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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UACAGUA
Z-value: 0.66
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miRNA associated with seed UACAGUA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-101-3p.2
|
Network of associatons between targets according to the STRING database.
First level regulatory network of UACAGUA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | GO:0006301 | postreplication repair(GO:0006301) |
| 1.8 | 12.3 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 10.6 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.2 | 8.9 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 8.3 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.7 | 8.0 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.4 | 8.0 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.2 | 8.0 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.5 | 7.9 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.9 | 7.4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 12.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.2 | 12.3 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 10.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 10.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 9.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 8.3 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.1 | 8.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.4 | 7.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 7.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 16.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 13.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 11.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 3.5 | 10.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 9.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.4 | 8.8 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.2 | 8.8 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.2 | 8.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.5 | 8.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 12.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 12.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 9.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 8.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 8.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 7.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.2 | 6.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 5.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 10.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 9.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.4 | 8.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.3 | 8.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 8.8 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 8.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.6 | 7.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.3 | 7.8 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 7.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |