GO:0005902 microvillus(GO:0005902)
0.1 4.3 GO:0000791 euchromatin(GO:0000791)
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.1 614.5 GO:0005886 plasma membrane(GO:0005886)
0.1 14.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.7 GO:0002102 podosome(GO:0002102)
0.1 3.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.8 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 0.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 4.6 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
18.5 55.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
15.6 3668.9 GO:0003823 antigen binding(GO:0003823)
13.0 39.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
10.4 135.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
9.5 28.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
4.9 34.4 GO:0043208 glycosphingolipid binding(GO:0043208)
4.2 80.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
3.8 15.3 GO:0016160 amylase activity(GO:0016160)
3.5 20.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
3.1 15.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
3.1 12.6 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
2.9 8.8 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
2.9 17.3 GO:0043237 laminin-1 binding(GO:0043237)
2.7 48.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
2.7 8.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
2.4 9.6 GO:0004657 proline dehydrogenase activity(GO:0004657)
2.3 18.3 GO:0070324 thyroid hormone binding(GO:0070324)
2.2 6.5 GO:0097100 supercoiled DNA binding(GO:0097100)
2.1 12.5 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
2.1 20.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
2.0 14.3 GO:0008142 oxysterol binding(GO:0008142)
2.0 8.2 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
2.0 6.1 GO:0017129 triglyceride binding(GO:0017129)
2.0 17.9 GO:0043426 MRF binding(GO:0043426)
2.0 5.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
2.0 9.8 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
1.9 23.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.9 7.7 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.9 29.8 GO:0042809 vitamin D receptor binding(GO:0042809)
1.8 124.6 GO:0050840 extracellular matrix binding(GO:0050840)
1.8 7.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.8 5.5 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
1.7 6.8 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
1.7 9.9 GO:0004522 ribonuclease A activity(GO:0004522)
1.6 19.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
1.6 21.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
1.6 4.8 GO:0030158 protein xylosyltransferase activity(GO:0030158)
1.5 6.2 GO:0099609 microtubule lateral binding(GO:0099609)
1.5 20.8 GO:0035325 Toll-like receptor binding(GO:0035325)
1.5 10.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
1.4 7.1 GO:0046625 sphingolipid binding(GO:0046625)
1.4 14.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
1.3 9.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.3 18.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.3 7.8 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.3 3.9 GO:0032427 GBD domain binding(GO:0032427)
1.2 22.3 GO:0019992 diacylglycerol binding(GO:0019992)
1.2 4.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.2 19.2 GO:0097109 neuroligin family protein binding(GO:0097109)
1.2 13.1 GO:0051525 NFAT protein binding(GO:0051525)
1.2 10.6 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
1.1 4.6 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.1 5.6 GO:0070097 delta-catenin binding(GO:0070097)
1.1 4.4 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.1 3.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.1 4.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
1.1 5.3 GO:0004925 prolactin receptor activity(GO:0004925)
1.1 4.2 GO:0047708 biotinidase activity(GO:0047708)
1.0 6.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
1.0 7.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 2.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.9 14.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.9 27.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.9 6.9 GO:0070412 R-SMAD binding(GO:0070412)
0.8 2.5 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.8 5.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.8 4.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.8 4.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.8 5.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.8 10.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.7 2.9 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.7 2.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.7 11.8 GO:0005522 profilin binding(GO:0005522)
0.7 2.0 GO:1904288 BAT3 complex binding(GO:1904288)
0.7 11.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7 7.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.6 13.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.6 7.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 3.9 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 8.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.6 10.5 GO:0038191 neuropilin binding(GO:0038191)
0.6 3.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.6 1.8 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.6 3.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.6 6.0 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.6 5.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.6 6.3 GO:0005504 fatty acid binding(GO:0005504)
0.6 4.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.6 3.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.5 3.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.5 5.9 GO:0071837 HMG box domain binding(GO:0071837)
0.5 5.6 GO:0050811 GABA receptor binding(GO:0050811)
0.5 16.2 GO:0001671 ATPase activator activity(GO:0001671)
0.5 2.0 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.5 1.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.5 1.5 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.5 11.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.5 2.9 GO:0003796 lysozyme activity(GO:0003796)
0.5 4.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.5 5.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.5 1.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.5 9.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.5 5.1 GO:0051434 BH3 domain binding(GO:0051434)
0.5 4.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.8 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.4 6.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.4 6.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 6.4 GO:0016918 retinal binding(GO:0016918)
0.4 7.7 GO:0070628 proteasome binding(GO:0070628)
0.4 7.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 0.8 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.4 5.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 2.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.4 12.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 13.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.4 8.8 GO:0070403 NAD+ binding(GO:0070403)
0.4 1.6 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.4 2.7 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 3.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 3.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 6.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.4 1.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.4 4.9 GO:0031432 titin binding(GO:0031432)
0.4 8.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.4 2.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 13.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 2.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 8.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 2.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 6.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 10.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 3.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 8.0 GO:0045503 dynein light chain binding(GO:0045503)
0.3 4.5 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 9.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.5 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.3 7.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 2.3 GO:0004064 arylesterase activity(GO:0004064)
0.3 4.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 7.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 2.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 1.9 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3 5.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.3 6.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 3.6 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979)
0.2 3.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 8.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 4.0 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.2 5.1 GO:0035198 miRNA binding(GO:0035198)
0.2 5.0 GO:0030553 cGMP binding(GO:0030553)
0.2 10.1 GO:0050699 WW domain binding(GO:0050699)
0.2 19.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 2.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.5 GO:0048018 receptor agonist activity(GO:0048018)
0.2 0.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 11.2 GO:0043531 ADP binding(GO:0043531)
0.2 0.8 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 13.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 1.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 1.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 32.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 2.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 4.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 5.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 8.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 15.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 7.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 1.4 GO:0031386 protein tag(GO:0031386)
0.2 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 54.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 5.8 GO:0005109 frizzled binding(GO:0005109)
0.2 2.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 4.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 28.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 5.6 GO:0044325 ion channel binding(GO:0044325)
0.1 1.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 2.5 GO:0042166 acetylcholine binding(GO:0042166)
0.1 4.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 3.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 2.7 GO:0005521 lamin binding(GO:0005521)
0.1 0.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.0 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 1.2 GO:0015250 water channel activity(GO:0015250)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 13.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 3.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.6 GO:0051400 BH domain binding(GO:0051400)
0.1 21.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.4 GO:0070905 serine binding(GO:0070905)
0.1 0.5 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.1 1.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.2 GO:0070888 E-box binding(GO:0070888)
0.1 2.1 GO:0030332 cyclin binding(GO:0030332)
0.1 2.3 GO:0008009 chemokine activity(GO:0008009)
0.1 1.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.5 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 2.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.3 GO:0022834 ligand-gated ion channel activity(GO:0015276) ligand-gated channel activity(GO:0022834)
0.0 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.5 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.0 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 131.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
2.9 31.9 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
2.7 106.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
2.2 123.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
1.7 98.2 PID BCR 5PATHWAY BCR signaling pathway
1.5 18.2 PID IL5 PATHWAY IL5-mediated signaling events
1.5 61.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
1.2 35.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.2 103.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.2 7.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.9 136.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.9 30.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.9 29.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.9 15.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.9 9.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.7 16.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.6 6.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.6 18.9 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.5 11.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.5 15.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.4 9.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 8.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4 3.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.4 16.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.4 6.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 6.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 4.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.3 11.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.3 11.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 2.7 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.3 15.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 11.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 3.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 7.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 9.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.2 15.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 23.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 11.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 18.5 PID CMYB PATHWAY C-MYB transcription factor network
0.2 1.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 7.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 2.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 5.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 24.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.5 PID IFNG PATHWAY IFN-gamma pathway
0.1 2.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.8 PID FGF PATHWAY FGF signaling pathway
0.1 3.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 20.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.9 PID ENDOTHELIN PATHWAY Endothelins
0.1 1.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 3.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 10.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.7 PID BMP PATHWAY BMP receptor signaling
0.0 8.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 129.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
3.4 94.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
3.0 106.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
2.9 55.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
2.4 131.9 REACTOME MYOGENESIS Genes involved in Myogenesis
1.9 20.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.8 17.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.7 30.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.3 30.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.3 40.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.2 34.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
1.2 13.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.9 16.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.8 22.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.8 19.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 32.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.6 4.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.6 8.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 18.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 6.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.5 6.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 7.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.4 9.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 9.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.4 13.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 6.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.4 15.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.3 6.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 9.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 7.6 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.3 6.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.3 14.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.3 1.8 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 64.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.3 5.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.3 5.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.3 6.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.3 9.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 4.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 8.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 2.3 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.3 17.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 9.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 6.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.0 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.2 3.8 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 6.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 5.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 4.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 5.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 12.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 16.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 9.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 3.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 3.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 4.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 8.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.3 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 17.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 7.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 9.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.7 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 4.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 4.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 6.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.9 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 1.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane