ISMARA results: TEAD4

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TEAD4

Z-value: 1.04

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Transcription factors associated with TEAD4

Gene Symbol	Gene ID	Gene Info
TEAD4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000197905.4	TEA domain transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TEAD4	hg19_v2_chr12_+_3068544_3068597, hg19_v2_chr12_+_3068466_3068496, hg19_v2_chr12_+_3069037_3069119	-0.46	6.7e-13	Click!

Activity profile of TEAD4 motif

Sorted Z-values of TEAD4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91539918 Show fit	24.34	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr17_-_29624343 Show fit	21.96	ENST00000247271.4	OMG Ensembl NCBI GeneCards UniProt NextProt Show fit	oligodendrocyte myelin glycoprotein
chr9_-_104249400 Show fit	18.27	ENST00000374848.3	TMEM246 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 246
chr1_+_153004800 Show fit	16.44	ENST00000392661.3	SPRR1B Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 1B
chr8_-_27115931 Show fit	14.49	ENST00000523048.1	STMN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin-like 4
chr19_+_35630022 Show fit	14.07	ENST00000589209.1	FXYD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 1
chr7_-_37024665 Show fit	14.03	ENST00000396040.2	ELMO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	engulfment and cell motility 1
chr5_+_173472607 Show fit	13.91	ENST00000303177.3 ENST00000519867.1	NSG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Neuron-specific protein family member 2
chr12_+_79258547 Show fit	13.51	ENST00000457153.2	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr15_+_81475047 Show fit	13.04	ENST00000559388.1	IL16 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 16

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	34.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
4.9	29.4	GO:0010734	protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.4	28.8	GO:0006910	phagocytosis, recognition(GO:0006910)
8.8	26.3	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.3	23.6	GO:0050771	negative regulation of axonogenesis(GO:0050771)
2.1	20.9	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.5	20.5	GO:0007019	microtubule depolymerization(GO:0007019)
0.4	18.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
1.2	17.4	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.2	17.3	GO:0002455	humoral immune response mediated by circulating immunoglobulin(GO:0002455)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	40.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
2.5	34.7	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	34.0	GO:0009986	cell surface(GO:0009986)
0.7	33.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	28.8	GO:0030426	growth cone(GO:0030426)
5.3	26.3	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1	21.0	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6	20.9	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2	16.8	GO:0005901	caveola(GO:0005901)
0.5	16.7	GO:0005859	muscle myosin complex(GO:0005859)

Showing 1 to 10 of 81 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	34.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.6	33.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.2	27.0	GO:0003823	antigen binding(GO:0003823)
5.3	26.3	GO:0030348	syntaxin-3 binding(GO:0030348)
0.5	26.0	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	21.6	GO:0015631	tubulin binding(GO:0015631)
0.7	20.9	GO:0005521	lamin binding(GO:0005521)
0.1	17.4	GO:0008565	protein transporter activity(GO:0008565)
0.8	17.3	GO:0042609	CD4 receptor binding(GO:0042609)
3.9	15.7	GO:0031716	calcitonin receptor activity(GO:0004948) calcitonin receptor binding(GO:0031716)

Showing 1 to 10 of 105 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	33.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	26.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.2	23.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.3	14.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	11.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.5	11.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	10.1	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	8.9	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	8.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	8.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	34.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	30.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
1.5	26.3	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	20.9	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.2	18.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.4	18.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.4	12.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.9	12.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.3	11.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.3	11.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation

Showing 1 to 10 of 56 entries

Results for TEAD4

Z-value: 1.04

Motif logo

Transcription factors associated with TEAD4

Activity-expression correlation:

Activity profile of TEAD4 motif

Sorted Z-values of TEAD4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: