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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SRF

Z-value: 1.96

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_431390940.091.8e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_35169885 122.26 ENST00000279022.2
ENST00000346786.2
MYL9
myosin, light chain 9, regulatory
chr9_-_35691017 57.10 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr17_-_79481666 54.90 ENST00000575659.1
ACTG1
actin, gamma 1
chr2_+_74120094 53.06 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_-_106015527 44.30 ENST00000344213.4
ENST00000358129.4
FHL2
four and a half LIM domains 2
chr2_-_106054952 44.10 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr2_-_106015491 43.85 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
FHL2
four and a half LIM domains 2
chr11_+_117070037 33.42 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr19_-_45826125 32.24 ENST00000221476.3
CKM
creatine kinase, muscle
chr10_-_90712520 32.11 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chrX_-_153602991 31.40 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr15_-_35088340 29.91 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr1_+_223889285 26.94 ENST00000433674.2
CAPN2
calpain 2, (m/II) large subunit
chr1_-_229569834 26.90 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr3_-_123339343 26.44 ENST00000578202.1
MYLK
myosin light chain kinase
chr3_-_123339418 26.10 ENST00000583087.1
MYLK
myosin light chain kinase
chr19_+_16178317 22.45 ENST00000344824.6
ENST00000538887.1
TPM4
tropomyosin 4
chr3_-_52486841 22.04 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr9_+_124088860 21.66 ENST00000373806.1
GSN
gelsolin
chr7_-_94285472 21.07 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr7_-_94285511 19.96 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr12_+_75874580 19.80 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr7_-_94285402 19.75 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr8_+_97597148 19.37 ENST00000521590.1
SDC2
syndecan 2
chr12_+_75874460 19.18 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr7_+_143078652 19.11 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr10_+_75757863 18.66 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
VCL
vinculin
chr14_+_75745477 18.01 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr22_-_36784035 17.99 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr15_+_74218787 17.37 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr5_+_150404904 17.10 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr11_-_65667997 16.59 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr15_+_96873921 16.52 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_-_65667884 16.37 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr17_+_42634844 15.97 ENST00000315323.3
FZD2
frizzled family receptor 2
chr3_-_99595037 15.47 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr7_-_107643674 14.48 ENST00000222399.6
LAMB1
laminin, beta 1
chr10_-_29923893 14.42 ENST00000355867.4
SVIL
supervillin
chr3_+_187930719 14.38 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_46904918 14.14 ENST00000395869.1
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr11_-_102323740 14.09 ENST00000398136.2
TMEM123
transmembrane protein 123
chr3_-_46904946 13.98 ENST00000292327.4
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr2_-_161264385 13.86 ENST00000409972.1
RBMS1
RNA binding motif, single stranded interacting protein 1
chr11_-_102323489 13.73 ENST00000361236.3
TMEM123
transmembrane protein 123
chr6_+_151561506 13.37 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_89531041 13.24 ENST00000370473.4
GBP1
guanylate binding protein 1, interferon-inducible
chr2_-_209118974 13.21 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr19_-_36247910 12.52 ENST00000587965.1
ENST00000004982.3
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr3_-_99594948 12.02 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr12_-_50616382 11.91 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr12_-_50616122 11.71 ENST00000552823.1
ENST00000552909.1
LIMA1
LIM domain and actin binding 1
chr6_+_151561085 11.63 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr4_-_10118469 11.27 ENST00000499869.2
WDR1
WD repeat domain 1
chr4_-_54930790 11.08 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr4_-_10118573 11.08 ENST00000382452.2
ENST00000382451.2
WDR1
WD repeat domain 1
chr19_+_1026298 10.71 ENST00000263097.4
CNN2
calponin 2
chr10_-_16859361 10.70 ENST00000377921.3
RSU1
Ras suppressor protein 1
chr19_+_45971246 10.55 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr10_-_16859442 10.44 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr19_+_2476116 9.89 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr19_+_1026566 9.28 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr10_+_123922941 9.21 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_11994715 9.15 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr14_+_74034310 8.90 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr2_-_128432639 8.65 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIMS2
LIM and senescent cell antigen-like domains 2
chr22_-_36357671 8.60 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_+_56965960 8.39 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_-_17659357 8.31 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr10_-_17659234 7.11 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr16_+_30383613 7.08 ENST00000568749.1
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr10_+_112257596 6.87 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr18_-_3220106 6.64 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chr8_+_1993173 6.47 ENST00000523438.1
MYOM2
myomesin 2
chr7_-_44180884 6.38 ENST00000458240.1
ENST00000223364.3
MYL7
myosin, light chain 7, regulatory
chr18_-_3219847 6.21 ENST00000261606.7
MYOM1
myomesin 1
chr1_-_89591749 6.18 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr7_-_44180673 6.13 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
MYL7
myosin, light chain 7, regulatory
chr8_+_1993152 6.11 ENST00000262113.4
MYOM2
myomesin 2
chr7_-_5570229 5.84 ENST00000331789.5
ACTB
actin, beta
chr14_-_23877474 5.61 ENST00000405093.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr17_-_79479789 5.43 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
ACTG1
actin, gamma 1
chr18_-_54318353 5.01 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr1_-_86043921 4.94 ENST00000535924.2
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_-_27183263 4.93 ENST00000222726.3
HOXA5
homeobox A5
chr1_+_206858328 4.93 ENST00000367103.3
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
chrX_-_11284095 4.89 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr5_-_169816638 4.79 ENST00000521859.1
ENST00000274629.4
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr5_-_176923803 4.73 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr16_-_11375179 4.50 ENST00000312511.3
PRM1
protamine 1
chr20_+_4702548 4.46 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr9_+_92219919 4.44 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_-_176923846 4.34 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr3_+_9834179 4.20 ENST00000498623.2
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr1_-_208084729 3.92 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr17_-_46671323 3.52 ENST00000239151.5
HOXB5
homeobox B5
chr3_-_185641681 3.48 ENST00000259043.7
TRA2B
transformer 2 beta homolog (Drosophila)
chr15_-_55581954 3.12 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr4_+_87928140 3.05 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr12_+_52445191 3.02 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr16_+_30077055 2.52 ENST00000564595.2
ENST00000569798.1
ALDOA
aldolase A, fructose-bisphosphate
chr11_-_65626753 2.50 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr11_-_47374246 2.50 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr5_+_92919043 2.44 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr10_+_31610064 2.39 ENST00000446923.2
ENST00000559476.1
ZEB1
zinc finger E-box binding homeobox 1
chr16_+_30077098 2.29 ENST00000395240.3
ENST00000566846.1
ALDOA
aldolase A, fructose-bisphosphate
chr7_+_94285637 2.05 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr2_-_208031943 1.70 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr11_+_34073195 1.56 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr6_-_99797522 1.55 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr19_-_17356697 1.44 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr6_-_16761678 1.29 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr20_-_62258394 1.26 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr6_-_111804905 1.08 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr12_+_59989918 1.04 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr3_+_9834227 1.03 ENST00000287613.7
ENST00000397261.3
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr17_+_7487146 0.74 ENST00000396501.4
ENST00000584378.1
ENST00000423172.2
ENST00000579445.1
ENST00000585217.1
ENST00000581380.1
MPDU1
mannose-P-dolichol utilization defect 1
chr5_-_33892046 0.64 ENST00000352040.3
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_+_47881744 0.63 ENST00000335071.2
FOXE3
forkhead box E3
chr5_-_33892204 0.43 ENST00000504830.1
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_179050660 0.39 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr10_+_88428206 0.21 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LDB3
LIM domain binding 3
chr4_+_87928413 0.20 ENST00000544085.1
AFF1
AF4/FMR2 family, member 1
chr2_-_231989808 0.17 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr11_-_71823796 0.16 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr17_-_4871085 0.14 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr2_-_161056762 0.13 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr5_+_40679584 0.09 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr11_-_71823266 0.01 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
26.5 132.3 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
23.7 142.0 GO:0090131 mesenchyme migration(GO:0090131)
6.6 39.7 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
6.6 52.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
5.7 17.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
5.6 22.3 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
5.5 22.0 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
5.5 33.0 GO:0007296 vitellogenesis(GO:0007296)
5.2 31.4 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
4.4 13.2 GO:0006097 glyoxylate cycle(GO:0006097)
4.1 16.5 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
3.6 14.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
3.4 17.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
3.2 25.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
3.1 9.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
2.9 32.2 GO:0006600 creatine metabolic process(GO:0006600)
2.8 19.4 GO:0008218 bioluminescence(GO:0008218)
2.5 2.5 GO:0032971 regulation of muscle filament sliding(GO:0032971)
2.3 18.0 GO:0001661 conditioned taste aversion(GO:0001661)
2.2 207.1 GO:0070527 platelet aggregation(GO:0070527)
2.0 16.0 GO:0003150 muscular septum morphogenesis(GO:0003150)
1.7 27.8 GO:0045793 positive regulation of cell size(GO:0045793)
1.7 8.6 GO:0060318 regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318)
1.7 25.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.6 4.9 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
1.6 4.8 GO:1903413 cellular response to bile acid(GO:1903413)
1.5 111.7 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.9 17.8 GO:0016540 protein autoprocessing(GO:0016540)
0.9 3.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.9 8.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.8 2.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.6 14.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 4.9 GO:0044351 macropinocytosis(GO:0044351)
0.6 8.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.5 3.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.5 10.6 GO:0051412 response to corticosterone(GO:0051412)
0.5 12.5 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.4 6.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 23.6 GO:0031529 ruffle organization(GO:0031529)
0.4 4.9 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.3 3.0 GO:0061469 response to corticotropin-releasing hormone(GO:0043435) regulation of type B pancreatic cell proliferation(GO:0061469) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.3 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.3 14.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 15.7 GO:0035904 aorta development(GO:0035904)
0.3 4.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 4.5 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.2 13.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 20.0 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.2 75.1 GO:0007160 cell-matrix adhesion(GO:0007160)
0.2 8.9 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 11.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 9.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 4.5 GO:0030261 chromosome condensation(GO:0030261)
0.1 28.3 GO:0007517 muscle organ development(GO:0007517)
0.1 9.2 GO:0021987 cerebral cortex development(GO:0021987)
0.1 1.4 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 5.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 6.2 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 23.1 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.1 1.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 3.5 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 10.6 GO:0006936 muscle contraction(GO:0006936)
0.0 1.7 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.1 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.0 2.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 1.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 12.7 GO:0007155 cell adhesion(GO:0007155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 31.4 GO:0031523 Myb complex(GO:0031523)
10.5 52.3 GO:0042643 actomyosin, actin portion(GO:0042643)
8.8 53.1 GO:0032982 myosin filament(GO:0032982)
8.0 32.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
7.6 60.8 GO:0016012 sarcoglycan complex(GO:0016012)
6.0 18.0 GO:0005826 actomyosin contractile ring(GO:0005826)
5.3 189.4 GO:0005859 muscle myosin complex(GO:0005859)
5.1 66.2 GO:0097433 dense body(GO:0097433)
4.8 14.5 GO:0005607 laminin-2 complex(GO:0005607)
4.2 79.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
3.7 22.0 GO:1990584 cardiac Troponin complex(GO:1990584)
3.4 137.1 GO:0031430 M band(GO:0031430)
2.3 18.0 GO:0035976 AP1 complex(GO:0035976)
2.1 14.4 GO:0036449 microtubule minus-end(GO:0036449)
1.6 151.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.6 18.7 GO:0005916 fascia adherens(GO:0005916)
1.4 21.7 GO:0030478 actin cap(GO:0030478)
1.4 8.4 GO:1990037 Lewy body core(GO:1990037)
1.1 17.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.7 12.5 GO:0031672 A band(GO:0031672)
0.5 39.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.4 9.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 33.0 GO:0042734 presynaptic membrane(GO:0042734)
0.3 3.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 16.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.2 13.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.9 GO:0046930 pore complex(GO:0046930)
0.2 19.4 GO:0005796 Golgi lumen(GO:0005796)
0.2 17.4 GO:0005604 basement membrane(GO:0005604)
0.1 11.1 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 0.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 2.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 27.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 53.5 GO:0005925 focal adhesion(GO:0005925)
0.1 4.5 GO:0000786 nucleosome(GO:0000786)
0.1 1.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 3.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.9 GO:0005884 actin filament(GO:0005884)
0.1 5.0 GO:0000502 proteasome complex(GO:0000502)
0.0 3.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 18.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 1.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.6 GO:0005815 microtubule organizing center(GO:0005815)
0.0 10.9 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 52.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
9.6 152.9 GO:0032036 myosin heavy chain binding(GO:0032036)
7.8 31.4 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
4.4 13.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
4.0 32.2 GO:0004111 creatine kinase activity(GO:0004111)
3.1 9.2 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
2.7 21.7 GO:0045159 myosin II binding(GO:0045159)
2.0 22.0 GO:0031013 troponin I binding(GO:0031013)
1.7 132.3 GO:0050681 androgen receptor binding(GO:0050681)
1.7 18.7 GO:0045294 alpha-catenin binding(GO:0045294)
1.6 25.0 GO:0008179 adenylate cyclase binding(GO:0008179)
1.6 17.1 GO:0008430 selenium binding(GO:0008430)
1.2 2.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.2 112.1 GO:0008307 structural constituent of muscle(GO:0008307)
1.1 17.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
1.1 23.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
1.0 4.9 GO:0016403 dimethylargininase activity(GO:0016403)
0.9 59.9 GO:0017022 myosin binding(GO:0017022)
0.8 8.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.7 5.0 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.7 16.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.6 5.8 GO:0030957 Tat protein binding(GO:0030957)
0.6 23.6 GO:0003785 actin monomer binding(GO:0003785)
0.5 17.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 13.2 GO:0030507 spectrin binding(GO:0030507)
0.5 12.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 4.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 62.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 16.5 GO:0001972 retinoic acid binding(GO:0001972)
0.4 3.9 GO:0043199 sulfate binding(GO:0043199)
0.4 18.0 GO:0070412 R-SMAD binding(GO:0070412)
0.4 54.8 GO:0051015 actin filament binding(GO:0051015)
0.3 4.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 1.3 GO:0034046 poly(G) binding(GO:0034046)
0.2 19.4 GO:0030165 PDZ domain binding(GO:0030165)
0.2 4.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 14.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.4 GO:0070888 E-box binding(GO:0070888)
0.1 3.5 GO:0070717 poly-purine tract binding(GO:0070717)
0.1 3.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 13.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 9.2 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 42.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.5 GO:0005507 copper ion binding(GO:0005507)
0.1 15.4 GO:0003779 actin binding(GO:0003779)
0.0 4.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 8.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 58.8 GO:0005524 ATP binding(GO:0005524)
0.0 2.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 15.7 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 132.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
3.2 186.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.7 143.2 PID ILK PATHWAY Integrin-linked kinase signaling
1.1 61.9 PID RHOA PATHWAY RhoA signaling pathway
0.7 38.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.6 14.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.6 33.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 21.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.5 16.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.5 9.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.5 19.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.4 14.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 52.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.3 17.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.3 30.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 6.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.2 16.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 4.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 14.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 7.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 7.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 4.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 15.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 358.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
1.2 171.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
1.1 54.2 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.7 21.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.7 19.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.7 21.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 4.9 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5 18.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 13.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 12.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 7.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 8.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 19.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 5.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 9.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 14.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 16.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 26.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 6.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 10.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 4.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors