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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TBX19

Z-value: 0.97

Motif logo

Transcription factors associated with TBX19

Gene Symbol Gene ID Gene Info
ENSG00000143178.8 T-box transcription factor 19

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX19hg19_v2_chr1_+_168250194_168250278-0.064.1e-01Click!

Activity profile of TBX19 motif

Sorted Z-values of TBX19 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_2842087 21.37 ENST00000537185.1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr19_-_40331345 21.10 ENST00000597224.1
fibrillarin
chr16_+_84801852 18.67 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chr6_-_36515177 18.46 ENST00000229812.7
serine/threonine kinase 38
chr6_-_2842219 14.99 ENST00000380739.5
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_-_85636928 14.84 ENST00000449030.1
capping protein (actin filament), gelsolin-like
chr15_-_55581954 14.74 ENST00000336787.1
RAB27A, member RAS oncogene family
chr9_-_116172946 12.93 ENST00000374171.4
polymerase (DNA directed), epsilon 3, accessory subunit
chr1_-_63988846 12.60 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
integrin beta 3 binding protein (beta3-endonexin)
chr10_-_95242044 11.96 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
myoferlin
chr12_-_49319265 11.44 ENST00000552878.1
ENST00000453172.2
FK506 binding protein 11, 19 kDa
chr2_+_90153696 11.43 ENST00000417279.2
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr7_-_148580563 11.15 ENST00000476773.1
enhancer of zeste homolog 2 (Drosophila)
chr10_-_95241951 11.08 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
myoferlin
chr2_-_89278535 10.66 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr14_+_24458093 10.15 ENST00000558753.1
ENST00000537912.1
dehydrogenase/reductase (SDR family) member 4 like 2
chr14_+_51706886 10.14 ENST00000457354.2
thioredoxin-related transmembrane protein 1
chr11_+_71938925 10.04 ENST00000538751.1
inositol polyphosphate phosphatase-like 1
chr14_+_21249200 9.79 ENST00000304677.2
ribonuclease, RNase A family, k6
chr7_-_132766800 9.44 ENST00000542753.1
ENST00000448878.1
coiled-coil-helix-coiled-coil-helix domain containing 3
chr5_+_33440802 9.35 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
threonyl-tRNA synthetase
chr7_-_132766818 9.33 ENST00000262570.5
coiled-coil-helix-coiled-coil-helix domain containing 3
chr7_+_2394445 9.01 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
eukaryotic translation initiation factor 3, subunit B
chr15_-_20170354 8.69 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr1_-_150947343 8.24 ENST00000271688.6
ENST00000368954.5
ceramide synthase 2
chr6_+_22569784 8.13 ENST00000510882.2
hepatoma derived growth factor-like 1
chr17_-_34207295 8.05 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr22_+_45072925 7.92 ENST00000006251.7
proline rich 5 (renal)
chr9_-_19127474 7.91 ENST00000380465.3
ENST00000380464.3
ENST00000411567.1
ENST00000276914.2
perilipin 2
chr12_+_104680659 7.67 ENST00000526691.1
ENST00000531691.1
ENST00000388854.3
ENST00000354940.6
ENST00000526390.1
ENST00000531689.1
thioredoxin reductase 1
chr2_+_143886877 7.66 ENST00000295095.6
Rho GTPase activating protein 15
chr12_-_10875831 7.66 ENST00000279550.7
ENST00000228251.4
Y box binding protein 3
chr2_-_89399845 7.52 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr1_-_146040968 7.48 ENST00000401010.3
neuroblastoma breakpoint family, member 11
chr5_+_96212185 7.45 ENST00000379904.4
endoplasmic reticulum aminopeptidase 2
chr10_+_12237924 7.36 ENST00000429258.2
ENST00000281141.4
cell division cycle 123
chr22_+_45072958 7.28 ENST00000403581.1
proline rich 5 (renal)
chr4_+_15704679 7.28 ENST00000382346.3
bone marrow stromal cell antigen 1
chr22_+_37678424 7.06 ENST00000248901.6
cytohesin 4
chr14_-_106963409 6.87 ENST00000390621.2
immunoglobulin heavy variable 1-45
chr1_-_19746236 6.86 ENST00000375144.1
capping protein (actin filament) muscle Z-line, beta
chr5_+_96211643 6.73 ENST00000437043.3
ENST00000510373.1
endoplasmic reticulum aminopeptidase 2
chr2_+_201754050 6.41 ENST00000426253.1
ENST00000416651.1
ENST00000454952.1
ENST00000409020.1
ENST00000359683.4
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr19_+_49496705 5.86 ENST00000595090.1
RuvB-like AAA ATPase 2
chr2_+_201754135 5.86 ENST00000409357.1
ENST00000409129.2
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr10_-_120938303 5.75 ENST00000356951.3
ENST00000298510.2
peroxiredoxin 3
chr8_-_134115118 5.71 ENST00000395352.3
ENST00000338087.5
Src-like-adaptor
chr5_-_70272055 5.65 ENST00000514857.2
NLR family, apoptosis inhibitory protein
chr12_+_75784850 5.46 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLI pathogenesis-related 1 like 2
chr1_+_117297007 5.36 ENST00000369478.3
ENST00000369477.1
CD2 molecule
chr4_+_15704573 5.35 ENST00000265016.4
bone marrow stromal cell antigen 1
chr14_-_106573756 5.29 ENST00000390601.2
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr2_-_113594279 5.28 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr19_+_535835 5.22 ENST00000607527.1
ENST00000606065.1
cell division cycle 34
chr12_-_9760482 5.03 ENST00000229402.3
killer cell lectin-like receptor subfamily B, member 1
chr19_+_38755042 4.94 ENST00000301244.7
serine peptidase inhibitor, Kunitz type, 2
chr17_-_56296580 4.83 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
Meckel syndrome, type 1
chr6_-_42713792 4.77 ENST00000372876.1
tubulin folding cofactor C
chr1_-_167522982 4.76 ENST00000370509.4
cellular repressor of E1A-stimulated genes 1
chr19_+_852291 4.70 ENST00000263621.1
elastase, neutrophil expressed
chr2_+_228337079 4.64 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
ArfGAP with FG repeats 1
chr5_+_54320078 4.53 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr17_+_7123125 4.52 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
acyl-CoA dehydrogenase, very long chain
chr20_-_5093673 4.17 ENST00000379299.2
ENST00000379286.2
ENST00000379279.2
ENST00000379283.2
transmembrane protein 230
chr2_-_162931052 4.05 ENST00000360534.3
dipeptidyl-peptidase 4
chr14_+_24458021 4.04 ENST00000397071.1
ENST00000559411.1
ENST00000335125.6
dehydrogenase/reductase (SDR family) member 4 like 2
chr10_+_76969909 4.00 ENST00000298468.5
ENST00000543351.1
voltage-dependent anion channel 2
chr1_+_168250194 3.96 ENST00000367821.3
T-box 19
chr22_-_31364187 3.93 ENST00000215862.4
ENST00000397641.3
MORC family CW-type zinc finger 2
chr12_+_8276433 3.89 ENST00000345999.3
ENST00000352620.3
ENST00000360500.3
C-type lectin domain family 4, member A
chr3_-_150264272 3.88 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
stress-associated endoplasmic reticulum protein 1
chr12_+_8276224 3.85 ENST00000229332.5
C-type lectin domain family 4, member A
chr9_+_78505581 3.82 ENST00000376767.3
ENST00000376752.4
proprotein convertase subtilisin/kexin type 5
chr10_+_17686124 3.82 ENST00000377524.3
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr1_+_207627575 3.69 ENST00000367058.3
ENST00000367057.3
ENST00000367059.3
complement component (3d/Epstein Barr virus) receptor 2
chr20_-_5093713 3.66 ENST00000342308.5
ENST00000202834.7
transmembrane protein 230
chr1_+_114471972 3.64 ENST00000369559.4
ENST00000369554.2
homeodomain interacting protein kinase 1
chr1_+_114471809 3.53 ENST00000426820.2
homeodomain interacting protein kinase 1
chr14_-_106816253 3.49 ENST00000390615.2
immunoglobulin heavy variable 3-33
chr8_-_6836156 3.44 ENST00000382679.2
defensin, alpha 1
chr19_-_8008533 3.26 ENST00000597926.1
translocase of inner mitochondrial membrane 44 homolog (yeast)
chr6_-_31651817 3.24 ENST00000375863.3
ENST00000375860.2
lymphocyte antigen 6 complex, locus G5C
chr11_+_57425209 3.17 ENST00000533905.1
ENST00000525602.1
ENST00000302731.4
cleavage and polyadenylation factor I subunit 1
chr11_-_64889252 3.09 ENST00000525297.1
ENST00000529259.1
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr17_+_4736627 3.04 ENST00000355280.6
ENST00000347992.7
misshapen-like kinase 1
chr14_+_24458123 3.01 ENST00000545240.1
ENST00000382755.4
dehydrogenase/reductase (SDR family) member 4 like 2
chrX_+_129535937 2.97 ENST00000305536.6
ENST00000370947.1
RNA binding motif protein, X-linked 2
chr15_-_60771280 2.97 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NMDA receptor regulated 2
chr20_-_44991813 2.94 ENST00000372227.1
solute carrier family 35 (GDP-fucose transporter), member C2
chr9_-_130890662 2.94 ENST00000277462.5
ENST00000338961.6
prostaglandin E synthase 2
chr9_+_78505554 2.89 ENST00000545128.1
proprotein convertase subtilisin/kexin type 5
chr1_+_114472222 2.86 ENST00000369558.1
ENST00000369561.4
homeodomain interacting protein kinase 1
chr14_-_107219365 2.77 ENST00000424969.2
immunoglobulin heavy variable 3-74
chr9_+_125137565 2.75 ENST00000373698.5
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_10694900 2.74 ENST00000379568.3
PAK1 interacting protein 1
chr6_+_52285046 2.74 ENST00000371068.5
EF-hand domain (C-terminal) containing 1
chr19_+_49496782 2.56 ENST00000601968.1
ENST00000596837.1
RuvB-like AAA ATPase 2
chr22_+_40322595 2.49 ENST00000420971.1
ENST00000544756.1
GRB2-related adaptor protein 2
chr11_+_7618413 2.41 ENST00000528883.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_+_93535866 2.36 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr17_+_35306175 2.36 ENST00000225402.5
apoptosis antagonizing transcription factor
chr22_+_40322623 2.29 ENST00000399090.2
GRB2-related adaptor protein 2
chr1_+_160765947 2.28 ENST00000263285.6
ENST00000368039.2
lymphocyte antigen 9
chr12_-_10605929 2.27 ENST00000347831.5
ENST00000359151.3
killer cell lectin-like receptor subfamily C, member 1
chr1_+_100810575 2.23 ENST00000542213.1
cell division cycle 14A
chr6_+_52285131 2.22 ENST00000433625.2
EF-hand domain (C-terminal) containing 1
chrX_-_119709637 2.18 ENST00000404115.3
cullin 4B
chr12_-_10962767 2.16 ENST00000240691.2
taste receptor, type 2, member 9
chr2_-_9563469 2.14 ENST00000484735.1
ENST00000456913.2
integrin beta 1 binding protein 1
chr22_+_31477296 2.11 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
smoothelin
chr8_+_125463048 2.09 ENST00000328599.3
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr20_-_22565101 2.08 ENST00000419308.2
forkhead box A2
chr10_+_90750378 2.06 ENST00000355740.2
ENST00000352159.4
Fas cell surface death receptor
chr21_+_39628655 1.98 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr14_-_58894332 1.97 ENST00000395159.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr20_-_7921090 1.93 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chr7_+_93535817 1.90 ENST00000248572.5
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr6_-_133035185 1.74 ENST00000367928.4
vanin 1
chr6_+_26158343 1.71 ENST00000377777.4
ENST00000289316.2
histone cluster 1, H2bd
chr17_+_41561317 1.61 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr1_+_41157361 1.57 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
nuclear transcription factor Y, gamma
chr19_+_4247070 1.56 ENST00000262962.7
coiled-coil domain containing 94
chr9_+_77230499 1.54 ENST00000396204.2
RAR-related orphan receptor B
chr12_+_8276495 1.53 ENST00000546339.1
C-type lectin domain family 4, member A
chr10_+_71561630 1.52 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr20_+_43835638 1.47 ENST00000372781.3
ENST00000244069.6
semenogelin I
chr6_-_26285737 1.37 ENST00000377727.1
ENST00000289352.1
histone cluster 1, H4h
chr1_+_153963227 1.33 ENST00000368567.4
ENST00000392558.4
ribosomal protein S27
chr5_-_39270725 1.33 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr3_-_194393206 1.29 ENST00000265245.5
large 60S subunit nuclear export GTPase 1
chr4_+_69962185 1.29 ENST00000305231.7
UDP glucuronosyltransferase 2 family, polypeptide B7
chrX_+_107288197 1.16 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chr7_-_76255444 1.03 ENST00000454397.1
POM121 and ZP3 fusion
chr19_-_46526304 1.01 ENST00000008938.4
peptidoglycan recognition protein 1
chr6_-_131277510 0.91 ENST00000525193.1
ENST00000527659.1
erythrocyte membrane protein band 4.1-like 2
chr12_-_11036844 0.87 ENST00000428168.2
proline-rich protein HaeIII subfamily 1
chr4_+_26321284 0.87 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
recombination signal binding protein for immunoglobulin kappa J region
chr8_-_6795823 0.73 ENST00000297435.2
defensin, alpha 4, corticostatin
chr1_-_19615744 0.73 ENST00000361640.4
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr2_+_152214098 0.72 ENST00000243347.3
tumor necrosis factor, alpha-induced protein 6
chr19_-_7766991 0.68 ENST00000597921.1
ENST00000346664.5
Fc fragment of IgE, low affinity II, receptor for (CD23)
chrX_+_107288239 0.52 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr17_-_33760269 0.51 ENST00000452764.3
schlafen family member 12
chr15_-_65809581 0.42 ENST00000341861.5
dipeptidyl-peptidase 8
chr19_+_49990811 0.32 ENST00000391857.4
ENST00000467825.2
ribosomal protein L13a
chr14_+_58894706 0.30 ENST00000261244.5
KIAA0586
chr19_+_21203426 0.28 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
zinc finger protein 430
chr20_+_43849941 0.26 ENST00000372769.3
semenogelin II
chr10_+_90750493 0.16 ENST00000357339.2
ENST00000355279.2
Fas cell surface death receptor
chr5_+_169010638 0.16 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
spindle apparatus coiled-coil protein 1
chr3_+_119499331 0.13 ENST00000393716.2
ENST00000466380.1
nuclear receptor subfamily 1, group I, member 2
chr1_+_46640750 0.07 ENST00000372003.1
tetraspanin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX19

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
3.7 11.2 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
3.1 9.4 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
2.5 14.7 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
2.1 8.4 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
2.0 8.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.9 23.0 GO:0001778 plasma membrane repair(GO:0001778)
1.9 5.8 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
1.8 5.3 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
1.6 8.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
1.4 15.2 GO:0038203 TORC2 signaling(GO:0038203)
1.4 6.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
1.3 6.7 GO:0032455 nerve growth factor processing(GO:0032455)
1.2 4.9 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.1 3.4 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.1 9.0 GO:0075525 viral translational termination-reinitiation(GO:0075525)
1.1 10.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
1.1 14.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.0 4.0 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
1.0 4.8 GO:0061009 common bile duct development(GO:0061009)
1.0 7.7 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.9 5.4 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.9 7.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.8 4.8 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.8 4.7 GO:1903238 positive regulation of leukocyte tethering or rolling(GO:1903238)
0.7 14.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.7 18.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.7 2.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.5 18.7 GO:0019985 translesion synthesis(GO:0019985)
0.5 3.8 GO:1903551 regulation of extracellular exosome assembly(GO:1903551)
0.5 3.2 GO:0035087 targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.5 4.6 GO:0001675 acrosome assembly(GO:0001675)
0.5 2.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.5 12.6 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.4 2.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.4 5.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951) positive regulation of inclusion body assembly(GO:0090261)
0.4 12.9 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.4 12.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 7.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 1.7 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.3 1.0 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.3 5.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 10.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.3 1.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 5.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.3 4.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.3 2.9 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) protein O-linked fucosylation(GO:0036066)
0.3 0.9 GO:1905068 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.3 3.9 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.3 38.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 10.5 GO:0019731 antibacterial humoral response(GO:0019731)
0.3 1.5 GO:0042670 amacrine cell differentiation(GO:0035881) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2 1.7 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.2 11.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 7.4 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.2 2.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 3.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 1.0 GO:0035803 egg coat formation(GO:0035803)
0.2 2.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 18.5 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.2 0.7 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 2.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.3 GO:0043373 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) T-helper 17 cell lineage commitment(GO:0072540)
0.1 3.0 GO:0000185 activation of MAPKKK activity(GO:0000185) regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 22.1 GO:0002377 immunoglobulin production(GO:0002377)
0.1 4.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 10.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 7.9 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 10.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 31.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 1.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 3.7 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 5.0 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.1 4.0 GO:0021983 pituitary gland development(GO:0021983)
0.1 0.9 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 8.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 1.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.0 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.7 GO:0030728 ovulation(GO:0030728)
0.0 2.7 GO:0060021 palate development(GO:0060021)
0.0 4.4 GO:0097480 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 4.9 GO:0008360 regulation of cell shape(GO:0008360)
0.0 3.0 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 1.3 GO:0051168 nuclear export(GO:0051168)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 21.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.6 12.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.8 12.4 GO:0061617 MICOS complex(GO:0061617)
1.4 21.7 GO:0008290 F-actin capping protein complex(GO:0008290)
1.3 3.8 GO:0033565 ESCRT-0 complex(GO:0033565)
1.2 14.7 GO:0033093 Weibel-Palade body(GO:0033093)
1.0 9.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.8 15.2 GO:0031932 TORC2 complex(GO:0031932)
0.8 8.4 GO:0097255 R2TP complex(GO:0097255)
0.8 3.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.7 11.2 GO:0045120 pronucleus(GO:0045120)
0.6 4.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 12.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.5 2.0 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.4 5.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.4 1.5 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.4 18.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 4.8 GO:0036038 MKS complex(GO:0036038)
0.3 2.2 GO:0060091 kinocilium(GO:0060091)
0.3 2.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 23.0 GO:0005901 caveola(GO:0005901)
0.2 0.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 5.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.0 GO:0046930 pore complex(GO:0046930)
0.2 4.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 1.0 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 1.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 4.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 3.0 GO:0005686 U2 snRNP(GO:0005686)
0.1 13.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 7.7 GO:0005844 polysome(GO:0005844)
0.1 12.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 2.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 7.9 GO:0005811 lipid particle(GO:0005811)
0.1 31.3 GO:0034774 secretory granule lumen(GO:0034774)
0.1 3.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 13.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.9 GO:0008091 spectrin(GO:0008091)
0.1 10.0 GO:0016605 PML body(GO:0016605)
0.1 0.3 GO:0097452 GAIT complex(GO:0097452)
0.1 5.3 GO:0005776 autophagosome(GO:0005776)
0.1 2.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.5 GO:0001650 fibrillar center(GO:0001650)
0.0 4.6 GO:0005643 nuclear pore(GO:0005643)
0.0 6.1 GO:0030175 filopodium(GO:0030175)
0.0 2.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 4.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 5.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 5.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 9.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 7.1 GO:0005769 early endosome(GO:0005769)
0.0 31.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.2 GO:0015030 Cajal body(GO:0015030)
0.0 10.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.2 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 GO:0050135 NAD+ nucleosidase activity(GO:0003953) NAD(P)+ nucleosidase activity(GO:0050135)
3.1 9.4 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
2.6 7.7 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
2.0 29.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.4 8.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.2 11.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.1 8.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.1 4.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
1.0 10.0 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.9 18.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.8 3.2 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.7 2.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.7 5.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.7 2.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.6 1.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.6 14.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.6 14.7 GO:0031489 myosin V binding(GO:0031489)
0.5 10.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 2.3 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.4 12.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 4.0 GO:0015288 porin activity(GO:0015288)
0.4 2.2 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.4 11.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.3 37.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.0 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.3 18.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 5.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 7.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 27.8 GO:0032947 protein complex scaffold(GO:0032947)
0.2 18.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 4.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 2.4 GO:0048156 tau protein binding(GO:0048156)
0.2 3.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 1.0 GO:0032190 acrosin binding(GO:0032190)
0.2 27.7 GO:0003823 antigen binding(GO:0003823)
0.1 1.9 GO:0004875 complement receptor activity(GO:0004875)
0.1 5.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 10.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 5.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 10.0 GO:0051087 chaperone binding(GO:0051087)
0.1 9.8 GO:0004540 ribonuclease activity(GO:0004540)
0.1 0.9 GO:0042731 PH domain binding(GO:0042731)
0.1 21.7 GO:0051015 actin filament binding(GO:0051015)
0.1 0.7 GO:0019863 IgE binding(GO:0019863)
0.1 0.9 GO:0000150 recombinase activity(GO:0000150)
0.1 7.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 2.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 14.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 5.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 2.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 20.1 GO:0008134 transcription factor binding(GO:0008134)
0.0 9.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 7.3 GO:0005543 phospholipid binding(GO:0005543)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.6 GO:0003924 GTPase activity(GO:0003924)
0.0 3.3 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 4.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 21.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 5.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 15.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 8.4 PID MYC PATHWAY C-MYC pathway
0.2 40.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 9.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 12.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 4.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 3.8 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 4.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 6.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.9 PID IFNG PATHWAY IFN-gamma pathway
0.1 7.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.7 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 5.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 9.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.6 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.5 2.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 10.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 9.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.2 REACTOME DEFENSINS Genes involved in Defensins
0.2 10.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 7.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 8.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 4.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 3.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 13.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 3.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 4.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 6.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 6.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 8.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 5.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 3.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 7.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 7.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 2.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.8 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 5.2 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation