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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIX6

Z-value: 0.76

Motif logo

Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
ENSG00000184302.6 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_609756730.385.9e-09Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_64708615 21.90 ENST00000338957.4
ENST00000423889.3
zinc finger CCCH-type containing 12B
chr8_+_84824920 16.88 ENST00000523678.1
RP11-120I21.2
chr18_+_74240610 16.40 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr4_+_113739244 10.31 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ankyrin 2, neuronal
chrX_+_8433376 8.57 ENST00000440654.2
ENST00000381029.4
variable charge, X-linked 3B
chr2_-_100939195 8.25 ENST00000393437.3
LON peptidase N-terminal domain and ring finger 2
chr1_+_21880560 7.06 ENST00000425315.2
alkaline phosphatase, liver/bone/kidney
chr3_+_8543533 6.73 ENST00000454244.1
LIM and cysteine-rich domains 1
chrY_-_16098393 6.54 ENST00000250825.4
variable charge, Y-linked
chr2_-_88427568 6.50 ENST00000393750.3
ENST00000295834.3
fatty acid binding protein 1, liver
chr9_-_21142144 6.06 ENST00000380229.2
interferon, omega 1
chr11_+_74699942 6.02 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
sialidase 3 (membrane sialidase)
chrY_+_16168097 5.73 ENST00000250823.4
variable charge, Y-linked 1B
chr12_-_122018859 5.60 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
lysine (K)-specific demethylase 2B
chr1_-_67142710 5.50 ENST00000502413.2
Uncharacterized protein
chr11_+_74699703 5.29 ENST00000529024.1
ENST00000544263.1
sialidase 3 (membrane sialidase)
chr1_+_160709055 5.22 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAM family member 7
chr3_+_151531810 4.99 ENST00000232892.7
arylacetamide deacetylase
chrX_-_55020511 4.79 ENST00000375006.3
ENST00000374992.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_-_36235559 4.71 ENST00000251195.5
claspin
chrX_-_53350522 4.64 ENST00000396435.3
ENST00000375368.5
IQ motif and Sec7 domain 2
chr1_+_160709029 4.39 ENST00000444090.2
ENST00000441662.2
SLAM family member 7
chr1_-_150669604 4.37 ENST00000427665.1
ENST00000540514.1
golgi phosphoprotein 3-like
chr6_+_26204825 4.35 ENST00000360441.4
histone cluster 1, H4e
chr7_-_44530479 4.35 ENST00000355451.7
NudC domain containing 3
chr3_+_125694347 4.17 ENST00000505382.1
ENST00000511082.1
rhophilin associated tail protein 1B
chr9_-_23821842 4.15 ENST00000544538.1
ELAV like neuron-specific RNA binding protein 2
chr1_+_86934526 4.06 ENST00000394711.1
chloride channel accessory 1
chrX_-_18238999 3.94 ENST00000380033.4
ENST00000380030.3
BEN domain containing 2
chr16_+_19467772 3.87 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
transmembrane channel-like 5
chr5_-_177207634 3.79 ENST00000513554.1
ENST00000440605.3
family with sequence similarity 153, member A
chr13_+_73629107 3.71 ENST00000539231.1
Kruppel-like factor 5 (intestinal)
chr1_-_13673511 3.61 ENST00000344998.3
ENST00000334600.6
PRAME family member 14
chr1_+_53308398 3.48 ENST00000371528.1
zyg-11 family member A, cell cycle regulator
chr2_-_208989225 3.45 ENST00000264376.4
crystallin, gamma D
chr1_+_160709076 3.43 ENST00000359331.4
ENST00000495334.1
SLAM family member 7
chr3_+_8543561 3.42 ENST00000397386.3
LIM and cysteine-rich domains 1
chr16_-_29517141 3.41 ENST00000550665.1
Uncharacterized protein
chr10_+_91061712 3.32 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr16_-_20364122 3.30 ENST00000396138.4
ENST00000577168.1
uromodulin
chr11_-_45307817 3.29 ENST00000020926.3
synaptotagmin XIII
chr7_+_117251671 3.24 ENST00000468795.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr3_-_9994021 3.21 ENST00000411976.2
ENST00000412055.1
proline-rich transmembrane protein 3
chr2_-_62081148 3.20 ENST00000404929.1
family with sequence similarity 161, member A
chr6_-_26189304 3.17 ENST00000340756.2
histone cluster 1, H4d
chr9_-_21351377 3.15 ENST00000380210.1
interferon, alpha 6
chr11_+_33902189 3.14 ENST00000330381.2
HCG1785179; PRO1787; Uncharacterized protein
chr16_-_20364030 2.98 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
uromodulin
chr6_+_146348782 2.96 ENST00000361719.2
ENST00000392299.2
glutamate receptor, metabotropic 1
chr10_-_61720640 2.88 ENST00000521074.1
ENST00000444900.1
chromosome 10 open reading frame 40
chr19_-_16008880 2.72 ENST00000011989.7
ENST00000221700.6
cytochrome P450, family 4, subfamily F, polypeptide 2
chr5_+_40909354 2.70 ENST00000313164.9
complement component 7
chr1_+_156119798 2.61 ENST00000355014.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_70826725 2.61 ENST00000353151.3
casein beta
chr17_-_42327236 2.58 ENST00000399246.2
AC003102.1
chr1_-_20446020 2.56 ENST00000375105.3
phospholipase A2, group IID
chr21_-_19775973 2.56 ENST00000284885.3
transmembrane protease, serine 15
chr6_-_26018007 2.41 ENST00000244573.3
histone cluster 1, H1a
chr8_+_101170257 2.31 ENST00000251809.3
sperm associated antigen 1
chr17_+_60501228 2.25 ENST00000311506.5
methyltransferase like 2A
chr4_-_155511887 2.24 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chr16_-_87350970 2.24 ENST00000567970.1
chromosome 16 open reading frame 95
chr19_+_55235969 2.23 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr16_+_72090053 2.19 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
haptoglobin
chr6_+_80816342 2.16 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
branched chain keto acid dehydrogenase E1, beta polypeptide
chr15_-_51397473 2.10 ENST00000327536.5
tumor necrosis factor, alpha-induced protein 8-like 3
chr14_+_22948510 2.06 ENST00000390483.1
T cell receptor alpha joining 56
chr12_-_121477039 2.01 ENST00000257570.5
2'-5'-oligoadenylate synthetase-like
chr22_-_17302589 2.01 ENST00000331428.5
XK, Kell blood group complex subunit-related family, member 3
chr18_+_55018044 1.95 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_-_161193349 1.91 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
apolipoprotein A-II
chr14_+_21152259 1.89 ENST00000555835.1
ENST00000336811.6
ribonuclease, RNase A family, 4
angiogenin, ribonuclease, RNase A family, 5
chr12_-_121476959 1.74 ENST00000339275.5
2'-5'-oligoadenylate synthetase-like
chr9_-_100684845 1.68 ENST00000375119.3
chromosome 9 open reading frame 156
chr2_-_228497888 1.65 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chr10_-_79397479 1.65 ENST00000404771.3
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_-_26043885 1.64 ENST00000357905.2
histone cluster 1, H2bb
chr16_-_21436459 1.58 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr6_+_146348810 1.52 ENST00000492807.2
glutamate receptor, metabotropic 1
chr5_+_175490540 1.51 ENST00000515817.1
family with sequence similarity 153, member B
chr20_+_54987305 1.48 ENST00000371336.3
ENST00000434344.1
Cas scaffolding protein family member 4
chr22_-_19137796 1.48 ENST00000086933.2
goosecoid homeobox 2
chr20_+_54987168 1.46 ENST00000360314.3
Cas scaffolding protein family member 4
chr21_-_43735446 1.41 ENST00000398431.2
trefoil factor 3 (intestinal)
chr6_+_52051171 1.32 ENST00000340057.1
interleukin 17A
chrY_-_24038660 1.30 ENST00000382677.3
RNA binding motif protein, Y-linked, family 1, member D
chr3_-_53916202 1.20 ENST00000335754.3
ARP8 actin-related protein 8 homolog (yeast)
chr12_-_11091862 1.18 ENST00000537503.1
taste receptor, type 2, member 14
chrX_-_118699325 1.18 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
chromosome X open reading frame 56
chr2_-_77749474 1.11 ENST00000409093.1
ENST00000409088.3
leucine rich repeat transmembrane neuronal 4
chr1_+_159557607 1.11 ENST00000255040.2
amyloid P component, serum
chr12_-_28123206 1.07 ENST00000542963.1
ENST00000535992.1
parathyroid hormone-like hormone
chr12_-_10978957 1.07 ENST00000240619.2
taste receptor, type 2, member 10
chr5_+_140201183 1.05 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
protocadherin alpha 5
chr8_+_1993152 1.04 ENST00000262113.4
myomesin 2
chr9_-_99382065 1.01 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
cell division cycle 14B
chrY_+_23698778 0.94 ENST00000303902.5
RNA binding motif protein, Y-linked, family 1, member A1
chr16_+_28648975 0.90 ENST00000529716.1
nuclear pore complex interacting protein family, member B8
chr10_+_52094298 0.81 ENST00000595931.1
HCG1745369; PRO3073; Uncharacterized protein
chr21_-_43735628 0.77 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr13_-_46679185 0.75 ENST00000439329.3
carboxypeptidase B2 (plasma)
chr13_-_46679144 0.75 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr4_-_123377880 0.74 ENST00000226730.4
interleukin 2
chr16_+_22524844 0.67 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
nuclear pore complex interacting protein family, member B5
chr4_-_13546632 0.66 ENST00000382438.5
NK3 homeobox 2
chr20_-_4990931 0.62 ENST00000379333.1
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_+_63063152 0.59 ENST00000371129.3
angiopoietin-like 3
chr12_-_121476750 0.59 ENST00000543677.1
2'-5'-oligoadenylate synthetase-like
chr8_+_24241969 0.58 ENST00000522298.1
ADAM-like, decysin 1
chr16_-_21868978 0.57 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
nuclear pore complex interacting protein family, member B4
chr19_+_3136115 0.49 ENST00000262958.3
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr8_+_24241789 0.37 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr8_+_1993173 0.33 ENST00000523438.1
myomesin 2
chr11_+_30253410 0.32 ENST00000533718.1
follicle stimulating hormone, beta polypeptide
chr19_-_1650666 0.26 ENST00000588136.1
transcription factor 3
chr8_+_32579341 0.19 ENST00000519240.1
ENST00000539990.1
neuregulin 1
chr16_-_21868739 0.18 ENST00000415645.2
nuclear pore complex interacting protein family, member B4
chr2_+_177134201 0.18 ENST00000452865.1
metaxin 2
chr3_-_111314230 0.14 ENST00000317012.4
zinc finger, BED-type containing 2
chr4_+_74301880 0.03 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.4 7.1 GO:0071529 cementum mineralization(GO:0071529)
1.9 5.6 GO:0021678 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.4 11.3 GO:0006689 ganglioside catabolic process(GO:0006689)
1.3 6.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.1 3.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.9 4.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 2.7 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.9 2.6 GO:1903487 regulation of lactation(GO:1903487)
0.8 4.8 GO:1903301 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.7 2.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.6 6.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.6 1.9 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.6 4.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 1.6 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.5 2.6 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.5 5.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.5 9.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.4 3.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 1.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 1.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.4 4.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.3 1.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 7.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.3 3.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 0.7 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.2 4.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 4.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 2.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.2 14.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 1.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 1.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 2.7 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 2.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 3.9 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 0.6 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.6 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 2.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 2.3 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.5 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 3.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 3.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 2.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 2.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 8.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.3 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.7 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 4.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 16.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 2.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 2.1 GO:0015914 phospholipid transport(GO:0015914)
0.0 4.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 6.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 3.5 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.0 1.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 14.8 GO:0007420 brain development(GO:0007420)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
1.1 4.5 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.8 6.5 GO:0045179 apical cortex(GO:0045179)
0.6 3.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.5 2.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 2.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.3 1.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 2.7 GO:0005579 membrane attack complex(GO:0005579)
0.2 4.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 11.7 GO:0031430 M band(GO:0031430)
0.2 2.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 4.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 5.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 3.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 4.1 GO:0000786 nucleosome(GO:0000786)
0.1 6.3 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 4.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.6 GO:0005903 brush border(GO:0005903)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 10.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 1.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 49.1 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.1 3.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
1.0 7.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.0 4.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.9 6.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.9 2.7 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.8 4.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 2.2 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.7 5.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 9.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.6 4.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 1.6 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.5 1.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 2.3 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.4 4.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4 2.2 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.4 2.2 GO:0030492 hemoglobin binding(GO:0030492)
0.3 6.3 GO:0019864 IgG binding(GO:0019864)
0.3 1.9 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 1.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 4.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 8.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 2.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 10.3 GO:0030507 spectrin binding(GO:0030507)
0.2 0.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 2.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 5.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 4.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 21.9 GO:0004519 endonuclease activity(GO:0004519)
0.2 2.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 2.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 4.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 3.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0046790 virion binding(GO:0046790)
0.1 4.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 3.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 4.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 2.4 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 3.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 6.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 11.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 2.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 6.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 10.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 3.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 2.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 6.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 2.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 3.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell