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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPI1
Z-value: 3.04
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Transcription factors associated with SPI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPI1 | hg19_v2_chr11_-_47400078_47400127, hg19_v2_chr11_-_47399942_47399961 | 0.59 | 1.3e-21 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPI1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 236.6 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 1.7 | 210.8 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 24.7 | 197.8 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 1.1 | 153.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 38.3 | 153.2 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 7.8 | 147.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 8.9 | 143.1 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 28.3 | 141.5 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539) |
| 6.1 | 127.9 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 10.4 | 124.3 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 548.0 | GO:0005829 | cytosol(GO:0005829) |
| 0.9 | 274.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 21.5 | 236.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 4.0 | 216.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 2.2 | 167.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 8.2 | 164.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 19.4 | 155.2 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.3 | 145.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.5 | 132.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 9.0 | 125.9 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 241.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 7.8 | 211.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.9 | 211.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.6 | 187.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 15.3 | 153.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.7 | 148.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 8.1 | 146.4 | GO:0005522 | profilin binding(GO:0005522) |
| 2.3 | 142.9 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 13.3 | 133.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 2.9 | 132.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 684.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 4.7 | 407.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 4.5 | 316.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 6.1 | 280.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 4.3 | 225.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.4 | 211.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 2.6 | 186.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.7 | 163.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 2.1 | 150.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 2.5 | 73.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.9 | 429.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.2 | 368.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 4.3 | 349.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.2 | 315.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 5.4 | 310.9 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 5.8 | 253.3 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.8 | 124.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.4 | 103.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.0 | 101.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 16.4 | 98.2 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |