ISMARA results: TWIST1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TWIST1_SNAI1

Z-value: 0.90

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Transcription factors associated with TWIST1_SNAI1

Gene Symbol	Gene ID	Gene Info
TWIST1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000122691.8	twist family bHLH transcription factor 1
SNAI1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000124216.3	snail family transcriptional repressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TWIST1	hg19_v2_chr7_-_19157248_19157295	-0.02	7.9e-01	Click!
SNAI1	hg19_v2_chr20_+_48599506_48599536	0.02	8.3e-01	Click!

Activity profile of TWIST1_SNAI1 motif

Sorted Z-values of TWIST1_SNAI1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_175870085 Show fit	13.93	ENST00000409156.3	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr19_+_36359341 Show fit	12.88	ENST00000221891.4	APLP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	amyloid beta (A4) precursor-like protein 1
chr9_+_17579084 Show fit	12.43	ENST00000380607.4	SH3GL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 2
chr3_-_149688896 Show fit	12.33	ENST00000239940.7	PFN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	profilin 2
chr12_+_52626898 Show fit	11.15	ENST00000331817.5	KRT7 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 7
chr17_-_57184260 Show fit	10.43	ENST00000376149.3 ENST00000393066.3	TRIM37 Ensembl NCBI GeneCards UniProt NextProt Show fit	tripartite motif containing 37
chr12_+_53342625 Show fit	9.94	ENST00000388837.2 ENST00000550600.1 ENST00000388835.3	KRT18 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 18
chr6_-_3227877 Show fit	8.77	ENST00000259818.7	TUBB2B Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, beta 2B class IIb
chr17_+_52978156 Show fit	8.29	ENST00000348161.4	TOM1L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	target of myb1 (chicken)-like 1
chr18_+_29077990 Show fit	8.24	ENST00000261590.8	DSG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	desmoglein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TWIST1_SNAI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	33.2	GO:0070268	cornification(GO:0070268)
3.5	28.0	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
2.0	24.3	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
2.2	19.6	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	19.0	GO:0043687	post-translational protein modification(GO:0043687)
0.6	18.7	GO:0008045	motor neuron axon guidance(GO:0008045)
0.6	16.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
5.2	15.6	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)
2.2	13.2	GO:0010734	protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
2.6	12.9	GO:0071874	cellular response to norepinephrine stimulus(GO:0071874)

Showing 1 to 10 of 395 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	31.8	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	27.9	GO:0043209	myelin sheath(GO:0043209)
0.4	27.7	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.8	26.6	GO:0030057	desmosome(GO:0030057)
0.3	24.4	GO:0043195	terminal bouton(GO:0043195)
0.6	22.6	GO:0045095	keratin filament(GO:0045095)
0.2	18.6	GO:0005604	basement membrane(GO:0005604)
0.6	16.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.6	16.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	14.6	GO:0005884	actin filament(GO:0005884)

Showing 1 to 10 of 164 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	39.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	29.0	GO:0005198	structural molecule activity(GO:0005198)
0.2	24.7	GO:0051015	actin filament binding(GO:0051015)
0.9	23.2	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.5	22.5	GO:0003785	actin monomer binding(GO:0003785)
2.2	19.6	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3	19.4	GO:0030276	clathrin binding(GO:0030276)
0.1	17.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	16.7	GO:0017080	sodium channel regulator activity(GO:0017080)
0.3	15.6	GO:0046875	ephrin receptor binding(GO:0046875)

Showing 1 to 10 of 253 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	25.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	18.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	18.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	13.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	12.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	12.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	11.4	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	11.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	10.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.4	10.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	43.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	23.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.5	22.8	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
1.1	20.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	18.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	18.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	15.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	15.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	13.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6	12.8	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling

Showing 1 to 10 of 95 entries

Results for TWIST1_SNAI1

Z-value: 0.90

Motif logo

Transcription factors associated with TWIST1_SNAI1

Activity-expression correlation:

Activity profile of TWIST1_SNAI1 motif

Sorted Z-values of TWIST1_SNAI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TWIST1_SNAI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: