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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TEAD3_TEAD1
Z-value: 2.74
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD3 | hg19_v2_chr6_-_35464727_35464738, hg19_v2_chr6_-_35464817_35464894 | 0.58 | 3.8e-21 | Click! |
| TEAD1 | hg19_v2_chr11_+_12766583_12766592, hg19_v2_chr11_+_12696102_12696164, hg19_v2_chr11_+_12695944_12695989 | 0.53 | 2.3e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 69.5 | 208.6 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 11.0 | 198.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 22.6 | 135.6 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 31.1 | 124.5 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.3 | 117.9 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.7 | 103.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.1 | 87.7 | GO:0035329 | hippo signaling(GO:0035329) |
| 27.7 | 83.0 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 9.0 | 81.3 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) chondroblast differentiation(GO:0060591) |
| 0.9 | 70.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 215.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 3.6 | 213.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 179.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.4 | 126.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 31.2 | 124.9 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 13.8 | 124.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 6.5 | 97.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 92.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 6.9 | 90.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 2.5 | 89.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 261.6 | GO:0001968 | fibronectin binding(GO:0001968) |
| 6.4 | 196.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 175.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 4.9 | 136.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 5.8 | 127.1 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 3.1 | 96.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.2 | 96.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 27.7 | 83.0 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.8 | 72.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 2.5 | 54.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 397.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 5.0 | 149.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 2.0 | 116.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.6 | 115.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.8 | 63.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.7 | 56.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 49.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 43.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.9 | 42.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.7 | 40.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 362.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 7.0 | 265.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 6.9 | 124.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 4.1 | 119.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 2.3 | 64.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 2.5 | 61.9 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 2.3 | 55.0 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.4 | 44.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 3.5 | 38.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 1.3 | 37.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |