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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPIB

Z-value: 2.77

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Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
SPIB
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.392.1e-09Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_15114492 143.03 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_160681593 122.48 ENST00000368045.3
ENST00000368046.3
CD48
CD48 molecule
chr12_-_15114603 91.99 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_31230650 90.05 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr16_+_30194916 88.03 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
CORO1A
coronin, actin binding protein, 1A
chr3_-_121379739 82.42 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_+_169064245 75.38 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr13_+_31309645 67.19 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_+_74188309 65.58 ENST00000289473.4
ENST00000433458.1
NCF1
neutrophil cytosolic factor 1
chr22_+_37309662 60.36 ENST00000403662.3
ENST00000262825.5
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chrX_-_47489244 56.72 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP
complement factor properdin
chr17_-_29641104 54.46 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr1_+_209941827 53.50 ENST00000367023.1
TRAF3IP3
TRAF3 interacting protein 3
chr21_-_46340884 51.10 ENST00000302347.5
ENST00000517819.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_68592305 50.58 ENST00000234313.7
PLEK
pleckstrin
chr21_-_46340770 49.91 ENST00000397854.3
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_143886877 49.82 ENST00000295095.6
ARHGAP15
Rho GTPase activating protein 15
chr6_+_31582961 49.20 ENST00000376059.3
ENST00000337917.7
AIF1
allograft inflammatory factor 1
chr22_-_37640277 47.13 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_+_26644441 46.98 ENST00000374213.2
CD52
CD52 molecule
chr11_-_64512803 45.05 ENST00000377489.1
ENST00000354024.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_+_54891495 43.91 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr19_+_48828788 43.84 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
EMP3
epithelial membrane protein 3
chr20_-_62710832 43.76 ENST00000395042.1
RGS19
regulator of G-protein signaling 19
chr19_+_49838653 43.25 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr6_+_31554779 41.35 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr12_+_25205666 40.57 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr20_-_62711259 40.56 ENST00000332298.5
RGS19
regulator of G-protein signaling 19
chr11_-_64512273 40.06 ENST00000377497.3
ENST00000377487.1
ENST00000430645.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_48828582 40.01 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr10_-_121302195 39.68 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr19_-_10446449 39.56 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr6_-_24936170 39.48 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr17_-_29641084 39.27 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr11_-_3859089 38.94 ENST00000396979.1
RHOG
ras homolog family member G
chr2_-_231084820 38.27 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr1_-_153919128 37.99 ENST00000361217.4
DENND4B
DENN/MADD domain containing 4B
chr12_+_7060432 36.86 ENST00000318974.9
ENST00000456013.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_8276433 36.39 ENST00000345999.3
ENST00000352620.3
ENST00000360500.3
CLEC4A
C-type lectin domain family 4, member A
chr7_-_36764004 36.19 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr11_+_65408273 35.74 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr22_-_37640456 35.56 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_-_36764142 34.98 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr10_+_11207438 34.27 ENST00000609692.1
ENST00000354897.3
CELF2
CUGBP, Elav-like family member 2
chr4_+_103423055 34.01 ENST00000505458.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr12_+_25205568 33.97 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr6_+_31553901 32.32 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr7_+_139528952 32.16 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr20_+_30640004 32.12 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
HCK
hemopoietic cell kinase
chr3_-_151047327 32.08 ENST00000325602.5
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr6_+_31553978 30.48 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr2_-_231084659 30.36 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr12_+_25205446 30.36 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr12_+_8276224 30.21 ENST00000229332.5
CLEC4A
C-type lectin domain family 4, member A
chr14_-_23288930 30.16 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_231084617 29.93 ENST00000409815.2
SP110
SP110 nuclear body protein
chr7_+_139529040 29.64 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr11_-_64512469 29.52 ENST00000377485.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_+_161475208 29.39 ENST00000367972.4
ENST00000271450.6
FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr19_+_6772710 28.86 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
VAV1
vav 1 guanine nucleotide exchange factor
chr12_+_8276495 28.31 ENST00000546339.1
CLEC4A
C-type lectin domain family 4, member A
chr17_+_7462103 27.74 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr6_-_133079022 27.71 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr17_-_73389854 26.85 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
GRB2
growth factor receptor-bound protein 2
chr11_-_33891362 26.30 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_31554826 26.27 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr8_-_101734308 25.85 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr7_+_50344289 25.45 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr19_+_42381337 25.42 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr8_-_101734170 25.35 ENST00000522387.1
ENST00000518196.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_+_233925064 25.28 ENST00000359570.5
ENST00000538935.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr1_+_161632937 24.85 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr9_+_93564191 24.73 ENST00000375747.1
SYK
spleen tyrosine kinase
chr19_-_13213662 24.72 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr17_-_73389737 24.62 ENST00000392563.1
GRB2
growth factor receptor-bound protein 2
chr9_+_93564039 24.42 ENST00000375754.4
ENST00000375751.4
SYK
spleen tyrosine kinase
chrX_+_11777671 24.40 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr8_+_74903580 24.03 ENST00000284818.2
ENST00000518893.1
LY96
lymphocyte antigen 96
chr14_+_88471468 23.91 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr10_+_11206925 23.83 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr5_-_140013275 23.72 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chr11_-_47399942 23.35 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_-_7656357 22.76 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr17_+_7461781 22.36 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_+_16926441 22.34 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr3_+_121774202 22.07 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr15_+_77287426 21.77 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr17_+_7461849 21.43 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_-_16555150 21.13 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr11_-_47400078 20.96 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_+_54398463 20.88 ENST00000274306.6
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr15_+_91427642 20.64 ENST00000328850.3
ENST00000414248.2
FES
feline sarcoma oncogene
chr19_-_10230562 20.39 ENST00000587146.1
ENST00000588709.1
ENST00000253108.4
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr14_+_102228123 20.37 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chrX_+_24072833 20.07 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr1_+_15736359 20.05 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr9_+_93589734 19.49 ENST00000375746.1
SYK
spleen tyrosine kinase
chr3_+_46395219 19.23 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr1_+_149754227 19.12 ENST00000444948.1
ENST00000369168.4
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr15_-_65809991 18.99 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
DPP8
dipeptidyl-peptidase 8
chr15_-_65810042 18.70 ENST00000321147.6
DPP8
dipeptidyl-peptidase 8
chr1_+_90287480 18.47 ENST00000394593.3
LRRC8D
leucine rich repeat containing 8 family, member D
chr2_+_162087577 18.42 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr22_-_37880543 18.40 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_98656693 18.08 ENST00000519934.1
MTDH
metadherin
chr1_-_159893507 17.88 ENST00000368096.1
TAGLN2
transgelin 2
chr2_-_74405929 17.82 ENST00000396049.4
MOB1A
MOB kinase activator 1A
chr3_-_52273098 17.72 ENST00000499914.2
ENST00000305533.5
ENST00000597542.1
TWF2
TLR9
twinfilin actin-binding protein 2
toll-like receptor 9
chr15_-_65809581 17.39 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chrX_+_11776701 17.34 ENST00000476743.1
ENST00000421368.2
ENST00000398527.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr17_+_7462031 17.15 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr19_-_18391708 17.14 ENST00000600972.1
JUND
jun D proto-oncogene
chr20_+_2821340 17.06 ENST00000380445.3
ENST00000380469.3
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr10_-_98031310 16.85 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr1_-_120935894 16.69 ENST00000369383.4
ENST00000369384.4
FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr19_-_10230540 16.48 ENST00000589454.1
EIF3G
eukaryotic translation initiation factor 3, subunit G
chrX_+_109246285 16.25 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164
transmembrane protein 164
chr6_+_15246501 16.05 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chr6_+_31554456 15.97 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr11_-_47400062 15.79 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_31554612 15.74 ENST00000211921.7
LST1
leukocyte specific transcript 1
chr17_+_7461580 15.70 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chrX_+_123094672 15.47 ENST00000354548.5
ENST00000458700.1
STAG2
stromal antigen 2
chr11_+_46366918 15.28 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr3_+_121796697 15.24 ENST00000482356.1
ENST00000393627.2
CD86
CD86 molecule
chr1_+_44440575 15.24 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_-_47813940 15.20 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC1
CXXC finger protein 1
chr6_-_132834184 15.02 ENST00000367941.2
ENST00000367937.4
STX7
syntaxin 7
chr17_+_65373531 14.86 ENST00000580974.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_-_64889529 14.85 ENST00000531743.1
ENST00000527548.1
ENST00000526555.1
ENST00000279259.3
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr11_-_60719213 14.16 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_91427691 14.01 ENST00000559355.1
ENST00000394302.1
FES
feline sarcoma oncogene
chr19_+_3136115 13.98 ENST00000262958.3
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr19_-_54746600 13.93 ENST00000245621.5
ENST00000270464.5
ENST00000419410.2
ENST00000391735.3
ENST00000396365.2
ENST00000440558.2
ENST00000407860.2
LILRA6
LILRB3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr10_-_98031265 13.88 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr11_-_64889252 13.77 ENST00000525297.1
ENST00000529259.1
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chrX_-_74376108 13.74 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr17_+_7461613 13.69 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr18_-_47018769 13.40 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr5_+_112312416 13.38 ENST00000389063.2
DCP2
decapping mRNA 2
chr5_+_35856951 13.36 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr19_+_2476116 13.12 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr1_+_39456895 13.12 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr17_+_65374075 12.81 ENST00000581322.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_-_64546202 12.58 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
SF1
splicing factor 1
chr6_-_41254403 12.49 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr2_+_113931513 12.48 ENST00000245796.6
ENST00000441564.3
PSD4
pleckstrin and Sec7 domain containing 4
chr12_-_9102549 12.46 ENST00000000412.3
M6PR
mannose-6-phosphate receptor (cation dependent)
chr2_+_202125219 12.28 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr11_-_64889649 12.10 ENST00000434372.2
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr1_+_159272111 12.01 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr2_+_127413677 11.99 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr9_+_82186872 11.89 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_+_114133773 11.80 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_-_65028817 11.70 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr1_+_32757668 11.35 ENST00000373548.3
HDAC1
histone deacetylase 1
chr7_-_37488834 11.26 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr11_-_67120974 11.13 ENST00000539074.1
ENST00000312419.3
POLD4
polymerase (DNA-directed), delta 4, accessory subunit
chr2_+_127413704 10.95 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr15_+_59279851 10.93 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr9_-_35618364 10.84 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72
CD72 molecule
chr9_+_127624387 10.79 ENST00000353214.2
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr1_+_40505891 10.65 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_30960375 10.59 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI3
ORAI calcium release-activated calcium modulator 3
chrX_+_11776410 10.52 ENST00000361672.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr19_+_51728316 10.41 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr20_-_33732952 10.24 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr19_-_54726850 10.18 ENST00000245620.9
ENST00000346401.6
ENST00000424807.1
ENST00000445347.1
LILRB3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr2_+_3622795 10.18 ENST00000304921.5
RPS7
ribosomal protein S7
chr14_+_102276132 10.14 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_102276209 10.05 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr22_-_32026810 9.86 ENST00000266095.5
ENST00000397500.1
PISD
phosphatidylserine decarboxylase
chr1_-_47069955 9.74 ENST00000341183.5
ENST00000496619.1
MKNK1
MAP kinase interacting serine/threonine kinase 1
chr14_+_102276192 9.64 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr4_+_68424434 9.60 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr2_-_161350305 9.59 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr2_-_208031943 9.46 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_-_3786253 9.44 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chrX_+_123094369 9.40 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr5_-_39270725 9.34 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr4_+_113568207 9.25 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr17_-_8868991 9.22 ENST00000447110.1
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr21_+_34638656 9.05 ENST00000290200.2
IL10RB
interleukin 10 receptor, beta
chr12_-_8218997 9.05 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr17_-_61819229 9.00 ENST00000447001.3
ENST00000392950.4
STRADA
STE20-related kinase adaptor alpha
chr12_-_51785182 8.96 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
GALNT6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr14_-_74417096 8.95 ENST00000286544.3
FAM161B
family with sequence similarity 161, member B
chr7_-_102213030 8.95 ENST00000511313.1
ENST00000513438.1
ENST00000513506.1
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr5_-_66492562 8.84 ENST00000256447.4
CD180
CD180 molecule
chr1_+_41174988 8.80 ENST00000372652.1
NFYC
nuclear transcription factor Y, gamma
chr1_+_14075865 8.75 ENST00000413440.1
PRDM2
PR domain containing 2, with ZNF domain
chr1_+_161551101 8.75 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr18_-_32924372 8.40 ENST00000261332.6
ENST00000399061.3
ZNF24
zinc finger protein 24
chr19_+_14551066 8.31 ENST00000342216.4
PKN1
protein kinase N1
chr2_+_3622932 8.14 ENST00000406376.1
RPS7
ribosomal protein S7
chr2_-_242089677 8.10 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr1_-_47069886 7.98 ENST00000371946.4
ENST00000371945.4
ENST00000428112.2
ENST00000529170.1
MKNK1
MAP kinase interacting serine/threonine kinase 1
chr17_+_75137034 7.80 ENST00000436233.4
ENST00000443798.4
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr11_+_75110530 7.78 ENST00000531188.1
ENST00000530164.1
ENST00000422465.2
ENST00000278572.6
ENST00000534440.1
ENST00000527446.1
ENST00000526608.1
ENST00000527273.1
ENST00000524851.1
RPS3
ribosomal protein S3
chr10_+_104503727 7.68 ENST00000448841.1
WBP1L
WW domain binding protein 1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
58.8 235.0 GO:0071461 cellular response to redox state(GO:0071461)
22.0 88.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
20.2 60.7 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
20.2 80.6 GO:0032672 regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
15.0 60.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
15.0 45.0 GO:0042097 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
14.6 43.9 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588)
13.2 52.8 GO:0002434 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
10.7 32.1 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
9.8 49.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
9.8 118.1 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
9.4 75.4 GO:0044351 macropinocytosis(GO:0044351)
9.2 36.9 GO:0033277 abortive mitotic cell cycle(GO:0033277)
8.4 50.6 GO:0070560 protein secretion by platelet(GO:0070560)
8.4 25.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
7.6 128.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
7.5 82.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
7.5 67.2 GO:2001300 lipoxin metabolic process(GO:2001300)
7.4 22.3 GO:0001923 B-1 B cell differentiation(GO:0001923)
7.1 35.7 GO:0042631 cellular response to water deprivation(GO:0042631)
6.8 34.0 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
6.2 36.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
5.9 23.7 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
5.7 51.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
5.7 56.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
5.0 30.2 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
4.9 98.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
4.6 36.9 GO:0075525 viral translational termination-reinitiation(GO:0075525)
4.4 17.7 GO:0032661 regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
4.2 20.8 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
4.1 24.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
4.1 12.3 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
3.9 66.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
3.8 76.3 GO:0032060 bleb assembly(GO:0032060)
3.7 32.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
3.4 61.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.2 25.8 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
3.2 54.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
3.1 12.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
3.1 18.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.0 21.1 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
3.0 12.0 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
3.0 53.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.8 27.7 GO:0015939 pantothenate metabolic process(GO:0015939)
2.5 12.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
2.5 24.7 GO:0001955 blood vessel maturation(GO:0001955)
2.4 17.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
2.4 28.7 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
2.3 11.4 GO:0061198 fungiform papilla formation(GO:0061198)
2.2 43.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.9 13.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.8 59.0 GO:0043984 histone H4-K16 acetylation(GO:0043984)
1.8 58.1 GO:0006376 mRNA splice site selection(GO:0006376)
1.7 5.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.7 13.4 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
1.7 15.0 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
1.6 164.2 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.6 1.6 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
1.6 16.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.5 18.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.5 124.8 GO:0071277 cellular response to calcium ion(GO:0071277)
1.4 50.2 GO:0016601 Rac protein signal transduction(GO:0016601)
1.4 5.7 GO:0018094 protein polyglycylation(GO:0018094)
1.4 7.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
1.4 10.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.3 8.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
1.3 14.6 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
1.3 5.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
1.3 3.9 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
1.2 13.7 GO:0015886 heme transport(GO:0015886)
1.2 5.0 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
1.2 12.5 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.1 6.9 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
1.1 33.1 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.1 5.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.1 26.3 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
1.1 10.6 GO:0002115 store-operated calcium entry(GO:0002115)
1.1 22.1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
1.1 8.4 GO:0042552 myelination(GO:0042552)
1.0 27.7 GO:0045730 respiratory burst(GO:0045730)
1.0 4.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
1.0 3.9 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.0 6.7 GO:0031642 negative regulation of myelination(GO:0031642)
1.0 23.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.9 108.2 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.9 9.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.8 108.2 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.8 13.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.7 17.9 GO:0030855 epithelial cell differentiation(GO:0030855)
0.7 4.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.7 7.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.7 2.9 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.7 5.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.7 4.3 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.7 19.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.7 8.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.7 110.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.6 15.3 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.6 12.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 11.7 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.6 57.8 GO:0030183 B cell differentiation(GO:0030183)
0.6 78.1 GO:0007338 single fertilization(GO:0007338)
0.6 15.2 GO:0007035 vacuolar acidification(GO:0007035)
0.5 3.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.5 5.9 GO:0090168 Golgi reassembly(GO:0090168)
0.5 23.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 1.5 GO:2000397 ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.5 18.1 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.5 3.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.4 27.7 GO:0015914 phospholipid transport(GO:0015914)
0.4 4.7 GO:0051168 nuclear export(GO:0051168)
0.4 11.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.4 13.9 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.4 15.6 GO:0035329 hippo signaling(GO:0035329)
0.4 5.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.4 4.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 2.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.4 4.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 2.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 17.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.3 11.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.3 11.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 18.2 GO:0006953 acute-phase response(GO:0006953)
0.3 4.4 GO:0015671 oxygen transport(GO:0015671)
0.3 25.5 GO:0030218 erythrocyte differentiation(GO:0030218)
0.3 10.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.3 39.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.3 1.6 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.3 6.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 15.8 GO:0006611 protein export from nucleus(GO:0006611)
0.2 5.1 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.2 4.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 8.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 9.0 GO:0016266 O-glycan processing(GO:0016266)
0.2 24.8 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.2 30.2 GO:0045047 protein targeting to ER(GO:0045047)
0.2 2.7 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.2 3.4 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.2 6.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 8.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 10.4 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2 96.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 18.5 GO:0044070 regulation of anion transport(GO:0044070)
0.1 2.9 GO:0030225 macrophage differentiation(GO:0030225)
0.1 4.0 GO:0006308 DNA catabolic process(GO:0006308)
0.1 0.5 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 4.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 5.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 5.1 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 14.1 GO:0006413 translational initiation(GO:0006413)
0.1 3.1 GO:0007566 embryo implantation(GO:0007566)
0.1 1.5 GO:0003094 glomerular filtration(GO:0003094)
0.1 40.3 GO:0006954 inflammatory response(GO:0006954)
0.1 41.2 GO:0016032 viral process(GO:0016032)
0.1 4.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 3.4 GO:0006468 protein phosphorylation(GO:0006468)
0.0 6.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 3.1 GO:0015992 proton transport(GO:0015992)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.3 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 2.5 GO:0002250 adaptive immune response(GO:0002250)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
20.2 101.0 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
13.4 94.1 GO:0019815 B cell receptor complex(GO:0019815)
8.5 42.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
8.4 59.0 GO:0072487 MSL complex(GO:0072487)
8.2 65.6 GO:0032010 phagolysosome(GO:0032010)
7.8 7.8 GO:0071159 NF-kappaB complex(GO:0071159)
7.5 45.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
6.9 137.2 GO:0001891 phagocytic cup(GO:0001891)
4.7 14.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
3.5 17.7 GO:0032009 early phagosome(GO:0032009)
3.4 36.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
3.1 43.9 GO:0031209 SCAR complex(GO:0031209)
2.8 34.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.8 11.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.7 51.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
2.6 18.1 GO:0046581 intercellular canaliculus(GO:0046581)
2.1 17.1 GO:0035976 AP1 complex(GO:0035976)
1.8 98.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.8 25.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.8 10.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.7 15.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.5 36.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
1.4 125.8 GO:0035580 specific granule lumen(GO:0035580)
1.4 75.2 GO:0001772 immunological synapse(GO:0001772)
1.3 3.9 GO:0034657 GID complex(GO:0034657)
1.3 3.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.2 17.1 GO:0030897 HOPS complex(GO:0030897)
1.2 21.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.2 15.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.2 4.6 GO:0032044 DSIF complex(GO:0032044)
1.2 163.6 GO:0032587 ruffle membrane(GO:0032587)
1.1 37.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.1 78.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.1 4.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
1.1 74.8 GO:0035577 azurophil granule membrane(GO:0035577)
1.0 5.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
1.0 154.6 GO:0031225 anchored component of membrane(GO:0031225)
1.0 5.9 GO:0008537 proteasome activator complex(GO:0008537)
0.9 11.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.9 6.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.9 3.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.9 16.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.8 13.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.8 25.8 GO:0030686 90S preribosome(GO:0030686)
0.8 8.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 5.1 GO:0005787 signal peptidase complex(GO:0005787)
0.7 5.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 77.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.7 12.3 GO:0097342 ripoptosome(GO:0097342)
0.6 11.4 GO:0016580 Sin3 complex(GO:0016580)
0.6 16.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 33.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.5 18.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 9.4 GO:0030904 retromer complex(GO:0030904)
0.4 5.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 115.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 7.1 GO:0031932 TORC2 complex(GO:0031932)
0.4 3.4 GO:0005955 calcineurin complex(GO:0005955)
0.4 60.7 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.3 82.7 GO:0030667 secretory granule membrane(GO:0030667)
0.3 80.3 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 8.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 70.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 32.8 GO:0043679 axon terminus(GO:0043679)
0.3 2.7 GO:0000815 ESCRT III complex(GO:0000815)
0.3 7.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 5.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 22.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 103.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 60.3 GO:0000790 nuclear chromatin(GO:0000790)
0.2 72.7 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 19.2 GO:0043204 perikaryon(GO:0043204)
0.2 3.9 GO:0097225 sperm midpiece(GO:0097225)
0.2 1.5 GO:0000813 ESCRT I complex(GO:0000813)
0.2 2.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 2.5 GO:0000974 Prp19 complex(GO:0000974)
0.2 15.4 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.2 110.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 17.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 213.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.9 GO:0005682 U5 snRNP(GO:0005682)
0.1 10.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 17.5 GO:0005681 spliceosomal complex(GO:0005681)
0.1 22.4 GO:0005911 cell-cell junction(GO:0005911)
0.1 14.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 28.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 3.5 GO:0005882 intermediate filament(GO:0005882)
0.1 4.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.4 GO:0016605 PML body(GO:0016605)
0.1 121.2 GO:0070062 extracellular exosome(GO:0070062)
0.0 82.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
23.5 235.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
22.4 67.2 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
20.6 61.8 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
20.2 60.7 GO:0004914 interleukin-5 receptor activity(GO:0004914)
14.4 101.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
11.0 32.9 GO:0045322 unmethylated CpG binding(GO:0045322)
8.4 25.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
8.4 33.6 GO:0019770 IgG receptor activity(GO:0019770)
7.9 23.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
7.2 28.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
6.6 65.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
6.4 19.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
6.4 114.6 GO:0019992 diacylglycerol binding(GO:0019992)
5.8 75.4 GO:0042608 T cell receptor binding(GO:0042608)
5.5 27.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
5.5 88.0 GO:0032036 myosin heavy chain binding(GO:0032036)
5.5 60.1 GO:0051525 NFAT protein binding(GO:0051525)
4.7 14.2 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
4.6 18.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
4.5 13.4 GO:0004917 interleukin-7 receptor activity(GO:0004917)
4.0 48.5 GO:0019864 IgG binding(GO:0019864)
4.0 68.6 GO:0035325 receptor signaling protein tyrosine kinase activity(GO:0004716) Toll-like receptor binding(GO:0035325)
3.8 116.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
3.7 51.5 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
3.7 40.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
3.6 10.9 GO:0032184 SUMO polymer binding(GO:0032184)
3.3 9.9 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
3.1 27.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
3.1 9.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
3.1 18.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.0 51.2 GO:0008494 translation activator activity(GO:0008494)
2.7 30.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
2.7 27.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
2.7 130.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.6 43.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
2.5 55.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.4 14.6 GO:0039552 RIG-I binding(GO:0039552)
2.4 19.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
2.3 100.4 GO:0001784 phosphotyrosine binding(GO:0001784)
2.3 50.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.8 18.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
1.7 6.7 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.5 70.7 GO:0036002 pre-mRNA binding(GO:0036002)
1.5 15.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.5 13.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.5 8.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.4 5.7 GO:0070735 protein-glycine ligase activity(GO:0070735)
1.4 8.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.4 13.7 GO:0015232 heme transporter activity(GO:0015232)
1.3 9.0 GO:0004920 interleukin-10 receptor activity(GO:0004920)
1.1 6.9 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
1.0 7.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.9 17.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 10.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.9 4.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.9 15.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.8 5.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.8 23.5 GO:0032452 histone demethylase activity(GO:0032452)
0.8 5.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.8 59.0 GO:0035064 methylated histone binding(GO:0035064)
0.8 10.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.8 11.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.8 20.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.8 3.8 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.8 15.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.7 134.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.7 19.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.7 35.6 GO:0015026 coreceptor activity(GO:0015026)
0.7 5.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.7 50.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 10.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.7 15.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.7 34.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.6 9.0 GO:0004875 complement receptor activity(GO:0004875)
0.6 10.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 34.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 24.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.6 9.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 58.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.6 18.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.6 17.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.6 5.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 9.8 GO:0005537 mannose binding(GO:0005537)
0.5 5.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 12.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 2.9 GO:0042296 ISG15 transferase activity(GO:0042296)
0.4 14.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.4 22.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 2.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 11.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 117.1 GO:0003924 GTPase activity(GO:0003924)
0.4 10.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.4 7.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.4 3.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 4.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 37.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 1.5 GO:0046790 virion binding(GO:0046790)
0.3 15.3 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
0.3 2.9 GO:0051434 BH3 domain binding(GO:0051434)
0.3 68.6 GO:0030246 carbohydrate binding(GO:0030246)
0.2 12.8 GO:0019843 rRNA binding(GO:0019843)
0.2 21.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 6.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 48.0 GO:0051015 actin filament binding(GO:0051015)
0.2 60.4 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 8.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.9 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.1 8.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 5.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 8.3 GO:0097110 scaffold protein binding(GO:0097110)
0.1 5.5 GO:0043022 ribosome binding(GO:0043022)
0.1 5.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 139.9 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1 0.4 GO:0001016 RNA polymerase III regulatory region DNA binding(GO:0001016)
0.1 9.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 29.5 GO:0045296 cadherin binding(GO:0045296)
0.1 4.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 3.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 3.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 11.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 5.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 6.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 10.3 GO:0004871 signal transducer activity(GO:0004871)
0.0 1.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 4.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 112.2 PID IL5 PATHWAY IL5-mediated signaling events
3.7 128.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
3.5 187.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
3.3 170.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.1 235.0 PID RHOA REG PATHWAY Regulation of RhoA activity
2.8 114.6 PID RAS PATHWAY Regulation of Ras family activation
2.6 186.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
2.0 142.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
1.8 141.9 PID IL4 2PATHWAY IL4-mediated signaling events
1.6 42.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.0 45.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
1.0 63.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.8 11.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.8 36.3 PID BCR 5PATHWAY BCR signaling pathway
0.7 24.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.6 8.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.6 27.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.6 15.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.6 54.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.6 34.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.5 10.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 24.9 PID PLK1 PATHWAY PLK1 signaling events
0.4 5.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 53.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 9.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3 110.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 4.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 2.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 11.1 PID LKB1 PATHWAY LKB1 signaling events
0.2 10.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 9.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 16.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 8.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 211.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
5.5 33.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
3.6 42.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
3.6 74.7 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
3.4 156.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
3.1 36.9 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
2.9 109.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
2.5 271.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
2.5 60.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
2.3 43.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
2.2 86.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
2.1 33.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
1.9 19.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.8 181.2 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.7 13.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.6 267.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.6 17.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
1.4 17.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.3 14.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.2 71.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
1.2 135.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.1 21.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.1 25.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.1 88.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.0 12.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.0 61.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.9 11.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.6 15.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.6 17.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.5 9.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.5 15.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.5 10.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.4 5.5 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.4 11.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.4 10.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 9.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 5.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 4.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 6.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 10.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 24.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.2 1.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 2.9 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 15.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 20.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 9.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 2.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 8.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 10.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 1.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.2 7.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 7.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 10.7 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.1 4.6 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 3.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.9 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 4.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 11.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.2 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 1.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.7 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha