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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPIC
Z-value: 2.30
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Transcription factors associated with SPIC
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 153.4 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 3.8 | 122.0 | GO:0045730 | respiratory burst(GO:0045730) |
| 27.2 | 108.8 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.6 | 97.0 | GO:0006906 | vesicle fusion(GO:0006906) |
| 4.5 | 95.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.6 | 91.9 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 17.0 | 85.1 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 19.6 | 78.6 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358) |
| 12.5 | 75.0 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 18.6 | 74.3 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 295.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.3 | 174.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 7.5 | 149.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 16.5 | 132.0 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.4 | 118.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 7.2 | 101.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 1.6 | 90.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 16.5 | 82.3 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 7.2 | 78.9 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.9 | 77.3 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.9 | 128.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 10.9 | 108.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.9 | 91.5 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.5 | 78.8 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 2.9 | 77.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 4.0 | 76.8 | GO:0015923 | mannosidase activity(GO:0015923) |
| 6.8 | 75.0 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 3.7 | 66.8 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 3.8 | 64.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 8.8 | 61.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 288.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 2.5 | 199.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 3.8 | 199.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.0 | 142.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.5 | 71.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.2 | 69.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.4 | 54.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 39.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.1 | 34.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 2.7 | 32.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 279.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 162.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 3.4 | 147.4 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 3.9 | 121.2 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 2.4 | 120.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.5 | 85.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.3 | 81.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.7 | 70.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 3.9 | 51.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 2.7 | 51.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |