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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SP1
Z-value: 1.98
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53773944_53773993 | -0.52 | 1.6e-16 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 285.3 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 4.5 | 197.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.4 | 178.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 2.4 | 173.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 161.2 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 3.5 | 151.8 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 8.4 | 125.7 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 2.7 | 123.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 7.1 | 113.1 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 7.5 | 113.0 | GO:0051639 | actin filament network formation(GO:0051639) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2207.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.8 | 993.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 3.6 | 510.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 2.8 | 452.9 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.9 | 201.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 4.1 | 190.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.6 | 152.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 2.1 | 128.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 6.4 | 122.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 4.2 | 114.3 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 825.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.7 | 636.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.8 | 434.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 6.1 | 281.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 3.5 | 249.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.9 | 167.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 153.9 | GO:0003723 | RNA binding(GO:0003723) |
| 4.2 | 143.7 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 2.5 | 121.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 2.3 | 103.4 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 325.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.7 | 292.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 4.9 | 282.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 6.2 | 253.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 4.9 | 171.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 3.3 | 164.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 3.3 | 123.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 2.6 | 120.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 1.1 | 119.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 2.0 | 104.4 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 351.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 2.3 | 333.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.9 | 285.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.3 | 240.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 4.9 | 234.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.0 | 228.8 | REACTOME TRANSLATION | Genes involved in Translation |
| 4.1 | 207.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 7.3 | 197.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 2.8 | 190.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 2.7 | 188.5 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |