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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX1
Z-value: 0.51
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Transcription factors associated with SOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX1 | hg19_v2_chr13_+_112721913_112721913 | -0.12 | 7.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_74417096 Show fit | 5.95 |
ENST00000286544.3
|
family with sequence similarity 161, member B |
|
| chr5_-_95158644 Show fit | 5.74 |
ENST00000237858.6
|
glutaredoxin (thioltransferase) |
|
| chr7_-_36634181 Show fit | 5.72 |
ENST00000538464.1
|
acyloxyacyl hydrolase (neutrophil) |
|
| chr13_-_22178284 Show fit | 5.49 |
ENST00000468222.2
ENST00000382374.4 |
mitochondrial calcium uptake 2 |
|
| chr4_+_154622652 Show fit | 5.28 |
ENST00000260010.6
|
toll-like receptor 2 |
|
| chr16_+_12058961 Show fit | 5.12 |
ENST00000053243.1
|
tumor necrosis factor receptor superfamily, member 17 |
|
| chr16_+_12059050 Show fit | 4.99 |
ENST00000396495.3
|
tumor necrosis factor receptor superfamily, member 17 |
|
| chr19_-_10491234 Show fit | 4.86 |
ENST00000524462.1
ENST00000531836.1 ENST00000525621.1 |
tyrosine kinase 2 |
|
| chr12_+_75874460 Show fit | 4.58 |
ENST00000266659.3
|
GLI pathogenesis-related 1 |
|
| chr11_-_47399942 Show fit | 4.57 |
ENST00000227163.4
|
spleen focus forming virus (SFFV) proviral integration oncogene |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 3.0 | 12.1 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.0 | 10.7 | GO:0050776 | regulation of immune response(GO:0050776) |
| 0.3 | 5.7 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.9 | 5.5 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 1.8 | 5.3 | GO:0032289 | central nervous system myelin formation(GO:0032289) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
| 0.9 | 5.2 | GO:0061083 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.1 | 4.9 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.0 | 4.7 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.7 | 4.6 | GO:0032596 | protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.4 | 5.5 | GO:1990246 | uniplex complex(GO:1990246) |
| 1.8 | 5.3 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.4 | 5.2 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 4.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 4.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 4.6 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 4.0 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 3.7 | GO:0005769 | early endosome(GO:0005769) |
| 0.4 | 2.5 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.6 | 7.4 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 1.9 | 5.7 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.6 | 5.7 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.0 | 5.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.6 | 5.3 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.5 | 5.2 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.4 | 4.9 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 4.8 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 4.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 5.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 4.9 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 3.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 5.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.3 | 4.9 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 4.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 4.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 4.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 2.9 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 2.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.7 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |