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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RUNX1_RUNX2
Z-value: 2.28
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Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX1 | hg19_v2_chr21_-_36260980_36261011 | 0.41 | 3.9e-10 | Click! |
| RUNX2 | hg19_v2_chr6_+_45389893_45389914, hg19_v2_chr6_+_45296391_45296464 | 0.38 | 4.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 264.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.4 | 99.8 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.7 | 94.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 9.7 | 77.2 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 3.9 | 70.4 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 12.8 | 63.8 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 20.9 | 62.6 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 2.9 | 61.8 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.6 | 57.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.6 | 56.4 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 230.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 177.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 123.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.9 | 91.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.6 | 85.1 | GO:0031901 | early endosome membrane(GO:0031901) |
| 3.9 | 81.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 3.7 | 74.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.8 | 68.5 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 67.6 | GO:0005615 | extracellular space(GO:0005615) |
| 1.4 | 65.8 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 318.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.6 | 143.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 93.1 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.6 | 83.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 2.9 | 77.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 4.6 | 64.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 20.9 | 62.6 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.8 | 61.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 3.1 | 48.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 1.7 | 48.2 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 194.6 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 3.0 | 76.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.4 | 72.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.1 | 68.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.6 | 66.2 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 65.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.8 | 57.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 1.4 | 45.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.5 | 45.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 44.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 157.8 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 1.5 | 124.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.6 | 100.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 3.6 | 97.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.9 | 69.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 3.3 | 68.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.4 | 67.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.4 | 66.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 2.3 | 65.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.3 | 51.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |