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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU6F2

Z-value: 0.72

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Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
POU6F2
ENSG00000106536.15 POU class 6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F2hg19_v2_chr7_+_39017504_39017598,
hg19_v2_chr7_+_39125365_39125489		0.393.3e-09Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_13835147 18.60 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_+_50571949 12.79 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr5_-_134914673 12.15 ENST00000512158.1
CXCL14
chemokine (C-X-C motif) ligand 14
chr8_-_90769422 11.63 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr3_+_111718036 10.89 ENST00000455401.2
TAGLN3
transgelin 3
chr6_+_151042224 10.73 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr4_+_175204818 10.59 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr3_+_111717600 10.42 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 10.04 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr19_-_7968427 9.94 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr3_+_111718173 9.86 ENST00000494932.1
TAGLN3
transgelin 3
chr11_-_129062093 8.95 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr3_-_127541194 8.54 ENST00000453507.2
MGLL
monoglyceride lipase
chr14_+_22984601 8.04 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr14_-_27066960 7.81 ENST00000539517.2
NOVA1
neuro-oncological ventral antigen 1
chr17_-_29624343 7.43 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr12_-_16761007 7.35 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_10271674 7.05 ENST00000377086.1
KIF1B
kinesin family member 1B
chr13_+_58206655 6.97 ENST00000377918.3
PCDH17
protocadherin 17
chrX_-_19988382 6.80 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr22_-_50524298 6.77 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_+_189507460 6.72 ENST00000434928.1
TP63
tumor protein p63
chr3_+_159557637 6.71 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr22_-_50523760 6.58 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_50574585 6.23 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr20_+_58515417 6.07 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr7_-_73038822 6.04 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr13_-_110438914 5.89 ENST00000375856.3
IRS2
insulin receptor substrate 2
chr5_-_140998481 5.71 ENST00000518047.1
DIAPH1
diaphanous-related formin 1
chr16_-_4852915 5.52 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr7_-_73038867 5.36 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr12_+_54332535 5.31 ENST00000243056.3
HOXC13
homeobox C13
chrX_-_38186811 5.23 ENST00000318842.7
RPGR
retinitis pigmentosa GTPase regulator
chr10_+_18549645 4.81 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr4_-_74486347 4.65 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr9_-_79520989 4.62 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr11_+_45918092 4.26 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_-_57199397 4.24 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chrX_-_38186775 4.14 ENST00000339363.3
ENST00000309513.3
ENST00000338898.3
ENST00000342811.3
ENST00000378505.2
RPGR
retinitis pigmentosa GTPase regulator
chr6_+_151646800 3.93 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_8064567 3.87 ENST00000543936.1
ENST00000397457.2
BLOC1S5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr14_-_50698276 3.58 ENST00000216373.5
SOS2
son of sevenless homolog 2 (Drosophila)
chr8_+_119294456 3.55 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr14_-_69261310 3.54 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr1_-_208417620 3.51 ENST00000367033.3
PLXNA2
plexin A2
chr4_-_74486217 3.46 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_30887948 3.29 ENST00000433722.2
CAPRIN2
caprin family member 2
chr5_+_67586465 3.26 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_+_131062367 3.18 ENST00000601297.1
AL359091.2
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr21_-_42219065 3.17 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr14_+_32798547 3.02 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr2_-_217559517 2.85 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr3_-_33686743 2.83 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr20_+_56136136 2.73 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr15_+_93443419 2.52 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chrX_+_43515467 2.48 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr11_-_70672645 2.36 ENST00000423696.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr7_-_14028488 2.36 ENST00000405358.4
ETV1
ets variant 1
chr10_+_114710425 2.35 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr2_+_44502597 2.30 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr22_+_30792846 2.19 ENST00000312932.9
ENST00000428195.1
SEC14L2
SEC14-like 2 (S. cerevisiae)
chrX_+_107288239 2.14 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr22_-_32767017 2.00 ENST00000400234.1
RFPL3S
RFPL3 antisense
chrX_+_86772707 1.99 ENST00000373119.4
KLHL4
kelch-like family member 4
chr20_+_42187608 1.97 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr4_+_88571429 1.95 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr6_+_25754927 1.95 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr20_+_42187682 1.95 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_47655686 1.91 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr5_-_140998616 1.91 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chr2_-_182545603 1.84 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr6_-_111136513 1.77 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr14_+_32798462 1.75 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_133035185 1.74 ENST00000367928.4
VNN1
vanin 1
chrX_+_68835911 1.61 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr17_-_39553844 1.58 ENST00000251645.2
KRT31
keratin 31
chr11_+_65554493 1.57 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr1_-_21606013 1.56 ENST00000357071.4
ECE1
endothelin converting enzyme 1
chr6_-_100912785 1.55 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr7_+_129007964 1.48 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr2_+_138721850 1.48 ENST00000329366.4
ENST00000280097.3
HNMT
histamine N-methyltransferase
chrX_+_107288197 1.47 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr3_-_101039402 1.47 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr3_-_45838011 1.41 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr12_-_71031185 1.26 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr6_-_33160231 1.19 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr16_+_31885079 1.17 ENST00000300870.10
ENST00000394846.3
ZNF267
zinc finger protein 267
chr20_-_45035223 1.15 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
ELMO2
engulfment and cell motility 2
chr5_-_156486120 1.14 ENST00000522693.1
HAVCR1
hepatitis A virus cellular receptor 1
chr12_-_71031220 1.09 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_+_77593448 1.06 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr6_+_50786414 1.04 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr6_+_42123141 1.02 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr8_+_77593474 1.02 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr3_-_18466787 1.00 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr17_-_40337470 1.00 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr15_+_58702742 0.99 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr7_-_14029283 0.95 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr12_-_53045948 0.87 ENST00000309680.3
KRT2
keratin 2
chr6_-_155635583 0.81 ENST00000367166.4
TFB1M
transcription factor B1, mitochondrial
chr1_-_204329013 0.78 ENST00000272203.3
ENST00000414478.1
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr2_-_217560248 0.76 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chrX_-_23926004 0.70 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr10_-_75415825 0.70 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr4_+_110834033 0.65 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr11_+_125034586 0.62 ENST00000298282.9
PKNOX2
PBX/knotted 1 homeobox 2
chrX_+_99839799 0.59 ENST00000373031.4
TNMD
tenomodulin
chr3_+_189507523 0.57 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr12_+_15699286 0.57 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr10_+_120967072 0.52 ENST00000392870.2
GRK5
G protein-coupled receptor kinase 5
chr6_-_89927151 0.44 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr17_+_4613776 0.34 ENST00000269260.2
ARRB2
arrestin, beta 2
chr11_+_31531291 0.34 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr19_+_50016610 0.25 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_169757750 0.14 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr1_+_175036966 0.11 ENST00000239462.4
TNN
tenascin N
chr9_-_13165457 0.08 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr12_-_86230315 0.01 ENST00000361228.3
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:1904647 response to rotenone(GO:1904647)
1.9 18.6 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.8 7.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
1.7 12.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.6 11.4 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
1.2 7.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.2 8.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.2 3.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.2 4.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.2 3.5 GO:0048382 mesendoderm development(GO:0048382)
1.0 7.0 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
1.0 5.9 GO:1903960 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960)
0.9 13.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.8 4.8 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.7 2.7 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.6 7.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.5 4.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 1.6 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.5 5.3 GO:0043587 tongue morphogenesis(GO:0043587)
0.4 2.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 1.2 GO:0060023 soft palate development(GO:0060023)
0.4 1.6 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.4 2.3 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.4 1.8 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 3.5 GO:0060174 limb bud formation(GO:0060174)
0.3 1.4 GO:0015824 proline transport(GO:0015824)
0.3 3.9 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)
0.3 1.6 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.3 3.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.2 1.5 GO:0001692 histamine metabolic process(GO:0001692)
0.2 2.0 GO:0070166 enamel mineralization(GO:0070166)
0.2 3.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.2 3.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 0.6 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 3.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.2 0.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 1.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 1.7 GO:2000400 pantothenate metabolic process(GO:0015939) positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.2 9.4 GO:0042073 intraciliary transport(GO:0042073)
0.2 1.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 2.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.6 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 1.0 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.1 3.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.4 GO:0071625 vocalization behavior(GO:0071625)
0.1 3.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 2.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 1.0 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 1.0 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 6.5 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 5.5 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 11.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.6 GO:0001657 ureteric bud development(GO:0001657) mesonephros development(GO:0001823) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.1 0.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.9 GO:0003334 keratinocyte development(GO:0003334)
0.0 3.9 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.8 GO:0031167 rRNA methylation(GO:0031167)
0.0 7.9 GO:0007626 locomotory behavior(GO:0007626)
0.0 0.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 2.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 4.5 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.7 GO:0042407 cristae formation(GO:0042407)
0.0 2.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 15.4 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.8 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 1.6 GO:0070268 cornification(GO:0070268)
0.0 0.7 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 1.2 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.7 4.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.5 4.3 GO:0044294 dendritic growth cone(GO:0044294)
0.4 3.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 1.6 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.4 4.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 3.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 2.8 GO:0045180 basal cortex(GO:0045180)
0.2 2.4 GO:0005883 neurofilament(GO:0005883)
0.2 3.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 41.3 GO:0043209 myelin sheath(GO:0043209)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.1 13.1 GO:0005901 caveola(GO:0005901)
0.1 9.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 7.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 9.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 10.6 GO:0030496 midbody(GO:0030496)
0.1 8.7 GO:0001650 fibrillar center(GO:0001650)
0.1 1.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 2.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 3.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.3 GO:0031526 brush border membrane(GO:0031526)
0.0 12.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.0 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 7.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.1 GO:0031514 motile cilium(GO:0031514)
0.0 3.7 GO:0030426 growth cone(GO:0030426)
0.0 1.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.7 GO:0043235 receptor complex(GO:0043235)
0.0 2.7 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.7 8.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 22.6 GO:0017091 AU-rich element binding(GO:0017091)
0.6 4.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.6 4.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.6 7.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.5 2.2 GO:0008431 vitamin E binding(GO:0008431)
0.5 8.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 2.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.4 4.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 1.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.3 2.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 3.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 3.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3 2.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 5.9 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 11.7 GO:0008009 chemokine activity(GO:0008009)
0.2 1.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 3.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.0 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 0.5 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 41.8 GO:0051015 actin filament binding(GO:0051015)
0.2 1.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 2.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.2 0.8 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 3.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 14.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.1 GO:0019894 kinesin binding(GO:0019894)
0.1 2.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 2.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 13.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.6 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 7.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0031762 alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762) platelet activating factor receptor binding(GO:0031859)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 7.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 7.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.1 GO:0001618 virus receptor activity(GO:0001618)
0.0 4.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 3.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.7 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 8.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 9.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.3 PID REELIN PATHWAY Reelin signaling pathway
0.1 9.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 7.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.2 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 PID CONE PATHWAY Visual signal transduction: Cones
0.0 3.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 8.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 5.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 2.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 3.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 3.5 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2 3.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 3.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 4.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 11.4 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 7.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.6 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 4.2 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)