ISMARA results: TLX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TLX1_NFIC

Z-value: 2.07

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Transcription factors associated with TLX1_NFIC

Gene Symbol	Gene ID	Gene Info
TLX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000107807.8	T cell leukemia homeobox 1
NFIC Ensembl NCBI GeneCards UniProt NextProt	ENSG00000141905.13	nuclear factor I C

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIC	hg19_v2_chr19_+_3366547_3366619	0.45	2.9e-12	Click!
TLX1	hg19_v2_chr10_+_102891048_102891078	0.35	1.3e-07	Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_-_74728998 Show fit	76.22	ENST00000359645.3 ENST00000397875.3 ENST00000397869.3 ENST00000578193.1 ENST00000578873.1 ENST00000397866.4 ENST00000528160.1 ENST00000527041.1 ENST00000526111.1 ENST00000397865.5 ENST00000382582.3	MBP Ensembl NCBI GeneCards UniProt NextProt Show fit	myelin basic protein
chr16_+_226658 Show fit	70.91	ENST00000320868.5 ENST00000397797.1	HBA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, alpha 1
chr8_-_27468842 Show fit	66.99	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr11_-_111783919 Show fit	62.47	ENST00000531198.1 ENST00000533879.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr11_-_111784005 Show fit	53.52	ENST00000527899.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr3_-_58613323 Show fit	52.84	ENST00000474531.1 ENST00000465970.1	FAM107A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 107, member A
chr9_+_139871948 Show fit	52.40	ENST00000224167.2 ENST00000457950.1 ENST00000371625.3 ENST00000371623.3	PTGDS Ensembl NCBI GeneCards UniProt NextProt Show fit	prostaglandin D2 synthase 21kDa (brain)
chr8_-_27468945 Show fit	52.25	ENST00000405140.3	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr16_+_222846 Show fit	49.53	ENST00000251595.6 ENST00000397806.1	HBA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, alpha 2
chr11_-_111781454 Show fit	49.17	ENST00000533280.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.6	165.8	GO:0061518	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
9.2	165.2	GO:0007021	tubulin complex assembly(GO:0007021)
15.2	76.2	GO:1904209	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
4.7	70.9	GO:0015671	oxygen transport(GO:0015671)
0.2	54.5	GO:0051480	regulation of cytosolic calcium ion concentration(GO:0051480)
2.0	53.7	GO:0031639	plasminogen activation(GO:0031639)
3.0	53.3	GO:0019371	cyclooxygenase pathway(GO:0019371)
8.9	44.4	GO:1903974	positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
3.0	39.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.1	38.2	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)

Showing 1 to 10 of 197 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.2	195.4	GO:0097418	neurofibrillary tangle(GO:0097418)
10.3	165.2	GO:0097512	cardiac myofibril(GO:0097512)
10.9	76.2	GO:0033269	internode region of axon(GO:0033269)
17.7	70.9	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.6	56.2	GO:0043195	terminal bouton(GO:0043195)
0.1	51.7	GO:0045177	apical part of cell(GO:0045177)
0.1	47.0	GO:0016607	nuclear speck(GO:0016607)
7.4	44.4	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.2	43.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.5	41.8	GO:0005791	rough endoplasmic reticulum(GO:0005791)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	178.9	GO:0005212	structural constituent of eye lens(GO:0005212)
8.3	166.7	GO:0051787	misfolded protein binding(GO:0051787)
0.7	76.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
6.4	76.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
5.5	70.9	GO:0005344	oxygen transporter activity(GO:0005344)
0.3	53.8	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.4	52.7	GO:0051219	phosphoprotein binding(GO:0051219)
13.1	52.4	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.1	50.6	GO:0046982	protein heterodimerization activity(GO:0046982)
7.4	44.4	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)

Showing 1 to 10 of 135 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	156.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.9	107.2	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
1.8	93.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
1.4	70.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.8	62.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.4	60.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	56.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.1	46.6	PID ALK1 PATHWAY	ALK1 signaling events
1.3	43.0	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.8	38.2	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	179.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.0	81.4	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.8	50.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.5	38.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.2	31.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.0	29.7	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5	28.8	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.8	26.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.2	26.3	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.5	25.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis

Showing 1 to 10 of 59 entries

Results for TLX1_NFIC

Z-value: 2.07

Motif logo

Transcription factors associated with TLX1_NFIC

Activity-expression correlation:

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: