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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX18

Z-value: 0.72

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Transcription factors associated with SOX18

Gene Symbol Gene ID Gene Info
SOX18
ENSG00000203883.5 SRY-box transcription factor 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX18hg19_v2_chr20_-_62680984_626809990.082.4e-01Click!

Activity profile of SOX18 motif

Sorted Z-values of SOX18 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_5710919 13.52 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chrX_-_70329118 12.19 ENST00000374188.3
IL2RG
interleukin 2 receptor, gamma
chr4_+_154387480 11.37 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
KIAA0922
chr3_-_121379739 11.12 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr13_-_46756351 9.72 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_46716969 9.39 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_158345462 7.40 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr1_+_209929377 6.11 ENST00000400959.3
ENST00000367025.3
TRAF3IP3
TRAF3 interacting protein 3
chr5_+_156607829 5.93 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr11_-_104817919 5.43 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr7_-_150329421 5.31 ENST00000493969.1
ENST00000328902.5
GIMAP6
GTPase, IMAP family member 6
chr11_-_5248294 5.19 ENST00000335295.4
HBB
hemoglobin, beta
chr1_+_209929494 4.99 ENST00000367026.3
TRAF3IP3
TRAF3 interacting protein 3
chr12_+_25205446 4.39 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr21_-_15918618 4.36 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_+_109541772 4.35 ENST00000506397.1
ENST00000394668.2
RPL34
ribosomal protein L34
chr6_-_26235206 4.29 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr6_-_152489484 4.19 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_89790490 4.11 ENST00000336032.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr16_-_68034470 4.02 ENST00000412757.2
DPEP2
dipeptidase 2
chr14_-_107219365 3.97 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr6_+_89790459 3.81 ENST00000369472.1
PNRC1
proline-rich nuclear receptor coactivator 1
chr13_+_111806083 3.77 ENST00000375736.4
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr4_+_69962212 3.64 ENST00000508661.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr11_+_71238313 3.61 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr6_-_32908792 3.34 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_+_22963806 3.23 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chr4_+_69962185 3.21 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr16_+_33629600 3.05 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr6_-_33385854 2.99 ENST00000488478.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr4_-_57524061 2.95 ENST00000508121.1
HOPX
HOP homeobox
chr6_-_33385870 2.80 ENST00000488034.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr6_-_33385655 2.75 ENST00000440279.3
ENST00000607266.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr4_+_109541740 2.67 ENST00000394665.1
RPL34
ribosomal protein L34
chr17_+_41150479 2.65 ENST00000589913.1
RPL27
ribosomal protein L27
chr4_+_109541722 2.63 ENST00000394667.3
ENST00000502534.1
RPL34
ribosomal protein L34
chr17_+_41150290 2.58 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr1_+_22979474 2.55 ENST00000509305.1
C1QB
complement component 1, q subcomponent, B chain
chr6_-_33385902 2.54 ENST00000374500.5
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr1_-_206785898 2.43 ENST00000271764.2
EIF2D
eukaryotic translation initiation factor 2D
chr17_+_68071389 2.43 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_772901 2.41 ENST00000305108.4
NINJ2
ninjurin 2
chr3_+_186435137 2.40 ENST00000447445.1
KNG1
kininogen 1
chr2_+_1418154 2.40 ENST00000423320.1
ENST00000382198.1
TPO
thyroid peroxidase
chr11_-_89224139 2.37 ENST00000413594.2
NOX4
NADPH oxidase 4
chr1_-_153517473 2.36 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr5_+_54398463 2.36 ENST00000274306.6
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr4_+_156588115 2.35 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chrX_-_154033661 2.30 ENST00000393531.1
MPP1
membrane protein, palmitoylated 1, 55kDa
chr6_-_33385823 2.28 ENST00000494751.1
ENST00000374496.3
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr17_+_68071458 2.19 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chrX_+_100645812 2.18 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr1_-_206785789 2.14 ENST00000437518.1
ENST00000367114.3
EIF2D
eukaryotic translation initiation factor 2D
chr19_+_41256764 2.14 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr22_+_37678424 2.12 ENST00000248901.6
CYTH4
cytohesin 4
chr2_+_1488435 2.09 ENST00000446278.1
ENST00000469607.1
TPO
thyroid peroxidase
chr7_-_148725733 2.09 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr3_+_108541545 2.08 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr18_+_32621324 2.08 ENST00000300249.5
ENST00000538170.2
ENST00000588910.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_-_89224508 2.02 ENST00000525196.1
NOX4
NADPH oxidase 4
chr19_+_8117881 2.01 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr11_-_6677018 2.00 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr3_+_186330712 1.97 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr10_+_70715884 1.95 ENST00000354185.4
DDX21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr7_+_99933730 1.94 ENST00000610247.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr15_+_44084040 1.93 ENST00000249786.4
SERF2
small EDRK-rich factor 2
chr11_+_64949343 1.90 ENST00000279247.6
ENST00000532285.1
ENST00000534373.1
CAPN1
calpain 1, (mu/I) large subunit
chr11_+_13299186 1.87 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_-_26216872 1.82 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chrX_+_47004639 1.81 ENST00000345781.6
RBM10
RNA binding motif protein 10
chr4_+_156588249 1.76 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr13_-_45992473 1.76 ENST00000539591.1
ENST00000519676.1
ENST00000519547.1
SLC25A30
solute carrier family 25, member 30
chr1_-_32801825 1.75 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chrX_+_47004599 1.73 ENST00000329236.7
RBM10
RNA binding motif protein 10
chr11_-_89224299 1.72 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4
NADPH oxidase 4
chr8_-_86253888 1.64 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr2_+_202125219 1.59 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chrX_-_47004437 1.58 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr19_+_41257084 1.57 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr2_+_217277137 1.56 ENST00000430374.1
ENST00000357276.4
ENST00000444508.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr13_-_45992541 1.54 ENST00000522438.1
SLC25A30
solute carrier family 25, member 30
chr3_+_186435065 1.54 ENST00000287611.2
ENST00000265023.4
KNG1
kininogen 1
chr19_+_8117636 1.54 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr15_+_91473403 1.48 ENST00000394275.2
UNC45A
unc-45 homolog A (C. elegans)
chr3_+_20081515 1.47 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr1_-_182360918 1.47 ENST00000339526.4
GLUL
glutamate-ammonia ligase
chr2_+_217277466 1.42 ENST00000358207.5
ENST00000434435.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr1_-_157746909 1.41 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chr12_-_11002063 1.38 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr11_-_89224488 1.36 ENST00000534731.1
ENST00000527626.1
NOX4
NADPH oxidase 4
chr12_-_371994 1.36 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr2_-_211168332 1.34 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_+_133465228 1.33 ENST00000482271.1
ENST00000264998.3
TF
transferrin
chr12_+_96252706 1.33 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr1_-_182361327 1.32 ENST00000331872.6
ENST00000311223.5
GLUL
glutamate-ammonia ligase
chr12_+_15475462 1.30 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr15_-_68497657 1.29 ENST00000448060.2
ENST00000467889.1
CALML4
calmodulin-like 4
chr2_+_79252822 1.27 ENST00000272324.5
REG3G
regenerating islet-derived 3 gamma
chr19_+_44576296 1.27 ENST00000421176.3
ZNF284
zinc finger protein 284
chr6_-_160679905 1.27 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr12_-_8088871 1.24 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr11_+_64949899 1.23 ENST00000531068.1
ENST00000527699.1
ENST00000533909.1
ENST00000527323.1
CAPN1
calpain 1, (mu/I) large subunit
chr2_-_208031943 1.22 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_-_144940477 1.20 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
GYPB
glycophorin B (MNS blood group)
chr2_+_44502597 1.18 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr22_-_22292934 1.14 ENST00000538191.1
ENST00000424647.1
ENST00000407142.1
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr9_-_123812542 1.14 ENST00000223642.1
C5
complement component 5
chr4_-_76944621 1.07 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr12_-_11422739 1.07 ENST00000279573.7
PRB3
proline-rich protein BstNI subfamily 3
chr2_+_90259593 1.07 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr2_+_79252834 1.05 ENST00000409471.1
REG3G
regenerating islet-derived 3 gamma
chr11_-_89223883 1.04 ENST00000528341.1
NOX4
NADPH oxidase 4
chr9_-_127533519 1.03 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr1_+_66258846 1.03 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr16_-_787771 1.03 ENST00000568545.1
NARFL
nuclear prelamin A recognition factor-like
chrX_+_55744228 1.03 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr19_+_33571786 1.00 ENST00000170564.2
GPATCH1
G patch domain containing 1
chr1_+_171154347 1.00 ENST00000209929.7
ENST00000441535.1
FMO2
flavin containing monooxygenase 2 (non-functional)
chr15_+_64386261 0.99 ENST00000560829.1
SNX1
sorting nexin 1
chr12_+_113344755 0.98 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_+_56315936 0.96 ENST00000543544.1
LPO
lactoperoxidase
chr1_+_13521973 0.96 ENST00000327795.5
PRAMEF21
PRAME family member 21
chr1_+_36348790 0.91 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr11_+_134201911 0.88 ENST00000389881.3
GLB1L2
galactosidase, beta 1-like 2
chr2_+_79252804 0.87 ENST00000393897.2
REG3G
regenerating islet-derived 3 gamma
chr5_+_32711419 0.85 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_-_118047376 0.83 ENST00000278947.5
SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr17_+_3118915 0.82 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chrX_-_101726732 0.82 ENST00000457521.2
ENST00000412230.2
ENST00000453326.2
NXF2B
TCP11X2
nuclear RNA export factor 2B
t-complex 11 family, X-linked 2
chr5_-_179050066 0.82 ENST00000329433.6
ENST00000510411.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr10_-_105992059 0.80 ENST00000369720.1
ENST00000369719.1
ENST00000357060.3
ENST00000428666.1
ENST00000278064.2
WDR96
WD repeat domain 96
chr1_-_12958101 0.80 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr9_-_99064386 0.79 ENST00000375262.2
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr8_+_40010989 0.78 ENST00000315792.3
C8orf4
chromosome 8 open reading frame 4
chr11_+_20620946 0.76 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr8_-_37707356 0.76 ENST00000520601.1
ENST00000521170.1
ENST00000220659.6
BRF2
BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
chr9_-_74525658 0.74 ENST00000333421.6
ABHD17B
abhydrolase domain containing 17B
chr12_-_10562356 0.73 ENST00000309384.1
KLRC4
killer cell lectin-like receptor subfamily C, member 4
chr1_-_156828810 0.73 ENST00000368195.3
INSRR
insulin receptor-related receptor
chr11_+_74699942 0.70 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
NEU3
sialidase 3 (membrane sialidase)
chrX_+_101470280 0.69 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
NXF2
TCP11X1
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chr12_-_110939870 0.68 ENST00000447578.2
ENST00000546588.1
ENST00000360579.7
ENST00000549970.1
ENST00000549578.1
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr9_-_74525847 0.65 ENST00000377041.2
ABHD17B
abhydrolase domain containing 17B
chr12_-_68647281 0.61 ENST00000328087.4
ENST00000538666.1
IL22
interleukin 22
chr6_+_26217159 0.61 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr17_+_72427477 0.60 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_+_28770025 0.59 ENST00000435324.2
NPIPB9
nuclear pore complex interacting protein family, member B9
chr5_+_140800638 0.59 ENST00000398587.2
ENST00000518882.1
PCDHGA11
protocadherin gamma subfamily A, 11
chrX_+_55744166 0.59 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr3_-_37034702 0.59 ENST00000322716.5
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr5_-_75919217 0.58 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr8_+_38644778 0.57 ENST00000276520.8
TACC1
transforming, acidic coiled-coil containing protein 1
chr9_-_21351377 0.57 ENST00000380210.1
IFNA6
interferon, alpha 6
chr19_+_36132631 0.55 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr6_-_133035185 0.55 ENST00000367928.4
VNN1
vanin 1
chr1_+_160051319 0.54 ENST00000368088.3
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr11_-_75236867 0.53 ENST00000376282.3
ENST00000336898.3
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr3_-_197300194 0.53 ENST00000358186.2
ENST00000431056.1
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chrX_+_119495934 0.51 ENST00000218008.3
ENST00000361319.3
ENST00000539306.1
ATP1B4
ATPase, Na+/K+ transporting, beta 4 polypeptide
chr14_+_24458123 0.48 ENST00000545240.1
ENST00000382755.4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4 like 2
chr9_+_33240157 0.46 ENST00000379721.3
SPINK4
serine peptidase inhibitor, Kazal type 4
chr7_-_6048702 0.45 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr8_-_102218292 0.41 ENST00000518336.1
ENST00000520454.1
ZNF706
zinc finger protein 706
chr10_-_127505167 0.41 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr11_+_60970852 0.39 ENST00000325558.6
PGA3
pepsinogen 3, group I (pepsinogen A)
chr2_-_39347524 0.36 ENST00000395038.2
ENST00000402219.2
SOS1
son of sevenless homolog 1 (Drosophila)
chr1_+_153003671 0.35 ENST00000307098.4
SPRR1B
small proline-rich protein 1B
chr17_+_25799008 0.35 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
KSR1
kinase suppressor of ras 1
chr6_+_42883727 0.34 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr11_-_76155618 0.34 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr4_-_39367949 0.34 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
RFC1
replication factor C (activator 1) 1, 145kDa
chrX_+_2984874 0.31 ENST00000359361.2
ARSF
arylsulfatase F
chr12_-_48963829 0.31 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr9_+_117350009 0.29 ENST00000374050.3
ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr5_+_135468516 0.29 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5
SMAD family member 5
chr3_-_184971853 0.28 ENST00000231887.3
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr7_-_142176790 0.27 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr1_+_206223941 0.27 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr17_+_48503519 0.27 ENST00000300441.4
ENST00000541920.1
ENST00000506582.1
ENST00000504392.1
ENST00000427954.2
ACSF2
acyl-CoA synthetase family member 2
chr2_+_105953972 0.26 ENST00000410049.1
C2orf49
chromosome 2 open reading frame 49
chr6_+_29427548 0.25 ENST00000377132.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr17_+_48503603 0.23 ENST00000502667.1
ACSF2
acyl-CoA synthetase family member 2
chrX_-_2847366 0.22 ENST00000381154.1
ARSD
arylsulfatase D
chr2_+_241544834 0.22 ENST00000319838.5
ENST00000403859.1
ENST00000438013.2
GPR35
G protein-coupled receptor 35
chr4_+_54243798 0.21 ENST00000337488.6
ENST00000358575.5
ENST00000507922.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr7_-_6048650 0.21 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr1_-_241799232 0.21 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chr4_+_164265035 0.21 ENST00000338566.3
NPY5R
neuropeptide Y receptor Y5
chr12_+_69633317 0.21 ENST00000435070.2
CPSF6
cleavage and polyadenylation specific factor 6, 68kDa
chr9_-_99064429 0.20 ENST00000375263.3
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr2_-_49381646 0.20 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr19_-_57347415 0.20 ENST00000601070.1
ZIM2
zinc finger, imprinted 2
chr5_+_32711829 0.19 ENST00000415167.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr13_-_99630233 0.18 ENST00000376460.1
ENST00000442173.1
DOCK9
dedicator of cytokinesis 9
chr2_-_49381572 0.18 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr9_+_74526384 0.18 ENST00000334731.2
ENST00000377031.3
C9orf85
chromosome 9 open reading frame 85
chr12_+_113344582 0.17 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_-_46105411 0.14 ENST00000323040.4
ENST00000544371.1
GPR4
OPA3
G protein-coupled receptor 4
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr1_+_100316041 0.13 ENST00000370165.3
ENST00000370163.3
ENST00000294724.4
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr9_+_33629119 0.12 ENST00000331828.4
TRBV21OR9-2
T cell receptor beta variable 21/OR9-2 (pseudogene)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX18

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 12.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
1.3 5.2 GO:0030185 nitric oxide transport(GO:0030185)
1.2 19.1 GO:0051639 actin filament network formation(GO:0051639)
1.1 3.3 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.1 3.2 GO:0044278 cell wall disruption in other organism(GO:0044278)
1.0 7.9 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 12.7 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.7 3.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.7 2.8 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.7 4.1 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.7 2.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.6 5.9 GO:0001865 NK T cell differentiation(GO:0001865)
0.5 4.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.5 4.3 GO:0032790 ribosome disassembly(GO:0032790)
0.5 5.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.5 1.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.5 1.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.4 1.3 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.4 4.2 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.4 1.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.4 1.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.4 3.8 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 0.3 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.3 3.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.3 2.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 13.5 GO:0070206 protein trimerization(GO:0070206)
0.2 3.1 GO:0060056 mammary gland involution(GO:0060056)
0.2 8.5 GO:0050667 homocysteine metabolic process(GO:0050667)
0.2 2.4 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.2 1.6 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 5.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 1.3 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2 1.1 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 1.0 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.2 1.2 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.2 0.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 4.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.2 3.9 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.2 3.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.1 0.8 GO:0046684 response to pyrethroid(GO:0046684)
0.1 3.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.8 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 1.3 GO:1901374 acetate ester transport(GO:1901374)
0.1 1.0 GO:0070995 NADPH oxidation(GO:0070995)
0.1 1.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 1.0 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 1.1 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 0.6 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.1 5.2 GO:0010107 potassium ion import(GO:0010107)
0.1 4.4 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 17.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.4 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
0.1 7.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.8 GO:0015816 glycine transport(GO:0015816)
0.1 0.4 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 1.0 GO:0032364 oxygen homeostasis(GO:0032364)
0.1 1.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 2.0 GO:0030502 pinocytosis(GO:0006907) negative regulation of bone mineralization(GO:0030502)
0.1 0.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 1.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.6 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 1.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.4 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 1.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 2.3 GO:0046710 GDP metabolic process(GO:0046710)
0.1 0.6 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 3.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.7 GO:0030238 male sex determination(GO:0030238)
0.1 0.5 GO:0040034 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.1 0.2 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.0 2.5 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.3 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 1.3 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 1.4 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.3 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.7 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 4.4 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 1.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 9.0 GO:0010038 response to metal ion(GO:0010038)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0072144 renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 2.5 GO:0048839 inner ear development(GO:0048839)
0.0 0.3 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.4 GO:0007586 digestion(GO:0007586)
0.0 0.1 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.0 0.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 2.4 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)
0.0 0.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.5 GO:0042493 response to drug(GO:0042493)
0.0 1.4 GO:0031424 keratinization(GO:0031424)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.0 19.1 GO:0001891 phagocytic cup(GO:0001891)
0.9 5.4 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.5 2.5 GO:0005602 complement component C1 complex(GO:0005602)
0.5 8.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 3.8 GO:0000322 storage vacuole(GO:0000322)
0.3 4.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 1.6 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.3 1.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.2 0.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.0 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 3.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 12.5 GO:0015030 Cajal body(GO:0015030)
0.2 1.9 GO:0033391 chromatoid body(GO:0033391)
0.2 1.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.2 4.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 2.8 GO:0097386 glial cell projection(GO:0097386)
0.2 1.5 GO:0000125 PCAF complex(GO:0000125)
0.2 17.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.0 GO:0097361 CIA complex(GO:0097361)
0.1 7.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 1.1 GO:0005579 membrane attack complex(GO:0005579)
0.1 4.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.9 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.1 1.6 GO:0097342 ripoptosome(GO:0097342)
0.1 3.6 GO:0045095 keratin filament(GO:0045095)
0.1 2.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 2.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 7.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 4.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 2.4 GO:0001772 immunological synapse(GO:0001772)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 12.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 4.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:0033647 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 8.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 7.4 GO:0005769 early endosome(GO:0005769)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.0 9.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 1.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.2 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.9 3.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.9 5.2 GO:0030492 hemoglobin binding(GO:0030492)
0.9 8.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.7 4.5 GO:0004447 iodide peroxidase activity(GO:0004447)
0.7 2.8 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.5 3.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.4 1.3 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 1.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.4 5.4 GO:0050700 CARD domain binding(GO:0050700)
0.3 1.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 1.3 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.3 3.0 GO:0036310 annealing helicase activity(GO:0036310)
0.3 3.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 5.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 1.9 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 1.4 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.2 1.6 GO:0004064 arylesterase activity(GO:0004064)
0.2 1.0 GO:1990460 leptin receptor binding(GO:1990460)
0.2 1.2 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.2 0.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 4.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 4.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 0.5 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.2 0.7 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 1.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 1.0 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.2 4.2 GO:0005521 lamin binding(GO:0005521)
0.2 12.7 GO:0005507 copper ion binding(GO:0005507)
0.2 0.8 GO:0001016 transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III regulatory region DNA binding(GO:0001016)
0.1 2.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 5.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 7.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 2.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 3.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 2.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.7 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.1 0.4 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 5.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.7 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 10.6 GO:0017124 SH3 domain binding(GO:0017124)
0.1 14.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 4.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 12.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.9 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 1.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 3.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 10.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 1.1 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 4.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 4.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.0 GO:0019210 kinase inhibitor activity(GO:0019210)
0.0 0.1 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 1.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.1 GO:0003823 antigen binding(GO:0003823)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 17.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 11.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 3.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 4.3 PID AURORA A PATHWAY Aurora A signaling
0.1 7.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.5 PID ATR PATHWAY ATR signaling pathway
0.0 2.3 PID BMP PATHWAY BMP receptor signaling
0.0 1.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 11.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.3 PID FAS PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 2.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 5.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 3.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 4.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 5.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 7.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 1.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 5.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 17.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 4.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 6.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 5.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 3.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway