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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7L2

Z-value: 0.81

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114709999_1147100310.466.4e-13Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_69455855 21.60 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr5_-_16936340 17.13 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr11_+_114128522 16.30 ENST00000535401.1
NNMT
nicotinamide N-methyltransferase
chr17_-_40169659 12.31 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chrX_-_10588459 11.46 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_10588595 10.63 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr13_+_76334795 10.48 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr10_+_54074033 10.44 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr3_-_134093275 10.38 ENST00000513145.1
ENST00000422605.2
AMOTL2
angiomotin like 2
chr13_+_76334567 9.85 ENST00000321797.8
LMO7
LIM domain 7
chr3_-_134093395 9.53 ENST00000249883.5
AMOTL2
angiomotin like 2
chr4_-_157892498 9.16 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr1_-_94079648 9.16 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr10_+_114709999 8.78 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr3_-_149375783 8.71 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr2_+_234621551 8.58 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr5_+_102201509 8.10 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr10_+_114710211 7.99 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr5_-_175815565 7.43 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16
NOP16 nucleolar protein
chr7_+_73868439 6.86 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr7_-_27213893 6.47 ENST00000283921.4
HOXA10
homeobox A10
chr1_-_54303934 6.10 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr4_-_139163491 5.95 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_-_54304212 5.90 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr5_+_102201430 5.60 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr1_-_54303949 5.15 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr6_+_32146131 5.15 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr1_-_110933663 5.13 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr10_+_105005644 4.90 ENST00000441178.2
RP11-332O19.5
ribulose-5-phosphate-3-epimerase-like 1
chr1_-_110933611 4.82 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr5_-_16742330 4.75 ENST00000505695.1
ENST00000427430.2
MYO10
myosin X
chr10_+_71561630 4.70 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr2_-_9770706 4.68 ENST00000381844.4
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr17_-_56065484 4.62 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr5_-_148930960 4.57 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chrX_+_54835493 4.55 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr14_-_65409502 4.52 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_9771075 4.44 ENST00000446619.1
ENST00000238081.3
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr17_+_34848049 4.34 ENST00000588902.1
ENST00000591067.1
ZNHIT3
zinc finger, HIT-type containing 3
chr1_+_147013182 4.33 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr10_+_71561649 4.31 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr5_+_131593364 4.29 ENST00000253754.3
ENST00000379018.3
PDLIM4
PDZ and LIM domain 4
chr16_-_73082274 4.15 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr17_+_75447326 4.13 ENST00000591088.1
SEPT9
septin 9
chr10_+_71561704 4.07 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr6_-_11779403 3.90 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr2_+_69240302 3.88 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chrX_-_47004878 3.88 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr15_+_43985725 3.87 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chrX_-_47004437 3.87 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr2_+_69240415 3.77 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr12_-_49582593 3.62 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr17_+_37618257 3.60 ENST00000447079.4
CDK12
cyclin-dependent kinase 12
chr19_-_3061397 3.59 ENST00000586839.1
AES
amino-terminal enhancer of split
chr10_+_101542462 3.57 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_69240511 3.55 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr7_-_27219849 3.54 ENST00000396344.4
HOXA10
homeobox A10
chr5_+_140797296 3.47 ENST00000398594.2
PCDHGB7
protocadherin gamma subfamily B, 7
chr22_+_41347363 3.39 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr6_+_64281906 3.33 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_110091189 3.32 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr7_-_148581251 3.20 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr13_+_102142296 3.10 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_-_11779174 2.98 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr11_-_108422926 2.83 ENST00000428840.1
ENST00000526312.1
EXPH5
exophilin 5
chr3_-_113465065 2.83 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_-_148581360 2.75 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr15_+_57511609 2.75 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr21_-_35284635 2.74 ENST00000429238.1
AP000304.12
AP000304.12
chr2_+_201936707 2.62 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr12_+_122326662 2.59 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr12_+_122326630 2.57 ENST00000541212.1
ENST00000340175.5
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr16_+_29819372 2.55 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr15_+_43885252 2.54 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chrX_-_153599578 2.51 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr1_-_109935819 2.50 ENST00000538502.1
SORT1
sortilin 1
chr15_+_43985084 2.46 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr6_-_32145861 2.41 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr17_-_39093672 2.38 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_88427568 2.30 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr7_-_148725733 2.30 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chrX_-_43832711 2.25 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr6_-_11779840 2.22 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr9_-_27005686 2.15 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr6_-_112575912 2.14 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr8_-_16859690 2.09 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr19_-_39924349 2.02 ENST00000602153.1
RPS16
ribosomal protein S16
chr12_+_1738363 1.99 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr5_+_170846640 1.95 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr1_-_153522562 1.87 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr17_-_46035187 1.81 ENST00000300557.2
PRR15L
proline rich 15-like
chr5_+_140734570 1.80 ENST00000571252.1
PCDHGA4
protocadherin gamma subfamily A, 4
chr2_+_228678550 1.72 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr8_+_32579341 1.68 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr10_-_104192405 1.64 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr12_-_49582978 1.60 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chrX_-_39956656 1.57 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr10_+_115312766 1.56 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr17_+_68100989 1.55 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_135290705 1.54 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr4_+_30721968 1.51 ENST00000361762.2
PCDH7
protocadherin 7
chr16_+_29819446 1.50 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_71357434 1.49 ENST00000244230.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr15_-_31393910 1.39 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr5_-_157002775 1.32 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr2_+_201936458 1.29 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chrX_+_100646190 1.24 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr5_+_175815732 1.20 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr17_-_73389737 1.19 ENST00000392563.1
GRB2
growth factor receptor-bound protein 2
chr3_+_141106643 1.13 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr6_-_112575687 1.13 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr16_+_72088376 1.12 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr12_+_85673868 1.09 ENST00000316824.3
ALX1
ALX homeobox 1
chr17_+_42923686 1.05 ENST00000591513.1
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr17_-_7297519 1.02 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr14_+_23235886 1.01 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like
chr8_-_119964434 0.96 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr14_+_75230011 0.96 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chrX_+_100645812 0.95 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr1_+_16693578 0.83 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr6_-_112575838 0.83 ENST00000455073.1
LAMA4
laminin, alpha 4
chr1_+_154244987 0.82 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chrX_+_15525426 0.77 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr1_+_62417957 0.76 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr3_+_29323043 0.73 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr5_+_112074029 0.73 ENST00000512211.2
APC
adenomatous polyposis coli
chr14_+_21236586 0.70 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr7_-_80141328 0.66 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr17_+_79679299 0.65 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr10_-_105677427 0.56 ENST00000369764.1
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chrX_+_47004639 0.52 ENST00000345781.6
RBM10
RNA binding motif protein 10
chr7_-_75452673 0.51 ENST00000416943.1
CCL24
chemokine (C-C motif) ligand 24
chr8_+_29953163 0.49 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr12_-_52779433 0.47 ENST00000257951.3
KRT84
keratin 84
chr19_-_40791302 0.45 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr6_+_152130240 0.45 ENST00000427531.2
ESR1
estrogen receptor 1
chrX_+_47004599 0.43 ENST00000329236.7
RBM10
RNA binding motif protein 10
chr20_-_17511962 0.43 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr6_-_112575758 0.40 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr14_+_32798547 0.28 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr22_+_19950060 0.28 ENST00000449653.1
COMT
catechol-O-methyltransferase
chrX_+_69488155 0.28 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chrX_+_152760397 0.27 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chrX_-_63005405 0.25 ENST00000374878.1
ENST00000437457.2
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr8_-_133123406 0.24 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr6_+_29427548 0.23 ENST00000377132.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr17_-_38256973 0.18 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr17_-_7297833 0.18 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_-_58335281 0.17 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_52056548 0.16 ENST00000545061.1
ENST00000355133.3
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr7_-_16505440 0.14 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr5_+_175288631 0.12 ENST00000509837.1
CPLX2
complexin 2
chr1_-_32801825 0.10 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr1_+_151138526 0.07 ENST00000368902.1
SCNM1
sodium channel modifier 1
chr14_-_75179774 0.06 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr8_-_95220775 0.03 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr17_-_39646116 0.01 ENST00000328119.6
KRT36
keratin 36
chr2_-_55647057 0.00 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0030474 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
3.7 11.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
3.5 10.4 GO:0009996 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
3.4 13.7 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
2.5 15.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
2.2 21.6 GO:0070141 response to UV-A(GO:0070141)
2.0 6.0 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
1.7 8.6 GO:0070980 biphenyl catabolic process(GO:0070980)
1.7 22.1 GO:0035372 protein localization to microtubule(GO:0035372)
1.4 6.9 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.4 16.3 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.2 3.6 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) response to antineoplastic agent(GO:0097327)
1.0 4.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.0 5.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.9 12.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.8 8.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.8 5.3 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.7 2.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.7 4.6 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.6 2.5 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.6 6.3 GO:0006600 creatine metabolic process(GO:0006600)
0.6 1.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.6 2.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 2.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.4 10.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 2.5 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.4 2.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 18.0 GO:0035329 hippo signaling(GO:0035329)
0.4 1.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.4 9.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.4 10.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.3 3.4 GO:0010265 SCF complex assembly(GO:0010265)
0.3 1.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.3 1.6 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.3 3.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 5.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.3 21.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 6.0 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 13.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 2.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 2.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 0.7 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.2 2.4 GO:0070307 lens fiber cell development(GO:0070307)
0.2 0.6 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2 9.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 4.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 11.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 3.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.2 2.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 2.8 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 2.5 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 0.8 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 7.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.5 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 4.3 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.1 1.4 GO:0046548 retinal rod cell development(GO:0046548)
0.1 3.3 GO:0046039 GTP metabolic process(GO:0046039)
0.1 4.8 GO:0001885 endothelial cell development(GO:0001885)
0.1 0.2 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.1 0.3 GO:0045963 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) positive regulation of homocysteine metabolic process(GO:0050668)
0.1 0.8 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 2.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.5 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 2.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 19.6 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.5 GO:0035878 nail development(GO:0035878)
0.0 2.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 5.1 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 3.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0002576 platelet degranulation(GO:0002576)
0.0 2.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 2.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 2.4 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 1.9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.1 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 1.8 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
3.3 13.1 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
2.5 15.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.1 3.4 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
1.1 21.9 GO:0032433 filopodium tip(GO:0032433)
0.8 2.5 GO:0031523 Myb complex(GO:0031523)
0.5 3.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 5.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.5 8.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.4 6.0 GO:0045120 pronucleus(GO:0045120)
0.4 5.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.4 2.8 GO:0031415 NatA complex(GO:0031415)
0.4 25.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 27.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.4 GO:0035838 growing cell tip(GO:0035838)
0.3 11.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 2.3 GO:0045179 apical cortex(GO:0045179)
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 5.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 4.1 GO:0031105 septin complex(GO:0031105)
0.2 11.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 3.3 GO:0042588 zymogen granule(GO:0042588)
0.1 0.8 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 18.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 4.5 GO:0005605 basal lamina(GO:0005605)
0.1 1.8 GO:0005882 intermediate filament(GO:0005882)
0.1 2.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 6.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 10.6 GO:0043204 perikaryon(GO:0043204)
0.1 17.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.1 2.2 GO:0070469 respiratory chain(GO:0070469)
0.0 7.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 4.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 10.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 10.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 9.1 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.3 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
3.4 13.7 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.4 21.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
1.2 6.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.9 10.4 GO:0039706 co-receptor binding(GO:0039706)
0.8 6.3 GO:0004111 creatine kinase activity(GO:0004111)
0.7 21.6 GO:0070064 proline-rich region binding(GO:0070064)
0.7 13.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.7 6.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 2.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.6 17.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 1.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 2.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.5 2.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 5.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 3.4 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.4 9.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 12.3 GO:0001671 ATPase activator activity(GO:0001671)
0.3 2.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 9.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 3.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.3 3.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 8.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.6 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.2 1.1 GO:0030492 hemoglobin binding(GO:0030492)
0.2 21.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 10.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 1.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 3.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.5 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 11.2 GO:0005518 collagen binding(GO:0005518)
0.1 2.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 4.2 GO:0005109 frizzled binding(GO:0005109)
0.1 4.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 1.9 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 9.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 11.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 8.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 13.1 GO:0008201 heparin binding(GO:0008201)
0.1 0.8 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 12.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.6 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 10.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 5.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 21.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.5 11.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 21.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.3 10.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 10.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 13.1 NABA COLLAGENS Genes encoding collagen proteins
0.3 3.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 7.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 9.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 10.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 4.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 5.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 15.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 6.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.8 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 19.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 28.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.9 21.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 9.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 21.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 8.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 4.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 5.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 13.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 3.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 5.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 16.6 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 6.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 5.2 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.1 2.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 3.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 9.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation