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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UGCAGUC

Z-value: 0.28

Motif logo

logo of

miRNA associated with seed UGCAGUC

NamemiRBASE accession
hsa-miR-455-3p.2

Activity profile of UGCAGUC motif

Sorted Z-values of UGCAGUC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_149632783 2.75 ENST00000435030.1
KIF5C
kinesin family member 5C
chr6_-_46293378 2.71 ENST00000330430.6
RCAN2
regulator of calcineurin 2
chr14_+_100150622 2.52 ENST00000261835.3
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr2_-_2334888 2.18 ENST00000428368.2
ENST00000399161.2
MYT1L
myelin transcription factor 1-like
chr11_-_134281812 2.15 ENST00000392580.1
ENST00000312527.4
B3GAT1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr12_-_16761007 2.14 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_93389425 1.73 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr2_-_169104651 1.54 ENST00000355999.4
STK39
serine threonine kinase 39
chr17_-_78450398 1.50 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr1_-_70671216 1.48 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr10_-_62149433 1.48 ENST00000280772.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_110906169 1.46 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr7_-_44365020 1.41 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr16_-_66785699 1.33 ENST00000258198.2
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr9_-_131790550 1.23 ENST00000372554.4
ENST00000372564.3
SH3GLB2
SH3-domain GRB2-like endophilin B2
chr11_-_132813566 1.15 ENST00000331898.7
OPCML
opioid binding protein/cell adhesion molecule-like
chr3_-_18466787 1.15 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr1_-_21377447 1.11 ENST00000374937.3
ENST00000264211.8
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_11484710 1.09 ENST00000315872.6
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr5_-_133561752 1.06 ENST00000519718.1
ENST00000481195.1
CTD-2410N18.5
PPP2CA
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme
chr1_+_87794150 1.03 ENST00000370544.5
LMO4
LIM domain only 4
chr15_-_83316254 1.00 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr15_-_42749711 0.91 ENST00000565611.1
ENST00000263805.4
ENST00000565948.1
ZNF106
zinc finger protein 106
chr15_+_49170083 0.86 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr1_+_244214577 0.85 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_+_152870106 0.85 ENST00000285900.5
GRIA1
glutamate receptor, ionotropic, AMPA 1
chr7_+_94139105 0.83 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr12_+_120933904 0.77 ENST00000550178.1
ENST00000550845.1
ENST00000549989.1
ENST00000552870.1
DYNLL1
dynein, light chain, LC8-type 1
chr11_-_73472096 0.77 ENST00000541588.1
ENST00000336083.3
ENST00000540771.1
ENST00000310653.6
RAB6A
RAB6A, member RAS oncogene family
chr6_-_16761678 0.73 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr19_-_12834739 0.71 ENST00000589337.1
ENST00000425528.1
ENST00000441499.1
ENST00000588216.1
TNPO2
transportin 2
chr10_-_47213626 0.71 ENST00000452145.2
AGAP10
ArfGAP with GTPase domain, ankyrin repeat and PH domain 10
chr4_-_76598296 0.65 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr10_+_48189612 0.65 ENST00000453919.1
AGAP9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr11_-_70507901 0.64 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_-_123304017 0.64 ENST00000383657.5
PTPLB
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr1_-_23670817 0.61 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr2_+_166326157 0.60 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr4_-_99851766 0.59 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr3_-_53880401 0.58 ENST00000315251.6
CHDH
choline dehydrogenase
chr15_+_33603147 0.55 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr12_+_862089 0.54 ENST00000315939.6
ENST00000537687.1
ENST00000447667.2
WNK1
WNK lysine deficient protein kinase 1
chr10_-_75255724 0.52 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr13_-_50367057 0.50 ENST00000261667.3
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr10_-_104262426 0.49 ENST00000487599.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr20_+_56884752 0.49 ENST00000244040.3
RAB22A
RAB22A, member RAS oncogene family
chr10_+_112679301 0.48 ENST00000265277.5
ENST00000369452.4
SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr21_+_17102311 0.46 ENST00000285679.6
ENST00000351097.5
ENST00000285681.2
ENST00000400183.2
USP25
ubiquitin specific peptidase 25
chr3_-_164913777 0.43 ENST00000475390.1
SLITRK3
SLIT and NTRK-like family, member 3
chr4_-_42659102 0.43 ENST00000264449.10
ENST00000510289.1
ENST00000381668.5
ATP8A1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr2_-_154335300 0.42 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr19_-_3700388 0.41 ENST00000589578.1
ENST00000537021.1
ENST00000539785.1
ENST00000335312.3
PIP5K1C
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
chr15_+_66161871 0.39 ENST00000569896.1
RAB11A
RAB11A, member RAS oncogene family
chr1_+_237205476 0.32 ENST00000366574.2
RYR2
ryanodine receptor 2 (cardiac)
chr17_+_66508537 0.31 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr14_+_103243813 0.30 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr4_+_170541660 0.30 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr12_-_53893399 0.30 ENST00000267079.2
MAP3K12
mitogen-activated protein kinase kinase kinase 12
chr14_+_57046500 0.26 ENST00000261556.6
TMEM260
transmembrane protein 260
chr1_-_35658736 0.26 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr7_+_101928380 0.25 ENST00000536178.1
SH2B2
SH2B adaptor protein 2
chr2_-_148778258 0.24 ENST00000392857.5
ENST00000457954.1
ENST00000392858.1
ENST00000542387.1
ORC4
origin recognition complex, subunit 4
chr1_-_43833628 0.23 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr17_-_62502639 0.22 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr3_+_126707437 0.22 ENST00000393409.2
ENST00000251772.4
PLXNA1
plexin A1
chr20_+_3451650 0.22 ENST00000262919.5
ATRN
attractin
chr1_-_115880852 0.21 ENST00000369512.2
NGF
nerve growth factor (beta polypeptide)
chr14_+_71108460 0.21 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr7_-_32931387 0.20 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr16_-_4897266 0.20 ENST00000591451.1
ENST00000436648.5
ENST00000381983.3
ENST00000588297.1
ENST00000321919.9
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr20_-_14318248 0.18 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr2_-_69870835 0.15 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr3_+_58291965 0.15 ENST00000445193.3
ENST00000295959.5
ENST00000466547.1
RPP14
ribonuclease P/MRP 14kDa subunit
chr14_-_21737610 0.15 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr3_-_129407535 0.14 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chr1_+_29063271 0.14 ENST00000373812.3
YTHDF2
YTH domain family, member 2
chr6_+_161412759 0.13 ENST00000366919.2
ENST00000392142.4
ENST00000366920.2
ENST00000348824.7
MAP3K4
mitogen-activated protein kinase kinase kinase 4
chr3_+_178866199 0.13 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr2_+_48010221 0.12 ENST00000234420.5
MSH6
mutS homolog 6
chr15_+_77287426 0.11 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr5_+_122110691 0.11 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr6_+_4021554 0.11 ENST00000337659.6
PRPF4B
pre-mRNA processing factor 4B
chrX_+_107683096 0.11 ENST00000328300.6
ENST00000361603.2
COL4A5
collagen, type IV, alpha 5
chr5_+_167718604 0.10 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr1_-_205326022 0.09 ENST00000367155.3
KLHDC8A
kelch domain containing 8A
chr1_+_171454659 0.09 ENST00000367742.3
ENST00000338920.4
PRRC2C
proline-rich coiled-coil 2C
chr9_+_112403088 0.07 ENST00000448454.2
PALM2
paralemmin 2
chr3_-_15106747 0.05 ENST00000449354.2
ENST00000444840.2
ENST00000253686.2
MRPS25
mitochondrial ribosomal protein S25
chr9_-_123555655 0.04 ENST00000340778.5
ENST00000453291.1
ENST00000608872.1
FBXW2
F-box and WD repeat domain containing 2
chr8_-_68255912 0.04 ENST00000262215.3
ENST00000519436.1
ARFGEF1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr1_-_53793584 0.04 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr1_+_11751748 0.03 ENST00000294485.5
DRAXIN
dorsal inhibitory axon guidance protein
chr14_-_55878538 0.03 ENST00000247178.5
ATG14
autophagy related 14
chr3_-_11762202 0.03 ENST00000445411.1
ENST00000404339.1
ENST00000273038.3
VGLL4
vestigial like 4 (Drosophila)
chr3_-_38835501 0.03 ENST00000449082.2
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr3_+_137906109 0.02 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8
armadillo repeat containing 8
chr6_+_142468361 0.02 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr5_-_81046922 0.02 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr5_-_32444828 0.00 ENST00000265069.8
ZFR
zinc finger RNA binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of UGCAGUC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.6 1.7 GO:2000705 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.4 1.5 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 2.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.3 1.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.3 2.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 0.8 GO:0018125 peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385)
0.2 1.5 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 1.0 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.6 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.3 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.1 0.4 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 3.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.4 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 1.4 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 0.6 GO:0042426 choline catabolic process(GO:0042426)
0.1 0.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 1.9 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.1 0.8 GO:0035721 intraciliary retrograde transport(GO:0035721) positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 2.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.3 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 2.0 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.5 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.2 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 1.3 GO:0051642 centrosome localization(GO:0051642)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0007538 primary sex determination(GO:0007538)
0.0 0.8 GO:0061157 mRNA destabilization(GO:0061157)
0.0 1.0 GO:0008038 neuron recognition(GO:0008038)
0.0 0.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.6 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.2 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 1.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.0 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.0 0.5 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.9 GO:0035065 regulation of histone acetylation(GO:0035065)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0035253 ciliary rootlet(GO:0035253)
0.2 0.8 GO:0044308 axonal spine(GO:0044308)
0.1 0.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 2.2 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.5 GO:0043194 axon initial segment(GO:0043194)
0.1 0.5 GO:0002177 manchette(GO:0002177)
0.1 0.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 2.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 2.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0030681 multimeric ribonuclease P complex(GO:0030681)
0.0 0.0 GO:1903349 omegasome membrane(GO:1903349)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.5 2.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 0.9 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.5 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.7 GO:0034046 poly(G) binding(GO:0034046)
0.1 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.4 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 1.7 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 2.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 1.2 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.0 1.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0032143 single thymine insertion binding(GO:0032143)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0005165 neurotrophin receptor binding(GO:0005165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.0 PID AURORA A PATHWAY Aurora A signaling
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 2.0 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 1.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs