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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPDEF

Z-value: 1.46

Motif logo

Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524093_34524135-0.362.9e-08Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_56082455 50.34 ENST00000578794.1
Uncharacterized protein
chr14_-_69864993 46.16 ENST00000555373.1
enhancer of rudimentary homolog (Drosophila)
chr2_+_198380763 37.67 ENST00000448447.2
ENST00000409360.1
MOB family member 4, phocein
chr14_-_24615805 35.02 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_-_102513843 33.35 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr1_+_84944926 27.56 ENST00000370656.1
ENST00000370654.5
ribosome production factor 1 homolog (S. cerevisiae)
chr14_-_64010046 27.46 ENST00000337537.3
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr15_-_59949693 27.00 ENST00000396063.1
ENST00000396064.3
ENST00000484743.1
ENST00000559706.1
ENST00000396060.2
general transcription factor IIA, 2, 12kDa
chr1_-_193028632 26.30 ENST00000421683.1
ubiquitin carboxyl-terminal hydrolase L5
chr8_-_101964265 26.07 ENST00000395958.2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr10_-_120840309 25.81 ENST00000369144.3
eukaryotic translation initiation factor 3, subunit A
chrX_-_135962876 25.22 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chr1_-_43638168 25.06 ENST00000431635.2
EBNA1 binding protein 2
chr5_+_110074685 24.96 ENST00000355943.3
ENST00000447245.2
solute carrier family 25, member 46
chr15_-_59949667 24.46 ENST00000396061.1
general transcription factor IIA, 2, 12kDa
chr17_+_65713925 23.73 ENST00000253247.4
nucleolar protein 11
chr1_-_193028621 23.68 ENST00000367455.4
ENST00000367454.1
ubiquitin carboxyl-terminal hydrolase L5
chr1_+_110091189 23.22 ENST00000369851.4
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr14_-_23058063 22.95 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
defender against cell death 1
chr2_+_198380289 22.87 ENST00000233892.4
ENST00000409916.1
MOB family member 4, phocein
chr14_+_75348592 22.71 ENST00000334220.4
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr15_-_65282232 22.18 ENST00000416889.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr14_-_67826486 22.04 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr1_-_67896069 21.93 ENST00000370995.2
ENST00000361219.6
SERPINE1 mRNA binding protein 1
chr5_+_892745 21.23 ENST00000166345.3
thyroid hormone receptor interactor 13
chr1_-_43637915 21.19 ENST00000236051.2
EBNA1 binding protein 2
chr11_-_46142948 21.05 ENST00000257821.4
PHD finger protein 21A
chr17_-_62658186 20.92 ENST00000262435.9
SMAD specific E3 ubiquitin protein ligase 2
chr1_-_67896095 20.51 ENST00000370994.4
SERPINE1 mRNA binding protein 1
chr1_-_67896009 20.22 ENST00000370990.5
SERPINE1 mRNA binding protein 1
chr15_-_65282274 20.09 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr14_-_24615523 20.04 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chrX_+_47053208 19.70 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
ubiquitin-like modifier activating enzyme 1
chr12_+_69080734 19.68 ENST00000378905.2
nucleoporin 107kDa
chr1_-_19811996 18.74 ENST00000264203.3
ENST00000401084.2
capping protein (actin filament) muscle Z-line, beta
chr14_+_35761580 18.70 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
proteasome (prosome, macropain) subunit, alpha type, 6
chr3_-_133380731 18.51 ENST00000260810.5
topoisomerase (DNA) II binding protein 1
chr11_-_71823796 18.32 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chrX_+_69509927 17.97 ENST00000374403.3
kinesin family member 4A
chr12_-_121019165 17.69 ENST00000341039.2
ENST00000357500.4
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr5_+_86564739 17.56 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RAS p21 protein activator (GTPase activating protein) 1
chr14_+_60715928 17.40 ENST00000395076.4
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr20_-_2451395 17.28 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
small nuclear ribonucleoprotein polypeptides B and B1
chr22_+_44351419 17.04 ENST00000396202.3
SAMM50 sorting and assembly machinery component
chr5_-_31532160 16.84 ENST00000511367.2
ENST00000513349.1
drosha, ribonuclease type III
chr1_-_193028426 16.76 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
ubiquitin carboxyl-terminal hydrolase L5
chr14_-_21737551 16.68 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr7_+_98923505 16.48 ENST00000432884.2
ENST00000262942.5
actin related protein 2/3 complex, subunit 1A, 41kDa
chr14_+_35761540 16.41 ENST00000261479.4
proteasome (prosome, macropain) subunit, alpha type, 6
chr8_-_117768023 16.11 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chrX_-_153775426 15.42 ENST00000393562.2
glucose-6-phosphate dehydrogenase
chr14_-_21737610 15.42 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr19_+_58898627 15.31 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
ribosomal protein S5
chr4_-_10118348 15.26 ENST00000502702.1
WD repeat domain 1
chr11_-_71823266 15.14 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr5_+_31532373 15.03 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
chromosome 5 open reading frame 22
chr6_+_134274322 15.02 ENST00000367871.1
ENST00000237264.4
TBP-like 1
chr1_+_43124087 14.95 ENST00000304979.3
ENST00000372550.1
ENST00000440068.1
peptidylprolyl isomerase H (cyclophilin H)
chr2_+_187350883 14.85 ENST00000337859.6
zinc finger CCCH-type containing 15
chr22_+_44351301 14.82 ENST00000350028.4
SAMM50 sorting and assembly machinery component
chrX_+_47444613 14.78 ENST00000445623.1
TIMP metallopeptidase inhibitor 1
chr8_-_56987057 14.54 ENST00000518875.1
ribosomal protein S20
chr11_-_71823715 14.51 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr2_+_65454926 14.50 ENST00000542850.1
ENST00000377982.4
ARP2 actin-related protein 2 homolog (yeast)
chr1_+_235492300 14.47 ENST00000476121.1
ENST00000497327.1
geranylgeranyl diphosphate synthase 1
chr1_-_19811962 14.20 ENST00000375142.1
ENST00000264202.6
capping protein (actin filament) muscle Z-line, beta
chr1_+_151129135 13.65 ENST00000602841.1
sodium channel modifier 1
chr14_+_67826709 13.61 ENST00000256383.4
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr13_+_27998681 13.44 ENST00000381140.4
general transcription factor IIIA
chr8_-_130951940 13.27 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
family with sequence similarity 49, member B
chr11_+_63754294 13.26 ENST00000543988.1
OTU domain, ubiquitin aldehyde binding 1
chr19_+_19496624 13.26 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATA zinc finger domain containing 2A
chr20_-_34252759 13.22 ENST00000414711.1
ENST00000416778.1
ENST00000397442.1
ENST00000440240.1
ENST00000412056.1
ENST00000352393.4
ENST00000458038.1
ENST00000420363.1
ENST00000434795.1
ENST00000437100.1
ENST00000414664.1
ENST00000359646.1
ENST00000424458.1
ENST00000374104.3
ENST00000374114.3
copine I
RNA binding motif protein 12
chr2_+_187350973 12.99 ENST00000544130.1
zinc finger CCCH-type containing 15
chr3_-_32022733 12.91 ENST00000438237.2
ENST00000396556.2
oxysterol binding protein-like 10
chr2_+_65454863 12.86 ENST00000260641.5
ARP2 actin-related protein 2 homolog (yeast)
chr1_-_235324530 12.80 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RNA binding motif protein 34
chr3_+_33840050 12.69 ENST00000457054.2
ENST00000413073.1
programmed cell death 6 interacting protein
chr3_-_196669248 12.44 ENST00000447325.1
nuclear cap binding protein subunit 2, 20kDa
chr7_+_44240520 12.34 ENST00000496112.1
ENST00000223369.2
YKT6 v-SNARE homolog (S. cerevisiae)
chr1_+_84630645 12.14 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr17_+_65714018 12.12 ENST00000581106.1
ENST00000535137.1
nucleolar protein 11
chr1_-_235324772 12.10 ENST00000408888.3
RNA binding motif protein 34
chr7_-_6098770 11.97 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
eukaryotic translation initiation factor 2-alpha kinase 1
chr6_-_170862322 11.97 ENST00000262193.6
proteasome (prosome, macropain) subunit, beta type, 1
chr17_-_56065484 11.92 ENST00000581208.1
vascular endothelial zinc finger 1
chr11_+_57480046 11.69 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr10_+_75504105 11.60 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
SEC24 family member C
chr19_+_9938562 11.28 ENST00000586895.1
ENST00000358666.3
ENST00000590068.1
ENST00000593087.1
ubiquitin-like 5
chr14_+_24701819 11.16 ENST00000560139.1
ENST00000559910.1
guanosine monophosphate reductase 2
chr7_+_128379346 11.12 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
calumenin
chr13_+_25670268 10.95 ENST00000281589.3
poly(A) binding protein, cytoplasmic 3
chr14_+_24702073 10.93 ENST00000399440.2
guanosine monophosphate reductase 2
chr3_-_196669298 10.86 ENST00000411704.1
ENST00000452404.2
nuclear cap binding protein subunit 2, 20kDa
chr3_+_100428316 10.63 ENST00000479672.1
ENST00000476228.1
ENST00000463568.1
TRK-fused gene
chr20_-_34252847 10.53 ENST00000317619.3
ENST00000397446.1
ENST00000397445.1
ENST00000397443.1
ENST00000430570.1
ENST00000439806.2
ENST00000437340.1
ENST00000435161.1
ENST00000431148.1
copine I
RNA binding motif protein 12
chr19_+_7701985 10.38 ENST00000595950.1
ENST00000441779.2
ENST00000221283.5
ENST00000414284.2
syntaxin binding protein 2
chr17_-_74733404 10.27 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
serine/arginine-rich splicing factor 2
chr1_-_20987851 10.24 ENST00000464364.1
ENST00000602624.2
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr14_-_24701539 10.21 ENST00000534348.1
ENST00000524927.1
ENST00000250495.5
NEDD8-MDP1 readthrough
neural precursor cell expressed, developmentally down-regulated 8
chr7_+_77428149 10.17 ENST00000415251.2
ENST00000275575.7
putative homeodomain transcription factor 2
chr12_-_49961883 10.14 ENST00000553173.1
ENST00000550165.1
ENST00000546244.1
ENST00000343810.4
microspherule protein 1
chr3_+_100428268 10.08 ENST00000240851.4
TRK-fused gene
chr7_+_128379449 10.03 ENST00000479257.1
calumenin
chr2_-_128784846 9.95 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
Sin3A-associated protein, 130kDa
chr16_+_70557685 9.91 ENST00000302516.5
ENST00000566095.2
ENST00000577085.1
ENST00000567654.1
splicing factor 3b, subunit 3, 130kDa
chr18_+_21032781 9.87 ENST00000339486.3
RIO kinase 3
chr1_-_20987889 9.82 ENST00000415136.2
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr12_+_50135588 9.81 ENST00000423828.1
ENST00000550445.1
transmembrane BAX inhibitor motif containing 6
chr20_+_34129770 9.70 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
ERGIC and golgi 3
chr11_+_73498898 9.60 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
mitochondrial ribosomal protein L48
chr14_+_24701628 9.58 ENST00000355299.4
ENST00000559836.1
guanosine monophosphate reductase 2
chr2_+_96931834 9.47 ENST00000488633.1
cytosolic iron-sulfur protein assembly 1
chr8_-_101734170 9.38 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr19_+_41257084 9.15 ENST00000601393.1
small nuclear ribonucleoprotein polypeptide A
chr6_+_7541808 9.13 ENST00000379802.3
desmoplakin
chr15_+_44092784 9.12 ENST00000458412.1
huntingtin interacting protein K
chr8_-_101965146 9.08 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_-_10118573 8.88 ENST00000382452.2
ENST00000382451.2
WD repeat domain 1
chr22_-_41215291 8.80 ENST00000542412.1
ENST00000544408.1
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr3_+_100428188 8.80 ENST00000418917.2
ENST00000490574.1
TRK-fused gene
chr11_-_58345569 8.76 ENST00000528954.1
ENST00000528489.1
leupaxin
chr20_+_60962143 8.70 ENST00000343986.4
ribosomal protein S21
chr2_+_63816087 8.61 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
malate dehydrogenase 1, NAD (soluble)
chr5_-_177580855 8.45 ENST00000514354.1
ENST00000511078.1
NHP2 ribonucleoprotein
chr7_+_93551011 8.40 ENST00000248564.5
guanine nucleotide binding protein (G protein), gamma 11
chr17_-_47755436 8.37 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr3_-_196669371 8.36 ENST00000427641.2
ENST00000321256.5
nuclear cap binding protein subunit 2, 20kDa
chrX_-_131352152 8.15 ENST00000342983.2
RAP2C, member of RAS oncogene family
chr4_-_83812402 7.71 ENST00000395310.2
SEC31 homolog A (S. cerevisiae)
chr4_-_83295103 7.62 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr1_-_169337176 7.53 ENST00000472647.1
ENST00000367811.3
NME/NM23 family member 7
chr7_+_100273736 7.50 ENST00000412215.1
ENST00000393924.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr4_+_41992489 7.49 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr12_+_102513950 7.40 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chrX_-_152486108 7.35 ENST00000356661.5
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr12_+_50794592 7.13 ENST00000293618.8
ENST00000429001.3
ENST00000548174.1
ENST00000548697.1
ENST00000548993.1
ENST00000398473.2
ENST00000522085.1
ENST00000518444.1
ENST00000551886.1
La ribonucleoprotein domain family, member 4
chr8_-_77912431 7.11 ENST00000357039.4
ENST00000522527.1
peroxisomal biogenesis factor 2
chr5_-_177580933 6.97 ENST00000274606.3
NHP2 ribonucleoprotein
chr2_+_178077477 6.87 ENST00000411529.2
ENST00000435711.1
heterogeneous nuclear ribonucleoprotein A3
chr1_+_193028552 6.86 ENST00000400968.2
ENST00000432079.1
TROVE domain family, member 2
chr7_+_77428066 6.76 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr6_+_33257427 6.64 ENST00000463584.1
prefoldin subunit 6
chr1_-_20987982 6.55 ENST00000375048.3
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr1_+_24117627 6.50 ENST00000400061.1
lysophospholipase II
chr1_+_84630053 6.37 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr14_+_89029253 6.37 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
zinc finger CCCH-type containing 14
chr1_+_39456895 6.37 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chrX_+_123480194 6.31 ENST00000371139.4
SH2 domain containing 1A
chr4_-_83812248 6.24 ENST00000514326.1
ENST00000505434.1
ENST00000503058.1
ENST00000348405.4
ENST00000505984.1
ENST00000513858.1
ENST00000508479.1
ENST00000443462.2
ENST00000508502.1
ENST00000509142.1
ENST00000432794.1
ENST00000448323.1
ENST00000326950.5
ENST00000311785.7
SEC31 homolog A (S. cerevisiae)
chr7_+_114562172 6.16 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr15_-_65810042 6.15 ENST00000321147.6
dipeptidyl-peptidase 8
chr4_-_10118469 6.09 ENST00000499869.2
WD repeat domain 1
chr1_+_24117693 6.07 ENST00000374503.3
ENST00000374502.3
lysophospholipase II
chr3_-_139108475 6.06 ENST00000515006.1
ENST00000513274.1
ENST00000514508.1
ENST00000507777.1
ENST00000512153.1
ENST00000333188.5
coatomer protein complex, subunit beta 2 (beta prime)
chr15_-_65809991 5.93 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
dipeptidyl-peptidase 8
chr9_+_36190905 5.89 ENST00000345519.5
ENST00000470744.1
ENST00000242285.6
ENST00000466396.1
ENST00000396603.2
clathrin, light chain A
chr11_-_33183006 5.75 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr6_+_43484760 5.75 ENST00000372389.3
ENST00000372344.2
ENST00000304004.3
ENST00000423780.1
polymerase (RNA) I polypeptide C, 30kDa
chr9_+_36190853 5.52 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
clathrin, light chain A
chr19_-_12780211 5.52 ENST00000597961.1
ENST00000598732.1
ENST00000222190.5
Uncharacterized protein
WD repeat domain 83 opposite strand
chr6_-_116381918 5.43 ENST00000606080.1
fyn-related kinase
chrX_+_123480375 5.28 ENST00000360027.4
SH2 domain containing 1A
chr6_-_31560729 5.27 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
natural cytotoxicity triggering receptor 3
chr1_-_156698181 5.17 ENST00000313146.6
interferon stimulated exonuclease gene 20kDa-like 2
chr12_+_120972147 5.14 ENST00000325954.4
ENST00000542438.1
ring finger protein 10
chr11_+_111957497 5.13 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
succinate dehydrogenase complex, subunit D, integral membrane protein
chr16_-_28503357 5.12 ENST00000333496.9
ENST00000561505.1
ENST00000567963.1
ENST00000354630.5
ENST00000355477.5
ENST00000357076.5
ENST00000565688.1
ENST00000359984.7
ceroid-lipofuscinosis, neuronal 3
chr19_-_1650666 5.04 ENST00000588136.1
transcription factor 3
chr14_-_78083112 4.98 ENST00000216484.2
serine palmitoyltransferase, long chain base subunit 2
chr16_-_28503327 4.92 ENST00000535392.1
ENST00000395653.4
ceroid-lipofuscinosis, neuronal 3
chr12_+_54422142 4.92 ENST00000243108.4
homeobox C6
chr16_+_31044812 4.88 ENST00000313843.3
syntaxin 4
chr8_+_15397732 4.75 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
tumor suppressor candidate 3
chr11_-_111957451 4.71 ENST00000504148.2
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr16_-_28503080 4.58 ENST00000565316.1
ENST00000565778.1
ENST00000357857.9
ENST00000568558.1
ENST00000357806.7
ceroid-lipofuscinosis, neuronal 3
chr22_+_38201114 4.52 ENST00000340857.2
H1 histone family, member 0
chr8_-_56986768 4.49 ENST00000523936.1
ribosomal protein S20
chr6_-_42713792 4.28 ENST00000372876.1
tubulin folding cofactor C
chr20_-_42839378 4.26 ENST00000255174.2
oxidative stress responsive serine-rich 1
chr5_-_892648 4.26 ENST00000483173.1
ENST00000435709.2
bromodomain containing 9
chr20_-_62199427 4.12 ENST00000427522.2
helicase with zinc finger 2, transcriptional coactivator
chr7_-_38948774 4.11 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_-_91875109 4.09 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1, ankyrin repeat containing
chrX_+_123480421 4.05 ENST00000477673.2
SH2 domain containing 1A
chr5_-_114961858 4.02 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr12_-_123187890 4.02 ENST00000328880.5
hydroxycarboxylic acid receptor 2
chr12_+_50135351 3.90 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
transmembrane BAX inhibitor motif containing 6
chr7_+_6414128 3.49 ENST00000348035.4
ENST00000356142.4
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
chr1_-_111506562 3.20 ENST00000485275.2
ENST00000369763.4
ligand dependent nuclear receptor interacting factor 1
chr12_+_50135327 3.13 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
transmembrane BAX inhibitor motif containing 6
chr10_+_5726764 3.05 ENST00000328090.5
ENST00000496681.1
family with sequence similarity 208, member B
chrX_+_49091920 3.04 ENST00000376227.3
coiled-coil domain containing 22
chr14_+_60716159 2.98 ENST00000325658.3
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr20_-_33999766 2.94 ENST00000349714.5
ENST00000438533.1
ENST00000359226.2
ENST00000374384.2
ENST00000374377.5
ENST00000407996.2
ENST00000424405.1
ENST00000542501.1
ENST00000397554.1
ENST00000540457.1
ENST00000374380.2
ENST00000374385.5
ubiquinol-cytochrome c reductase complex assembly factor 1
chr14_+_89029366 2.92 ENST00000555799.1
ENST00000555755.1
ENST00000393514.5
zinc finger CCCH-type containing 14
chr14_+_22931924 2.87 ENST00000390477.2
T cell receptor delta constant
chr19_+_41256764 2.77 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
small nuclear ribonucleoprotein polypeptide A
chr14_+_89029336 2.68 ENST00000556945.1
ENST00000556158.1
ENST00000557607.1
zinc finger CCCH-type containing 14
chr2_+_162016804 2.48 ENST00000392749.2
ENST00000440506.1
TRAF family member-associated NFKB activator

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 27.4 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
8.6 25.8 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732) translation reinitiation(GO:0002188)
8.3 25.0 GO:0090149 mitochondrial membrane fission(GO:0090149)
7.9 31.7 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
7.6 22.7 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
7.6 30.2 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
6.6 32.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
5.2 20.9 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
5.1 15.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
4.5 13.6 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
4.2 12.7 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
4.2 66.7 GO:0021670 lateral ventricle development(GO:0021670)
3.9 19.7 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
3.8 15.0 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
3.7 18.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
3.7 18.5 GO:0097338 response to clozapine(GO:0097338)
3.7 14.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
3.4 20.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
3.4 10.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
3.1 15.4 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
3.0 12.0 GO:0006447 regulation of translational initiation by iron(GO:0006447)
2.9 31.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
2.8 16.8 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
2.8 35.9 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
2.7 46.0 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
2.6 7.7 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
2.5 7.6 GO:1901355 response to rapamycin(GO:1901355)
2.5 7.6 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
2.5 12.6 GO:0002084 protein depalmitoylation(GO:0002084)
2.3 35.1 GO:0090168 Golgi reassembly(GO:0090168)
2.3 6.8 GO:0043132 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132)
2.2 13.3 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.2 23.7 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
2.1 21.2 GO:0007144 female meiosis I(GO:0007144)
1.9 13.3 GO:1900045 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.8 14.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.8 17.7 GO:0009249 protein lipoylation(GO:0009249)
1.8 5.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
1.7 5.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.7 16.8 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
1.6 4.9 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
1.3 53.7 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
1.3 9.1 GO:0071896 protein localization to adherens junction(GO:0071896)
1.3 32.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.3 25.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.3 31.7 GO:0006144 purine nucleobase metabolic process(GO:0006144)
1.3 25.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.3 23.9 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
1.2 5.0 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
1.2 18.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.2 3.5 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
1.1 8.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
1.1 8.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
1.1 27.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
1.0 9.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.0 58.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.0 44.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.0 102.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.9 10.2 GO:0045116 protein neddylation(GO:0045116)
0.9 51.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.8 4.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.8 4.0 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.8 15.6 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.7 33.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.7 2.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.7 8.6 GO:0006108 malate metabolic process(GO:0006108)
0.7 4.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.7 15.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.7 4.0 GO:0071651 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.6 22.0 GO:0090383 phagosome acidification(GO:0090383)
0.6 5.1 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.6 5.0 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.6 17.3 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.6 11.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.6 62.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.6 12.9 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.6 9.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.5 10.3 GO:0033197 response to vitamin E(GO:0033197)
0.5 23.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.5 1.0 GO:2000644 regulation of receptor catabolic process(GO:2000644)
0.4 23.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.4 29.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.4 17.6 GO:0000281 mitotic cytokinesis(GO:0000281)
0.3 15.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.3 13.1 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.3 13.7 GO:0008380 RNA splicing(GO:0008380)
0.3 5.8 GO:0006379 mRNA cleavage(GO:0006379)
0.3 1.8 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.3 2.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 7.1 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.2 7.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 16.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 3.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 4.5 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 5.5 GO:2000352 negative regulation of endothelial cell apoptotic process(GO:2000352)
0.2 11.9 GO:0001885 endothelial cell development(GO:0001885)
0.2 5.8 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363)
0.2 6.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of viral transcription(GO:0050434)
0.1 4.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 9.6 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 6.1 GO:1901998 toxin transport(GO:1901998)
0.1 26.8 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.1 6.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 13.0 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1 5.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 7.5 GO:0006289 nucleotide-excision repair(GO:0006289)
0.1 21.1 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 1.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 4.7 GO:0007605 sensory perception of sound(GO:0007605)
0.0 11.5 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.7 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 3.6 GO:0051028 mRNA transport(GO:0051028)
0.0 2.2 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 0.1 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.7 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 1.5 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
12.0 35.9 GO:0034455 t-UTP complex(GO:0034455)
9.2 55.1 GO:0008537 proteasome activator complex(GO:0008537)
8.3 66.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
7.9 31.7 GO:0005846 nuclear cap binding complex(GO:0005846)
6.0 30.2 GO:0042643 actomyosin, actin portion(GO:0042643)
5.3 31.7 GO:1902560 GMP reductase complex(GO:1902560)
5.0 25.2 GO:0044530 supraspliceosomal complex(GO:0044530)
4.7 32.9 GO:0071203 WASH complex(GO:0071203)
4.7 41.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
4.5 13.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
4.5 54.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
4.1 12.3 GO:0097441 basilar dendrite(GO:0097441)
3.7 15.0 GO:0071001 U4/U6 snRNP(GO:0071001)
3.7 76.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
3.5 63.4 GO:0034709 methylosome(GO:0034709)
3.3 53.0 GO:0031080 nuclear pore outer ring(GO:0031080)
3.2 22.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
2.9 35.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.9 31.9 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
2.8 39.7 GO:0001673 male germ cell nucleus(GO:0001673)
2.6 15.4 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
2.5 17.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
2.4 73.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
2.3 43.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
2.1 10.3 GO:0035061 interchromatin granule(GO:0035061)
2.0 56.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.9 21.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.8 16.2 GO:0071439 clathrin complex(GO:0071439)
1.6 48.0 GO:0005680 anaphase-promoting complex(GO:0005680)
1.6 9.5 GO:0071817 MMXD complex(GO:0071817)
1.4 42.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
1.3 32.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.3 5.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.3 7.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.2 5.0 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
1.2 15.6 GO:0030127 COPII vesicle coat(GO:0030127)
1.2 10.4 GO:0044194 cytolytic granule(GO:0044194)
1.0 16.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.0 17.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.9 18.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.9 28.8 GO:0030057 desmosome(GO:0030057)
0.8 27.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.7 12.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.7 7.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.7 22.0 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.7 60.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.7 6.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.7 4.6 GO:0016272 prefoldin complex(GO:0016272)
0.6 4.7 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.6 31.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.6 9.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.6 41.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 16.8 GO:1902555 endoribonuclease complex(GO:1902555)
0.5 11.9 GO:0005685 U1 snRNP(GO:0005685)
0.5 44.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 4.9 GO:0035749 myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)
0.4 18.0 GO:1904115 axon cytoplasm(GO:1904115)
0.4 23.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 5.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 1.8 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.2 38.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 9.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 28.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 14.6 GO:0005795 Golgi stack(GO:0005795)
0.2 10.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 8.8 GO:0002102 podosome(GO:0002102)
0.2 1.0 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 4.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 25.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 8.2 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 20.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 4.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 20.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 68.2 GO:0070062 extracellular exosome(GO:0070062)
0.0 5.8 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
7.9 55.1 GO:0061133 endopeptidase activator activity(GO:0061133)
5.7 22.7 GO:0016748 succinyltransferase activity(GO:0016748)
5.4 54.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
5.3 31.7 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
5.1 15.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
4.0 12.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
4.0 31.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
3.5 17.3 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
3.4 16.8 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
3.3 66.7 GO:0070628 proteasome binding(GO:0070628)
3.3 19.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
3.2 12.7 GO:0031871 proteinase activated receptor binding(GO:0031871)
2.8 16.8 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
2.6 15.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
2.5 32.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
2.3 6.8 GO:0015230 FAD transmembrane transporter activity(GO:0015230) coenzyme transporter activity(GO:0051185)
2.2 13.3 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.1 10.4 GO:0030348 syntaxin-3 binding(GO:0030348)
2.0 20.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
2.0 10.1 GO:0034046 poly(G) binding(GO:0034046)
1.9 23.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
1.9 42.3 GO:0042609 CD4 receptor binding(GO:0042609)
1.7 8.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.7 5.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.7 11.9 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.7 5.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
1.6 12.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.6 47.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.5 7.7 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.4 15.7 GO:0016018 cyclosporin A binding(GO:0016018)
1.3 13.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.3 31.6 GO:0008327 methyl-CpG binding(GO:0008327)
1.3 33.9 GO:0008143 poly(A) binding(GO:0008143)
1.3 13.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.3 17.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
1.2 4.9 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.2 51.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.2 18.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
1.1 6.9 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
1.1 17.7 GO:0004526 ribonuclease P activity(GO:0004526)
1.0 9.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
1.0 5.0 GO:0070644 vitamin D response element binding(GO:0070644)
1.0 6.9 GO:0030620 U2 snRNA binding(GO:0030620)
1.0 13.4 GO:0008097 5S rRNA binding(GO:0008097)
1.0 11.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.9 11.3 GO:0031386 protein tag(GO:0031386)
0.8 12.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.8 55.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 12.1 GO:0003680 AT DNA binding(GO:0003680)
0.7 19.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.7 14.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 57.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.6 7.6 GO:0089720 caspase binding(GO:0089720)
0.6 14.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 3.5 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.5 24.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.5 21.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 107.0 GO:0051015 actin filament binding(GO:0051015)
0.4 6.2 GO:0030957 Tat protein binding(GO:0030957)
0.4 12.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 7.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 5.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 20.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 10.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 43.1 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 7.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 35.1 GO:0044325 ion channel binding(GO:0044325)
0.2 21.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 3.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 4.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 21.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 2.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 17.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 5.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 8.2 GO:0019003 GDP binding(GO:0019003)
0.1 14.2 GO:0051082 unfolded protein binding(GO:0051082)
0.1 3.2 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 4.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 7.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 5.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 16.0 GO:0030674 protein binding, bridging(GO:0030674)
0.1 4.3 GO:0051087 chaperone binding(GO:0051087)
0.1 4.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.0 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 7.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 1.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 6.7 GO:0045296 cadherin binding(GO:0045296)
0.0 11.2 GO:0019900 kinase binding(GO:0019900)
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 23.2 PID S1P S1P4 PATHWAY S1P4 pathway
1.0 53.7 PID IL3 PATHWAY IL3-mediated signaling events
0.6 29.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.6 36.4 PID BMP PATHWAY BMP receptor signaling
0.5 17.6 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.5 27.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.5 11.4 PID ARF 3PATHWAY Arf1 pathway
0.4 10.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.4 18.5 PID BARD1 PATHWAY BARD1 signaling events
0.2 14.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 13.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 13.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 15.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 32.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 5.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 10.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 48.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
2.4 16.8 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
2.1 87.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
1.6 39.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
1.5 102.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
1.4 53.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
1.4 35.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
1.3 31.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.3 95.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.2 27.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
1.2 27.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.9 26.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.8 20.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.8 25.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.8 17.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.8 18.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.8 22.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.7 44.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.7 84.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.7 18.0 REACTOME KINESINS Genes involved in Kinesins
0.6 11.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.6 36.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.6 6.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.5 9.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5 71.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 15.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.3 5.8 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.3 4.0 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.3 27.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.3 4.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 3.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 7.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 8.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 4.3