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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TP73

Z-value: 0.76

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.10 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3569129_35691500.421.5e-10Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_222846 33.40 ENST00000251595.6
ENST00000397806.1
HBA2
hemoglobin, alpha 2
chr14_+_75746340 25.85 ENST00000555686.1
ENST00000555672.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr14_+_75745477 24.23 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_-_91573249 11.16 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr3_-_48936272 10.43 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr15_+_74466744 8.57 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr20_+_48807351 8.15 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr6_-_46703069 7.47 ENST00000538237.1
ENST00000274793.7
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr8_+_120885949 7.23 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr10_-_105212059 7.23 ENST00000260743.5
CALHM2
calcium homeostasis modulator 2
chr10_-_105212141 6.80 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr1_-_236228417 6.79 ENST00000264187.6
NID1
nidogen 1
chr17_+_73750699 6.68 ENST00000584939.1
ITGB4
integrin, beta 4
chr2_-_230135937 6.67 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
PID1
phosphotyrosine interaction domain containing 1
chr11_+_65154070 6.48 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
FRMD8
FERM domain containing 8
chr7_-_100171270 6.33 ENST00000538735.1
SAP25
Sin3A-associated protein, 25kDa
chr2_+_220283091 6.29 ENST00000373960.3
DES
desmin
chr3_-_50340996 6.19 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1
hyaluronoglucosaminidase 1
chr1_-_236228403 6.15 ENST00000366595.3
NID1
nidogen 1
chr9_+_6757634 5.91 ENST00000543771.1
ENST00000401787.3
ENST00000381306.3
ENST00000381309.3
KDM4C
lysine (K)-specific demethylase 4C
chr15_+_41136216 5.90 ENST00000562057.1
ENST00000344051.4
SPINT1
serine peptidase inhibitor, Kunitz type 1
chrX_-_38186811 5.81 ENST00000318842.7
RPGR
retinitis pigmentosa GTPase regulator
chr22_-_37976082 5.56 ENST00000215886.4
LGALS2
lectin, galactoside-binding, soluble, 2
chr16_+_84178874 5.05 ENST00000378553.5
DNAAF1
dynein, axonemal, assembly factor 1
chr8_+_37654693 4.58 ENST00000412232.2
GPR124
G protein-coupled receptor 124
chr17_-_42452063 4.52 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chrX_-_38186775 4.52 ENST00000339363.3
ENST00000309513.3
ENST00000338898.3
ENST00000342811.3
ENST00000378505.2
RPGR
retinitis pigmentosa GTPase regulator
chr15_+_41136586 4.49 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr6_-_46703430 4.31 ENST00000537365.1
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_-_79818354 4.23 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr11_+_60197069 4.13 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr11_+_60197040 4.03 ENST00000300190.2
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr1_-_203055129 3.97 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr16_+_67197288 3.63 ENST00000264009.8
ENST00000421453.1
HSF4
heat shock transcription factor 4
chr10_-_47173994 3.52 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
ANXA8L1
LINC00842
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr10_+_47746929 3.37 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
ANXA8L2
AL603965.1
annexin A8-like 2
Protein LOC100996760
chr8_+_37654424 3.37 ENST00000315215.7
GPR124
G protein-coupled receptor 124
chrX_+_77166172 3.25 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr18_-_53253323 3.16 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr19_+_17326521 3.09 ENST00000593597.1
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr17_+_43318434 2.90 ENST00000587489.1
FMNL1
formin-like 1
chr18_-_53253112 2.86 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr1_+_155146318 2.85 ENST00000368385.4
ENST00000545012.1
ENST00000392451.2
ENST00000368383.3
ENST00000368382.1
ENST00000334634.4
TRIM46
tripartite motif containing 46
chr12_-_117319236 2.68 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr16_+_8891670 2.65 ENST00000268261.4
ENST00000539622.1
ENST00000569958.1
ENST00000537352.1
PMM2
phosphomannomutase 2
chr1_-_160832642 2.62 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr16_-_20367584 2.62 ENST00000570689.1
UMOD
uromodulin
chr11_-_65686496 2.61 ENST00000449692.3
C11orf68
chromosome 11 open reading frame 68
chr6_-_112194484 2.55 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr6_-_72130472 2.53 ENST00000426635.2
LINC00472
long intergenic non-protein coding RNA 472
chr8_-_145016692 2.52 ENST00000357649.2
PLEC
plectin
chr6_+_35995552 2.50 ENST00000468133.1
MAPK14
mitogen-activated protein kinase 14
chr18_+_77623668 2.43 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr17_-_2614927 2.42 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr3_+_42201653 2.39 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chr12_+_44152740 2.25 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
IRAK4
interleukin-1 receptor-associated kinase 4
chr1_-_241799232 2.20 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chr8_-_70745575 2.15 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr12_-_57505121 2.12 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr17_+_37356555 2.11 ENST00000579374.1
RPL19
ribosomal protein L19
chr17_+_37356528 2.09 ENST00000225430.4
RPL19
ribosomal protein L19
chr6_+_31515337 2.00 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr17_+_4835580 1.90 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr7_-_2883928 1.89 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr16_-_2581409 1.88 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
CEMP1
cementum protein 1
chr17_+_37356586 1.86 ENST00000579260.1
ENST00000582193.1
RPL19
ribosomal protein L19
chr1_-_68698197 1.85 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr19_-_36233332 1.79 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGFLR1
IGF-like family receptor 1
chrX_-_138724994 1.69 ENST00000536274.1
MCF2
MCF.2 cell line derived transforming sequence
chr10_-_91295304 1.63 ENST00000341233.4
ENST00000371790.4
SLC16A12
solute carrier family 16, member 12
chr14_-_25045446 1.63 ENST00000216336.2
CTSG
cathepsin G
chr16_+_21312170 1.61 ENST00000338573.5
ENST00000561968.1
CRYM-AS1
CRYM antisense RNA 1
chrX_+_72667090 1.56 ENST00000373514.2
CDX4
caudal type homeobox 4
chr22_+_39966758 1.55 ENST00000407673.1
ENST00000401624.1
ENST00000404898.1
ENST00000402142.3
ENST00000336649.4
ENST00000400164.3
CACNA1I
calcium channel, voltage-dependent, T type, alpha 1I subunit
chr6_+_35995531 1.40 ENST00000229794.4
MAPK14
mitogen-activated protein kinase 14
chr1_-_78444738 1.36 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr1_-_111148241 1.33 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr18_-_4455260 1.31 ENST00000581527.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr17_-_40835076 1.25 ENST00000591765.1
CCR10
chemokine (C-C motif) receptor 10
chr1_+_26485511 1.20 ENST00000374268.3
FAM110D
family with sequence similarity 110, member D
chr16_-_8891481 1.13 ENST00000333050.6
TMEM186
transmembrane protein 186
chr15_+_75498355 1.12 ENST00000567617.1
C15orf39
chromosome 15 open reading frame 39
chrX_-_138724677 1.11 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr5_+_43120985 1.06 ENST00000515326.1
ZNF131
zinc finger protein 131
chr2_+_114163945 1.04 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr19_+_49622646 0.99 ENST00000334186.4
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_96858454 0.98 ENST00000555570.1
AK7
adenylate kinase 7
chr15_+_75498739 0.88 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr1_-_68698222 0.74 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr14_-_105531759 0.72 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
GPR132
G protein-coupled receptor 132
chr7_-_100493744 0.61 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr14_+_72399833 0.57 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr17_+_21191341 0.51 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr7_-_128045984 0.31 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr15_+_64680003 0.28 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr9_+_87285257 0.22 ENST00000323115.4
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr1_-_52344471 0.19 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr10_-_97200772 0.08 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr18_-_28681950 0.04 ENST00000251081.6
DSC2
desmocollin 2
chr17_+_72427477 0.02 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 50.1 GO:0001661 conditioned taste aversion(GO:0001661)
2.2 6.7 GO:0090298 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
2.1 6.2 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.0 11.8 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.3 4.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.1 3.3 GO:0071284 cellular response to lead ion(GO:0071284)
0.9 11.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.9 2.6 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.9 2.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.8 5.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.8 12.9 GO:0032836 glomerular basement membrane development(GO:0032836)
0.8 3.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.7 5.9 GO:1900113 histone H3-K36 demethylation(GO:0070544) negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.7 2.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.6 10.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.6 7.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.5 2.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.5 4.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.5 2.6 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.5 10.4 GO:0006853 carnitine shuttle(GO:0006853)
0.5 2.5 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.5 6.7 GO:0035878 nail development(GO:0035878)
0.5 7.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.4 2.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.3 1.3 GO:0021633 optic nerve structural organization(GO:0021633)
0.3 2.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.3 6.3 GO:0045109 intermediate filament organization(GO:0045109)
0.3 2.9 GO:0099612 protein localization to axon(GO:0099612)
0.2 2.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 3.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 1.6 GO:0070943 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.2 10.3 GO:0042073 intraciliary transport(GO:0042073)
0.2 2.9 GO:0051014 actin filament severing(GO:0051014)
0.1 6.1 GO:0097421 liver regeneration(GO:0097421)
0.1 2.7 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 2.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 2.3 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 1.9 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 1.6 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 4.5 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 0.5 GO:0035897 proteolysis in other organism(GO:0035897)
0.1 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 1.6 GO:0072337 modified amino acid transport(GO:0072337)
0.1 2.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.9 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 0.2 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 8.6 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.6 GO:0060711 labyrinthine layer development(GO:0060711)
0.0 3.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 2.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.1 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 6.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.0 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 16.1 GO:0098655 cation transmembrane transport(GO:0098655)
0.0 1.2 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 50.1 GO:0035976 AP1 complex(GO:0035976)
1.4 4.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.8 11.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 2.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.5 2.9 GO:1990769 proximal neuron projection(GO:1990769)
0.4 9.2 GO:0030056 hemidesmosome(GO:0030056)
0.4 11.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 6.3 GO:0005916 fascia adherens(GO:0005916)
0.4 6.5 GO:0005856 cytoskeleton(GO:0005856)
0.3 13.0 GO:0005605 basal lamina(GO:0005605)
0.2 5.9 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 2.9 GO:0032059 bleb(GO:0032059)
0.1 4.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.3 GO:0033010 paranodal junction(GO:0033010)
0.1 10.3 GO:0036126 sperm flagellum(GO:0036126)
0.1 3.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 2.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 8.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 8.1 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.1 5.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 2.4 GO:1904115 axon cytoplasm(GO:1904115)
0.1 6.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 10.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 6.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 7.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.4 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
2.2 12.9 GO:0043237 laminin-1 binding(GO:0043237)
2.1 6.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.5 6.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.5 11.8 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
1.4 5.6 GO:0016936 galactoside binding(GO:0016936)
1.1 4.5 GO:0070051 fibrinogen binding(GO:0070051)
1.1 3.3 GO:0032767 copper-dependent protein binding(GO:0032767)
1.0 50.1 GO:0070412 R-SMAD binding(GO:0070412)
0.8 4.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.7 5.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 1.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.5 6.7 GO:0038132 neuregulin binding(GO:0038132)
0.5 6.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 8.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 2.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.4 3.9 GO:0051525 NFAT protein binding(GO:0051525)
0.3 1.9 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 2.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 2.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 11.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 2.9 GO:0005522 profilin binding(GO:0005522)
0.1 5.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 2.6 GO:0019864 IgG binding(GO:0019864)
0.1 3.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 10.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.9 GO:0050780 dopamine receptor binding(GO:0050780)
0.1 2.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.6 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 2.5 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.1 1.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 2.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 14.0 GO:0005261 cation channel activity(GO:0005261)
0.0 0.2 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 6.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 12.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 3.6 GO:0043565 sequence-specific DNA binding(GO:0043565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 50.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 12.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.3 6.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 11.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.8 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 11.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 8.1 PID IL3 PATHWAY IL3-mediated signaling events
0.1 7.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 6.3 PID AURORA B PATHWAY Aurora B signaling
0.1 7.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 11.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 8.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 2.1 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 4.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 5.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 9.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 6.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 54.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 11.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 17.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 10.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.3 4.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 10.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 4.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 4.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 2.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 2.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 6.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 8.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 9.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 3.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 6.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction