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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RFX3_RFX2

Z-value: 4.01

Motif logo

Transcription factors associated with RFX3_RFX2

Gene Symbol Gene ID Gene Info
ENSG00000080298.11 regulatory factor X3
ENSG00000087903.8 regulatory factor X2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX2hg19_v2_chr19_-_6110474_61105510.601.8e-22Click!
RFX3hg19_v2_chr9_-_3525968_35260160.385.3e-09Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_48693955 132.33 ENST00000218230.5
proprotein convertase subtilisin/kexin type 1 inhibitor
chr15_+_43803143 112.16 ENST00000382031.1
microtubule-associated protein 1A
chr3_-_58563094 103.82 ENST00000464064.1
family with sequence similarity 107, member A
chr1_-_204380919 98.27 ENST00000367188.4
protein phosphatase 1, regulatory subunit 15B
chr16_+_8806800 98.10 ENST00000561870.1
ENST00000396600.2
4-aminobutyrate aminotransferase
chr2_-_175869936 81.69 ENST00000409900.3
chimerin 1
chr19_-_57352064 75.20 ENST00000326441.9
ENST00000593695.1
ENST00000599577.1
ENST00000594389.1
ENST00000423103.2
ENST00000598410.1
ENST00000593711.1
ENST00000391708.3
ENST00000221722.5
ENST00000599935.1
paternally expressed 3
zinc finger, imprinted 2
chr11_+_133938820 74.99 ENST00000299106.4
ENST00000529443.2
junctional adhesion molecule 3
chr15_+_71184931 73.56 ENST00000560369.1
ENST00000260382.5
leucine rich repeat containing 49
chr2_-_175870085 71.36 ENST00000409156.3
chimerin 1
chr19_-_46974741 69.77 ENST00000313683.10
ENST00000602246.1
paraneoplastic Ma antigen family-like 1
chr11_+_133938955 69.72 ENST00000534549.1
ENST00000441717.3
junctional adhesion molecule 3
chr11_-_62473706 69.64 ENST00000403550.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_31391381 67.77 ENST00000465995.1
ENST00000536040.1
DnaJ (Hsp40) homolog, subfamily C, member 24
chr19_-_55690758 67.56 ENST00000590851.1
synaptotagmin V
chr19_-_46974664 67.52 ENST00000438932.2
paraneoplastic Ma antigen family-like 1
chr19_-_58609570 64.72 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
zinc finger and SCAN domain containing 18
chr14_-_74181106 63.05 ENST00000316836.3
paraneoplastic Ma antigen 1
chr19_+_35630022 61.89 ENST00000589209.1
FXYD domain containing ion transport regulator 1
chr19_+_35630926 60.84 ENST00000588081.1
ENST00000589121.1
FXYD domain containing ion transport regulator 1
chr15_+_71185148 60.27 ENST00000443425.2
ENST00000560755.1
leucine rich repeat containing 49
chr3_-_149688896 58.66 ENST00000239940.7
profilin 2
chr11_-_62473776 58.55 ENST00000278893.7
ENST00000407022.3
ENST00000421906.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_-_98290087 57.51 ENST00000322128.3
TSPY-like 5
chr5_-_11588907 56.61 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chr16_+_84178874 54.78 ENST00000378553.5
dynein, axonemal, assembly factor 1
chr16_+_19729586 54.58 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQ motif containing K
chr16_+_4784458 53.71 ENST00000590191.1
chromosome 16 open reading frame 71
chr7_+_102715315 52.45 ENST00000428183.2
ENST00000323716.3
ENST00000441711.2
ENST00000454559.1
ENST00000425331.1
ENST00000541300.1
armadillo repeat containing 10
chr16_+_58283814 52.09 ENST00000443128.2
ENST00000219299.4
coiled-coil domain containing 113
chr6_-_116575226 51.74 ENST00000420283.1
TSPY-like 4
chr19_+_35630628 51.44 ENST00000588715.1
ENST00000588607.1
FXYD domain containing ion transport regulator 1
chr20_-_48532019 51.21 ENST00000289431.5
spermatogenesis associated 2
chr5_-_11589131 51.18 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr2_+_27193480 51.10 ENST00000233121.2
ENST00000405074.3
microtubule-associated protein, RP/EB family, member 3
chr13_-_30881621 50.55 ENST00000380615.3
katanin p60 subunit A-like 1
chr1_-_21978312 48.95 ENST00000359708.4
ENST00000290101.4
RAP1 GTPase activating protein
chr12_-_54978086 47.97 ENST00000553113.1
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr10_-_135150367 47.88 ENST00000368555.3
ENST00000252939.4
ENST00000368558.1
ENST00000368556.2
calcyon neuron-specific vesicular protein
chr4_+_128554081 45.66 ENST00000335251.6
ENST00000296461.5
inturned planar cell polarity protein
chr19_+_35634146 45.30 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD domain containing ion transport regulator 7
chr4_-_87281196 44.14 ENST00000359221.3
mitogen-activated protein kinase 10
chrX_+_129473859 44.13 ENST00000424447.1
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr16_+_67840668 44.00 ENST00000415766.3
translin-associated factor X interacting protein 1
chr10_-_120514720 43.84 ENST00000369151.3
ENST00000340214.4
CDK2-associated, cullin domain 1
chr1_-_48937682 43.73 ENST00000371843.3
spermatogenesis associated 6
chr11_-_64885111 41.44 ENST00000528598.1
ENST00000310597.4
zinc finger, HIT-type containing 2
chr1_-_109584716 40.50 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WD repeat domain 47
chr1_+_38022513 40.44 ENST00000296218.7
dynein, axonemal, light intermediate chain 1
chr17_-_74137374 40.33 ENST00000322957.6
forkhead box J1
chr1_+_183605200 40.27 ENST00000304685.4
ral guanine nucleotide dissociation stimulator-like 1
chr1_-_48937821 39.81 ENST00000396199.3
spermatogenesis associated 6
chr19_+_56652556 39.73 ENST00000337080.3
zinc finger protein 444
chr7_-_45128472 39.59 ENST00000490531.2
NAC alpha domain containing
chr2_+_55746746 39.48 ENST00000406691.3
ENST00000349456.4
ENST00000407816.3
ENST00000403007.3
coiled-coil domain containing 104
chr7_-_129845188 39.42 ENST00000462753.1
ENST00000471077.1
ENST00000473456.1
ENST00000336804.8
transmembrane protein 209
chr20_+_44509857 39.38 ENST00000372523.1
ENST00000372520.1
zinc finger, SWIM-type containing 1
chr1_-_48937838 39.14 ENST00000371847.3
spermatogenesis associated 6
chr17_-_64187973 38.94 ENST00000583358.1
ENST00000392769.2
centrosomal protein 112kDa
chr17_-_8079648 38.85 ENST00000449985.2
ENST00000532998.1
ENST00000437139.2
ENST00000533070.1
ENST00000316425.5
transmembrane protein 107
chr2_-_44588624 38.76 ENST00000438314.1
ENST00000409936.1
prolyl endopeptidase-like
chr2_+_79740118 38.63 ENST00000496558.1
ENST00000451966.1
catenin (cadherin-associated protein), alpha 2
chr6_-_35109080 38.32 ENST00000486638.1
ENST00000505400.1
ENST00000412155.2
ENST00000373979.2
ENST00000507706.1
ENST00000444780.2
ENST00000492680.2
t-complex 11, testis-specific
chr2_-_2334888 38.21 ENST00000428368.2
ENST00000399161.2
myelin transcription factor 1-like
chr11_-_116968987 38.15 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
SIK family kinase 3
chr8_+_21912328 38.07 ENST00000432128.1
ENST00000443491.2
ENST00000517600.1
ENST00000523782.2
dematin actin binding protein
chr4_-_87281224 37.92 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr6_+_31783291 37.81 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
heat shock 70kDa protein 1A
chr22_+_38453378 37.77 ENST00000437453.1
ENST00000356976.3
protein interacting with PRKCA 1
chr19_+_10217364 37.34 ENST00000430370.1
peter pan homolog (Drosophila)
chr8_+_42010464 37.14 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
adaptor-related protein complex 3, mu 2 subunit
chr3_-_50383096 37.08 ENST00000442887.1
ENST00000360165.3
zinc finger, MYND-type containing 10
chr7_+_99699280 37.05 ENST00000421755.1
adaptor-related protein complex 4, mu 1 subunit
chr17_-_64188177 36.98 ENST00000535342.2
centrosomal protein 112kDa
chr1_-_109584768 36.97 ENST00000357672.3
WD repeat domain 47
chr1_-_15735925 36.96 ENST00000427824.1
RP3-467K16.4
chr11_+_46958248 36.28 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
chromosome 11 open reading frame 49
chr8_+_85618155 36.25 ENST00000523850.1
ENST00000521376.1
RALY RNA binding protein-like
chr19_+_5681011 35.98 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
hydroxysteroid (11-beta) dehydrogenase 1-like
chr19_+_10217270 35.67 ENST00000446223.1
peter pan homolog (Drosophila)
chr7_-_129845313 35.60 ENST00000397622.2
transmembrane protein 209
chr2_-_44588694 35.51 ENST00000409957.1
prolyl endopeptidase-like
chr5_-_74062930 35.44 ENST00000509430.1
ENST00000345239.2
ENST00000427854.2
ENST00000506778.1
G elongation factor, mitochondrial 2
chr22_+_38453207 34.68 ENST00000404072.3
ENST00000424694.1
protein interacting with PRKCA 1
chr10_+_12171636 34.67 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
Sec61 alpha 2 subunit (S. cerevisiae)
chr16_+_67840986 34.59 ENST00000561639.1
ENST00000567852.1
ENST00000565148.1
ENST00000388833.3
ENST00000561654.1
ENST00000431934.2
translin-associated factor X interacting protein 1
chr6_-_35109145 34.40 ENST00000373974.4
ENST00000244645.3
t-complex 11, testis-specific
chr7_+_99699179 34.13 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
adaptor-related protein complex 4, mu 1 subunit
chr2_-_44588679 33.99 ENST00000409411.1
prolyl endopeptidase-like
chr1_-_169396646 33.99 ENST00000367806.3
coiled-coil domain containing 181
chr12_+_7014064 33.97 ENST00000443597.2
leucine rich repeat containing 23
chr19_-_56826157 33.96 ENST00000592509.1
ENST00000592679.1
ENST00000588442.1
ENST00000593106.1
ENST00000587492.1
ENST00000254165.3
zinc finger and SCAN domain containing 5A
chr19_-_4457776 33.79 ENST00000301281.6
UBX domain protein 6
chr6_-_32145861 33.55 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr7_-_51384451 33.36 ENST00000441453.1
ENST00000265136.7
ENST00000395542.2
ENST00000395540.2
cordon-bleu WH2 repeat protein
chr14_-_77787198 33.31 ENST00000261534.4
protein-O-mannosyltransferase 2
chr5_-_132073210 33.25 ENST00000378735.1
ENST00000378746.4
kinesin family member 3A
chr7_-_100965011 33.08 ENST00000498704.2
ENST00000517481.1
ENST00000437644.2
ENST00000315322.4
RAB, member RAS oncogene family-like 5
chr1_-_109584608 32.77 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WD repeat domain 47
chr10_+_134145614 32.60 ENST00000368615.3
ENST00000392638.2
ENST00000344079.5
ENST00000356571.4
ENST00000368614.3
leucine rich repeat containing 27
chr3_+_196439170 32.44 ENST00000392391.3
ENST00000314118.4
phosphatidylinositol glycan anchor biosynthesis, class X
chr1_+_245133278 32.38 ENST00000366522.2
EF-hand calcium binding domain 2
chr12_+_70132632 31.91 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3A interacting protein
chr1_-_156217822 31.88 ENST00000368270.1
progestin and adipoQ receptor family member VI
chr7_-_37026108 31.82 ENST00000396045.3
engulfment and cell motility 1
chr2_-_44588893 31.40 ENST00000409272.1
ENST00000410081.1
ENST00000541738.1
prolyl endopeptidase-like
chr1_-_156217875 31.22 ENST00000292291.5
progestin and adipoQ receptor family member VI
chr11_-_115375107 31.21 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
cell adhesion molecule 1
chr11_-_132813566 30.84 ENST00000331898.7
opioid binding protein/cell adhesion molecule-like
chr1_-_156217829 30.81 ENST00000356983.2
ENST00000335852.1
ENST00000340183.5
ENST00000540423.1
progestin and adipoQ receptor family member VI
chr1_-_6240183 30.80 ENST00000262450.3
ENST00000378021.1
chromodomain helicase DNA binding protein 5
chr3_+_38080691 30.65 ENST00000308059.6
ENST00000346219.3
ENST00000452631.2
deleted in lung and esophageal cancer 1
chr22_-_43485381 30.58 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
tubulin tyrosine ligase-like family, member 1
chr12_+_7014126 30.35 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr9_+_135754263 30.07 ENST00000356311.5
ENST00000350499.6
chromosome 9 open reading frame 9
chr12_+_6930964 29.54 ENST00000382315.3
G protein-coupled receptor 162
chr6_-_31940065 29.31 ENST00000375349.3
ENST00000337523.5
decapping exoribonuclease
chr12_+_7013897 29.27 ENST00000007969.8
ENST00000323702.5
leucine rich repeat containing 23
chr1_+_169337172 28.97 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
basic leucine zipper nuclear factor 1
chr11_-_66360548 28.88 ENST00000333861.3
coiled-coil domain containing 87
chr2_-_62733476 28.82 ENST00000335390.5
transmembrane protein 17
chr10_+_12171721 28.62 ENST00000379020.4
ENST00000379017.3
Sec61 alpha 2 subunit (S. cerevisiae)
chr11_+_28129795 28.46 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
methyltransferase like 15
chr22_+_23487513 28.10 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr8_+_38243821 28.09 ENST00000519476.2
leucine zipper-EF-hand containing transmembrane protein 2
chr4_+_114214125 28.06 ENST00000509550.1
ankyrin 2, neuronal
chr3_-_196439065 27.96 ENST00000399942.4
ENST00000409690.3
centrosomal protein 19kDa
chr1_+_244998602 27.96 ENST00000411948.2
COX20 cytochrome C oxidase assembly factor
chr21_+_40817749 27.85 ENST00000380637.3
ENST00000380634.1
ENST00000458295.1
ENST00000440288.2
ENST00000380631.1
SH3 domain binding glutamic acid-rich protein
chr15_+_90777424 27.64 ENST00000561433.1
ENST00000559204.1
ENST00000558291.1
GDP-D-glucose phosphorylase 1
chr20_+_62185491 27.62 ENST00000370097.1
chromosome 20 open reading frame 195
chr5_-_114505624 27.61 ENST00000513154.1
tripartite motif containing 36
chr15_-_72978490 27.50 ENST00000311755.3
HIG1 hypoxia inducible domain family, member 2B
chr2_+_173600514 27.47 ENST00000264111.6
Rap guanine nucleotide exchange factor (GEF) 4
chr22_+_30752606 27.44 ENST00000399824.2
ENST00000405659.1
ENST00000338306.3
coiled-coil domain containing 157
chr3_+_9851632 27.37 ENST00000426895.4
tubulin tyrosine ligase-like family, member 3
chr3_-_49055991 27.21 ENST00000441576.2
ENST00000420952.2
ENST00000341949.4
ENST00000395462.4
DALR anticodon binding domain containing 3
chr20_-_3762087 26.30 ENST00000379756.3
sperm flagellar 1
chr16_+_89724263 26.30 ENST00000564238.1
spermatogenesis associated 33
chr15_-_55700457 25.92 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
cell cycle progression 1
chr7_+_138916231 25.88 ENST00000473989.3
ENST00000288561.8
ubinuclein 2
chr12_+_9067327 25.83 ENST00000433083.2
ENST00000544916.1
ENST00000544539.1
ENST00000539063.1
polyhomeotic homolog 1 (Drosophila)
chr11_-_6426635 25.82 ENST00000608645.1
ENST00000608394.1
ENST00000529519.1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr5_-_132073111 25.75 ENST00000403231.1
kinesin family member 3A
chr19_+_58962971 25.62 ENST00000336614.4
ENST00000545523.1
ENST00000599194.1
ENST00000598244.1
ENST00000599193.1
ENST00000594214.1
ENST00000391696.1
zinc finger protein 324B
chr14_+_102829300 25.45 ENST00000359520.7
tectonin beta-propeller repeat containing 2
chr1_-_169396666 25.28 ENST00000456107.1
ENST00000367805.3
coiled-coil domain containing 181
chr13_+_37005967 25.22 ENST00000440264.1
ENST00000449823.1
cyclin A1
chr1_-_40157345 25.20 ENST00000372844.3
hippocalcin like 4
chr7_+_156433573 25.11 ENST00000311822.8
ring finger protein 32
chr7_+_156433396 24.94 ENST00000432459.2
ring finger protein 32
chr20_+_43160409 24.85 ENST00000372894.3
ENST00000372892.3
ENST00000372891.3
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr11_-_119252425 24.80 ENST00000260187.2
ubiquitin specific peptidase 2
chr12_+_9067123 24.77 ENST00000543824.1
polyhomeotic homolog 1 (Drosophila)
chr6_-_84937314 24.58 ENST00000257766.4
ENST00000403245.3
KIAA1009
chr1_+_180601139 24.49 ENST00000367590.4
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr19_+_18263928 24.45 ENST00000222254.8
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
chr1_-_154155675 24.21 ENST00000330188.9
ENST00000341485.5
tropomyosin 3
chr14_+_74416989 24.03 ENST00000334571.2
ENST00000554920.1
coenzyme Q6 monooxygenase
chr11_-_119252359 23.77 ENST00000455332.2
ubiquitin specific peptidase 2
chr4_+_153701081 23.77 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ADP-ribosylation factor interacting protein 1
chr2_+_173600565 23.76 ENST00000397081.3
Rap guanine nucleotide exchange factor (GEF) 4
chr11_+_66278080 23.71 ENST00000318312.7
ENST00000526815.1
ENST00000537537.1
ENST00000525809.1
ENST00000455748.2
ENST00000393994.2
Bardet-Biedl syndrome 1
chr1_+_15573757 23.48 ENST00000358897.4
ENST00000417793.1
ENST00000375999.3
ENST00000433640.2
forkhead-associated (FHA) phosphopeptide binding domain 1
chr21_-_37432764 23.47 ENST00000399212.1
ENST00000446166.1
SET domain containing 4
chr1_-_67390474 23.42 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
WD repeat domain 78
chr21_-_37432832 23.38 ENST00000332131.4
SET domain containing 4
chr19_+_54371114 23.38 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
myeloid-associated differentiation marker
chr13_-_31736132 23.37 ENST00000429785.2
heat shock 105kDa/110kDa protein 1
chr8_-_125486755 23.37 ENST00000499418.2
ENST00000530778.1
RNF139 antisense RNA 1 (head to head)
chr1_-_154155595 23.28 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
tropomyosin 3
chr14_+_74486043 23.17 ENST00000464394.1
ENST00000394009.3
coiled-coil domain containing 176
chr15_+_42066632 23.10 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
mitogen-activated protein kinase binding protein 1
chr1_-_114301755 22.95 ENST00000393357.2
ENST00000369596.2
ENST00000446739.1
putative homeodomain transcription factor 1
chr4_-_186125077 22.91 ENST00000458385.2
ENST00000514798.1
ENST00000296775.6
KIAA1430
chr1_-_86861936 22.86 ENST00000394733.2
ENST00000359242.3
ENST00000294678.2
ENST00000479890.1
ENST00000317336.7
ENST00000370567.1
ENST00000394731.1
ENST00000478286.2
ENST00000370566.3
outer dense fiber of sperm tails 2-like
chr9_-_35812236 22.81 ENST00000340291.2
sperm associated antigen 8
chr19_+_10527449 22.80 ENST00000592685.1
ENST00000380702.2
phosphodiesterase 4A, cAMP-specific
chr7_+_156433461 22.75 ENST00000317955.5
ENST00000405335.1
ring finger protein 32
chr19_+_38826477 22.56 ENST00000409410.2
ENST00000215069.4
catsper channel auxiliary subunit gamma
chr7_-_44229022 22.54 ENST00000403799.3
glucokinase (hexokinase 4)
chr17_-_80656528 22.20 ENST00000538809.2
ENST00000269347.6
ENST00000571995.1
RAB40B, member RAS oncogene family
chr4_+_56814968 22.18 ENST00000422247.2
centrosomal protein 135kDa
chr2_+_27070964 22.04 ENST00000288699.6
dihydropyrimidinase-like 5
chr10_-_99393242 22.02 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN repeat containing 4
chr3_+_49027308 21.96 ENST00000383729.4
ENST00000343546.4
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr20_+_43160458 21.95 ENST00000372889.1
ENST00000372887.1
ENST00000372882.3
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr13_+_42846272 21.89 ENST00000025301.2
A kinase (PRKA) anchor protein 11
chrX_+_135251783 21.82 ENST00000394153.2
four and a half LIM domains 1
chr11_-_85565906 21.81 ENST00000544076.1
CDNA FLJ26432 fis, clone KDN01418; Uncharacterized protein
chr19_+_1450112 21.71 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
adenomatosis polyposis coli 2
chr10_-_104179682 21.59 ENST00000406432.1
pleckstrin and Sec7 domain containing
chr1_+_38022572 21.52 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr19_-_4535233 21.48 ENST00000381848.3
ENST00000588887.1
ENST00000586133.1
perilipin 5
chr9_+_112403088 21.48 ENST00000448454.2
paralemmin 2
chr10_-_120101804 21.42 ENST00000369183.4
ENST00000369172.4
family with sequence similarity 204, member A
chr19_-_5680499 21.42 ENST00000587589.1
chromosome 19 open reading frame 70
chr21_-_37432540 21.36 ENST00000443703.1
ENST00000399207.1
ENST00000399215.1
ENST00000442559.1
ENST00000399205.1
ENST00000429161.1
ENST00000424303.1
ENST00000399208.2
SET domain containing 4
chr4_+_113970772 21.31 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr9_+_131218336 21.20 ENST00000372814.3
outer dense fiber of sperm tails 2

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
32.1 192.4 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
29.0 116.2 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
24.2 72.7 GO:1902490 regulation of sperm capacitation(GO:1902490)
17.7 159.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
17.0 51.1 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
16.5 49.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
16.3 49.0 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
13.4 40.3 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
11.6 69.8 GO:0070560 protein secretion by platelet(GO:0070560)
11.1 122.2 GO:0036159 inner dynein arm assembly(GO:0036159)
10.9 98.3 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
10.4 72.5 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
10.3 82.1 GO:0007258 JUN phosphorylation(GO:0007258)
9.7 38.9 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
9.6 38.3 GO:0018094 protein polyglycylation(GO:0018094)
9.5 37.8 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
9.4 28.2 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
9.3 55.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
9.1 27.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
8.6 25.8 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
8.4 50.6 GO:0051013 microtubule severing(GO:0051013)
8.4 42.0 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
8.3 33.4 GO:0001757 somite specification(GO:0001757)
8.2 147.1 GO:0044458 motile cilium assembly(GO:0044458)
8.0 72.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
7.8 31.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
7.4 36.8 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
7.2 28.8 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
7.2 21.5 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
7.0 21.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
7.0 27.8 GO:0044375 regulation of peroxisome size(GO:0044375)
6.9 6.9 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
6.8 68.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
6.7 33.3 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
6.6 132.3 GO:0002021 response to dietary excess(GO:0002021)
6.0 18.0 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
5.8 23.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
5.8 23.1 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
5.7 40.0 GO:0007288 sperm axoneme assembly(GO:0007288)
5.6 128.2 GO:0034389 lipid particle organization(GO:0034389)
5.4 16.3 GO:0071988 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
5.4 21.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
5.4 16.2 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
5.0 15.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
4.9 24.7 GO:0097338 response to clozapine(GO:0097338)
4.9 9.9 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
4.9 19.7 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
4.9 58.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
4.8 14.5 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
4.5 22.6 GO:1902775 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
4.5 153.0 GO:0008045 motor neuron axon guidance(GO:0008045)
4.5 35.8 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
4.4 35.4 GO:0032790 ribosome disassembly(GO:0032790)
4.4 30.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
4.3 13.0 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
4.3 12.9 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
4.2 33.8 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
4.2 21.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
3.9 31.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
3.6 10.9 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
3.6 139.7 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
3.6 28.5 GO:0070475 rRNA base methylation(GO:0070475)
3.5 24.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
3.4 78.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.3 19.8 GO:0048549 positive regulation of pinocytosis(GO:0048549)
3.2 22.5 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
3.1 12.6 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
3.1 34.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
3.0 48.6 GO:0045475 locomotor rhythm(GO:0045475)
2.9 20.5 GO:0006572 tyrosine catabolic process(GO:0006572)
2.8 71.2 GO:0006895 Golgi to endosome transport(GO:0006895)
2.8 8.5 GO:1900060 glucosylceramide biosynthetic process(GO:0006679) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
2.7 16.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
2.7 65.1 GO:0007141 male meiosis I(GO:0007141)
2.6 7.9 GO:0018874 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
2.6 34.0 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
2.5 37.1 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
2.4 21.9 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
2.4 75.9 GO:0097120 receptor localization to synapse(GO:0097120)
2.3 22.9 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
2.2 33.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
2.2 17.8 GO:0035721 intraciliary retrograde transport(GO:0035721)
2.2 21.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
2.2 32.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.1 8.4 GO:0008089 anterograde axonal transport(GO:0008089)
2.1 29.3 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
2.1 16.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
1.9 5.8 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
1.9 20.9 GO:0015886 heme transport(GO:0015886)
1.9 24.7 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
1.8 34.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.8 3.5 GO:0071426 ribonucleoprotein complex export from nucleus(GO:0071426)
1.8 31.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
1.8 57.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.7 26.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
1.7 13.9 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
1.7 17.3 GO:0015889 cobalamin transport(GO:0015889)
1.7 53.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
1.6 6.5 GO:0042360 vitamin E metabolic process(GO:0042360)
1.6 4.9 GO:1904504 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
1.6 4.9 GO:1990523 bone regeneration(GO:1990523)
1.6 20.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
1.6 23.8 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
1.5 38.2 GO:0048665 neuron fate specification(GO:0048665)
1.5 3.0 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
1.5 94.6 GO:0060997 dendritic spine morphogenesis(GO:0060997)
1.4 5.7 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
1.4 8.4 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.4 5.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
1.4 10.9 GO:0070995 NADPH oxidation(GO:0070995)
1.4 52.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
1.3 15.5 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
1.3 12.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.3 16.4 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
1.2 55.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
1.2 18.8 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
1.2 3.5 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) negative regulation by host of viral genome replication(GO:0044828)
1.1 10.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.1 57.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
1.1 10.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.1 21.0 GO:0042340 keratan sulfate catabolic process(GO:0042340)
1.1 31.8 GO:0016601 Rac protein signal transduction(GO:0016601)
1.1 4.3 GO:2000232 regulation of ribosome biogenesis(GO:0090069) regulation of rRNA processing(GO:2000232)
1.1 8.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
1.0 3.1 GO:2000282 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of adrenergic receptor signaling pathway(GO:0071878) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) regulation of cellular amino acid biosynthetic process(GO:2000282) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
1.0 33.0 GO:0007340 acrosome reaction(GO:0007340)
1.0 60.3 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
1.0 16.1 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
1.0 21.5 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.9 52.7 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.9 24.4 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.9 15.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.9 17.4 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.9 47.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.9 9.9 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.9 0.9 GO:0032423 regulation of mismatch repair(GO:0032423) positive regulation of mismatch repair(GO:0032425)
0.9 46.7 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.9 50.5 GO:0009060 aerobic respiration(GO:0009060)
0.8 33.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.8 30.8 GO:0008038 neuron recognition(GO:0008038)
0.8 58.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.8 2.4 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.8 22.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.8 9.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.7 9.6 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.7 13.2 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.7 56.1 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.7 18.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.7 10.8 GO:0006004 fucose metabolic process(GO:0006004)
0.7 73.1 GO:0007224 smoothened signaling pathway(GO:0007224)
0.6 18.2 GO:0007062 sister chromatid cohesion(GO:0007062)
0.6 35.6 GO:0032570 response to progesterone(GO:0032570)
0.6 4.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.6 5.9 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.6 51.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.6 1.7 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.5 14.2 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.5 3.4 GO:0045007 depurination(GO:0045007)
0.5 8.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.5 12.9 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.5 3.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.5 1.8 GO:1902613 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.5 41.0 GO:0005977 glycogen metabolic process(GO:0005977)
0.5 12.7 GO:0003091 renal water homeostasis(GO:0003091)
0.5 5.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.4 23.3 GO:0016574 histone ubiquitination(GO:0016574)
0.4 7.9 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.4 10.7 GO:0007520 myoblast fusion(GO:0007520)
0.4 22.0 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.4 14.0 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.4 6.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.4 1.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.4 2.5 GO:0009597 detection of virus(GO:0009597)
0.4 3.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.4 7.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.3 15.0 GO:0060996 dendritic spine development(GO:0060996)
0.3 3.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 4.4 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.3 1.7 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.3 1.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 5.9 GO:0003341 cilium movement(GO:0003341)
0.3 28.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 9.3 GO:0010107 potassium ion import(GO:0010107)
0.3 5.7 GO:0001975 response to amphetamine(GO:0001975)
0.3 18.4 GO:0045453 bone resorption(GO:0045453)
0.3 133.5 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.3 7.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.3 7.7 GO:0050919 negative chemotaxis(GO:0050919)
0.3 11.4 GO:0006986 response to unfolded protein(GO:0006986)
0.3 2.5 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 3.6 GO:0032526 response to retinoic acid(GO:0032526)
0.3 9.2 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.3 9.3 GO:0006284 base-excision repair(GO:0006284)
0.3 25.7 GO:0022900 electron transport chain(GO:0022900)
0.2 73.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.2 29.5 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.2 0.8 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.2 7.6 GO:0014047 glutamate secretion(GO:0014047)
0.2 6.3 GO:0019228 neuronal action potential(GO:0019228)
0.2 2.0 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.2 17.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.2 11.1 GO:0046785 microtubule polymerization(GO:0046785)
0.2 1.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 14.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.2 1.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 3.4 GO:1901661 quinone metabolic process(GO:1901661)
0.2 2.0 GO:0006379 mRNA cleavage(GO:0006379)
0.2 1.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 9.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.3 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 6.3 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 0.6 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 22.0 GO:0007411 axon guidance(GO:0007411)
0.1 13.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 2.2 GO:0000910 cytokinesis(GO:0000910)
0.0 0.4 GO:0022029 cerebral cortex cell migration(GO:0021795) telencephalon cell migration(GO:0022029)
0.0 13.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 2.1 GO:0006970 response to osmotic stress(GO:0006970)
0.0 1.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 2.6 GO:0007416 synapse assembly(GO:0007416)
0.0 0.6 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.0 4.9 GO:0030335 positive regulation of cell migration(GO:0030335)
0.0 2.6 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 7.6 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 3.9 GO:0045860 positive regulation of protein kinase activity(GO:0045860)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
30.7 122.7 GO:0097224 sperm connecting piece(GO:0097224)
29.0 116.2 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
19.9 19.9 GO:0002199 zona pellucida receptor complex(GO:0002199)
14.7 59.0 GO:0016939 kinesin II complex(GO:0016939)
13.0 65.1 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
12.1 144.7 GO:0033010 paranodal junction(GO:0033010)
11.9 71.2 GO:0000138 Golgi trans cisterna(GO:0000138)
11.4 68.7 GO:0002177 manchette(GO:0002177)
11.4 34.1 GO:0044609 DBIRD complex(GO:0044609)
11.3 67.6 GO:1990769 proximal neuron projection(GO:1990769)
9.6 192.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
7.1 35.6 GO:0036128 CatSper complex(GO:0036128)
6.7 46.9 GO:0001520 outer dense fiber(GO:0001520)
6.3 75.9 GO:0060077 inhibitory synapse(GO:0060077)
5.9 52.8 GO:0034464 BBSome(GO:0034464)
5.7 39.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
5.5 77.2 GO:0036038 MKS complex(GO:0036038)
5.4 65.4 GO:0035869 ciliary transition zone(GO:0035869)
5.4 16.3 GO:0055028 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
4.9 83.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
4.4 21.9 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
4.2 33.4 GO:0044294 dendritic growth cone(GO:0044294)
4.0 19.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
3.9 65.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
3.9 54.0 GO:0035102 PRC1 complex(GO:0035102)
3.8 80.6 GO:0034451 centriolar satellite(GO:0034451)
3.8 72.7 GO:0097225 sperm midpiece(GO:0097225)
3.7 25.8 GO:0097427 microtubule bundle(GO:0097427)
3.3 177.8 GO:0016235 aggresome(GO:0016235)
3.2 31.6 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
3.1 21.7 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
3.1 33.6 GO:0097431 mitotic spindle pole(GO:0097431)
3.0 56.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.9 25.8 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.8 25.2 GO:0032797 SMN complex(GO:0032797)
2.7 10.9 GO:1990031 pinceau fiber(GO:1990031)
2.7 72.1 GO:0035371 microtubule plus-end(GO:0035371)
2.7 31.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
2.6 21.0 GO:0030992 intraciliary transport particle B(GO:0030992)
2.6 216.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
2.6 12.9 GO:0070847 core mediator complex(GO:0070847)
2.6 28.2 GO:0002116 semaphorin receptor complex(GO:0002116)
2.5 12.7 GO:0000137 Golgi cis cisterna(GO:0000137)
2.1 25.7 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.8 21.7 GO:0016342 catenin complex(GO:0016342)
1.5 10.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
1.5 90.8 GO:0036064 ciliary basal body(GO:0036064)
1.4 18.1 GO:0008091 spectrin(GO:0008091)
1.4 4.2 GO:0031251 PAN complex(GO:0031251)
1.4 15.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
1.3 13.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
1.3 10.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.2 13.6 GO:0035686 sperm fibrous sheath(GO:0035686)
1.2 24.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.1 97.7 GO:0001669 acrosomal vesicle(GO:0001669)
1.1 27.8 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
1.0 49.4 GO:0043034 costamere(GO:0043034)
1.0 24.2 GO:0097546 ciliary base(GO:0097546)
0.9 35.1 GO:1904115 axon cytoplasm(GO:1904115)
0.8 58.7 GO:0043195 terminal bouton(GO:0043195)
0.7 16.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.7 47.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7 20.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 2.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.7 67.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.6 35.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.6 16.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 8.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 3.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.5 45.2 GO:0032587 ruffle membrane(GO:0032587)
0.5 37.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.5 2.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.5 3.0 GO:0043196 varicosity(GO:0043196)
0.5 174.2 GO:0005874 microtubule(GO:0005874)
0.5 66.5 GO:0031901 early endosome membrane(GO:0031901)
0.5 23.4 GO:0005801 cis-Golgi network(GO:0005801)
0.5 24.1 GO:0005814 centriole(GO:0005814)
0.5 71.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.5 88.9 GO:0005802 trans-Golgi network(GO:0005802)
0.5 56.8 GO:0043204 perikaryon(GO:0043204)
0.4 3.1 GO:0097228 sperm principal piece(GO:0097228)
0.3 85.6 GO:0005938 cell cortex(GO:0005938)
0.3 20.8 GO:0005811 lipid particle(GO:0005811)
0.3 7.6 GO:0048786 presynaptic active zone(GO:0048786)
0.3 38.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 7.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 40.3 GO:0001650 fibrillar center(GO:0001650)
0.3 17.3 GO:0005776 autophagosome(GO:0005776)
0.3 4.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.3 24.1 GO:0030027 lamellipodium(GO:0030027)
0.3 27.8 GO:0008021 synaptic vesicle(GO:0008021)
0.3 3.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.2 1.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 26.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 16.7 GO:0000922 spindle pole(GO:0000922)
0.2 18.3 GO:0031902 late endosome membrane(GO:0031902)
0.2 30.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.9 GO:0005921 gap junction(GO:0005921)
0.2 1.0 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 9.0 GO:0001726 ruffle(GO:0001726)
0.2 126.6 GO:0043005 neuron projection(GO:0043005)
0.2 1.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 22.4 GO:0030055 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.1 2.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 5.3 GO:0005903 brush border(GO:0005903)
0.1 1.4 GO:0005771 multivesicular body(GO:0005771)
0.1 7.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 6.2 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 3.3 GO:0005882 intermediate filament(GO:0005882)
0.0 3.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.1 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
29.0 116.2 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
13.7 82.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
13.4 40.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
10.2 122.7 GO:0032027 myosin light chain binding(GO:0032027)
9.8 29.3 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
9.6 38.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
9.5 28.5 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
9.1 27.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
9.1 72.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
8.8 26.4 GO:0015439 heme-transporting ATPase activity(GO:0015439)
8.4 50.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
7.7 30.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
6.1 24.5 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
6.1 30.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
6.1 139.7 GO:0070008 serine-type exopeptidase activity(GO:0070008)
5.8 17.3 GO:0015235 cobalamin transporter activity(GO:0015235)
5.6 33.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
5.3 47.9 GO:0032051 clathrin light chain binding(GO:0032051)
4.7 19.0 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
4.6 18.4 GO:0035473 lipase binding(GO:0035473)
4.4 242.2 GO:0017080 sodium channel regulator activity(GO:0017080)
4.3 86.3 GO:0045504 dynein heavy chain binding(GO:0045504)
4.3 12.9 GO:1904288 BAT3 complex binding(GO:1904288)
4.2 12.7 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
4.1 32.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
4.0 23.7 GO:0005119 smoothened binding(GO:0005119)
3.9 19.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
3.5 165.6 GO:0030507 spectrin binding(GO:0030507)
3.2 12.7 GO:0008158 hedgehog receptor activity(GO:0008158)
3.1 15.5 GO:0050815 phosphoserine binding(GO:0050815)
3.0 35.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
2.9 143.6 GO:0046875 ephrin receptor binding(GO:0046875)
2.9 8.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
2.8 8.5 GO:0050405 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
2.8 22.6 GO:0034452 dynactin binding(GO:0034452)
2.8 22.5 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.8 13.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.5 27.6 GO:0004645 phosphorylase activity(GO:0004645)
2.5 92.0 GO:0030552 cAMP binding(GO:0030552)
2.3 11.6 GO:0070568 guanylyltransferase activity(GO:0070568)
2.3 62.3 GO:0008198 ferrous iron binding(GO:0008198)
2.3 96.9 GO:0003785 actin monomer binding(GO:0003785)
2.2 24.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
2.2 72.5 GO:0070840 dynein complex binding(GO:0070840)
2.2 25.8 GO:0048156 tau protein binding(GO:0048156)
2.1 35.4 GO:0003746 translation elongation factor activity(GO:0003746)
2.1 41.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
2.0 28.2 GO:0030215 semaphorin receptor binding(GO:0030215)
2.0 10.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.0 23.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
2.0 31.6 GO:0004526 ribonuclease P activity(GO:0004526)
1.8 10.9 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
1.6 16.4 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
1.6 90.0 GO:0043022 ribosome binding(GO:0043022)
1.5 33.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
1.5 78.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.5 20.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
1.4 35.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
1.4 21.7 GO:0008179 adenylate cyclase binding(GO:0008179)
1.3 35.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.3 34.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.3 23.6 GO:0031418 L-ascorbic acid binding(GO:0031418)
1.3 82.2 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
1.3 21.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.2 13.6 GO:0043015 gamma-tubulin binding(GO:0043015)
1.2 21.5 GO:0017049 GTP-Rho binding(GO:0017049)
1.2 9.3 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
1.1 5.7 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
1.1 124.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.1 114.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
1.1 9.9 GO:0001222 transcription corepressor binding(GO:0001222)
1.1 117.0 GO:0008013 beta-catenin binding(GO:0008013)
1.1 3.2 GO:0070984 SET domain binding(GO:0070984)
1.1 16.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.0 27.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
1.0 37.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.0 16.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.9 18.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.9 60.3 GO:0019843 rRNA binding(GO:0019843)
0.9 7.9 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.9 3.4 GO:0032406 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.8 15.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.8 22.1 GO:0071949 FAD binding(GO:0071949)
0.8 93.9 GO:0005496 steroid binding(GO:0005496)
0.8 7.7 GO:0038191 neuropilin binding(GO:0038191)
0.8 136.4 GO:0005178 integrin binding(GO:0005178)
0.7 64.7 GO:0030165 PDZ domain binding(GO:0030165)
0.7 188.1 GO:0008017 microtubule binding(GO:0008017)
0.7 13.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 66.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.7 19.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.7 20.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.7 6.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.6 3.4 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.6 25.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 44.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.5 9.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 17.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.5 6.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 2.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 2.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.5 13.6 GO:0051018 protein kinase A binding(GO:0051018)
0.5 1.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.4 6.9 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 59.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 7.0 GO:0008483 transaminase activity(GO:0008483)
0.4 61.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 10.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 2.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 4.7 GO:0008417 fucosyltransferase activity(GO:0008417)
0.3 0.9 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.3 40.3 GO:0017124 SH3 domain binding(GO:0017124)
0.3 90.5 GO:0003924 GTPase activity(GO:0003924)
0.3 3.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 6.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 3.4 GO:0016594 glycine binding(GO:0016594)
0.2 3.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 10.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 8.5 GO:0005504 fatty acid binding(GO:0005504)
0.2 2.5 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 5.9 GO:0017091 AU-rich element binding(GO:0017091)
0.2 2.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 10.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 10.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 12.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 9.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 12.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 5.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 4.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 3.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 40.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.6 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.1 15.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 9.2 GO:0005525 GTP binding(GO:0005525)
0.1 1.4 GO:0005537 mannose binding(GO:0005537)
0.1 29.7 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 223.6 GO:0046872 metal ion binding(GO:0046872)
0.1 12.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.5 GO:0045503 dynein light chain binding(GO:0045503)
0.1 2.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 3.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.9 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 198.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
2.7 141.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
2.2 13.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.7 111.9 ST ADRENERGIC Adrenergic Pathway
1.2 19.8 ST G ALPHA S PATHWAY G alpha s Pathway
1.1 60.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.6 29.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.6 37.5 PID PLK1 PATHWAY PLK1 signaling events
0.5 32.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.5 19.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.5 31.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 49.9 PID CMYB PATHWAY C-MYB transcription factor network
0.4 15.5 PID MYC PATHWAY C-MYC pathway
0.3 14.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.3 10.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 12.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 5.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 11.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 7.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.8 PID ALK2 PATHWAY ALK2 signaling events
0.1 8.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 5.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 21.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 5.2 PID P73PATHWAY p73 transcription factor network
0.0 10.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 31.8 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
3.7 82.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
2.9 101.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
2.4 65.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.3 36.8 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
2.0 92.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.7 15.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.5 16.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
1.5 28.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
1.4 73.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
1.4 20.7 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
1.2 169.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
1.2 12.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
1.1 73.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
1.0 166.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.0 31.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
1.0 31.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.9 22.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.8 12.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.7 12.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.7 26.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.7 63.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.7 33.5 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.7 13.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.6 6.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.6 18.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 8.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 15.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.4 7.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.4 27.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 7.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 21.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 6.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 4.0 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.3 120.1 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.3 22.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 2.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 8.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 5.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 5.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 10.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 2.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 6.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 5.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 2.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 2.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 7.3 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 1.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 0.9 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.1 7.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 1.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters