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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SIX1_SIX3_SIX2
Z-value: 0.73
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Transcription factors associated with SIX1_SIX3_SIX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX3 | hg19_v2_chr2_+_45168875_45168916 | 0.72 | 4.2e-36 | Click! |
| SIX2 | hg19_v2_chr2_-_45236540_45236577 | 0.67 | 7.2e-30 | Click! |
| SIX1 | hg19_v2_chr14_-_61124977_61125037 | 0.37 | 2.1e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX1_SIX3_SIX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.4 | GO:0045596 | negative regulation of cell differentiation(GO:0045596) |
| 1.3 | 16.3 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 12.4 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 2.1 | 10.3 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.0 | 9.8 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.3 | 9.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 1.0 | 9.2 | GO:0015747 | urate transport(GO:0015747) |
| 0.1 | 9.0 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.8 | 8.8 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
| 0.1 | 8.3 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 15.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 14.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 12.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 11.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 10.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 10.5 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 8.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.7 | 7.9 | GO:0043203 | axon hillock(GO:0043203) |
| 1.0 | 7.0 | GO:0032437 | cuticular plate(GO:0032437) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 20.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 15.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 10.3 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.9 | 9.2 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 8.9 | GO:0016410 | N-acyltransferase activity(GO:0016410) |
| 0.5 | 8.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 8.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.6 | 8.2 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.4 | 7.9 | GO:0015101 | organic cation transmembrane transporter activity(GO:0015101) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 16.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 12.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 9.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 7.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 7.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 6.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 5.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.0 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 15.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.7 | 10.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.4 | 9.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 7.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 6.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 5.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 5.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 5.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 5.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |