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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX17
Z-value: 1.21
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Transcription factors associated with SOX17
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX17 | hg19_v2_chr8_+_55370487_55370503 | 0.12 | 7.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX17
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 106.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.0 | 26.9 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.2 | 23.5 | GO:0007338 | single fertilization(GO:0007338) |
| 0.1 | 16.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 16.7 | GO:0031295 | T cell costimulation(GO:0031295) |
| 3.7 | 14.8 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.2 | 14.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 14.2 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 13.2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 13.0 | GO:0007127 | meiosis I(GO:0007127) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.5 | 31.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 25.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 2.1 | 16.9 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 4.1 | 16.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.2 | 15.8 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 14.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.2 | 12.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 11.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.2 | 11.4 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 97.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.6 | 34.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 28.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 21.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 20.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 18.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 17.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 16.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 1.4 | 16.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.9 | 13.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 9.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 6.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.7 | 25.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 16.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.8 | 16.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 14.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 8.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 8.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 8.4 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 1.7 | 8.3 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.2 | 7.3 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |