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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for YY1_YY2
Z-value: 1.94
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg19_v2_chr14_+_100705322_100705360 | 0.53 | 1.9e-17 | Click! |
| YY2 | hg19_v2_chrX_+_21874105_21874105 | -0.47 | 2.2e-13 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_1303462 Show fit | 72.71 |
ENST00000573026.1
ENST00000575977.1 ENST00000571732.1 ENST00000264335.8 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
|
| chr14_-_69864993 Show fit | 67.50 |
ENST00000555373.1
|
enhancer of rudimentary homolog (Drosophila) |
|
| chr19_-_13044494 Show fit | 67.02 |
ENST00000593021.1
ENST00000587981.1 ENST00000423140.2 ENST00000314606.4 |
phenylalanyl-tRNA synthetase, alpha subunit |
|
| chr16_-_87903079 Show fit | 52.70 |
ENST00000261622.4
|
solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
|
| chr14_-_23504337 Show fit | 45.49 |
ENST00000361611.6
|
proteasome (prosome, macropain) subunit, beta type, 5 |
|
| chr14_-_23504087 Show fit | 44.06 |
ENST00000493471.2
ENST00000460922.2 |
proteasome (prosome, macropain) subunit, beta type, 5 |
|
| chr14_-_23504432 Show fit | 43.50 |
ENST00000425762.2
|
proteasome (prosome, macropain) subunit, beta type, 5 |
|
| chr13_-_37679803 Show fit | 42.93 |
ENST00000379800.3
|
casein kinase 1, alpha 1-like |
|
| chr1_-_149900122 Show fit | 41.22 |
ENST00000271628.8
|
splicing factor 3b, subunit 4, 49kDa |
|
| chr7_+_73097890 Show fit | 40.90 |
ENST00000265758.2
ENST00000423166.2 ENST00000423497.1 |
Williams Beuren syndrome chromosome region 22 |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 403.6 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 3.9 | 357.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 4.8 | 310.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 2.1 | 304.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 1.1 | 195.2 | GO:0000910 | cytokinesis(GO:0000910) |
| 4.5 | 139.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 9.3 | 111.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 2.5 | 101.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 1.1 | 101.1 | GO:0048208 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 1.9 | 89.8 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 231.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 13.2 | 211.6 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 7.6 | 206.4 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.9 | 204.5 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 4.6 | 193.3 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 1.5 | 158.8 | GO:0005840 | ribosome(GO:0005840) |
| 0.6 | 149.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 6.2 | 112.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 5.9 | 111.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 6.2 | 104.9 | GO:0034709 | methylosome(GO:0034709) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 519.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.1 | 271.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 8.1 | 242.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.7 | 184.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 3.6 | 165.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.2 | 118.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 2.3 | 105.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 3.3 | 88.7 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 2.5 | 85.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 77.7 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 211.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 2.6 | 158.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.6 | 146.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 2.0 | 82.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 3.1 | 81.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.8 | 78.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.7 | 78.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 74.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.3 | 65.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.6 | 55.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 415.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 5.5 | 406.5 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 2.3 | 367.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 3.6 | 270.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 5.2 | 186.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 2.7 | 159.4 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 3.9 | 153.8 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 2.0 | 125.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 5.3 | 123.0 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 2.2 | 113.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |