ISMARA results: RAD21

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RAD21_SMC3

Z-value: 0.80

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Transcription factors associated with RAD21_SMC3

Gene Symbol	Gene ID	Gene Info
RAD21 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000164754.8	RAD21 cohesin complex component
SMC3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108055.9	structural maintenance of chromosomes 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMC3	hg19_v2_chr10_+_112327425_112327516	-0.39	3.5e-09	Click!
RAD21	hg19_v2_chr8_-_117886955_117887105	-0.36	7.0e-08	Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_30032610 Show fit	24.13	ENST00000574405.1	DOC2A Ensembl NCBI GeneCards UniProt NextProt Show fit	double C2-like domains, alpha
chr13_-_88323218 Show fit	18.98	ENST00000436290.2 ENST00000453832.2 ENST00000606590.1	MIR4500HG Ensembl NCBI GeneCards UniProt NextProt Show fit	MIR4500 host gene (non-protein coding)
chr3_-_138763734 Show fit	16.11	ENST00000413199.1 ENST00000502927.2	PRR23C Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 23C
chr1_+_10270863 Show fit	15.65	ENST00000377093.4 ENST00000263934.6	KIF1B Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 1B
chr5_-_136834982 Show fit	15.58	ENST00000510689.1 ENST00000394945.1	SPOCK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr8_+_24772455 Show fit	14.46	ENST00000433454.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr1_+_10003486 Show fit	13.78	ENST00000403197.1 ENST00000377205.1	NMNAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nicotinamide nucleotide adenylyltransferase 1
chr1_-_35325400 Show fit	12.51	ENST00000521580.2	SMIM12 Ensembl NCBI GeneCards UniProt NextProt Show fit	small integral membrane protein 12
chr16_-_19897455 Show fit	12.42	ENST00000568214.1 ENST00000569479.1	GPRC5B Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor, family C, group 5, member B
chr1_-_156390128 Show fit	11.79	ENST00000368242.3	C1orf61 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 61

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	31.5	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.6	24.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
7.8	23.3	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
5.2	15.7	GO:1904647	response to rotenone(GO:1904647)
0.5	15.7	GO:0043984	histone H4-K16 acetylation(GO:0043984)
4.8	14.5	GO:0033693	neurofilament bundle assembly(GO:0033693)
1.5	13.8	GO:0006531	aspartate metabolic process(GO:0006531)
0.2	13.1	GO:0010812	negative regulation of cell-substrate adhesion(GO:0010812)
0.7	12.4	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.2	11.8	GO:0051865	protein autoubiquitination(GO:0051865)

Showing 1 to 10 of 214 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	23.8	GO:0001917	photoreceptor inner segment(GO:0001917)
0.2	21.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	21.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.7	18.7	GO:0033268	node of Ranvier(GO:0033268)
2.4	16.9	GO:0072487	MSL complex(GO:0072487)
0.4	15.7	GO:1904115	axon cytoplasm(GO:1904115)
1.1	14.5	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	13.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	13.2	GO:0032587	ruffle membrane(GO:0032587)
0.0	11.1	GO:0043235	receptor complex(GO:0043235)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	39.7	GO:0008017	microtubule binding(GO:0008017)
0.0	24.8	GO:0003779	actin binding(GO:0003779)
0.5	24.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	23.3	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.4	19.3	GO:0019894	kinesin binding(GO:0019894)
0.0	16.6	GO:0005509	calcium ion binding(GO:0005509)
0.6	15.6	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.2	15.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	14.1	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
4.6	13.8	GO:0004515	nicotinate-nucleotide adenylyltransferase activity(GO:0004515)

Showing 1 to 10 of 145 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	26.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	18.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	17.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	15.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	10.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	8.5	PID AURORA A PATHWAY	Aurora A signaling
0.1	7.3	PID AURORA B PATHWAY	Aurora B signaling
0.4	6.8	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	6.7	PID SHP2 PATHWAY	SHP2 signaling
0.2	6.0	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	23.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.4	15.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.4	14.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	13.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	10.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	10.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	8.9	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.4	7.9	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.3	7.3	REACTOME KINESINS	Genes involved in Kinesins
0.1	6.4	REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

Showing 1 to 10 of 62 entries

Results for RAD21_SMC3

Z-value: 0.80

Motif logo

Transcription factors associated with RAD21_SMC3

Activity-expression correlation:

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: