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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TBX2

Z-value: 0.79

Motif logo

Transcription factors associated with TBX2

Gene Symbol Gene ID Gene Info
ENSG00000121068.9 T-box transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX2hg19_v2_chr17_+_59477233_59477263-0.186.5e-03Click!

Activity profile of TBX2 motif

Sorted Z-values of TBX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_113247543 13.54 ENST00000414971.1
ENST00000534717.1
ras homolog family member C
chr8_+_82192501 13.12 ENST00000297258.6
fatty acid binding protein 5 (psoriasis-associated)
chr17_+_35849937 12.80 ENST00000394389.4
dual specificity phosphatase 14
chr7_+_141438393 11.52 ENST00000484178.1
ENST00000473783.1
ENST00000481508.1
single-stranded DNA binding protein 1, mitochondrial
chrX_+_70503037 11.44 ENST00000535149.1
non-POU domain containing, octamer-binding
chr2_+_201994042 11.35 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr19_+_50180317 11.10 ENST00000534465.1
protein arginine methyltransferase 1
chr12_-_56121580 11.07 ENST00000550776.1
CD63 molecule
chr9_+_131447342 10.87 ENST00000409104.3
SET nuclear oncogene
chrX_-_53461288 10.87 ENST00000375298.4
ENST00000375304.5
hydroxysteroid (17-beta) dehydrogenase 10
chr16_-_66968055 10.68 ENST00000568572.1
family with sequence similarity 96, member B
chr12_+_96252706 10.54 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
small nuclear ribonucleoprotein polypeptide F
chr7_+_73106926 10.51 ENST00000453316.1
Williams Beuren syndrome chromosome region 22
chr10_+_54074033 9.94 ENST00000373970.3
dickkopf WNT signaling pathway inhibitor 1
chr9_+_131452239 9.88 ENST00000372688.4
ENST00000372686.5
SET nuclear oncogene
chr12_-_56121612 9.19 ENST00000546939.1
CD63 molecule
chrX_-_53461305 8.96 ENST00000168216.6
hydroxysteroid (17-beta) dehydrogenase 10
chr19_+_36236491 8.94 ENST00000591949.1
presenilin enhancer gamma secretase subunit
chr12_-_56120838 8.69 ENST00000548160.1
CD63 molecule
chr19_+_52932435 8.66 ENST00000301085.4
zinc finger protein 534
chr11_-_14380664 8.51 ENST00000545643.1
ENST00000256196.4
related RAS viral (r-ras) oncogene homolog 2
chr19_-_51875894 8.47 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
natural killer cell group 7 sequence
chr12_-_56122220 8.28 ENST00000552692.1
CD63 molecule
chr16_-_88717423 8.09 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr3_+_160117087 8.07 ENST00000357388.3
structural maintenance of chromosomes 4
chr19_+_47634039 7.99 ENST00000597808.1
ENST00000413379.3
ENST00000600706.1
ENST00000540850.1
ENST00000598840.1
ENST00000600753.1
ENST00000270225.7
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr15_-_55581954 7.96 ENST00000336787.1
RAB27A, member RAS oncogene family
chr19_+_36236514 7.96 ENST00000222266.2
presenilin enhancer gamma secretase subunit
chr1_+_15736359 7.73 ENST00000375980.4
EF-hand domain family, member D2
chr14_-_55658252 7.45 ENST00000395425.2
discs, large (Drosophila) homolog-associated protein 5
chr14_-_100841670 7.40 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
tryptophanyl-tRNA synthetase
chr10_+_95256356 7.35 ENST00000371485.3
centrosomal protein 55kDa
chr13_-_46543805 7.34 ENST00000378921.2
zinc finger CCCH-type containing 13
chr19_-_47353547 7.15 ENST00000601498.1
adaptor-related protein complex 2, sigma 1 subunit
chr5_+_52856456 7.13 ENST00000296684.5
ENST00000506765.1
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr2_-_169769787 7.11 ENST00000451987.1
SPC25, NDC80 kinetochore complex component
chr11_-_6704513 7.07 ENST00000532203.1
ENST00000288937.6
mitochondrial ribosomal protein L17
chr1_+_93544821 6.95 ENST00000370303.4
metal response element binding transcription factor 2
chr2_+_201994208 6.91 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr14_-_55658323 6.89 ENST00000554067.1
ENST00000247191.2
discs, large (Drosophila) homolog-associated protein 5
chr12_-_56122124 6.75 ENST00000552754.1
CD63 molecule
chr3_+_142315225 6.73 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
plastin 1
chr12_-_49318715 6.63 ENST00000444214.2
FK506 binding protein 11, 19 kDa
chr7_-_76255444 6.52 ENST00000454397.1
POM121 and ZP3 fusion
chr16_-_67493110 6.46 ENST00000602876.1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr12_-_56122426 6.42 ENST00000551173.1
CD63 molecule
chr4_+_140222609 6.33 ENST00000296543.5
ENST00000398947.1
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr12_-_121019165 6.31 ENST00000341039.2
ENST00000357500.4
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr14_-_24664540 6.30 ENST00000530563.1
ENST00000528895.1
ENST00000528669.1
ENST00000532632.1
transmembrane 9 superfamily member 1
chr19_+_50180409 6.30 ENST00000391851.4
protein arginine methyltransferase 1
chr14_-_45603657 6.27 ENST00000396062.3
FK506 binding protein 3, 25kDa
chr5_+_154320623 6.26 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
mitochondrial ribosomal protein L22
chr1_+_32716840 6.26 ENST00000336890.5
lymphocyte-specific protein tyrosine kinase
chr20_+_25388293 6.21 ENST00000262460.4
ENST00000429262.2
GINS complex subunit 1 (Psf1 homolog)
chr6_-_160166218 6.17 ENST00000537657.1
superoxide dismutase 2, mitochondrial
chr8_-_67974552 6.06 ENST00000357849.4
COP9 signalosome subunit 5
chr1_-_6260896 6.02 ENST00000497965.1
ribosomal protein L22
chr11_+_108535752 6.00 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chrX_+_114795489 6.00 ENST00000355899.3
ENST00000537301.1
ENST00000289290.3
plastin 3
chr7_+_100271446 5.99 ENST00000419828.1
ENST00000427895.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_+_50180507 5.96 ENST00000454376.2
ENST00000524771.1
protein arginine methyltransferase 1
chr12_-_111180644 5.93 ENST00000551676.1
ENST00000550991.1
ENST00000335007.5
ENST00000340766.5
protein phosphatase 1, catalytic subunit, gamma isozyme
chr1_+_32716857 5.86 ENST00000482949.1
ENST00000495610.2
lymphocyte-specific protein tyrosine kinase
chr3_+_112709804 5.85 ENST00000383677.3
GTP-binding protein 8 (putative)
chr17_-_7590745 5.79 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr17_+_48823896 5.70 ENST00000511974.1
LUC7-like 3 (S. cerevisiae)
chr19_+_13049413 5.61 ENST00000316448.5
ENST00000588454.1
calreticulin
chr9_-_179018 5.59 ENST00000431099.2
ENST00000382447.4
ENST00000382389.1
ENST00000377447.3
ENST00000314367.10
ENST00000356521.4
ENST00000382393.1
ENST00000377400.4
COBW domain containing 1
chr11_-_6633799 5.58 ENST00000299424.4
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr7_+_872107 5.49 ENST00000405266.1
ENST00000401592.1
ENST00000403868.1
ENST00000425407.2
Sad1 and UNC84 domain containing 1
chr12_-_56122761 5.45 ENST00000552164.1
ENST00000420846.3
ENST00000257857.4
CD63 molecule
chr2_-_209118974 5.40 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr9_-_127177703 5.39 ENST00000259457.3
ENST00000536392.1
ENST00000441097.1
proteasome (prosome, macropain) subunit, beta type, 7
chr2_+_136343820 5.37 ENST00000410054.1
R3H domain containing 1
chr19_-_51875523 5.37 ENST00000593572.1
ENST00000595157.1
natural killer cell group 7 sequence
chr11_+_114270752 5.35 ENST00000540163.1
RNA binding motif protein 7
chr1_+_156105878 5.20 ENST00000508500.1
lamin A/C
chr2_+_219081817 5.15 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
actin related protein 2/3 complex, subunit 2, 34kDa
chr16_-_88717482 5.12 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr14_-_51411194 5.07 ENST00000544180.2
phosphorylase, glycogen, liver
chr7_+_107220899 5.05 ENST00000379117.2
ENST00000473124.1
B-cell receptor-associated protein 29
chr21_+_30502806 4.91 ENST00000399928.1
ENST00000399926.1
MAP3K7 C-terminal like
chr17_-_39684550 4.85 ENST00000455635.1
ENST00000361566.3
keratin 19
chr8_-_124428569 4.82 ENST00000521903.1
ATPase family, AAA domain containing 2
chr13_+_34392185 4.73 ENST00000380071.3
replication factor C (activator 1) 3, 38kDa
chr14_+_90864504 4.73 ENST00000544280.2
calmodulin 1 (phosphorylase kinase, delta)
chr1_-_146040968 4.70 ENST00000401010.3
neuroblastoma breakpoint family, member 11
chrX_-_10645773 4.69 ENST00000453318.2
midline 1 (Opitz/BBB syndrome)
chr12_-_56120865 4.66 ENST00000548898.1
ENST00000552067.1
CD63 molecule
chr5_-_9630463 4.61 ENST00000382492.2
taste receptor, type 2, member 1
chr11_+_114271251 4.61 ENST00000375490.5
RNA binding motif protein 7
chr11_-_58345569 4.54 ENST00000528954.1
ENST00000528489.1
leupaxin
chr1_-_205744205 4.52 ENST00000446390.2
RAB7, member RAS oncogene family-like 1
chr6_+_32936353 4.51 ENST00000374825.4
bromodomain containing 2
chr7_+_107220660 4.50 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
B-cell receptor-associated protein 29
chr8_+_1993173 4.49 ENST00000523438.1
myomesin 2
chr12_+_21525818 4.49 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr11_-_615570 4.44 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_-_14628645 4.35 ENST00000598235.1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr14_-_75643296 4.34 ENST00000303575.4
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_+_75874984 4.28 ENST00000550491.1
GLI pathogenesis-related 1
chr10_+_60028818 4.22 ENST00000333926.5
CDGSH iron sulfur domain 1
chr20_-_24973318 4.14 ENST00000447138.1
adipocyte plasma membrane associated protein
chr11_+_69455855 4.13 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr5_-_71616043 4.12 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
mitochondrial ribosomal protein S27
chr8_-_49834299 4.12 ENST00000396822.1
snail family zinc finger 2
chr16_-_4395905 4.12 ENST00000571941.1
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr19_-_41942344 4.08 ENST00000594660.1
ATP5S-like
chrX_-_70329118 4.02 ENST00000374188.3
interleukin 2 receptor, gamma
chr9_-_70488865 4.01 ENST00000377392.5
COBW domain containing 5
chr5_+_82767583 3.91 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
versican
chrX_+_51636629 3.91 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
melanoma antigen family D, 1
chr3_+_112709755 3.78 ENST00000383678.2
GTP-binding protein 8 (putative)
chr2_-_85581701 3.73 ENST00000295802.4
retinol saturase (all-trans-retinol 13,14-reductase)
chr11_-_414948 3.73 ENST00000530494.1
ENST00000528209.1
ENST00000431843.2
ENST00000528058.1
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr7_+_148892557 3.72 ENST00000262085.3
zinc finger protein 282
chr13_+_114238997 3.70 ENST00000538138.1
ENST00000375370.5
transcription factor Dp-1
chr19_-_45982076 3.65 ENST00000423698.2
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_-_30440530 3.62 ENST00000568434.1
dCTP pyrophosphatase 1
chr12_+_19358228 3.56 ENST00000424268.1
ENST00000543806.1
pleckstrin homology domain containing, family A member 5
chr1_-_25256368 3.51 ENST00000308873.6
runt-related transcription factor 3
chr3_+_184033135 3.51 ENST00000424196.1
eukaryotic translation initiation factor 4 gamma, 1
chr3_-_183967296 3.46 ENST00000455059.1
ENST00000445626.2
ALG3, alpha-1,3- mannosyltransferase
chr22_-_31328881 3.37 ENST00000445980.1
MORC family CW-type zinc finger 2
chrX_-_7066159 3.36 ENST00000486446.2
ENST00000412827.2
ENST00000424830.2
ENST00000381077.5
ENST00000540122.1
haloacid dehalogenase-like hydrolase domain containing 1
chr2_+_169312725 3.35 ENST00000392687.4
ceramide synthase 6
chr12_+_1800179 3.33 ENST00000357103.4
adiponectin receptor 2
chr6_+_30585486 3.32 ENST00000259873.4
ENST00000506373.2
mitochondrial ribosomal protein S18B
chr12_-_49351228 3.31 ENST00000541959.1
ENST00000447318.2
ADP-ribosylation factor 3
chr14_+_103058948 3.21 ENST00000262241.6
REST corepressor 1
chr15_-_52483566 3.21 ENST00000261837.7
guanine nucleotide binding protein (G protein), beta 5
chr19_+_55897699 3.18 ENST00000558131.1
ENST00000558752.1
ENST00000458349.2
ribosomal protein L28
chr2_-_191878874 3.18 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
signal transducer and activator of transcription 1, 91kDa
chr3_-_79068594 3.13 ENST00000436010.2
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_211752073 3.12 ENST00000367001.4
solute carrier family 30 (zinc transporter), member 1
chr11_-_28129656 3.12 ENST00000263181.6
kinesin family member 18A
chr8_+_21823726 3.06 ENST00000433566.4
exportin 7
chr1_+_20915409 3.05 ENST00000375071.3
cytidine deaminase
chr3_-_120170052 3.05 ENST00000295633.3
follistatin-like 1
chr11_-_66112555 3.04 ENST00000425825.2
ENST00000359957.3
breast cancer metastasis suppressor 1
chr9_+_35829208 3.03 ENST00000439587.2
ENST00000377991.4
transmembrane protein 8B
chr5_+_35856951 3.00 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr19_-_44174330 2.96 ENST00000340093.3
plasminogen activator, urokinase receptor
chr2_+_234621551 2.96 ENST00000608381.1
ENST00000373414.3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr16_+_30212378 2.95 ENST00000569485.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr22_+_24823517 2.91 ENST00000496258.1
ENST00000337539.7
adenosine A2a receptor
chr1_+_93544791 2.89 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
metal response element binding transcription factor 2
chr19_-_39108552 2.87 ENST00000591517.1
mitogen-activated protein kinase kinase kinase kinase 1
chr19_-_43702231 2.86 ENST00000597374.1
ENST00000599371.1
pregnancy specific beta-1-glycoprotein 4
chr12_-_49351303 2.85 ENST00000256682.4
ADP-ribosylation factor 3
chrX_-_119709637 2.85 ENST00000404115.3
cullin 4B
chr12_+_112279782 2.82 ENST00000550735.2
mitogen-activated protein kinase-activated protein kinase 5
chr5_-_137514333 2.78 ENST00000411594.2
ENST00000430331.1
bromodomain containing 8
chr14_-_104028595 2.77 ENST00000337322.4
ENST00000445922.2
BCL2-associated athanogene 5
chr20_-_21378666 2.71 ENST00000351817.4
NK2 homeobox 4
chr3_+_157827841 2.71 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
arginine/serine-rich coiled-coil 1
chr8_-_99954788 2.69 ENST00000523601.1
serine/threonine kinase 3
chr6_+_30035307 2.65 ENST00000376765.2
ENST00000376763.1
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr1_+_8021713 2.63 ENST00000338639.5
ENST00000493678.1
ENST00000377493.5
parkinson protein 7
chr22_+_40441456 2.62 ENST00000402203.1
trinucleotide repeat containing 6B
chr3_-_125094093 2.61 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
zinc finger protein 148
chr22_+_23522552 2.58 ENST00000359540.3
ENST00000398512.5
breakpoint cluster region
chr2_+_189156586 2.57 ENST00000409830.1
GULP, engulfment adaptor PTB domain containing 1
chr11_+_237016 2.55 ENST00000352303.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr11_+_122709200 2.54 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr19_-_39108643 2.53 ENST00000396857.2
mitogen-activated protein kinase kinase kinase kinase 1
chr2_+_26467825 2.52 ENST00000545822.1
ENST00000425035.1
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
chr1_-_200589859 2.51 ENST00000367350.4
kinesin family member 14
chr13_-_48669232 2.48 ENST00000258648.2
ENST00000378586.1
mediator complex subunit 4
chr7_-_87849340 2.48 ENST00000419179.1
ENST00000265729.2
sorcin
chr10_-_5060147 2.47 ENST00000604507.1
aldo-keto reductase family 1, member C2
chr17_+_28804380 2.47 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
golgi SNAP receptor complex member 1
chr11_-_85779971 2.46 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr1_+_161736072 2.45 ENST00000367942.3
activating transcription factor 6
chr10_-_112678904 2.45 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBSome interacting protein 1
chr7_-_35077653 2.42 ENST00000310974.4
dpy-19-like 1 (C. elegans)
chr17_-_61996136 2.35 ENST00000342364.4
growth hormone 1
chr3_+_42190714 2.35 ENST00000449246.1
trafficking protein, kinesin binding 1
chr2_+_26467762 2.33 ENST00000317799.5
ENST00000405867.3
ENST00000537713.1
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
chr3_-_119379719 2.31 ENST00000493094.1
popeye domain containing 2
chr12_-_57522813 2.31 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_+_236959 2.29 ENST00000431206.2
ENST00000528906.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr1_+_44444865 2.28 ENST00000372324.1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chrX_+_123480194 2.25 ENST00000371139.4
SH2 domain containing 1A
chr10_-_112678692 2.24 ENST00000605742.1
BBSome interacting protein 1
chr11_+_20409070 2.12 ENST00000331079.6
protein arginine methyltransferase 3
chr2_-_136743169 2.11 ENST00000264161.4
aspartyl-tRNA synthetase
chr22_+_38597889 2.11 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr5_-_176433350 2.11 ENST00000377227.4
ENST00000377219.2
ubiquitin interaction motif containing 1
chr17_+_34538310 2.11 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
chemokine (C-C motif) ligand 4-like 1
chr1_-_205290865 2.10 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr2_-_26467557 2.10 ENST00000380649.3
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr16_+_67906919 2.09 ENST00000358933.5
enhancer of mRNA decapping 4
chr2_-_40679186 2.01 ENST00000406785.2
solute carrier family 8 (sodium/calcium exchanger), member 1
chr16_+_12059091 2.01 ENST00000562385.1
tumor necrosis factor receptor superfamily, member 17
chr22_-_41215291 2.00 ENST00000542412.1
ENST00000544408.1
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr11_-_61735103 1.98 ENST00000529191.1
ENST00000529631.1
ENST00000530019.1
ENST00000529548.1
ENST00000273550.7
ferritin, heavy polypeptide 1
chr3_-_105588231 1.97 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr6_+_43603552 1.97 ENST00000372171.4
MAD2L1 binding protein
chr14_-_23904861 1.96 ENST00000355349.3
myosin, heavy chain 7, cardiac muscle, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.8 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
4.7 60.5 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
3.9 23.4 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
3.3 9.9 GO:0009996 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
2.6 13.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
2.4 14.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
2.3 14.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
2.3 13.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
1.9 5.8 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
1.8 18.3 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.8 5.4 GO:0006097 glyoxylate cycle(GO:0006097)
1.6 9.8 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.5 7.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.4 4.1 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
1.4 5.5 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
1.3 6.7 GO:1902896 terminal web assembly(GO:1902896)
1.3 8.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.2 6.2 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
1.2 6.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
1.2 6.9 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
1.2 11.5 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
1.1 6.5 GO:0035803 egg coat formation(GO:0035803)
1.1 4.3 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
1.1 3.2 GO:0061317 regulation of Wnt signaling pathway involved in heart development(GO:0003307) arterial endothelial cell fate commitment(GO:0060844) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
1.1 9.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
1.1 6.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
1.1 4.2 GO:0043457 regulation of cellular respiration(GO:0043457)
1.0 3.1 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.0 5.2 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
1.0 4.0 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
1.0 8.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.0 2.9 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
1.0 18.2 GO:0007220 Notch receptor processing(GO:0007220)
0.9 4.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.9 5.6 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.9 2.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.8 2.4 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.8 3.2 GO:2000697 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.8 12.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.8 4.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.7 3.7 GO:0000720 meiotic mismatch repair(GO:0000710) pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.7 3.6 GO:0009213 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.7 5.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.7 18.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.7 2.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.6 4.5 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.6 4.4 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.6 6.3 GO:0009249 protein lipoylation(GO:0009249)
0.6 1.9 GO:0019858 cytosine metabolic process(GO:0019858)
0.6 3.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.6 6.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 1.8 GO:0006788 heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806)
0.6 3.0 GO:0070980 biphenyl catabolic process(GO:0070980)
0.6 4.0 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.6 1.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.6 1.7 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.5 4.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.5 3.7 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.5 4.8 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 2.5 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.5 2.0 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.5 2.5 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.5 10.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.5 2.8 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.4 3.5 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.4 5.6 GO:0070365 hepatocyte differentiation(GO:0070365)
0.4 6.0 GO:0051639 actin filament network formation(GO:0051639)
0.4 1.3 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.4 2.9 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.4 3.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.4 4.1 GO:0070141 response to UV-A(GO:0070141)
0.4 7.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.4 6.1 GO:0043248 proteasome assembly(GO:0043248)
0.4 6.1 GO:0000338 protein deneddylation(GO:0000338)
0.4 7.2 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.4 3.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.4 2.5 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.4 4.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.4 4.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 2.5 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.4 2.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.3 1.7 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.3 2.7 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.3 3.6 GO:0061458 reproductive system development(GO:0061458)
0.3 11.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 1.6 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 2.8 GO:0090400 stress-induced premature senescence(GO:0090400)
0.3 6.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 2.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.3 6.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 13.5 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.3 3.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.3 13.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 2.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.3 20.8 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.3 0.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.3 0.8 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.3 4.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.3 2.9 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 2.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 2.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.3 2.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 0.5 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 3.1 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 5.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 1.4 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.2 3.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2 10.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 2.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 2.3 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.2 2.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 3.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 1.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.6 GO:0043132 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132)
0.2 2.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 4.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 0.6 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.2 0.5 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 5.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 2.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 0.7 GO:1904379 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.2 17.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 2.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 4.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 12.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.2 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 4.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 6.3 GO:0006914 autophagy(GO:0006914)
0.2 2.2 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.2 11.2 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.5 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 0.7 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 1.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 3.9 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 0.7 GO:0051586 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.1 3.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.7 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.5 GO:0071461 cellular response to redox state(GO:0071461)
0.1 1.8 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 3.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.4 GO:0051958 methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.1 0.9 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 3.6 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.1 1.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.6 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.6 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 2.0 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.1 GO:0007567 parturition(GO:0007567)
0.1 0.5 GO:2001034 chromatin silencing at telomere(GO:0006348) positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.9 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401) cellular response to steroid hormone stimulus(GO:0071383)
0.1 1.0 GO:0030101 natural killer cell activation(GO:0030101)
0.1 2.3 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 0.5 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.1 0.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 0.6 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.1 4.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.8 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 2.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 3.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 6.0 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 0.6 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 6.7 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 2.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 3.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.6 GO:0002027 regulation of heart rate(GO:0002027)
0.0 1.2 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 2.6 GO:0021762 substantia nigra development(GO:0021762)
0.0 1.3 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108) peptidyl-tyrosine modification(GO:0018212)
0.0 3.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.7 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.9 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.5 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.6 GO:0019985 translesion synthesis(GO:0019985)
0.0 1.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 4.9 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0016101 retinoid metabolic process(GO:0001523) diterpenoid metabolic process(GO:0016101)
0.0 2.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.2 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 1.7 GO:0032355 response to estradiol(GO:0032355)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.6 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 60.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
4.0 19.8 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
2.4 7.1 GO:0031262 Ndc80 complex(GO:0031262)
2.1 22.6 GO:0070765 gamma-secretase complex(GO:0070765)
2.0 8.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
1.9 11.6 GO:1990357 terminal web(GO:1990357)
1.9 33.9 GO:0034709 methylosome(GO:0034709)
1.8 10.7 GO:0071817 MMXD complex(GO:0071817)
1.7 5.2 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.6 6.2 GO:0000811 GINS complex(GO:0000811)
1.4 11.4 GO:0042382 paraspeckles(GO:0042382)
1.2 3.6 GO:0070195 growth hormone receptor complex(GO:0070195)
1.0 4.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
1.0 18.3 GO:0097342 ripoptosome(GO:0097342)
0.9 6.3 GO:0031415 NatA complex(GO:0031415)
0.9 6.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.8 14.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.8 8.1 GO:0000796 condensin complex(GO:0000796)
0.8 4.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.8 13.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.7 5.6 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.7 8.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.6 3.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.6 5.6 GO:0000125 PCAF complex(GO:0000125)
0.6 2.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.6 6.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.6 5.2 GO:0005638 lamin filament(GO:0005638)
0.5 12.1 GO:0000242 pericentriolar material(GO:0000242)
0.5 3.7 GO:0070522 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.5 5.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 9.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.5 7.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.5 2.5 GO:0070847 core mediator complex(GO:0070847)
0.5 2.0 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.5 7.4 GO:0090543 Flemming body(GO:0090543)
0.4 4.0 GO:0071438 invadopodium membrane(GO:0071438)
0.4 5.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4 3.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 9.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 13.5 GO:0032420 stereocilium(GO:0032420)
0.4 2.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4 2.5 GO:0044326 dendritic spine neck(GO:0044326)
0.3 1.7 GO:0042643 actomyosin, actin portion(GO:0042643)
0.3 2.1 GO:0034464 BBSome(GO:0034464)
0.3 18.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 9.1 GO:0032982 myosin filament(GO:0032982)
0.3 5.4 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.3 13.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 3.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 6.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 3.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 20.8 GO:0005811 lipid particle(GO:0005811)
0.2 4.4 GO:0000812 Swr1 complex(GO:0000812)
0.2 0.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 1.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 3.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.2 2.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.2 3.1 GO:0030125 clathrin vesicle coat(GO:0030125)
0.2 6.3 GO:0000421 autophagosome membrane(GO:0000421)
0.2 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 0.7 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 3.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 3.0 GO:0051233 spindle midzone(GO:0051233)
0.2 3.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.0 GO:0070822 Sin3-type complex(GO:0070822)
0.1 4.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.8 GO:0043196 varicosity(GO:0043196)
0.1 5.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 2.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.9 GO:0044754 autolysosome(GO:0044754)
0.1 2.9 GO:0030673 axolemma(GO:0030673)
0.1 1.9 GO:0030056 hemidesmosome(GO:0030056)
0.1 4.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 7.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 3.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.9 GO:0030686 90S preribosome(GO:0030686)
0.1 0.6 GO:0070652 HAUS complex(GO:0070652)
0.1 2.4 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 3.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 7.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 3.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.9 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.8 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.1 GO:0005840 ribosome(GO:0005840)
0.0 9.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 9.9 GO:0005774 vacuolar membrane(GO:0005774)
0.0 2.1 GO:0005635 nuclear envelope(GO:0005635)
0.0 2.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.5 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.3 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 23.4 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
2.3 7.0 GO:0004917 interleukin-7 receptor activity(GO:0004917)
2.0 12.1 GO:0042610 CD8 receptor binding(GO:0042610)
1.8 5.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.5 7.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.4 26.8 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
1.3 4.0 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
1.3 8.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.3 5.1 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
1.2 3.6 GO:0005148 prolactin receptor binding(GO:0005148)
1.2 3.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.1 6.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.0 10.6 GO:0039706 co-receptor binding(GO:0039706)
0.9 2.6 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.9 12.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 4.4 GO:0047115 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.7 5.6 GO:0001849 complement component C1q binding(GO:0001849)
0.7 6.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.7 4.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 2.0 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.7 13.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.6 5.8 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.6 6.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 5.4 GO:0032190 acrosin binding(GO:0032190)
0.6 1.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.6 18.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.6 2.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.6 2.3 GO:0004461 lactose synthase activity(GO:0004461)
0.6 1.7 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.6 3.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.5 2.6 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.5 3.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.5 4.1 GO:0004064 arylesterase activity(GO:0004064)
0.5 23.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 2.9 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.5 6.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 12.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 6.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.4 9.6 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 3.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.4 2.1 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469) protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.4 2.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.4 3.6 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.4 4.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 6.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 6.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.4 3.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 8.6 GO:0031489 myosin V binding(GO:0031489)
0.3 1.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.3 8.1 GO:0005521 lamin binding(GO:0005521)
0.3 0.9 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.3 3.2 GO:0000150 recombinase activity(GO:0000150)
0.3 4.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.3 3.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 5.8 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.2 3.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 1.4 GO:0017018 myosin phosphatase activity(GO:0017018)
0.2 2.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 2.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 4.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.6 GO:0015230 FAD transmembrane transporter activity(GO:0015230) coenzyme transporter activity(GO:0051185)
0.2 5.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 5.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 3.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 2.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 2.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 7.1 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 4.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.8 GO:0030957 Tat protein binding(GO:0030957)
0.1 2.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 9.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 3.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.6 GO:0051373 FATZ binding(GO:0051373)
0.1 2.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 6.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.4 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.1 6.5 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 4.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 2.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 23.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 9.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 0.4 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.1 11.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 8.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.5 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.5 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 7.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 3.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 4.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 1.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 12.4 GO:0051015 actin filament binding(GO:0051015)
0.1 1.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 17.7 GO:0003924 GTPase activity(GO:0003924)
0.1 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.6 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.5 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 4.7 GO:0044325 ion channel binding(GO:0044325)
0.0 3.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.8 GO:0005525 GTP binding(GO:0005525)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 2.4 GO:0005496 steroid binding(GO:0005496)
0.0 4.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.9 GO:0050681 androgen receptor binding(GO:0050681)
0.0 4.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869) Ran GTPase binding(GO:0008536)
0.0 3.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 16.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.5 16.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5 17.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 12.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 12.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 9.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 7.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 6.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 14.4 PID AURORA B PATHWAY Aurora B signaling
0.2 3.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 15.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 4.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 9.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 36.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 15.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 6.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.2 PID CONE PATHWAY Visual signal transduction: Cones
0.1 4.1 PID MYC PATHWAY C-MYC pathway
0.1 3.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 3.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 1.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 4.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 4.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.7 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 4.4 PID FOXO PATHWAY FoxO family signaling
0.1 2.0 PID ATM PATHWAY ATM pathway
0.1 1.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 6.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID AURORA A PATHWAY Aurora A signaling
0.0 1.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 18.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
1.0 19.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.6 11.8 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.6 8.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.6 15.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 16.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.4 18.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 5.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4 9.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.4 5.9 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.4 6.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 6.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 6.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 9.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 7.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 4.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 13.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 6.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.3 42.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 9.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 5.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 3.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 5.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 5.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 3.8 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.2 6.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 11.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 5.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 4.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 3.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.1 REACTOME KINESINS Genes involved in Kinesins
0.1 3.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 7.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 6.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 4.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 8.3 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 5.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 4.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.3 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 3.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis