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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX13_SOX12
Z-value: 1.21
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg19_v2_chr20_+_306221_306239 | -0.30 | 5.7e-06 | Click! |
| SOX13 | hg19_v2_chr1_+_204042723_204042784 | 0.17 | 1.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_49712147 Show fit | 20.35 |
ENST00000433368.2
ENST00000354620.4 |
cysteine-rich secretory protein 3 |
|
| chr2_+_90198535 Show fit | 19.39 |
ENST00000390276.2
|
immunoglobulin kappa variable 1D-12 |
|
| chr6_-_49712123 Show fit | 18.19 |
ENST00000263045.4
|
cysteine-rich secretory protein 3 |
|
| chr2_+_90273679 Show fit | 17.52 |
ENST00000423080.2
|
immunoglobulin kappa variable 3D-7 |
|
| chr1_-_153363452 Show fit | 16.45 |
ENST00000368732.1
ENST00000368733.3 |
S100 calcium binding protein A8 |
|
| chr2_+_90211643 Show fit | 16.31 |
ENST00000390277.2
|
immunoglobulin kappa variable 3D-11 |
|
| chr6_-_32498046 Show fit | 15.06 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr6_-_32557610 Show fit | 14.90 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr2_-_89327228 Show fit | 14.69 |
ENST00000483158.1
|
immunoglobulin kappa variable 3-11 |
|
| chr4_+_71337834 Show fit | 14.06 |
ENST00000304887.5
|
mucin 7, secreted |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 73.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 52.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 26.4 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.2 | 22.1 | GO:0031294 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.3 | 19.7 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.3 | 18.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.8 | 16.7 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 2.4 | 16.5 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.1 | 15.9 | GO:0006903 | vesicle targeting(GO:0006903) |
| 2.2 | 15.1 | GO:0010749 | regulation of nitric oxide mediated signal transduction(GO:0010749) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 118.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 63.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.9 | 39.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.4 | 37.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 26.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.4 | 20.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 20.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 4.7 | 14.1 | GO:0097679 | other organism cytoplasm(GO:0097679) |
| 1.1 | 13.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 12.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 147.1 | GO:0003823 | antigen binding(GO:0003823) |
| 1.0 | 30.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.3 | 28.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 19.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 18.1 | GO:0020037 | heme binding(GO:0020037) |
| 5.5 | 16.5 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.2 | 14.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.6 | 13.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 13.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 2.3 | 11.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 31.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 28.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.0 | 25.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 20.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.4 | 18.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 15.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 14.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.7 | 10.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 8.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 37.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 27.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 17.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.8 | 14.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 13.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 13.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.7 | 13.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.5 | 9.1 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 9.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 9.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |