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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX10_SOX15

Z-value: 0.81

Motif logo

Transcription factors associated with SOX10_SOX15

Gene Symbol Gene ID Gene Info
ENSG00000100146.12 SRY-box transcription factor 10
ENSG00000129194.3 SRY-box transcription factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX15hg19_v2_chr17_-_7493390_7493488-0.393.2e-09Click!
SOX10hg19_v2_chr22_-_38380543_38380569-0.283.7e-05Click!

Activity profile of SOX10_SOX15 motif

Sorted Z-values of SOX10_SOX15 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_80993010 16.90 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
tumor protein D52
chr13_-_41593425 16.55 ENST00000239882.3
E74-like factor 1 (ets domain transcription factor)
chr15_+_57210961 14.34 ENST00000557843.1
transcription factor 12
chr3_+_151986709 14.09 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr1_-_26233423 13.35 ENST00000357865.2
stathmin 1
chr4_+_154387480 12.74 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
chr2_+_10262857 11.83 ENST00000304567.5
ribonucleotide reductase M2
chr17_+_36861735 11.74 ENST00000378137.5
ENST00000325718.7
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr20_+_35202909 10.88 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr2_+_232573222 10.60 ENST00000341369.7
ENST00000409683.1
prothymosin, alpha
chr10_+_11206925 10.32 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr2_-_10588630 9.93 ENST00000234111.4
ornithine decarboxylase 1
chr5_-_175964366 9.88 ENST00000274811.4
ring finger protein 44
chr7_+_23146271 9.49 ENST00000545771.1
kelch-like family member 7
chr4_-_109090106 9.39 ENST00000379951.2
lymphoid enhancer-binding factor 1
chr2_+_232573208 9.03 ENST00000409115.3
prothymosin, alpha
chr15_+_52311398 8.77 ENST00000261845.5
mitogen-activated protein kinase 6
chr2_+_120517174 8.60 ENST00000263708.2
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_-_32801825 8.38 ENST00000329421.7
MARCKS-like 1
chrX_+_12993336 8.32 ENST00000380635.1
thymosin beta 4, X-linked
chr14_-_65409502 8.22 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr20_+_60718785 8.09 ENST00000421564.1
ENST00000450482.1
ENST00000331758.3
synovial sarcoma translocation gene on chromosome 18-like 1
chr6_+_119215308 7.95 ENST00000229595.5
anti-silencing function 1A histone chaperone
chr17_-_7297519 7.49 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3 readthrough (NMD candidate)
chr14_-_35344093 7.46 ENST00000382422.2
bromodomain adjacent to zinc finger domain, 1A
chrX_+_12993202 7.42 ENST00000451311.2
ENST00000380636.1
thymosin beta 4, X-linked
chr11_+_125496619 7.39 ENST00000532669.1
ENST00000278916.3
checkpoint kinase 1
chr17_-_7297833 7.14 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3 readthrough (NMD candidate)
chr1_-_200992827 7.02 ENST00000332129.2
ENST00000422435.2
kinesin family member 21B
chr5_+_159848807 6.99 ENST00000352433.5
pituitary tumor-transforming 1
chr12_+_69979113 6.60 ENST00000299300.6
chaperonin containing TCP1, subunit 2 (beta)
chr12_+_104359641 6.43 ENST00000537100.1
thymine-DNA glycosylase
chr20_-_45984401 6.32 ENST00000311275.7
zinc finger, MYND-type containing 8
chr12_+_69979210 6.12 ENST00000544368.2
chaperonin containing TCP1, subunit 2 (beta)
chr14_+_97263641 6.10 ENST00000216639.3
vaccinia related kinase 1
chr16_+_84801852 6.03 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chr14_+_20923350 6.01 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr17_+_75283973 5.98 ENST00000431235.2
ENST00000449803.2
septin 9
chr12_+_69979446 5.81 ENST00000543146.2
chaperonin containing TCP1, subunit 2 (beta)
chr13_+_111767650 5.80 ENST00000449979.1
ENST00000370623.3
Rho guanine nucleotide exchange factor (GEF) 7
chr4_-_83280767 5.76 ENST00000514671.1
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr14_-_65409438 5.71 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr14_-_71107921 5.70 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
chr3_-_18466026 5.59 ENST00000417717.2
SATB homeobox 1
chrX_+_70503433 5.56 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
non-POU domain containing, octamer-binding
chr3_-_141747950 5.49 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_30689350 5.46 ENST00000330914.3
tubulin, beta class I
chr11_-_102323489 5.35 ENST00000361236.3
transmembrane protein 123
chr10_+_22605374 5.20 ENST00000448361.1
COMM domain containing 3
chr2_-_85625857 5.20 ENST00000453973.1
capping protein (actin filament), gelsolin-like
chr10_+_114710211 5.13 ENST00000349937.2
ENST00000369397.4
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr12_+_69004619 5.02 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B, member of RAS oncogene family
chr7_-_27219849 5.01 ENST00000396344.4
homeobox A10
chrX_-_135962876 5.00 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chrX_+_70503037 4.95 ENST00000535149.1
non-POU domain containing, octamer-binding
chr11_-_102323740 4.92 ENST00000398136.2
transmembrane protein 123
chr15_+_57210818 4.92 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
transcription factor 12
chr4_-_109089573 4.88 ENST00000265165.1
lymphoid enhancer-binding factor 1
chr17_-_49124230 4.79 ENST00000510283.1
ENST00000510855.1
sperm associated antigen 9
chr2_+_181845843 4.78 ENST00000602710.1
ubiquitin-conjugating enzyme E2E 3
chr5_+_162930114 4.70 ENST00000280969.5
methionine adenosyltransferase II, beta
chr13_+_30002846 4.63 ENST00000542829.1
microtubule associated tumor suppressor candidate 2
chr5_+_137514834 4.46 ENST00000508792.1
ENST00000504621.1
kinesin family member 20A
chr7_+_116660246 4.46 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
suppression of tumorigenicity 7
chr2_-_176046391 4.45 ENST00000392541.3
ENST00000409194.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr15_+_75074410 4.43 ENST00000439220.2
c-src tyrosine kinase
chr12_+_104359576 4.43 ENST00000392872.3
ENST00000436021.2
thymine-DNA glycosylase
chr1_-_151431909 4.39 ENST00000361398.3
ENST00000271715.2
pogo transposable element with ZNF domain
chr14_-_35099315 4.38 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
sorting nexin 6
chr19_+_10765699 4.30 ENST00000590009.1
interleukin enhancer binding factor 3, 90kDa
chr17_+_75447326 4.19 ENST00000591088.1
septin 9
chr2_-_37899323 4.19 ENST00000295324.3
ENST00000457889.1
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_169312725 4.12 ENST00000392687.4
ceramide synthase 6
chr3_+_52719936 4.02 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr1_+_166808692 3.96 ENST00000367876.4
pogo transposable element with KRAB domain
chr20_-_45985172 3.95 ENST00000536340.1
zinc finger, MYND-type containing 8
chr12_-_76953284 3.94 ENST00000547544.1
ENST00000393249.2
oxysterol binding protein-like 8
chr5_+_137514687 3.92 ENST00000394894.3
kinesin family member 20A
chr3_+_111260954 3.89 ENST00000283285.5
CD96 molecule
chr21_-_40720974 3.84 ENST00000380748.1
high mobility group nucleosome binding domain 1
chr15_+_80364901 3.82 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
zinc finger, AN1-type domain 6
chr5_-_111093167 3.80 ENST00000446294.2
ENST00000419114.2
neuronal regeneration related protein
chr2_-_153573887 3.79 ENST00000493468.2
ENST00000545856.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr7_+_44788430 3.77 ENST00000457123.1
ENST00000309315.4
zinc finger, MIZ-type containing 2
chr21_-_40720995 3.77 ENST00000380749.5
high mobility group nucleosome binding domain 1
chrX_+_80457442 3.76 ENST00000373212.5
SH3 domain binding glutamic acid-rich protein like
chr2_+_114647504 3.72 ENST00000263238.2
ARP3 actin-related protein 3 homolog (yeast)
chr20_-_4804244 3.72 ENST00000379400.3
Ras association (RalGDS/AF-6) domain family member 2
chr4_-_24586140 3.69 ENST00000336812.4
DEAH (Asp-Glu-Ala-His) box helicase 15
chr12_-_49582593 3.68 ENST00000295766.5
tubulin, alpha 1a
chr17_-_73389737 3.65 ENST00000392563.1
growth factor receptor-bound protein 2
chr11_-_64013663 3.60 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_70056762 3.57 ENST00000282570.3
germ cell-less, spermatogenesis associated 1
chr11_+_63706444 3.54 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr13_-_24007815 3.52 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr10_+_22605304 3.51 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1 readthrough
COMM domain containing 3
chr11_-_10830463 3.39 ENST00000527419.1
ENST00000530211.1
ENST00000530702.1
ENST00000524932.1
ENST00000532570.1
eukaryotic translation initiation factor 4 gamma, 2
chr11_+_128563652 3.36 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr5_-_111092930 3.30 ENST00000257435.7
neuronal regeneration related protein
chr7_-_148581251 3.30 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
enhancer of zeste homolog 2 (Drosophila)
chr14_+_23791159 3.25 ENST00000557702.1
poly(A) binding protein, nuclear 1
chr4_-_74088800 3.21 ENST00000509867.2
ankyrin repeat domain 17
chr1_+_41174988 3.16 ENST00000372652.1
nuclear transcription factor Y, gamma
chr17_+_27071002 3.13 ENST00000262395.5
ENST00000422344.1
ENST00000444415.3
ENST00000262396.6
TNF receptor-associated factor 4
chr14_+_52456193 3.13 ENST00000261700.3
chromosome 14 open reading frame 166
chr9_+_131451480 3.11 ENST00000322030.8
SET nuclear oncogene
chr5_+_43602750 3.06 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
nicotinamide nucleotide transhydrogenase
chr7_+_111846643 3.03 ENST00000361822.3
zinc finger protein 277
chr11_+_63754294 3.03 ENST00000543988.1
OTU domain, ubiquitin aldehyde binding 1
chr12_-_109027643 3.03 ENST00000388962.3
ENST00000550948.1
selectin P ligand
chr1_-_35658736 2.98 ENST00000357214.5
splicing factor proline/glutamine-rich
chr6_+_27114861 2.92 ENST00000377459.1
histone cluster 1, H2ah
chr18_+_3448455 2.90 ENST00000549780.1
TGFB-induced factor homeobox 1
chr2_-_39348137 2.90 ENST00000426016.1
son of sevenless homolog 1 (Drosophila)
chr10_-_104953009 2.84 ENST00000470299.1
ENST00000343289.5
5'-nucleotidase, cytosolic II
chr17_-_73781567 2.84 ENST00000586607.1
H3 histone, family 3B (H3.3B)
chr4_-_164534657 2.77 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr15_+_65823092 2.77 ENST00000566074.1
protein tyrosine phosphatase-like A domain containing 1
chr1_+_32479430 2.71 ENST00000327300.7
ENST00000492989.1
KH domain containing, RNA binding, signal transduction associated 1
chr12_-_122985494 2.70 ENST00000336229.4
zinc finger, CCHC domain containing 8
chr1_-_113247543 2.64 ENST00000414971.1
ENST00000534717.1
ras homolog family member C
chr1_-_46152174 2.64 ENST00000290795.3
ENST00000355105.3
GC-rich promoter binding protein 1-like 1
chr19_+_41257084 2.60 ENST00000601393.1
small nuclear ribonucleoprotein polypeptide A
chr5_-_157002775 2.60 ENST00000257527.4
ADAM metallopeptidase domain 19
chr10_+_114709999 2.58 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr5_-_111092873 2.55 ENST00000509025.1
ENST00000515855.1
neuronal regeneration related protein
chr5_+_43603229 2.53 ENST00000344920.4
ENST00000512996.2
nicotinamide nucleotide transhydrogenase
chr8_-_8751068 2.52 ENST00000276282.6
malignant fibrous histiocytoma amplified sequence 1
chr3_+_152879985 2.51 ENST00000323534.2
RAP2B, member of RAS oncogene family
chr4_-_76598544 2.51 ENST00000515457.1
ENST00000357854.3
GTPase activating protein (SH3 domain) binding protein 2
chr3_+_107241783 2.48 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
bobby sox homolog (Drosophila)
chr6_-_79944336 2.42 ENST00000344726.5
ENST00000275036.7
high mobility group nucleosomal binding domain 3
chr1_-_151431647 2.40 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
pogo transposable element with ZNF domain
chr1_-_114355083 2.36 ENST00000261441.5
round spermatid basic protein 1
chr11_+_63753883 2.36 ENST00000538426.1
ENST00000543004.1
OTU domain, ubiquitin aldehyde binding 1
chr16_+_67906919 2.35 ENST00000358933.5
enhancer of mRNA decapping 4
chr4_-_83351294 2.35 ENST00000502762.1
heterogeneous nuclear ribonucleoprotein D-like
chr7_+_23145884 2.33 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr1_-_234614849 2.28 ENST00000040877.1
TAR (HIV-1) RNA binding protein 1
chr17_-_76713100 2.24 ENST00000585509.1
cytohesin 1
chr1_-_151162606 2.21 ENST00000354473.4
ENST00000368892.4
vacuolar protein sorting 72 homolog (S. cerevisiae)
chr17_-_7590745 2.20 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr1_+_192544857 2.19 ENST00000367459.3
ENST00000469578.2
regulator of G-protein signaling 1
chr4_-_143227088 2.19 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr6_-_27114577 2.19 ENST00000356950.1
ENST00000396891.4
histone cluster 1, H2bk
chr7_-_140178726 2.16 ENST00000480552.1
makorin ring finger protein 1
chr9_-_86595105 2.16 ENST00000457156.1
ENST00000360384.5
ENST00000376263.3
heterogeneous nuclear ribonucleoprotein K
chr15_-_50647347 2.13 ENST00000220429.8
ENST00000429662.2
GA binding protein transcription factor, beta subunit 1
chr2_+_32288725 2.12 ENST00000315285.3
spastin
chr19_+_47105309 2.10 ENST00000599839.1
ENST00000596362.1
calmodulin 3 (phosphorylase kinase, delta)
chr14_-_51027838 2.09 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_111093081 2.05 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chr6_+_30689401 2.03 ENST00000396389.1
ENST00000396384.1
tubulin, beta class I
chr15_-_70388943 2.03 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr5_+_147774275 2.02 ENST00000513826.1
F-box protein 38
chr4_+_41614720 2.01 ENST00000509277.1
LIM and calponin homology domains 1
chr10_+_99079008 2.01 ENST00000371021.3
frequently rearranged in advanced T-cell lymphomas
chr19_+_19303572 2.01 ENST00000407360.3
ENST00000540981.1
regulatory factor X-associated ankyrin-containing protein
chr20_+_11898507 2.00 ENST00000378226.2
BTB (POZ) domain containing 3
chr2_-_161350305 1.99 ENST00000348849.3
RNA binding motif, single stranded interacting protein 1
chr3_+_111260856 1.99 ENST00000352690.4
CD96 molecule
chr16_+_1359511 1.97 ENST00000397514.3
ENST00000397515.2
ENST00000567383.1
ENST00000403747.2
ENST00000566587.1
ubiquitin-conjugating enzyme E2I
chr12_-_122985067 1.96 ENST00000540586.1
ENST00000543897.1
zinc finger, CCHC domain containing 8
chr14_-_22005018 1.95 ENST00000546363.1
spalt-like transcription factor 2
chr7_-_27142290 1.93 ENST00000222718.5
homeobox A2
chr17_-_73389854 1.92 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
growth factor receptor-bound protein 2
chr2_-_47572105 1.88 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
chr17_-_53046058 1.84 ENST00000571584.1
ENST00000299335.3
cytochrome c oxidase assembly homolog 11 (yeast)
chr17_-_9940058 1.83 ENST00000585266.1
growth arrest-specific 7
chrX_-_110655306 1.82 ENST00000371993.2
doublecortin
chr14_-_50583271 1.81 ENST00000395860.2
ENST00000395859.2
valosin containing protein lysine (K) methyltransferase
chr2_-_153573965 1.79 ENST00000448428.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr12_-_90049878 1.77 ENST00000359142.3
ATPase, Ca++ transporting, plasma membrane 1
chrX_-_110655391 1.76 ENST00000356915.2
ENST00000356220.3
doublecortin
chr12_-_90049828 1.75 ENST00000261173.2
ENST00000348959.3
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_68150744 1.74 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr1_-_115259337 1.74 ENST00000369535.4
neuroblastoma RAS viral (v-ras) oncogene homolog
chr7_+_115850547 1.73 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
testis derived transcript (3 LIM domains)
chr1_-_226926864 1.73 ENST00000429204.1
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr13_-_99959641 1.66 ENST00000376414.4
G protein-coupled receptor 183
chr12_-_42631529 1.65 ENST00000548917.1
YY1 associated factor 2
chr1_+_24117627 1.64 ENST00000400061.1
lysophospholipase II
chr21_-_16437126 1.63 ENST00000318948.4
nuclear receptor interacting protein 1
chr17_+_67498538 1.61 ENST00000589647.1
mitogen-activated protein kinase kinase 6
chr12_-_71551868 1.60 ENST00000247829.3
tetraspanin 8
chr7_-_76247617 1.60 ENST00000441393.1
POM121 and ZP3 fusion
chr6_-_111888474 1.59 ENST00000368735.1
TRAF3 interacting protein 2
chr17_-_56065484 1.56 ENST00000581208.1
vascular endothelial zinc finger 1
chr14_-_91884150 1.53 ENST00000553403.1
coiled-coil domain containing 88C
chr7_+_50344289 1.52 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr9_-_134955246 1.51 ENST00000357028.2
ENST00000474263.1
ENST00000292035.5
mediator complex subunit 27
chr16_+_14980632 1.51 ENST00000565655.1
NODAL modulator 1
chr15_+_77224045 1.51 ENST00000320963.5
ENST00000394883.3
reticulocalbin 2, EF-hand calcium binding domain
chr17_-_79881408 1.51 ENST00000392366.3
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr2_-_161349909 1.47 ENST00000392753.3
RNA binding motif, single stranded interacting protein 1
chr11_+_35198118 1.46 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44 molecule (Indian blood group)
chr12_-_14133053 1.44 ENST00000609686.1
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr18_+_32558208 1.43 ENST00000436190.2
microtubule-associated protein, RP/EB family, member 2
chr7_-_150924121 1.42 ENST00000441774.1
ENST00000222388.2
ENST00000287844.2
ATP-binding cassette, sub-family F (GCN20), member 2
chr9_+_137218362 1.41 ENST00000481739.1
retinoid X receptor, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX10_SOX15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
2.9 14.3 GO:0071895 odontoblast differentiation(GO:0071895)
2.7 10.9 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
2.6 13.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
2.5 9.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
2.2 15.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
2.0 6.0 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
2.0 5.9 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
1.9 5.8 GO:1901355 response to rapamycin(GO:1901355)
1.8 10.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.7 10.3 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
1.4 1.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
1.3 7.7 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
1.2 3.7 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
1.2 7.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.2 6.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
1.2 4.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.1 5.6 GO:0006740 NADPH regeneration(GO:0006740)
1.1 3.3 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
1.1 3.3 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
1.0 3.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.9 4.4 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.8 3.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.8 8.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 5.4 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.7 2.2 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.7 3.5 GO:1990034 calcium ion export from cell(GO:1990034)
0.7 4.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.7 2.7 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.6 10.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.6 4.4 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.6 16.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.6 10.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.6 2.9 GO:1904693 midbrain morphogenesis(GO:1904693)
0.6 3.9 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.6 1.7 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.5 1.6 GO:0002084 protein depalmitoylation(GO:0002084)
0.5 2.2 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.5 1.6 GO:0072709 cellular response to sorbitol(GO:0072709)
0.5 1.6 GO:0021569 rhombomere 3 development(GO:0021569)
0.5 6.8 GO:0051382 kinetochore assembly(GO:0051382)
0.5 11.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.5 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.5 3.0 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 1.4 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.5 8.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.5 10.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 1.8 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.5 8.6 GO:0032486 Rap protein signal transduction(GO:0032486)
0.4 2.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.4 5.8 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.4 2.8 GO:0046085 adenosine metabolic process(GO:0046085)
0.4 1.2 GO:0060926 atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.4 1.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.4 3.7 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4 2.2 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.3 5.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 1.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.3 3.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.3 4.2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.3 2.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 1.7 GO:0051013 microtubule severing(GO:0051013)
0.3 5.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 1.7 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.3 0.9 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 0.8 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.3 3.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.3 2.5 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 10.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 1.6 GO:0035803 egg coat formation(GO:0035803)
0.3 7.6 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.3 3.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.3 1.3 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2 1.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 3.6 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.2 5.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 3.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 3.5 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.2 0.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 1.5 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 3.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 2.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 0.9 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 3.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2 17.1 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.2 2.0 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 4.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 5.0 GO:0060065 uterus development(GO:0060065)
0.2 6.0 GO:0019985 translesion synthesis(GO:0019985)
0.2 7.0 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.2 1.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.2 6.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 0.5 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.3 GO:0021873 forebrain neuroblast division(GO:0021873)
0.1 3.8 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 4.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 11.8 GO:0045445 myoblast differentiation(GO:0045445)
0.1 0.8 GO:0021764 amygdala development(GO:0021764)
0.1 16.9 GO:0030183 B cell differentiation(GO:0030183)
0.1 0.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.9 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.5 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.1 4.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 2.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 15.2 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 7.5 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 2.3 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.9 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 1.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.8 GO:0032276 regulation of gonadotropin secretion(GO:0032276) negative regulation of gonadotropin secretion(GO:0032277)
0.1 1.6 GO:0001783 B cell apoptotic process(GO:0001783)
0.1 1.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 2.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.1 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 1.4 GO:0045471 response to ethanol(GO:0045471)
0.1 1.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 5.6 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 8.0 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 2.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 0.9 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.8 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.5 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.1 1.2 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.3 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 1.8 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 2.0 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 7.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 2.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.7 GO:0034378 chylomicron assembly(GO:0034378)
0.1 2.2 GO:0043486 histone exchange(GO:0043486)
0.1 4.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.7 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.0 1.3 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 3.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 2.9 GO:0006342 chromatin silencing(GO:0006342)
0.0 3.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 3.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.8 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 25.0 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.8 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.3 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 2.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 1.6 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.1 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.5 GO:0045109 intermediate filament organization(GO:0045109)
0.0 3.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.7 GO:0060674 placenta blood vessel development(GO:0060674)
0.0 3.8 GO:0043279 response to alkaloid(GO:0043279)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 2.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.2 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 4.7 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.6 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 8.0 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.7 GO:0070671 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.0 0.7 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.7 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.6 GO:0006260 DNA replication(GO:0006260)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.4 GO:0003382 epithelial cell morphogenesis(GO:0003382)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 11.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.0 22.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.7 13.5 GO:0042382 paraspeckles(GO:0042382)
1.6 4.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.4 18.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.0 5.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 5.6 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.9 4.4 GO:0097422 tubular endosome(GO:0097422)
0.7 17.1 GO:0032156 septin cytoskeleton(GO:0032156)
0.7 3.7 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.7 5.8 GO:0000322 storage vacuole(GO:0000322)
0.7 7.5 GO:0031010 ISWI-type complex(GO:0031010)
0.5 3.5 GO:0070852 cell body fiber(GO:0070852)
0.5 7.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 3.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.4 8.1 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.4 2.5 GO:0097165 nuclear stress granule(GO:0097165)
0.3 5.2 GO:0008290 F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543)
0.3 3.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 9.2 GO:0005685 U1 snRNP(GO:0005685)
0.3 3.3 GO:0045120 pronucleus(GO:0045120)
0.2 4.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 0.7 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 14.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 13.6 GO:0005871 kinesin complex(GO:0005871)
0.2 3.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 3.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 7.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 1.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 3.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 13.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 3.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 10.0 GO:0043198 dendritic shaft(GO:0043198)
0.2 28.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 0.5 GO:0044305 calyx of Held(GO:0044305)
0.2 0.6 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 1.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.1 1.7 GO:0000815 ESCRT III complex(GO:0000815)
0.1 8.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 9.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 3.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 1.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 3.8 GO:0043596 nuclear replication fork(GO:0043596)
0.1 7.3 GO:0005811 lipid particle(GO:0005811)
0.1 8.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 8.3 GO:0016605 PML body(GO:0016605)
0.1 2.6 GO:0005859 muscle myosin complex(GO:0005859)
0.1 3.4 GO:0000786 nucleosome(GO:0000786)
0.1 9.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.0 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.1 6.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.6 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 21.0 GO:0000785 chromatin(GO:0000785)
0.1 12.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 1.5 GO:0016592 mediator complex(GO:0016592)
0.0 5.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 8.7 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 4.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 10.0 GO:0005874 microtubule(GO:0005874)
0.0 5.7 GO:0005819 spindle(GO:0005819)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.2 GO:0001772 immunological synapse(GO:0001772)
0.0 3.6 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 6.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 8.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 8.6 GO:0016604 nuclear body(GO:0016604)
0.0 0.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 7.3 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0030175 filopodium(GO:0030175)
0.0 27.4 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.1 GO:0001069 regulatory region RNA binding(GO:0001069)
3.6 10.9 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
3.0 11.8 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.0 6.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
1.5 6.1 GO:0031493 nucleosomal histone binding(GO:0031493)
1.4 1.4 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
1.2 7.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.0 21.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.9 19.3 GO:0035497 cAMP response element binding(GO:0035497)
0.8 2.3 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.7 3.5 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.7 4.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.6 3.2 GO:0034597 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.6 8.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 2.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.5 5.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.5 3.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.5 18.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 2.0 GO:0043398 HLH domain binding(GO:0043398)
0.5 8.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 13.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 1.3 GO:0035500 MH2 domain binding(GO:0035500)
0.4 5.8 GO:0003680 AT DNA binding(GO:0003680)
0.4 4.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 8.8 GO:0004707 MAP kinase activity(GO:0004707)
0.4 5.6 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.4 1.5 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.4 15.5 GO:0003785 actin monomer binding(GO:0003785)
0.4 3.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.4 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 10.0 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.7 GO:0034452 dynactin binding(GO:0034452)
0.3 1.2 GO:0038025 reelin receptor activity(GO:0038025)
0.3 1.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 1.7 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 0.8 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.3 10.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 4.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 2.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 5.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 4.7 GO:0070410 co-SMAD binding(GO:0070410)
0.2 2.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 10.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 1.7 GO:0008142 oxysterol binding(GO:0008142)
0.2 21.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 20.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 3.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 1.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 5.2 GO:0008143 poly(A) binding(GO:0008143)
0.2 3.1 GO:0031996 thioesterase binding(GO:0031996)
0.2 1.6 GO:0032190 acrosin binding(GO:0032190)
0.2 0.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 4.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 13.8 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 0.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 3.0 GO:0070628 proteasome binding(GO:0070628)
0.1 2.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 6.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 3.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 7.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 4.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 3.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 8.6 GO:0019003 GDP binding(GO:0019003)
0.1 4.8 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 3.3 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 1.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.3 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 5.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 3.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 7.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 3.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 8.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 7.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 13.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 7.7 GO:0042393 histone binding(GO:0042393)
0.1 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 15.2 GO:0003924 GTPase activity(GO:0003924)
0.1 3.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 9.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.8 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 5.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 11.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 6.2 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 1.1 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 10.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 16.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 4.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 6.1 GO:0003682 chromatin binding(GO:0003682)
0.0 3.3 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 15.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 17.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 25.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 8.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 19.6 PID CMYB PATHWAY C-MYB transcription factor network
0.2 23.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 2.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.2 17.3 PID E2F PATHWAY E2F transcription factor network
0.2 11.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 1.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 9.2 PID AP1 PATHWAY AP-1 transcription factor network
0.1 6.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.8 PID AURORA A PATHWAY Aurora A signaling
0.1 8.4 PID PLK1 PATHWAY PLK1 signaling events
0.1 13.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 4.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 4.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 3.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.4 PID REELIN PATHWAY Reelin signaling pathway
0.1 3.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 4.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 5.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 0.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 3.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 3.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.7 22.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.5 10.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.4 11.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 7.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 9.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.4 20.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 15.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 2.8 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.3 6.6 REACTOME KINESINS Genes involved in Kinesins
0.2 5.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 16.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 3.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 3.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 4.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 4.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 3.0 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 4.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 5.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 14.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 7.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 5.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 7.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.1 3.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 5.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 5.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 5.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 3.0 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors