ISMARA results: TCF7

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7

Z-value: 0.84

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Transcription factors associated with TCF7

Gene Symbol	Gene ID	Gene Info
TCF7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000081059.15	transcription factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF7	hg19_v2_chr5_+_133477868_133477885	-0.17	1.5e-02	Click!

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_151344172 Show fit	28.07	ENST00000375734.2 ENST00000263895.4 ENST00000454202.1	RND3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho family GTPase 3
chr5_+_34757309 Show fit	20.05	ENST00000397449.1	RAI14 Ensembl NCBI GeneCards UniProt NextProt Show fit	retinoic acid induced 14
chr10_+_54074033 Show fit	15.66	ENST00000373970.3	DKK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 1
chr1_+_68150744 Show fit	14.49	ENST00000370986.4 ENST00000370985.3	GADD45A Ensembl NCBI GeneCards UniProt NextProt Show fit	growth arrest and DNA-damage-inducible, alpha
chr22_-_42336209 Show fit	12.48	ENST00000472374.2	CENPM Ensembl NCBI GeneCards UniProt NextProt Show fit	centromere protein M
chr7_-_107643674 Show fit	11.87	ENST00000222399.6	LAMB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, beta 1
chr12_+_69080734 Show fit	11.40	ENST00000378905.2	NUP107 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleoporin 107kDa
chr12_+_6309963 Show fit	10.74	ENST00000382515.2	CD9 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD9 molecule
chr11_-_64013288 Show fit	10.42	ENST00000542235.1	PPP1R14B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_64013663 Show fit	9.52	ENST00000392210.2	PPP1R14B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 14B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.7	GO:0009996	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
1.0	15.3	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.8	14.5	GO:0071850	mitotic cell cycle arrest(GO:0071850)
4.7	14.0	GO:1904481	response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.4	12.5	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
3.0	11.9	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
2.3	11.4	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1	11.2	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.8	10.7	GO:0030913	paranodal junction assembly(GO:0030913)
3.5	10.6	GO:0006172	ADP biosynthetic process(GO:0006172)

Showing 1 to 10 of 157 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	27.9	GO:0005925	focal adhesion(GO:0005925)
0.2	25.7	GO:0005604	basement membrane(GO:0005604)
0.0	19.7	GO:0016607	nuclear speck(GO:0016607)
0.1	15.1	GO:0001650	fibrillar center(GO:0001650)
0.1	14.4	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	14.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	13.8	GO:0031901	early endosome membrane(GO:0031901)
0.1	12.5	GO:0000777	condensed chromosome kinetochore(GO:0000777)
4.0	11.9	GO:0005607	laminin-2 complex(GO:0005607)
0.6	11.9	GO:0005832	chaperonin-containing T-complex(GO:0005832)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	31.6	GO:0003924	GTPase activity(GO:0003924)
0.4	19.9	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
1.5	16.0	GO:0039706	co-receptor binding(GO:0039706)
0.1	15.7	GO:0047485	protein N-terminus binding(GO:0047485)
3.1	15.3	GO:0070404	NADH binding(GO:0070404)
0.1	14.5	GO:0005201	extracellular matrix structural constituent(GO:0005201)
2.8	14.0	GO:0070905	serine binding(GO:0070905)
0.5	13.9	GO:0005523	tropomyosin binding(GO:0005523)
0.1	11.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	11.7	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Showing 1 to 10 of 109 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	19.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.8	18.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	15.7	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	14.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	13.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	13.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	11.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	10.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.2	9.7	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	30.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.3	19.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	14.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	14.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	12.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	11.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.3	11.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1	11.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	10.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.6	10.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway

Showing 1 to 10 of 52 entries

Results for TCF7

Z-value: 0.84

Motif logo

Transcription factors associated with TCF7

Activity-expression correlation:

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: