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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for XBP1

Z-value: 2.06

Motif logo

Transcription factors associated with XBP1

Gene Symbol Gene ID Gene Info
ENSG00000100219.12 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
XBP1hg19_v2_chr22_-_29196546_291965850.407.0e-10Click!

Activity profile of XBP1 motif

Sorted Z-values of XBP1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_171758344 90.53 ENST00000336824.4
ENST00000423424.1
fibronectin type III domain containing 3B
chr3_-_57583185 68.28 ENST00000463880.1
ADP-ribosylation factor 4
chr1_-_24126023 57.35 ENST00000429356.1
UDP-galactose-4-epimerase
chr3_-_57583052 57.24 ENST00000496292.1
ENST00000489843.1
ADP-ribosylation factor 4
chr15_-_60690163 56.14 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
annexin A2
chr3_-_57583130 51.53 ENST00000303436.6
ADP-ribosylation factor 4
chr3_+_33155525 50.28 ENST00000449224.1
cartilage associated protein
chr15_+_79603404 42.94 ENST00000299705.5
transmembrane emp24 protein transport domain containing 3
chr3_+_127771212 42.65 ENST00000243253.3
ENST00000481210.1
Sec61 alpha 1 subunit (S. cerevisiae)
chr12_-_56123444 40.12 ENST00000546457.1
ENST00000549117.1
CD63 molecule
chr7_+_94023873 39.44 ENST00000297268.6
collagen, type I, alpha 2
chr21_-_18985158 38.33 ENST00000339775.6
BTG family, member 3
chr7_-_6523688 38.24 ENST00000490996.1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr7_-_6523755 37.99 ENST00000436575.1
ENST00000258739.4
diacylglycerol lipase, beta
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr7_+_128379346 35.08 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
calumenin
chr3_-_128369643 34.97 ENST00000296255.3
ribophorin I
chr2_-_69614373 34.74 ENST00000361060.5
ENST00000357308.4
glutamine--fructose-6-phosphate transaminase 1
chr12_-_109125285 34.13 ENST00000552871.1
ENST00000261401.3
coronin, actin binding protein, 1C
chr12_-_106641728 33.77 ENST00000378026.4
cytoskeleton-associated protein 4
chr7_+_128379449 33.19 ENST00000479257.1
calumenin
chr9_+_114393634 33.02 ENST00000556107.1
ENST00000374294.3
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr3_-_10362725 30.37 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13 homolog (S. cerevisiae)
chr2_-_33824336 30.27 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
family with sequence similarity 98, member A
chr19_+_16187816 29.32 ENST00000588410.1
tropomyosin 4
chr21_-_18985230 29.12 ENST00000457956.1
ENST00000348354.6
BTG family, member 3
chr1_-_11120057 27.79 ENST00000376957.2
spermidine synthase
chr3_+_105086056 27.63 ENST00000472644.2
activated leukocyte cell adhesion molecule
chr11_-_66056596 27.59 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_+_69455855 27.54 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr2_+_171785824 27.45 ENST00000452526.2
golgi reassembly stacking protein 2, 55kDa
chr6_+_63921351 27.24 ENST00000370659.1
FK506 binding protein 1C
chr2_-_33824382 26.44 ENST00000238823.8
family with sequence similarity 98, member A
chr10_+_89419370 26.41 ENST00000361175.4
ENST00000456849.1
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr11_+_32605350 25.47 ENST00000531120.1
ENST00000524896.1
ENST00000323213.5
eukaryotic translation initiation factor 3, subunit M
chr8_-_124054362 25.28 ENST00000405944.3
derlin 1
chr1_-_45988542 24.07 ENST00000424390.1
peroxiredoxin 1
chr8_-_124054484 23.82 ENST00000419562.2
derlin 1
chr2_+_242254507 23.64 ENST00000391973.2
septin 2
chr2_-_20251744 23.63 ENST00000175091.4
lysosomal protein transmembrane 4 alpha
chr4_-_119757239 23.38 ENST00000280551.6
SEC24 family member D
chr11_+_17298297 23.35 ENST00000529010.1
nucleobindin 2
chr17_+_15848231 23.30 ENST00000304222.2
adenosine A2b receptor
chr1_+_87170577 23.03 ENST00000482504.1
SH3-domain GRB2-like endophilin B1
chr5_-_121413974 22.76 ENST00000231004.4
lysyl oxidase
chr18_-_47017956 22.67 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32 readthrough
ribosomal protein L17
chr14_-_24664776 22.46 ENST00000530468.1
ENST00000528010.1
ENST00000396854.4
ENST00000524835.1
ENST00000261789.4
ENST00000525592.1
transmembrane 9 superfamily member 1
chr5_+_112196919 21.83 ENST00000505459.1
ENST00000282999.3
ENST00000515463.1
signal recognition particle 19kDa
chr14_-_24664540 20.95 ENST00000530563.1
ENST00000528895.1
ENST00000528669.1
ENST00000532632.1
transmembrane 9 superfamily member 1
chr11_+_17298255 20.65 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
nucleobindin 2
chr2_-_99952769 20.30 ENST00000409434.1
ENST00000434323.1
ENST00000264255.3
thioredoxin domain containing 9
chr1_-_87380002 20.12 ENST00000331835.5
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr4_-_119757322 19.03 ENST00000379735.5
SEC24 family member D
chr1_-_87379785 18.60 ENST00000401030.3
ENST00000370554.1
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr6_+_116692102 18.59 ENST00000359564.2
dermatan sulfate epimerase
chr19_-_4670345 18.28 ENST00000599630.1
ENST00000262947.3
chromosome 19 open reading frame 10
chr6_-_111927062 18.12 ENST00000359831.4
TRAF3 interacting protein 2
chr6_-_109702885 17.60 ENST00000504373.1
CD164 molecule, sialomucin
chr8_-_124054587 17.58 ENST00000259512.4
derlin 1
chr20_+_44044717 17.07 ENST00000279036.6
ENST00000279035.9
ENST00000372689.5
ENST00000545755.1
ENST00000341555.5
ENST00000535404.1
ENST00000543458.2
ENST00000432270.1
phosphatidylinositol glycan anchor biosynthesis, class T
chr7_-_30066233 16.85 ENST00000222803.5
FK506 binding protein 14, 22 kDa
chr2_+_242254679 16.85 ENST00000428282.1
ENST00000360051.3
septin 2
chr1_-_161087802 16.54 ENST00000368010.3
prefoldin subunit 2
chrX_+_153060090 16.25 ENST00000370086.3
ENST00000370085.3
signal sequence receptor, delta
chr11_+_118443098 16.12 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
archain 1
chr17_-_40575535 16.09 ENST00000357037.5
polymerase I and transcript release factor
chr11_-_118927816 15.59 ENST00000534233.1
ENST00000532752.1
ENST00000525859.1
ENST00000404233.3
ENST00000532421.1
ENST00000543287.1
ENST00000527310.2
ENST00000529972.1
hypoxia up-regulated 1
chr5_+_119799927 15.58 ENST00000407149.2
ENST00000379551.2
proline rich 16
chr21_+_45138941 15.32 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
pyridoxal (pyridoxine, vitamin B6) kinase
chr1_+_228270361 15.08 ENST00000272102.5
ENST00000540651.1
ADP-ribosylation factor 1
chr2_+_27255806 14.59 ENST00000238788.9
ENST00000404032.3
transmembrane protein 214
chr11_-_118972575 14.55 ENST00000432443.2
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr14_-_50087312 14.28 ENST00000298289.6
ribosomal protein L36a-like
chr3_-_139108475 14.23 ENST00000515006.1
ENST00000513274.1
ENST00000514508.1
ENST00000507777.1
ENST00000512153.1
ENST00000333188.5
coatomer protein complex, subunit beta 2 (beta prime)
chr19_-_29704448 14.21 ENST00000304863.4
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr7_+_16793160 13.72 ENST00000262067.4
tetraspanin 13
chr9_+_101984577 13.64 ENST00000223641.4
Sec61 beta subunit
chr2_+_85132749 13.59 ENST00000233143.4
thymosin beta 10
chr7_-_19157248 13.36 ENST00000242261.5
twist family bHLH transcription factor 1
chr8_-_81083890 12.78 ENST00000518937.1
tumor protein D52
chr2_-_242254595 12.63 ENST00000441124.1
ENST00000391976.2
high density lipoprotein binding protein
chr6_-_7313381 12.47 ENST00000489567.1
ENST00000479365.1
ENST00000462112.1
ENST00000397511.2
ENST00000534851.1
ENST00000474597.1
ENST00000244763.4
signal sequence receptor, alpha
chr18_-_47018869 12.37 ENST00000583036.1
ENST00000580261.1
ribosomal protein L17
chr22_+_38864041 12.23 ENST00000216014.4
ENST00000409006.3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr3_-_149688896 12.19 ENST00000239940.7
profilin 2
chr13_-_31040060 11.95 ENST00000326004.4
ENST00000341423.5
high mobility group box 1
chr1_+_93297622 11.83 ENST00000315741.5
ribosomal protein L5
chr11_-_62414070 11.83 ENST00000540933.1
ENST00000346178.4
ENST00000356638.3
ENST00000534779.1
ENST00000525994.1
glucosidase, alpha; neutral AB
chrX_+_153059608 11.42 ENST00000370087.1
signal sequence receptor, delta
chrX_+_47050236 11.40 ENST00000377351.4
ubiquitin-like modifier activating enzyme 1
chr3_-_149688502 11.19 ENST00000481767.1
ENST00000475518.1
profilin 2
chr18_-_47018897 11.07 ENST00000418495.1
ribosomal protein L17
chr3_-_150264272 10.47 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
stress-associated endoplasmic reticulum protein 1
chr9_-_35732362 10.33 ENST00000314888.9
ENST00000540444.1
talin 1
chr19_-_19030157 10.16 ENST00000349893.4
ENST00000351079.4
ENST00000600932.1
ENST00000262812.4
coatomer protein complex, subunit epsilon
chr22_-_43253189 10.12 ENST00000437119.2
ENST00000429508.2
ENST00000454099.1
ENST00000263245.5
ADP-ribosylation factor GTPase activating protein 3
chr1_+_110527308 9.96 ENST00000369799.5
adenosylhomocysteinase-like 1
chrX_-_41782249 9.72 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr5_+_154238042 9.50 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
CCR4-NOT transcription complex, subunit 8
chr11_+_207477 8.77 ENST00000526104.1
RIC8 guanine nucleotide exchange factor A
chr19_+_1026566 8.72 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
calponin 2
chr10_+_102106829 8.42 ENST00000370355.2
stearoyl-CoA desaturase (delta-9-desaturase)
chr18_-_34408693 8.21 ENST00000587382.1
ENST00000589049.1
ENST00000587129.1
tubulin polyglutamylase complex subunit 2
chr19_+_54619125 8.01 ENST00000445811.1
ENST00000419967.1
ENST00000445124.1
ENST00000447810.1
pre-mRNA processing factor 31
chr9_+_35732312 7.98 ENST00000353704.2
cAMP responsive element binding protein 3
chr4_-_83350580 7.93 ENST00000349655.4
ENST00000602300.1
heterogeneous nuclear ribonucleoprotein D-like
chrX_+_153627231 7.68 ENST00000406022.2
ribosomal protein L10
chr10_+_75504105 7.61 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
SEC24 family member C
chr4_-_159644507 7.60 ENST00000307720.3
peptidylprolyl isomerase D
chr5_+_154237778 7.54 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
CCR4-NOT transcription complex, subunit 8
chr7_+_127292234 7.32 ENST00000354725.3
staphylococcal nuclease and tudor domain containing 1
chr11_+_65819802 7.08 ENST00000528302.1
ENST00000322535.6
ENST00000524627.1
ENST00000533595.1
ENST00000530322.1
splicing factor 3b, subunit 2, 145kDa
chr19_+_49468558 7.03 ENST00000331825.6
ferritin, light polypeptide
chr5_+_126853301 6.82 ENST00000296666.8
ENST00000442138.2
ENST00000512635.2
proline-rich coiled-coil 1
chr6_-_43596899 6.79 ENST00000307126.5
ENST00000452781.1
GTP binding protein 2
chr6_+_33168637 6.54 ENST00000374677.3
solute carrier family 39 (zinc transporter), member 7
chr6_+_33168597 6.27 ENST00000374675.3
solute carrier family 39 (zinc transporter), member 7
chr3_+_132378741 6.24 ENST00000493720.2
ubiquitin-like modifier activating enzyme 5
chr20_+_25228669 5.91 ENST00000216962.4
phosphorylase, glycogen; brain
chr10_+_112257596 5.84 ENST00000369583.3
dual specificity phosphatase 5
chr6_+_7107999 5.79 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
ras responsive element binding protein 1
chr19_-_8373173 5.75 ENST00000537716.2
ENST00000301458.5
CD320 molecule
chr11_-_66056478 5.42 ENST00000431556.2
ENST00000528575.1
Yip1 interacting factor homolog A (S. cerevisiae)
chr14_+_100259666 5.41 ENST00000262233.6
ENST00000334192.4
echinoderm microtubule associated protein like 1
chr18_-_34409116 5.41 ENST00000334295.4
tubulin polyglutamylase complex subunit 2
chr19_+_39421556 5.32 ENST00000407800.2
ENST00000402029.3
mitochondrial ribosomal protein S12
chr19_+_7701985 5.23 ENST00000595950.1
ENST00000441779.2
ENST00000221283.5
ENST00000414284.2
syntaxin binding protein 2
chr6_-_108279369 5.20 ENST00000369002.4
SEC63 homolog (S. cerevisiae)
chr19_+_50354462 5.19 ENST00000601675.1
prostate tumor overexpressed 1
chr19_+_50354393 5.17 ENST00000391842.1
prostate tumor overexpressed 1
chr11_-_68039364 5.09 ENST00000533310.1
ENST00000304271.6
ENST00000527280.1
chromosome 11 open reading frame 24
chr4_+_26322185 5.00 ENST00000361572.6
recombination signal binding protein for immunoglobulin kappa J region
chr9_-_112260531 4.70 ENST00000374541.2
ENST00000262539.3
protein tyrosine phosphatase, non-receptor type 3
chr3_+_50284321 4.50 ENST00000451956.1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr2_-_170430277 4.36 ENST00000438035.1
ENST00000453929.2
FAST kinase domains 1
chr4_+_26322409 4.26 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
recombination signal binding protein for immunoglobulin kappa J region
chr19_+_36606654 4.19 ENST00000588385.1
ENST00000585746.1
tubulin folding cofactor B
chr18_-_34408902 3.84 ENST00000593035.1
ENST00000383056.3
ENST00000588909.1
ENST00000590337.1
tubulin polyglutamylase complex subunit 2
chr16_-_73082274 3.74 ENST00000268489.5
zinc finger homeobox 3
chr12_-_28122980 3.69 ENST00000395868.3
ENST00000534890.1
parathyroid hormone-like hormone
chr5_+_154238149 3.68 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CCR4-NOT transcription complex, subunit 8
chr5_+_154238096 3.66 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CCR4-NOT transcription complex, subunit 8
chr19_+_50354430 3.64 ENST00000599732.1
prostate tumor overexpressed 1
chr22_+_45148432 3.59 ENST00000389774.2
ENST00000396119.2
ENST00000336963.4
ENST00000356099.6
ENST00000412433.1
Rho GTPase activating protein 8
chrX_-_41782683 3.55 ENST00000378163.1
ENST00000378154.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr1_-_119682812 3.53 ENST00000537870.1
tryptophanyl tRNA synthetase 2, mitochondrial
chr8_+_67624653 3.42 ENST00000521198.2
serum/glucocorticoid regulated kinase family, member 3
chr7_-_128045984 3.31 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr2_-_170430366 3.21 ENST00000453153.2
ENST00000445210.1
FAST kinase domains 1
chr10_-_128077024 3.19 ENST00000368679.4
ENST00000368676.4
ENST00000448723.1
ADAM metallopeptidase domain 12
chr1_-_28241024 3.12 ENST00000313433.7
ENST00000444045.1
replication protein A2, 32kDa
chr16_-_28222797 2.95 ENST00000569951.1
ENST00000565698.1
exportin 6
chr16_+_56965960 2.74 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_72199721 2.71 ENST00000439590.2
ENST00000311111.6
ENST00000584577.1
ENST00000534490.1
ENST00000528433.2
ENST00000533498.1
ribosomal protein L38
chr3_-_105588231 2.69 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_-_28123206 2.37 ENST00000542963.1
ENST00000535992.1
parathyroid hormone-like hormone
chr14_+_31091511 2.20 ENST00000544052.2
ENST00000421551.3
ENST00000541123.1
ENST00000557076.1
ENST00000553693.1
ENST00000396629.2
sec1 family domain containing 1
chr19_-_54619006 2.13 ENST00000391759.1
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr19_-_54618650 2.12 ENST00000391757.1
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr16_-_66959429 2.05 ENST00000420652.1
ENST00000299759.6
Ras-related associated with diabetes
chr1_-_119683251 1.90 ENST00000369426.5
ENST00000235521.4
tryptophanyl tRNA synthetase 2, mitochondrial
chr14_+_102430855 1.74 ENST00000360184.4
dynein, cytoplasmic 1, heavy chain 1
chr1_-_144932464 1.73 ENST00000479408.2
phosphodiesterase 4D interacting protein
chr14_+_50087468 1.68 ENST00000305386.2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_-_90062543 1.38 ENST00000435041.2
ubiquitin-conjugating enzyme E2, J1
chr6_-_27841289 1.37 ENST00000355981.2
histone cluster 1, H4l
chr2_-_220408430 1.26 ENST00000243776.6
chondroitin polymerizing factor
chr6_+_132129151 1.12 ENST00000360971.2
ectonucleotide pyrophosphatase/phosphodiesterase 1
chrX_+_9431324 1.06 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr4_+_56262115 1.03 ENST00000506198.1
ENST00000381334.5
ENST00000542052.1
transmembrane protein 165
chr20_-_17662878 0.53 ENST00000377813.1
ENST00000377807.2
ENST00000360807.4
ENST00000398782.2
ribosome binding protein 1
chr20_-_8000426 0.50 ENST00000527925.1
ENST00000246024.2
thioredoxin-related transmembrane protein 4
chr5_-_115177496 0.49 ENST00000274459.4
ENST00000509910.1
autophagy related 12
chr5_-_9546180 0.35 ENST00000382496.5
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr18_-_34408802 0.34 ENST00000590842.1
tubulin polyglutamylase complex subunit 2
chr19_-_22379753 0.25 ENST00000397121.2
zinc finger protein 676
chr1_-_22109682 0.20 ENST00000400301.1
ENST00000532737.1
ubiquitin specific peptidase 48
chr19_+_47104493 0.11 ENST00000291295.9
ENST00000597743.1
calmodulin 3 (phosphorylase kinase, delta)
chr12_-_133405288 0.08 ENST00000204726.3
golgin A3

Network of associatons between targets according to the STRING database.

First level regulatory network of XBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.7 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
16.8 50.3 GO:1901873 regulation of post-translational protein modification(GO:1901873)
16.1 177.1 GO:0031584 activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176)
12.3 61.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
11.1 66.7 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
8.0 88.5 GO:0006621 protein retention in ER lumen(GO:0006621)
7.3 21.8 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
6.6 26.4 GO:0000103 sulfate assimilation(GO:0000103)
5.8 23.3 GO:0002880 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
5.8 23.0 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
5.1 15.3 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
5.1 20.3 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
5.0 15.1 GO:0097212 cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822)
4.5 13.4 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
4.4 57.4 GO:0019388 galactose catabolic process(GO:0019388)
4.0 16.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
4.0 27.8 GO:0008295 spermidine biosynthetic process(GO:0008295)
3.6 72.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
3.5 35.1 GO:0070141 response to UV-A(GO:0070141)
3.1 9.3 GO:1905068 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
3.1 40.1 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
3.0 12.0 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
3.0 11.8 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
2.9 14.5 GO:0019348 dolichol metabolic process(GO:0019348)
2.8 17.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
2.7 26.9 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
2.6 39.4 GO:0043589 skin morphogenesis(GO:0043589)
2.5 34.7 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
1.9 23.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
1.9 22.8 GO:0048251 elastic fiber assembly(GO:0048251)
1.6 8.0 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
1.6 15.6 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
1.4 10.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.3 8.0 GO:0048254 snoRNA localization(GO:0048254)
1.1 5.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.0 15.6 GO:0045793 positive regulation of cell size(GO:0045793)
1.0 14.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.0 7.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.0 44.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.9 3.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.9 28.0 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.9 13.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.9 1.7 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.8 8.8 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.8 18.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.8 69.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.8 66.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.7 18.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.7 5.7 GO:0015889 cobalamin transport(GO:0015889)
0.7 25.5 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.7 12.6 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.7 24.4 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.7 24.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.7 2.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.7 38.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.6 12.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.6 3.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.5 2.7 GO:0048318 axial mesoderm development(GO:0048318)
0.5 4.7 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045) regulation of membrane depolarization during action potential(GO:0098902)
0.4 5.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 29.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3 4.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.3 50.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 17.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 40.5 GO:0007224 smoothened signaling pathway(GO:0007224)
0.3 56.7 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.3 6.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 2.7 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.2 8.4 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.2 5.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 72.5 GO:0043687 post-translational protein modification(GO:0043687)
0.2 1.1 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 3.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.0 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.1 50.2 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 12.8 GO:0030183 B cell differentiation(GO:0030183)
0.1 9.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 28.9 GO:0006457 protein folding(GO:0006457)
0.1 5.2 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.1 3.6 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.1 1.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 13.7 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.1 14.6 GO:0006915 apoptotic process(GO:0006915)
0.1 5.3 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 3.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.1 2.9 GO:0006611 protein export from nucleus(GO:0006611)
0.1 7.3 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 5.4 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 6.8 GO:0002576 platelet degranulation(GO:0002576)
0.0 16.5 GO:0006914 autophagy(GO:0006914)
0.0 13.6 GO:0007015 actin filament organization(GO:0007015)
0.0 7.1 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 4.2 GO:0006310 DNA recombination(GO:0006310)
0.0 1.1 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.7 66.7 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
10.3 51.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
8.3 83.5 GO:0030126 COPI vesicle coat(GO:0030126)
8.1 56.7 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
6.9 41.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
6.2 68.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
5.7 17.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
4.3 30.4 GO:0061700 GATOR2 complex(GO:0061700)
3.3 40.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
3.3 39.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.9 35.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
2.9 40.5 GO:0097227 sperm annulus(GO:0097227)
2.8 25.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
2.7 21.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
2.6 34.1 GO:0016600 flotillin complex(GO:0016600)
2.4 24.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
2.4 50.0 GO:0030127 COPII vesicle coat(GO:0030127)
2.4 16.5 GO:0016272 prefoldin complex(GO:0016272)
1.9 9.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
1.8 66.4 GO:0000421 autophagosome membrane(GO:0000421)
1.8 7.0 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
1.7 32.7 GO:0042599 lamellar body(GO:0042599)
1.5 29.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.3 14.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.3 187.4 GO:0032587 ruffle membrane(GO:0032587)
1.1 15.1 GO:0030137 COPI-coated vesicle(GO:0030137)
1.0 53.4 GO:0005801 cis-Golgi network(GO:0005801)
0.9 33.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.9 27.6 GO:0042101 T cell receptor complex(GO:0042101)
0.8 13.3 GO:0005652 nuclear lamina(GO:0005652)
0.8 15.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.8 5.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.8 82.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 5.2 GO:0044194 cytolytic granule(GO:0044194)
0.7 37.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 11.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.6 42.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.6 7.3 GO:0097433 dense body(GO:0097433)
0.5 15.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.5 2.7 GO:1990037 Lewy body core(GO:1990037)
0.4 27.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 49.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.4 25.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 12.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 24.0 GO:0035580 specific granule lumen(GO:0035580)
0.3 23.4 GO:0043195 terminal bouton(GO:0043195)
0.3 22.8 GO:0005581 collagen trimer(GO:0005581)
0.3 71.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 3.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 17.8 GO:0005874 microtubule(GO:0005874)
0.2 4.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2 5.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 24.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 20.3 GO:0030496 midbody(GO:0030496)
0.1 11.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.5 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 6.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.4 GO:0055037 recycling endosome(GO:0055037)
0.1 6.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 19.8 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 7.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 4.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 21.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 3.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.8 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
19.1 57.4 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
19.1 76.2 GO:0005046 KDEL sequence binding(GO:0005046)
9.3 27.8 GO:0004766 spermidine synthase activity(GO:0004766)
8.8 26.4 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
8.6 51.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
7.3 190.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
6.2 18.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
5.7 17.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
4.8 14.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
4.1 20.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
3.7 66.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
3.5 35.0 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
3.3 23.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
3.0 24.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
2.8 39.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.8 8.4 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
2.4 12.2 GO:0046923 ER retention sequence binding(GO:0046923)
2.4 21.8 GO:0008312 7S RNA binding(GO:0008312)
2.0 14.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.0 12.0 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
1.9 5.7 GO:0015235 cobalamin transporter activity(GO:0015235)
1.9 11.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.7 10.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.6 8.0 GO:0030621 U4 snRNA binding(GO:0030621)
1.6 34.7 GO:0008483 transaminase activity(GO:0008483)
1.5 44.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.5 11.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.5 5.9 GO:0008184 glycogen phosphorylase activity(GO:0008184)
1.4 22.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
1.4 24.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
1.2 11.8 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.1 5.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.0 5.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.9 13.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.9 10.3 GO:0030274 LIM domain binding(GO:0030274)
0.9 27.5 GO:0070064 proline-rich region binding(GO:0070064)
0.9 37.0 GO:0003785 actin monomer binding(GO:0003785)
0.9 42.6 GO:0043022 ribosome binding(GO:0043022)
0.8 9.3 GO:0000150 recombinase activity(GO:0000150)
0.8 3.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 15.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.7 15.3 GO:0030955 potassium ion binding(GO:0030955)
0.7 12.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 56.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.6 25.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.5 7.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.5 7.0 GO:0008199 ferric iron binding(GO:0008199)
0.5 34.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.5 16.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 1.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.4 5.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 8.0 GO:0035497 cAMP response element binding(GO:0035497)
0.4 1.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.4 76.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 45.8 GO:0000149 SNARE binding(GO:0000149)
0.3 17.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 29.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 3.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.3 8.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 13.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 6.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 4.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 15.6 GO:0051087 chaperone binding(GO:0051087)
0.1 104.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 56.1 GO:0045296 cadherin binding(GO:0045296)
0.1 4.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 10.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 112.2 GO:0003723 RNA binding(GO:0003723)
0.0 24.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 3.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 1.7 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 12.2 GO:0032403 protein complex binding(GO:0032403)
0.0 1.0 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 27.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.8 39.4 NABA COLLAGENS Genes encoding collagen proteins
0.8 168.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.8 38.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.8 15.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.6 40.5 PID CDC42 PATHWAY CDC42 signaling events
0.6 23.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.5 10.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.5 13.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.5 4.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.5 24.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.5 8.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.4 12.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 22.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 50.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 31.5 PID CMYB PATHWAY C-MYB transcription factor network
0.3 6.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 5.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.1 PID ATR PATHWAY ATR signaling pathway
0.1 12.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 55.6 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
2.4 80.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.3 39.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.8 129.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.6 36.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
1.5 26.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.1 27.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.1 205.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
1.1 11.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
1.0 23.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.9 38.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.8 12.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.8 50.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.7 24.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.7 100.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.6 12.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 29.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.5 17.1 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.5 23.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 16.5 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.4 16.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.4 4.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 9.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 19.8 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.3 5.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 4.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.3 3.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 19.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 16.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 27.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.2 3.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 14.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 7.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 30.5 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 2.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 6.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 3.2 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions