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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SMAD4

Z-value: 1.59

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Transcription factors associated with SMAD4

Gene Symbol Gene ID Gene Info
SMAD4
ENSG00000141646.9 SMAD family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD4hg19_v2_chr18_+_48494361_484944260.544.3e-18Click!

Activity profile of SMAD4 motif

Sorted Z-values of SMAD4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117070037 34.46 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr22_+_23247030 33.92 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr11_-_111794446 27.73 ENST00000527950.1
CRYAB
crystallin, alpha B
chr14_-_106209368 22.50 ENST00000390548.2
ENST00000390549.2
ENST00000390542.2
IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_33048483 21.03 ENST00000419277.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_+_113033164 19.41 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr11_-_5248294 18.98 ENST00000335295.4
HBB
hemoglobin, beta
chr7_+_94023873 18.83 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr22_-_27620603 18.76 ENST00000418271.1
ENST00000444114.1
RP5-1172A22.1
RP5-1172A22.1
chr22_+_30752606 17.76 ENST00000399824.2
ENST00000405659.1
ENST00000338306.3
CCDC157
coiled-coil domain containing 157
chr5_-_42825983 17.65 ENST00000506577.1
SEPP1
selenoprotein P, plasma, 1
chr5_+_150404904 17.23 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr1_-_31230650 17.06 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr3_-_112127981 15.97 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chrX_+_38420783 15.77 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr22_+_22712087 15.67 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr9_+_124088860 15.32 ENST00000373806.1
GSN
gelsolin
chr11_-_111781454 15.30 ENST00000533280.1
CRYAB
crystallin, alpha B
chr7_+_20686946 15.29 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr11_-_111781610 15.01 ENST00000525823.1
CRYAB
crystallin, alpha B
chr14_-_106237742 14.85 ENST00000390551.2
IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_-_32908765 14.71 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_38420623 14.47 ENST00000378482.2
TSPAN7
tetraspanin 7
chr8_-_90769422 14.04 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr19_-_36643329 13.87 ENST00000589154.1
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr2_+_89901292 13.78 ENST00000448155.2
IGKV1D-39
immunoglobulin kappa variable 1D-39
chr9_+_139871948 13.60 ENST00000224167.2
ENST00000457950.1
ENST00000371625.3
ENST00000371623.3
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr15_-_45670924 13.44 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr22_+_22681656 13.33 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr6_+_32709119 13.26 ENST00000374940.3
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 2
chr12_-_91572278 13.24 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
DCN
decorin
chr5_-_149792295 12.94 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr12_-_15104040 12.89 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_30454390 12.51 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH
limb bud and heart development
chr12_-_12491608 12.48 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr3_+_52529346 12.44 ENST00000321725.6
STAB1
stabilin 1
chr11_-_111781554 12.33 ENST00000526167.1
ENST00000528961.1
CRYAB
crystallin, alpha B
chr12_-_16758304 12.12 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758059 12.01 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_6720686 11.81 ENST00000245907.6
C3
complement component 3
chr17_+_18128896 11.72 ENST00000316843.4
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr12_-_15103621 11.58 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr7_+_23286182 11.45 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr10_-_105452917 11.40 ENST00000427662.2
SH3PXD2A
SH3 and PX domains 2A
chr17_+_77681075 11.35 ENST00000397549.2
CTD-2116F7.1
CTD-2116F7.1
chr9_-_34691201 11.27 ENST00000378800.3
ENST00000311925.2
CCL19
chemokine (C-C motif) ligand 19
chr16_-_30032610 11.23 ENST00000574405.1
DOC2A
double C2-like domains, alpha
chr22_+_22735135 11.16 ENST00000390297.2
IGLV1-44
immunoglobulin lambda variable 1-44
chr3_+_183967409 10.93 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chr14_-_106406090 10.80 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr10_-_90712520 10.56 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_+_56186606 10.52 ENST00000085079.7
EPN1
epsin 1
chr5_-_149535421 10.50 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr14_-_107131560 10.34 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr16_-_25122785 10.28 ENST00000563962.1
ENST00000569920.1
RP11-449H11.1
RP11-449H11.1
chr1_+_159175201 10.11 ENST00000368121.2
DARC
Duffy blood group, atypical chemokine receptor
chr17_+_41003166 9.96 ENST00000308423.2
AOC3
amine oxidase, copper containing 3
chr19_-_54784937 9.91 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr5_+_156696362 9.72 ENST00000377576.3
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_-_67142710 9.60 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr22_+_22930626 9.58 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr1_+_9005917 9.49 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr9_+_124030338 9.48 ENST00000449773.1
ENST00000432226.1
ENST00000436847.1
ENST00000394353.2
ENST00000449733.1
ENST00000412819.1
ENST00000341272.2
ENST00000373808.2
GSN
gelsolin
chr1_-_11865982 9.46 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_57183114 9.43 ENST00000537055.2
ENST00000601659.1
ZNF835
zinc finger protein 835
chr22_-_24641027 9.32 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
GGT5
gamma-glutamyltransferase 5
chr22_+_22786288 9.28 ENST00000390301.2
IGLV1-36
immunoglobulin lambda variable 1-36
chr2_-_89459813 9.28 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr16_+_1583567 9.23 ENST00000566264.1
TMEM204
transmembrane protein 204
chr22_+_23241661 9.22 ENST00000390322.2
IGLJ2
immunoglobulin lambda joining 2
chr19_-_11688447 9.10 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr14_-_21491477 8.89 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr10_+_26505594 8.83 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr2_-_89340242 8.80 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr13_-_27334879 8.68 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr12_-_49365501 8.64 ENST00000403957.1
ENST00000301061.4
WNT10B
wingless-type MMTV integration site family, member 10B
chr7_+_99699280 8.54 ENST00000421755.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr6_+_31582961 8.51 ENST00000376059.3
ENST00000337917.7
AIF1
allograft inflammatory factor 1
chr2_-_89513402 8.50 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr8_-_120605194 8.49 ENST00000522167.1
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr16_-_3306587 8.42 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV
Mediterranean fever
chr6_-_32908792 8.31 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_-_139587225 8.28 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr19_-_36523709 8.23 ENST00000592017.1
ENST00000360535.4
CLIP3
CAP-GLY domain containing linker protein 3
chr22_+_23077065 8.22 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr14_-_106994333 8.22 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chr19_-_11688500 8.20 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr9_-_123476612 8.16 ENST00000426959.1
MEGF9
multiple EGF-like-domains 9
chr19_-_54784353 8.16 ENST00000391746.1
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr7_+_150130742 8.15 ENST00000477392.1
ENST00000486954.1
LINC00996
long intergenic non-protein coding RNA 996
chr12_+_124155652 8.05 ENST00000426174.2
ENST00000303372.5
TCTN2
tectonic family member 2
chr22_+_22707260 8.02 ENST00000390293.1
IGLV5-48
immunoglobulin lambda variable 5-48 (non-functional)
chr19_-_47164386 7.92 ENST00000391916.2
ENST00000410105.2
DACT3
dishevelled-binding antagonist of beta-catenin 3
chr1_+_89829610 7.89 ENST00000370456.4
ENST00000535065.1
GBP6
guanylate binding protein family, member 6
chr19_+_41768561 7.86 ENST00000599719.1
ENST00000601309.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_+_71927807 7.85 ENST00000298223.6
ENST00000454954.2
ENST00000541003.1
ENST00000539412.1
ENST00000536778.1
ENST00000535625.1
ENST00000321324.7
FOLR2
folate receptor 2 (fetal)
chr17_-_18585541 7.81 ENST00000285274.5
ENST00000545289.1
ENST00000580145.1
ZNF286B
zinc finger protein 286B
chr7_+_99699179 7.76 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr7_-_129845313 7.69 ENST00000397622.2
TMEM209
transmembrane protein 209
chr1_-_113615699 7.67 ENST00000421157.1
RP11-31F15.2
RP11-31F15.2
chr22_-_50968419 7.65 ENST00000425169.1
ENST00000395680.1
ENST00000395681.1
ENST00000395678.3
ENST00000252029.3
TYMP
thymidine phosphorylase
chr11_-_72385437 7.64 ENST00000418754.2
ENST00000542969.2
ENST00000334456.5
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_-_156390128 7.56 ENST00000368242.3
C1orf61
chromosome 1 open reading frame 61
chr2_+_89184868 7.56 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr1_-_11866034 7.51 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr8_-_48651648 7.49 ENST00000408965.3
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_+_33020496 7.43 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr17_+_47653178 7.37 ENST00000328741.5
NXPH3
neurexophilin 3
chr19_+_46171464 7.19 ENST00000590918.1
ENST00000263281.3
ENST00000304207.8
GIPR
gastric inhibitory polypeptide receptor
chr8_+_28747884 7.19 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr6_-_11807277 7.19 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr12_-_99038732 7.18 ENST00000393042.3
ENST00000420861.1
ENST00000299157.4
ENST00000342502.2
IKBIP
IKBKB interacting protein
chr20_-_524362 7.13 ENST00000460062.2
ENST00000608066.1
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr4_+_55524085 7.10 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr6_-_32095968 7.02 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr14_-_106878083 7.01 ENST00000390619.2
IGHV4-39
immunoglobulin heavy variable 4-39
chr15_+_43803143 6.96 ENST00000382031.1
MAP1A
microtubule-associated protein 1A
chr20_-_43883197 6.95 ENST00000338380.2
SLPI
secretory leukocyte peptidase inhibitor
chr1_+_156123359 6.94 ENST00000368284.1
ENST00000368286.2
ENST00000438830.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_+_90153696 6.91 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr19_+_36359341 6.88 ENST00000221891.4
APLP1
amyloid beta (A4) precursor-like protein 1
chr2_+_89923550 6.87 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr10_-_81708854 6.86 ENST00000372292.3
SFTPD
surfactant protein D
chr4_-_100242549 6.81 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr22_-_29711645 6.77 ENST00000401450.3
RASL10A
RAS-like, family 10, member A
chr17_+_15602891 6.77 ENST00000421016.1
ENST00000593105.1
ENST00000580259.1
ENST00000583566.1
ENST00000472486.1
ENST00000395894.2
ENST00000581529.1
ENST00000579694.1
ENST00000580393.1
ENST00000585194.1
ENST00000583031.1
ENST00000464847.2
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr2_+_220379052 6.75 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chr19_-_51529849 6.75 ENST00000600362.1
ENST00000453757.3
ENST00000601671.1
KLK11
kallikrein-related peptidase 11
chr22_-_38851205 6.74 ENST00000303592.3
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr3_+_133465228 6.71 ENST00000482271.1
ENST00000264998.3
TF
transferrin
chr12_+_53443963 6.65 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr14_-_23834411 6.64 ENST00000429593.2
EFS
embryonal Fyn-associated substrate
chr12_-_16759711 6.61 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_153321301 6.61 ENST00000368739.3
PGLYRP4
peptidoglycan recognition protein 4
chr12_-_11422739 6.61 ENST00000279573.7
PRB3
proline-rich protein BstNI subfamily 3
chr17_+_30813576 6.54 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_160681593 6.51 ENST00000368045.3
ENST00000368046.3
CD48
CD48 molecule
chr17_+_61562178 6.51 ENST00000490216.2
ACE
angiotensin I converting enzyme
chr4_+_74718906 6.49 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr2_+_127413481 6.47 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr17_-_61777459 6.47 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr14_-_106725723 6.46 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr16_-_28550348 6.42 ENST00000324873.6
NUPR1
nuclear protein, transcriptional regulator, 1
chr19_+_51728316 6.37 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr2_-_89417335 6.36 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr19_-_14952689 6.35 ENST00000248058.1
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr8_+_71383312 6.32 ENST00000520259.1
RP11-333A23.4
RP11-333A23.4
chr6_-_32731299 6.30 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr12_-_6798410 6.29 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr14_-_95942173 6.28 ENST00000334258.5
ENST00000557275.1
ENST00000553340.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr17_+_41006095 6.28 ENST00000591562.1
ENST00000588033.1
AOC3
amine oxidase, copper containing 3
chr2_+_16080659 6.27 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr5_-_35230434 6.26 ENST00000504500.1
PRLR
prolactin receptor
chr1_-_28520447 6.22 ENST00000539896.1
PTAFR
platelet-activating factor receptor
chr17_-_19290117 6.21 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr17_+_61562201 6.20 ENST00000290863.6
ENST00000413513.3
ENST00000421982.2
ACE
angiotensin I converting enzyme
chr10_-_73848531 6.19 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr3_+_111718036 6.17 ENST00000455401.2
TAGLN3
transgelin 3
chr15_-_60771128 6.16 ENST00000558512.1
ENST00000561114.1
NARG2
NMDA receptor regulated 2
chr20_-_56265680 6.10 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_-_151119087 6.07 ENST00000341697.3
ENST00000368914.3
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr8_-_82359662 6.01 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr11_+_124492749 6.01 ENST00000531667.1
ENST00000441174.3
ENST00000375005.4
TBRG1
transforming growth factor beta regulator 1
chr14_+_61654271 5.97 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr1_+_156123318 5.97 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_-_151345159 5.97 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1
selenium binding protein 1
chr1_-_38157877 5.96 ENST00000477060.1
ENST00000491981.1
ENST00000488137.1
C1orf109
chromosome 1 open reading frame 109
chrX_+_128913906 5.95 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr7_+_150497491 5.95 ENST00000484928.1
TMEM176A
transmembrane protein 176A
chr5_-_149492904 5.94 ENST00000286301.3
ENST00000511344.1
CSF1R
colony stimulating factor 1 receptor
chr1_-_111150048 5.92 ENST00000485317.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr19_-_17958832 5.84 ENST00000458235.1
JAK3
Janus kinase 3
chr3_-_16555150 5.80 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr4_-_186697044 5.80 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr6_+_31554962 5.80 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr12_-_42631529 5.77 ENST00000548917.1
YAF2
YY1 associated factor 2
chr5_-_168727786 5.77 ENST00000332966.8
SLIT3
slit homolog 3 (Drosophila)
chr16_-_30597000 5.75 ENST00000470110.1
ENST00000395216.2
ZNF785
zinc finger protein 785
chr12_+_121078355 5.74 ENST00000316803.3
CABP1
calcium binding protein 1
chr4_-_926069 5.72 ENST00000314167.4
ENST00000502656.1
GAK
cyclin G associated kinase
chr14_+_65007177 5.71 ENST00000247207.6
HSPA2
heat shock 70kDa protein 2
chr6_-_26189304 5.69 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr8_-_125486755 5.69 ENST00000499418.2
ENST00000530778.1
RNF139-AS1
RNF139 antisense RNA 1 (head to head)
chr9_-_123476719 5.57 ENST00000373930.3
MEGF9
multiple EGF-like-domains 9
chrX_-_153059958 5.57 ENST00000370092.3
ENST00000217901.5
IDH3G
isocitrate dehydrogenase 3 (NAD+) gamma
chr14_-_106830057 5.56 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr6_-_169654139 5.55 ENST00000366787.3
THBS2
thrombospondin 2
chr7_-_135433460 5.55 ENST00000415751.1
FAM180A
family with sequence similarity 180, member A
chr14_-_36989427 5.55 ENST00000354822.5
NKX2-1
NK2 homeobox 1
chr5_-_168728103 5.54 ENST00000519560.1
SLIT3
slit homolog 3 (Drosophila)
chr7_-_99573677 5.53 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chrX_+_18443703 5.51 ENST00000379996.3
CDKL5
cyclin-dependent kinase-like 5
chr1_+_44584522 5.51 ENST00000372299.3
KLF17
Kruppel-like factor 17
chr11_+_47270475 5.51 ENST00000481889.2
ENST00000436778.1
ENST00000531660.1
ENST00000407404.1
NR1H3
nuclear receptor subfamily 1, group H, member 3
chrX_-_17879356 5.50 ENST00000331511.1
ENST00000415486.3
ENST00000545871.1
ENST00000451717.1
RAI2
retinoic acid induced 2
chr14_-_106552755 5.49 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr15_+_32933866 5.46 ENST00000300175.4
ENST00000413748.2
ENST00000494364.1
ENST00000497208.1
SCG5
secretogranin V (7B2 protein)
chr1_-_158301312 5.45 ENST00000368168.3
CD1B
CD1b molecule
chr22_+_22676808 5.44 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chrX_-_99987088 5.44 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.0 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
6.1 24.5 GO:0071461 cellular response to redox state(GO:0071461)
5.8 17.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
5.1 30.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
5.0 24.8 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
4.8 19.3 GO:0030185 nitric oxide transport(GO:0030185)
4.3 17.0 GO:0071231 cellular response to folic acid(GO:0071231)
3.9 11.8 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
3.9 70.4 GO:0007021 tubulin complex assembly(GO:0007021)
3.8 15.3 GO:0048749 compound eye development(GO:0048749)
3.8 11.3 GO:0097026 dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
3.6 10.9 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
3.6 10.9 GO:1905224 clathrin-coated pit assembly(GO:1905224)
3.5 17.7 GO:1904306 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
3.5 10.5 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
3.5 17.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
3.4 17.0 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
3.3 13.4 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
3.1 24.5 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
3.1 9.2 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
2.9 8.6 GO:0051885 positive regulation of anagen(GO:0051885)
2.8 11.4 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
2.8 11.3 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
2.8 8.4 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
2.7 13.6 GO:2000035 regulation of stem cell division(GO:2000035)
2.7 8.1 GO:0001300 chronological cell aging(GO:0001300)
2.6 12.9 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
2.5 7.6 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
2.5 7.6 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
2.3 9.0 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
2.2 6.6 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
2.2 6.5 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
2.2 2.2 GO:0006680 glucosylceramide catabolic process(GO:0006680)
2.1 2.1 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
2.0 6.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
2.0 12.0 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
2.0 5.9 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
1.8 8.9 GO:0006311 meiotic gene conversion(GO:0006311) male meiosis chromosome segregation(GO:0007060)
1.8 5.3 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.8 10.6 GO:0090131 mesenchyme migration(GO:0090131)
1.7 6.9 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
1.7 5.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.7 8.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
1.7 3.4 GO:0002884 negative regulation of hypersensitivity(GO:0002884)
1.7 6.7 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.6 8.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.5 18.2 GO:0048251 elastic fiber assembly(GO:0048251)
1.5 7.6 GO:1904141 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
1.5 4.5 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.5 5.9 GO:0021633 optic nerve structural organization(GO:0021633)
1.5 4.4 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.4 9.9 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.4 4.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
1.4 29.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.4 4.2 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
1.4 6.9 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
1.3 198.7 GO:0006958 complement activation, classical pathway(GO:0006958)
1.3 8.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.3 2.7 GO:0090182 regulation of secretion of lysosomal enzymes(GO:0090182)
1.3 3.9 GO:0060018 astrocyte fate commitment(GO:0060018)
1.3 18.1 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.3 5.1 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
1.3 22.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.3 18.8 GO:0043589 skin morphogenesis(GO:0043589)
1.2 13.4 GO:0006600 creatine metabolic process(GO:0006600)
1.2 3.7 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
1.2 9.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.2 1.2 GO:0034756 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) response to iron ion starvation(GO:1990641)
1.2 10.8 GO:0045059 positive thymic T cell selection(GO:0045059)
1.2 6.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.2 4.8 GO:0014028 notochord formation(GO:0014028)
1.2 5.9 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
1.2 3.6 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
1.2 8.3 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
1.2 7.0 GO:0038161 prolactin signaling pathway(GO:0038161)
1.2 3.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
1.2 9.3 GO:0034587 piRNA metabolic process(GO:0034587)
1.2 1.2 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.2 5.8 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.1 3.3 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
1.1 10.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.0 4.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.0 3.1 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
1.0 3.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
1.0 7.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.0 9.0 GO:2001300 lipoxin metabolic process(GO:2001300)
1.0 3.0 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.0 4.9 GO:1902023 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
1.0 3.9 GO:0036343 psychomotor behavior(GO:0036343)
1.0 3.9 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
1.0 2.9 GO:0060433 bronchus development(GO:0060433) lobar bronchus epithelium development(GO:0060481) lobar bronchus development(GO:0060482)
1.0 1.9 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
1.0 2.9 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
1.0 2.9 GO:2000253 regulation of skeletal muscle hypertrophy(GO:1904204) positive regulation of feeding behavior(GO:2000253)
0.9 4.7 GO:0021759 globus pallidus development(GO:0021759)
0.9 4.7 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.9 3.7 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.9 2.8 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.9 4.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.9 3.6 GO:1990736 positive regulation of cardiac conduction(GO:1903781) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.9 3.6 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.9 3.6 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.9 3.5 GO:1902075 cellular response to salt(GO:1902075)
0.9 5.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.9 2.6 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.9 5.1 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.9 6.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.9 7.7 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
0.8 2.4 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.8 8.0 GO:0015889 cobalamin transport(GO:0015889)
0.8 2.4 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.8 9.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.8 3.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.8 3.9 GO:0051586 positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.7 3.7 GO:0032455 nerve growth factor processing(GO:0032455)
0.7 3.7 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.7 2.2 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.7 4.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.7 5.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.7 2.2 GO:0032328 alanine transport(GO:0032328)
0.7 7.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.7 19.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.7 10.6 GO:1904152 regulation of retrograde protein transport, ER to cytosol(GO:1904152)
0.7 4.9 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
0.7 7.0 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.7 2.8 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.7 3.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.7 1.4 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.7 3.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.7 2.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.7 4.7 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.7 2.0 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.7 16.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.6 2.6 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.6 5.1 GO:0015705 iodide transport(GO:0015705)
0.6 3.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.6 1.3 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.6 3.8 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.6 9.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.6 3.1 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.6 3.1 GO:0072143 renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.6 13.0 GO:0097320 membrane tubulation(GO:0097320)
0.6 1.8 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.6 3.0 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.6 4.2 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.6 2.4 GO:0000103 sulfate assimilation(GO:0000103)
0.6 8.9 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.6 2.3 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.6 3.5 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.6 1.7 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) membrane depolarization during bundle of His cell action potential(GO:0086048)
0.6 4.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 10.9 GO:0010002 cardioblast differentiation(GO:0010002)
0.6 2.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.6 6.8 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.6 1.7 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.6 2.3 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.6 8.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.6 5.5 GO:0034605 cellular response to heat(GO:0034605)
0.6 2.8 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.6 3.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.5 5.5 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.5 1.6 GO:0060168 regulation of axon diameter(GO:0031133) regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.5 5.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.5 2.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.5 2.6 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.5 21.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 2.6 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.5 2.0 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.5 11.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.5 2.5 GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.5 6.9 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.5 7.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.5 2.5 GO:0022614 membrane to membrane docking(GO:0022614)
0.5 8.8 GO:0007530 sex determination(GO:0007530)
0.5 2.9 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.5 0.5 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205)
0.5 11.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.5 4.3 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.5 4.3 GO:0006839 mitochondrial transport(GO:0006839)
0.5 3.8 GO:1902430 negative regulation of beta-amyloid formation(GO:1902430)
0.5 5.6 GO:0032836 glomerular basement membrane development(GO:0032836)
0.5 34.9 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.5 14.3 GO:0051354 negative regulation of oxidoreductase activity(GO:0051354)
0.5 9.2 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.5 2.3 GO:0001714 endodermal cell fate specification(GO:0001714)
0.5 1.8 GO:0009804 phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.5 2.3 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.5 5.0 GO:0048266 behavioral response to pain(GO:0048266)
0.4 6.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.4 3.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 7.6 GO:2000194 regulation of female gonad development(GO:2000194)
0.4 7.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.4 2.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 0.9 GO:0046533 negative regulation of photoreceptor cell differentiation(GO:0046533)
0.4 3.9 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.4 5.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.4 1.7 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.4 2.5 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.4 1.7 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.4 3.8 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.4 1.3 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.4 0.8 GO:0048867 stem cell fate determination(GO:0048867)
0.4 3.7 GO:0060137 maternal process involved in parturition(GO:0060137)
0.4 2.9 GO:0046541 saliva secretion(GO:0046541)
0.4 3.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.4 7.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.4 4.0 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.4 12.9 GO:0050919 negative chemotaxis(GO:0050919)
0.4 2.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 0.4 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.4 3.2 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 5.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.4 3.1 GO:0060768 epithelial cell proliferation involved in prostate gland development(GO:0060767) regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.4 3.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.4 1.5 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.4 55.7 GO:0002377 immunoglobulin production(GO:0002377)
0.4 2.6 GO:0008218 bioluminescence(GO:0008218)
0.4 5.8 GO:0002438 acute inflammatory response to antigenic stimulus(GO:0002438)
0.4 2.2 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 3.6 GO:0046520 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.4 3.9 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.3 0.7 GO:0070101 positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.3 3.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3 4.1 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.3 6.5 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 3.1 GO:0042574 retinal metabolic process(GO:0042574)
0.3 3.3 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.3 2.6 GO:0070475 rRNA base methylation(GO:0070475)
0.3 1.6 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.3 4.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 1.0 GO:0061743 motor learning(GO:0061743)
0.3 1.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.3 7.1 GO:0006590 thyroid hormone generation(GO:0006590)
0.3 1.8 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 3.7 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.3 1.2 GO:0046668 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) regulation of retinal cell programmed cell death(GO:0046668) negative regulation of retinal cell programmed cell death(GO:0046671)
0.3 10.2 GO:0010165 response to X-ray(GO:0010165)
0.3 1.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.3 1.5 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.3 1.5 GO:0002024 diet induced thermogenesis(GO:0002024)
0.3 4.1 GO:0007044 cell-substrate junction assembly(GO:0007044)
0.3 2.0 GO:0044245 polysaccharide digestion(GO:0044245)
0.3 2.0 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.3 5.1 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 2.8 GO:0042476 odontogenesis(GO:0042476)
0.3 1.7 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.3 0.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986) sensory system development(GO:0048880)
0.3 1.6 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.3 7.7 GO:0015695 organic cation transport(GO:0015695)
0.3 2.3 GO:0048702 protein sulfation(GO:0006477) embryonic neurocranium morphogenesis(GO:0048702)
0.3 6.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.3 7.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.3 1.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3 2.8 GO:0060019 radial glial cell differentiation(GO:0060019)
0.3 2.3 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.2 0.7 GO:0019417 sulfur oxidation(GO:0019417)
0.2 1.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 2.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 5.6 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.2 5.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.2 5.8 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 20.2 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 18.6 GO:0007608 sensory perception of smell(GO:0007608)
0.2 4.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 2.4 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.2 2.8 GO:0031053 primary miRNA processing(GO:0031053)
0.2 6.3 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.9 GO:0030259 lipid glycosylation(GO:0030259)
0.2 4.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.2 2.5 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.2 0.4 GO:0032899 neurotrophin production(GO:0032898) regulation of neurotrophin production(GO:0032899) negative regulation of neurotrophin production(GO:0032900)
0.2 2.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 2.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.2 4.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 14.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.2 1.8 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.2 9.4 GO:0010107 potassium ion import(GO:0010107)
0.2 2.8 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.2 4.2 GO:0042269 regulation of natural killer cell mediated cytotoxicity(GO:0042269)
0.2 7.5 GO:0050900 leukocyte migration(GO:0050900)
0.2 7.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.2 2.7 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.2 6.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 8.4 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.2 1.9 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.2 6.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.9 GO:0007000 nucleolus organization(GO:0007000)
0.2 3.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.2 6.3 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.2 3.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 1.5 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.2 0.9 GO:0007320 insemination(GO:0007320)
0.2 2.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 1.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.2 1.1 GO:0019532 oxalate transport(GO:0019532)
0.2 1.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 1.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.2 1.5 GO:0006069 ethanol oxidation(GO:0006069)
0.2 1.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 7.7 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.2 2.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.2 9.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 3.1 GO:0001502 cartilage condensation(GO:0001502)
0.2 1.3 GO:0097107 postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116) neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 9.5 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.2 0.5 GO:1904528 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) positive regulation of microtubule binding(GO:1904528)
0.2 0.3 GO:0001555 oocyte growth(GO:0001555)
0.2 4.8 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 0.9 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.2 3.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 0.3 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.2 1.6 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.2 5.1 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.2 15.8 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 0.5 GO:0061760 antifungal innate immune response(GO:0061760)
0.2 3.2 GO:0048536 spleen development(GO:0048536)
0.2 1.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.2 1.1 GO:0042346 positive regulation of NF-kappaB import into nucleus(GO:0042346)
0.1 0.4 GO:0007412 axon target recognition(GO:0007412)
0.1 3.2 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 4.0 GO:0019228 neuronal action potential(GO:0019228)
0.1 2.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 1.3 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.3 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 4.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 2.8 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.1 6.1 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.1 3.5 GO:0015813 L-glutamate transport(GO:0015813)
0.1 1.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 6.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 5.1 GO:0042073 intraciliary transport(GO:0042073)
0.1 2.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.5 GO:0045076 regulation of interleukin-2 biosynthetic process(GO:0045076)
0.1 9.6 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 2.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.6 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 7.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 5.8 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1 0.8 GO:0048485 sympathetic nervous system development(GO:0048485)
0.1 2.3 GO:0097435 fibril organization(GO:0097435)
0.1 1.9 GO:1901881 positive regulation of protein depolymerization(GO:1901881)
0.1 3.0 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 3.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 2.7 GO:0060976 coronary vasculature development(GO:0060976)
0.1 6.4 GO:0030574 collagen catabolic process(GO:0030574)
0.1 8.7 GO:0007041 lysosomal transport(GO:0007041)
0.1 0.9 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 3.0 GO:0055010 ventricular cardiac muscle tissue morphogenesis(GO:0055010)
0.1 1.8 GO:0006525 arginine metabolic process(GO:0006525)
0.1 1.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 2.6 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 1.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 4.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 5.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 3.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 2.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 0.6 GO:0051546 keratinocyte migration(GO:0051546)
0.1 1.5 GO:0042423 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.1 3.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 2.4 GO:0002250 adaptive immune response(GO:0002250)
0.1 2.9 GO:0001523 retinoid metabolic process(GO:0001523)
0.1 1.2 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.0 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 0.6 GO:0006568 tryptophan metabolic process(GO:0006568)
0.1 7.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 3.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 1.6 GO:0021987 cerebral cortex development(GO:0021987)
0.1 0.6 GO:0000305 response to oxygen radical(GO:0000305)
0.1 0.8 GO:0030575 nuclear body organization(GO:0030575)
0.1 1.4 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1 1.0 GO:0030155 regulation of cell adhesion(GO:0030155)
0.1 7.0 GO:0035821 modification of morphology or physiology of other organism(GO:0035821)
0.1 2.6 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 0.5 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.3 GO:0007566 embryo implantation(GO:0007566)
0.1 1.5 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.1 1.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 0.9 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0072538 T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539)
0.1 0.3 GO:0098911 regulation of ventricular cardiac muscle cell action potential(GO:0098911)
0.1 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.2 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.1 GO:0010193 response to ozone(GO:0010193)
0.1 0.8 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.5 GO:2001225 regulation of chloride transport(GO:2001225)
0.1 1.0 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 1.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 3.5 GO:0006342 chromatin silencing(GO:0006342)
0.0 3.2 GO:0042303 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0 0.9 GO:0009790 embryo development(GO:0009790)
0.0 4.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.5 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 2.0 GO:0007270 neuron-neuron synaptic transmission(GO:0007270)
0.0 0.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 3.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.2 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.1 GO:0097503 sialylation(GO:0097503)
0.0 1.4 GO:0033344 cholesterol efflux(GO:0033344)
0.0 1.3 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.0 1.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.8 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.8 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.5 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.8 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 1.1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.0 1.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 3.7 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 3.0 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 6.8 GO:0007517 muscle organ development(GO:0007517)
0.0 0.2 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.6 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 2.5 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.3 GO:0060292 long term synaptic depression(GO:0060292)
0.0 1.3 GO:0007498 mesoderm development(GO:0007498)
0.0 0.3 GO:0042026 protein refolding(GO:0042026)
0.0 0.8 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.3 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 0.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0 6.5 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 2.7 GO:0006869 lipid transport(GO:0006869)
0.0 0.5 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.6 GO:0006501 C-terminal protein lipidation(GO:0006501)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 6.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
4.7 19.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
4.4 70.4 GO:0097512 cardiac myofibril(GO:0097512)
3.9 82.0 GO:0042613 MHC class II protein complex(GO:0042613)
2.7 16.3 GO:0000138 Golgi trans cisterna(GO:0000138)
2.7 8.1 GO:0072563 endothelial microparticle(GO:0072563)
2.6 10.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
2.3 11.7 GO:0000137 Golgi cis cisterna(GO:0000137)
2.3 13.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.8 18.2 GO:0071953 elastic fiber(GO:0071953)
1.8 8.9 GO:0000801 central element(GO:0000801)
1.8 5.3 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.7 85.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.6 24.5 GO:0030478 actin cap(GO:0030478)
1.6 9.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.6 18.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.4 4.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
1.2 6.1 GO:0071546 pi-body(GO:0071546)
1.2 21.5 GO:0001891 phagocytic cup(GO:0001891)
1.2 13.8 GO:0060077 inhibitory synapse(GO:0060077)
1.1 5.7 GO:0036128 CatSper complex(GO:0036128)
1.1 3.3 GO:0097440 apical dendrite(GO:0097440)
1.1 11.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.1 17.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.0 4.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.0 1.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.9 13.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.9 3.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.9 3.6 GO:0034706 sodium channel complex(GO:0034706)
0.9 8.7 GO:0097486 multivesicular body lumen(GO:0097486)
0.8 2.5 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.8 3.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.8 4.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.7 1.5 GO:0031906 late endosome lumen(GO:0031906)
0.7 5.5 GO:0044294 dendritic growth cone(GO:0044294)
0.7 3.4 GO:0070847 core mediator complex(GO:0070847)
0.6 3.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.6 6.1 GO:0098644 complex of collagen trimers(GO:0098644)
0.6 2.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.6 8.1 GO:0036038 MKS complex(GO:0036038)
0.6 3.4 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.6 4.0 GO:0035976 AP1 complex(GO:0035976)
0.6 2.3 GO:0043293 apoptosome(GO:0043293)
0.6 2.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.5 32.0 GO:0005581 collagen trimer(GO:0005581)
0.5 5.9 GO:0033010 paranodal junction(GO:0033010)
0.5 0.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.5 8.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.5 3.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.4 3.1 GO:0036449 microtubule minus-end(GO:0036449)
0.4 9.0 GO:0042101 T cell receptor complex(GO:0042101)
0.4 3.2 GO:0033391 chromatoid body(GO:0033391)
0.4 4.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 3.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 1.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.4 6.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.4 2.9 GO:0031931 TORC1 complex(GO:0031931)
0.3 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 5.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.6 GO:0072687 meiotic spindle(GO:0072687)
0.3 4.1 GO:0000815 ESCRT III complex(GO:0000815)
0.3 4.1 GO:0035253 ciliary rootlet(GO:0035253)
0.3 2.5 GO:0036157 outer dynein arm(GO:0036157)
0.3 30.7 GO:0005604 basement membrane(GO:0005604)
0.3 11.9 GO:0002102 podosome(GO:0002102)
0.3 1.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.3 3.5 GO:0044327 dendritic spine head(GO:0044327)
0.3 2.0 GO:0000813 ESCRT I complex(GO:0000813)
0.3 3.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 7.7 GO:0016235 aggresome(GO:0016235)
0.3 5.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 2.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 6.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 5.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 7.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 5.3 GO:0048786 presynaptic active zone(GO:0048786)
0.3 2.1 GO:0030133 transport vesicle(GO:0030133)
0.3 27.0 GO:0070821 tertiary granule membrane(GO:0070821)
0.3 0.8 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 40.9 GO:0072562 blood microparticle(GO:0072562)
0.3 5.9 GO:0097228 sperm principal piece(GO:0097228)
0.3 2.8 GO:0005922 connexon complex(GO:0005922)
0.3 5.5 GO:0044420 extracellular matrix component(GO:0044420)
0.2 4.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2 0.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 8.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 11.0 GO:0016460 myosin II complex(GO:0016460)
0.2 2.1 GO:0016013 syntrophin complex(GO:0016013)
0.2 5.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 2.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 24.5 GO:0043202 lysosomal lumen(GO:0043202)
0.2 19.0 GO:0042734 presynaptic membrane(GO:0042734)
0.2 17.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 2.5 GO:1990909 Wnt signalosome(GO:1990909)
0.2 24.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.2 GO:0045179 apical cortex(GO:0045179)
0.2 5.1 GO:0035861 site of double-strand break(GO:0035861)
0.2 2.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 0.9 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.2 6.0 GO:0031904 endosome lumen(GO:0031904)
0.2 3.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 12.5 GO:0005902 microvillus(GO:0005902)
0.2 17.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 7.0 GO:0009986 cell surface(GO:0009986)
0.2 0.7 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 12.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 5.1 GO:0001772 immunological synapse(GO:0001772)
0.2 3.0 GO:0012506 vesicle membrane(GO:0012506)
0.2 3.4 GO:0005796 Golgi lumen(GO:0005796)
0.2 3.7 GO:0042629 mast cell granule(GO:0042629)
0.2 1.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 14.0 GO:0031970 organelle envelope lumen(GO:0031970)
0.2 2.3 GO:0005883 neurofilament(GO:0005883)
0.2 7.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 3.0 GO:0005861 troponin complex(GO:0005861)
0.1 189.9 GO:0005615 extracellular space(GO:0005615)
0.1 5.7 GO:0016459 myosin complex(GO:0016459)
0.1 10.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.8 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 7.6 GO:0043235 receptor complex(GO:0043235)
0.1 2.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 8.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 4.6 GO:0031526 brush border membrane(GO:0031526)
0.1 1.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.8 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 7.8 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 6.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 9.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 8.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 0.3 GO:0005916 fascia adherens(GO:0005916)
0.1 1.2 GO:0046930 pore complex(GO:0046930)
0.1 5.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 2.8 GO:1902555 endoribonuclease complex(GO:1902555)
0.1 0.9 GO:0016528 sarcoplasm(GO:0016528)
0.1 1.5 GO:0032590 dendrite membrane(GO:0032590)
0.1 2.9 GO:0035580 specific granule lumen(GO:0035580)
0.1 4.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 9.4 GO:0043209 myelin sheath(GO:0043209)
0.1 0.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 108.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 1.8 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.1 3.1 GO:0000791 euchromatin(GO:0000791)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.6 GO:0035579 specific granule membrane(GO:0035579)
0.1 2.6 GO:0001533 cornified envelope(GO:0001533)
0.1 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 6.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 4.2 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.9 GO:0000786 nucleosome(GO:0000786)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.2 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
4.3 17.0 GO:0061714 folic acid receptor activity(GO:0061714)
4.2 21.2 GO:0042289 MHC class II protein binding(GO:0042289)
4.2 21.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
4.0 15.8 GO:0097001 ceramide binding(GO:0097001)
3.6 14.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.5 46.0 GO:0032395 MHC class II receptor activity(GO:0032395)
3.4 17.0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
3.2 19.0 GO:0030492 hemoglobin binding(GO:0030492)
3.1 24.5 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
2.8 11.3 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
2.8 8.3 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
2.7 10.9 GO:0032810 sterol response element binding(GO:0032810)
2.5 27.0 GO:0008430 selenium binding(GO:0008430)
2.3 23.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.3 11.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
2.3 70.7 GO:0005212 structural constituent of eye lens(GO:0005212)
2.2 6.7 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
2.2 13.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
2.2 6.6 GO:0016019 peptidoglycan receptor activity(GO:0016019)
2.2 15.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
2.2 6.5 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
2.1 8.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.1 24.8 GO:0045159 myosin II binding(GO:0045159)
2.0 5.9 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
1.9 11.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.8 7.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.7 8.7 GO:0070097 delta-catenin binding(GO:0070097)
1.7 12.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.7 8.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
1.6 18.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.5 6.1 GO:0005502 11-cis retinal binding(GO:0005502)
1.5 4.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
1.5 21.2 GO:0003993 acid phosphatase activity(GO:0003993)
1.4 7.0 GO:0004925 prolactin receptor activity(GO:0004925)
1.4 5.6 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
1.4 4.2 GO:0061663 NEDD8 ligase activity(GO:0061663)
1.4 75.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.3 8.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
1.3 5.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.3 6.6 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
1.3 11.8 GO:0048495 Roundabout binding(GO:0048495)
1.3 18.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.3 5.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
1.3 7.6 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
1.3 7.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.3 3.8 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
1.2 9.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.1 25.1 GO:0048018 receptor agonist activity(GO:0048018)
1.1 3.4 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
1.1 9.0 GO:0005518 collagen binding(GO:0005518)
1.1 4.5 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
1.1 11.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
1.1 3.2 GO:0034584 piRNA binding(GO:0034584)
1.1 3.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
1.1 182.3 GO:0003823 antigen binding(GO:0003823)
1.0 3.1 GO:0019959 interleukin-8 binding(GO:0019959)
1.0 13.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.0 3.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0 5.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
1.0 6.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
1.0 5.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
1.0 8.1 GO:0005534 galactose binding(GO:0005534)
1.0 4.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0 4.9 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
1.0 3.0 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
1.0 2.9 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
1.0 5.7 GO:0042610 CD8 receptor binding(GO:0042610)
0.9 5.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.9 2.7 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.9 2.6 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.8 14.4 GO:0038191 neuropilin binding(GO:0038191)
0.8 3.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.8 20.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.8 2.4 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.8 4.6 GO:0004522 ribonuclease A activity(GO:0004522)
0.8 3.8 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.7 3.7 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.7 2.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.7 8.0 GO:0031419 cobalamin binding(GO:0031419)
0.7 3.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 10.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7 3.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.7 7.7 GO:0004645 phosphorylase activity(GO:0004645)
0.7 4.2 GO:0004882 androgen receptor activity(GO:0004882)
0.7 3.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 3.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.6 16.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 10.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.6 2.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.6 2.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.6 1.8 GO:0042806 fucose binding(GO:0042806)
0.6 6.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.6 2.3 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.6 1.7 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.6 2.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.6 9.0 GO:0019864 IgG binding(GO:0019864)
0.6 2.2 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.6 2.8 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.6 3.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.5 3.3 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.5 12.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.5 3.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.5 13.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 9.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 2.7 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.5 15.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 3.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.5 11.0 GO:0035497 cAMP response element binding(GO:0035497)
0.5 1.6 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.5 2.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 7.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.5 8.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.5 2.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 3.4 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.5 5.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.5 5.1 GO:0016918 retinal binding(GO:0016918)
0.5 1.8 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.5 4.1 GO:0034452 dynactin binding(GO:0034452)
0.5 9.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.5 2.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.4 6.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.4 7.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 1.7 GO:0017040 ceramidase activity(GO:0017040)
0.4 6.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.4 3.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.4 1.7 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.4 3.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.4 0.8 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.4 4.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 4.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 8.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.4 5.3 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.4 5.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.9 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 1.8 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.4 7.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 4.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.4 9.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 2.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.3 4.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 2.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.3 2.4 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.3 0.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 2.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.3 4.6 GO:0004065 arylsulfatase activity(GO:0004065)
0.3 1.9 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 8.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.3 3.6 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 3.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 6.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 2.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 10.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 1.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.3 4.3 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.3 4.0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.3 4.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.3 11.8 GO:0070412 R-SMAD binding(GO:0070412)
0.3 2.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.3 1.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 6.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 3.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 1.3 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.3 3.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.5 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.2 15.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 2.7 GO:0046935 phosphatidylinositol 3-kinase regulator activity(GO:0035014) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.2 GO:0050436 microfibril binding(GO:0050436)
0.2 5.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2 10.5 GO:0030332 cyclin binding(GO:0030332)
0.2 10.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 7.0 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 0.7 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.2 4.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 11.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 3.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 7.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 1.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 20.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 6.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 2.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 21.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 2.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 1.2 GO:0005113 patched binding(GO:0005113)
0.2 3.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 1.9 GO:0019215 intermediate filament binding(GO:0019215)
0.2 2.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 2.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 3.4 GO:0035257 nuclear hormone receptor binding(GO:0035257) hormone receptor binding(GO:0051427)
0.2 2.6 GO:0044548 S100 protein binding(GO:0044548)
0.2 1.8 GO:0051434 BH3 domain binding(GO:0051434)
0.2 17.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 37.4 GO:0051015 actin filament binding(GO:0051015)
0.2 2.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 3.6 GO:0043274 phospholipase binding(GO:0043274)
0.2 4.1 GO:0005272 sodium channel activity(GO:0005272)
0.2 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.2 3.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 0.8 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.2 0.8 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 1.5 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 2.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 5.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 5.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 4.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 4.8 GO:0017046 peptide hormone binding(GO:0017046)
0.1 12.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 4.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.4 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 1.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 2.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 8.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 5.7 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 3.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.2 GO:0051380 beta-adrenergic receptor activity(GO:0004939) norepinephrine binding(GO:0051380)
0.1 1.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 5.1 GO:0008289 lipid binding(GO:0008289)
0.1 1.1 GO:0005496 steroid binding(GO:0005496)
0.1 1.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 5.8 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 3.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 10.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.2 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.6 GO:0004969 histamine receptor activity(GO:0004969)
0.1 1.5 GO:0031489 myosin V binding(GO:0031489)
0.1 0.5 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.1 GO:0017022 myosin binding(GO:0017022)
0.1 0.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 6.2 GO:0005179 hormone activity(GO:0005179)
0.1 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.8 GO:0002039 p53 binding(GO:0002039)
0.1 2.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 4.4 GO:0000149 SNARE binding(GO:0000149)
0.0 0.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 2.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.7 GO:0051117 ATPase binding(GO:0051117)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.9 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 4.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.3 GO:0035326 enhancer binding(GO:0035326)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 2.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.9 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.5 GO:0015297 antiporter activity(GO:0015297)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 19.3 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.7 23.5 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.6 64.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.6 31.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.5 33.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.5 12.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.5 4.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.5 79.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.5 4.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4 15.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 20.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 4.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 2.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.3 48.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 11.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.3 3.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3 10.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.3 10.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 11.0 NABA COLLAGENS Genes encoding collagen proteins
0.2 11.3 PID AURORA A PATHWAY Aurora A signaling
0.2 2.8 PID IL27 PATHWAY IL27-mediated signaling events
0.2 10.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 6.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.0 PID REELIN PATHWAY Reelin signaling pathway
0.2 4.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 2.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 1.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 12.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 5.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 3.2 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 42.9 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.2 11.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 7.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 2.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 5.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.2 5.9 PID FGF PATHWAY FGF signaling pathway
0.1 6.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 6.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 3.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.2 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 6.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.8 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 1.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 1.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 14.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 50.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.5 25.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.7 11.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.7 22.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 14.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.6 15.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.6 21.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.6 48.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6 11.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.5 9.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 7.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 19.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.5 0.9 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.5 10.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.4 14.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 7.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.4 4.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 13.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.4 7.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 8.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.4 12.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.4 8.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 4.7 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.4 27.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 12.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.4 34.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 8.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.4 10.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.3 6.3 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.3 4.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 7.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 5.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.3 16.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 5.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.3 9.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 3.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 8.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.3 1.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 3.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.3 6.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 4.6 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.3 5.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 8.3 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.3 3.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 12.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 4.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 5.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 4.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 18.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.2 14.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 0.7 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.2 26.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.2 4.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 2.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 11.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 9.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 8.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 5.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 12.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 4.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 2.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 1.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 2.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 3.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 24.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 6.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 3.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 7.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 3.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 9.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.6 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 0.8 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 5.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 2.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 8.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 3.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 3.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.2 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling