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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB18

Z-value: 0.77

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Transcription factors associated with ZBTB18

Gene Symbol Gene ID Gene Info
ZBTB18
ENSG00000179456.9 zinc finger and BTB domain containing 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB18hg19_v2_chr1_+_244214577_244214593-0.342.1e-07Click!

Activity profile of ZBTB18 motif

Sorted Z-values of ZBTB18 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_189839046 20.64 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr3_+_100211412 10.14 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
TMEM45A
transmembrane protein 45A
chr7_+_100770328 9.68 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr8_-_49833978 9.52 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr8_-_49834299 9.52 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr2_-_163100045 9.12 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr2_-_163099885 9.07 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr14_+_94577074 8.15 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr15_-_90358048 7.44 ENST00000300060.6
ENST00000560137.1
ANPEP
alanyl (membrane) aminopeptidase
chr12_-_56122426 7.28 ENST00000551173.1
CD63
CD63 molecule
chr12_-_56121612 7.02 ENST00000546939.1
CD63
CD63 molecule
chr17_-_15168624 6.98 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr12_-_56121580 6.51 ENST00000550776.1
CD63
CD63 molecule
chr17_+_32582293 6.47 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr1_-_16344500 6.23 ENST00000406363.2
ENST00000411503.1
ENST00000545268.1
ENST00000487046.1
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr9_+_125137565 5.64 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr17_+_77020325 5.63 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr12_-_56122124 5.63 ENST00000552754.1
CD63
CD63 molecule
chr17_+_77020224 5.53 ENST00000339142.2
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_-_95241951 5.51 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr12_-_56122220 5.46 ENST00000552692.1
CD63
CD63 molecule
chr10_-_95242044 5.34 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr19_+_11649532 5.28 ENST00000252456.2
ENST00000592923.1
ENST00000535659.2
CNN1
calponin 1, basic, smooth muscle
chr11_+_32112431 5.22 ENST00000054950.3
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_+_152214098 4.87 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_+_47653178 4.56 ENST00000328741.5
NXPH3
neurexophilin 3
chr9_+_97488939 4.47 ENST00000277198.2
ENST00000297979.5
C9orf3
chromosome 9 open reading frame 3
chr17_-_41174424 4.37 ENST00000355653.3
VAT1
vesicle amine transport 1
chr1_-_168698433 4.00 ENST00000367817.3
DPT
dermatopontin
chr2_+_33359687 3.71 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
LTBP1
latent transforming growth factor beta binding protein 1
chr11_+_76494253 3.68 ENST00000333090.4
TSKU
tsukushi, small leucine rich proteoglycan
chr2_+_33359646 3.68 ENST00000390003.4
ENST00000418533.2
LTBP1
latent transforming growth factor beta binding protein 1
chrX_+_43515467 3.59 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr9_+_118916082 3.58 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr17_+_32597232 3.30 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
CCL7
chemokine (C-C motif) ligand 7
chr9_+_116263778 3.27 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr9_+_116263639 3.09 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chrX_+_99899180 3.07 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr1_-_153518270 3.07 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chrX_+_150151824 3.03 ENST00000455596.1
ENST00000448905.2
HMGB3
high mobility group box 3
chr6_-_163148780 3.00 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2
parkin RBR E3 ubiquitin protein ligase
chr11_-_94226964 2.70 ENST00000538923.1
ENST00000540013.1
ENST00000407439.3
ENST00000393241.4
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
chr12_-_104443890 2.58 ENST00000547583.1
ENST00000360814.4
ENST00000546851.1
GLT8D2
glycosyltransferase 8 domain containing 2
chr12_-_48119301 2.40 ENST00000545824.2
ENST00000422538.3
ENDOU
endonuclease, polyU-specific
chr6_+_163148973 2.29 ENST00000366888.2
PACRG
PARK2 co-regulated
chr17_+_32612687 2.20 ENST00000305869.3
CCL11
chemokine (C-C motif) ligand 11
chr8_+_1772132 2.13 ENST00000349830.3
ENST00000520359.1
ENST00000518288.1
ENST00000398560.1
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chrX_+_48242863 2.12 ENST00000376886.2
ENST00000375517.3
SSX4
synovial sarcoma, X breakpoint 4
chr12_-_48119340 2.10 ENST00000229003.3
ENDOU
endonuclease, polyU-specific
chr1_+_9005917 2.09 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr11_-_62323702 1.99 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr13_-_33780133 1.99 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_+_47487285 1.97 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr1_-_156647189 1.90 ENST00000368223.3
NES
nestin
chr11_-_119252425 1.86 ENST00000260187.2
USP2
ubiquitin specific peptidase 2
chr7_+_5919458 1.84 ENST00000416608.1
OCM
oncomodulin
chr4_+_75311019 1.70 ENST00000502307.1
AREG
amphiregulin
chr17_-_67138015 1.70 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_+_67707826 1.67 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr4_+_75480629 1.67 ENST00000380846.3
AREGB
amphiregulin B
chr6_-_74363803 1.60 ENST00000355773.5
SLC17A5
solute carrier family 17 (acidic sugar transporter), member 5
chr4_-_111563076 1.58 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2
chr14_-_61748550 1.56 ENST00000555868.1
TMEM30B
transmembrane protein 30B
chr11_-_34379546 1.55 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr11_+_71900703 1.41 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr3_+_121311966 1.41 ENST00000338040.4
FBXO40
F-box protein 40
chr15_+_92937144 1.41 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr4_+_75310851 1.41 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr2_-_89399845 1.38 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr4_+_88571429 1.37 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr3_-_160167540 1.29 ENST00000496222.1
ENST00000471396.1
ENST00000471155.1
ENST00000309784.4
TRIM59
tripartite motif containing 59
chr21_+_30502806 1.28 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr12_+_1738363 1.28 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr9_-_13165457 1.26 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr19_-_52148798 1.21 ENST00000534261.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr12_-_102874102 1.16 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_-_35883541 1.16 ENST00000399284.1
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr2_+_177053307 1.13 ENST00000331462.4
HOXD1
homeobox D1
chr5_-_151304337 1.13 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr15_+_92937058 1.09 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_-_39197226 1.07 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chrX_-_110513703 1.06 ENST00000324068.1
CAPN6
calpain 6
chr4_+_156824840 1.04 ENST00000536354.2
TDO2
tryptophan 2,3-dioxygenase
chr17_+_48638371 1.04 ENST00000360761.4
ENST00000352832.5
ENST00000354983.4
CACNA1G
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr5_+_140782351 1.03 ENST00000573521.1
PCDHGA9
protocadherin gamma subfamily A, 9
chr19_+_41119323 1.02 ENST00000599724.1
ENST00000597071.1
ENST00000243562.9
LTBP4
latent transforming growth factor beta binding protein 4
chr6_+_160542870 1.01 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr15_-_31453359 1.00 ENST00000542188.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr11_-_119252359 0.99 ENST00000455332.2
USP2
ubiquitin specific peptidase 2
chr16_+_28914680 0.99 ENST00000564112.1
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr6_+_160542821 0.98 ENST00000366963.4
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr19_-_15918936 0.93 ENST00000334920.2
OR10H1
olfactory receptor, family 10, subfamily H, member 1
chr11_+_59824127 0.90 ENST00000278865.3
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrX_-_48056199 0.88 ENST00000311798.1
ENST00000347757.1
SSX5
synovial sarcoma, X breakpoint 5
chr11_+_59824060 0.86 ENST00000395032.2
ENST00000358152.2
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrY_-_2655644 0.84 ENST00000525526.2
ENST00000534739.2
ENST00000383070.1
SRY
sex determining region Y
chr1_+_186265399 0.83 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr2_-_89597542 0.82 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr19_-_10341948 0.80 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
S1PR2
DNMT1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr17_-_62050278 0.74 ENST00000578147.1
ENST00000435607.1
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chr1_+_32608566 0.74 ENST00000545542.1
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr3_-_105588231 0.74 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr3_+_124303472 0.74 ENST00000291478.5
KALRN
kalirin, RhoGEF kinase
chr1_-_217262969 0.68 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chr1_-_11907829 0.66 ENST00000376480.3
NPPA
natriuretic peptide A
chr2_-_74692473 0.66 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
MOGS
mannosyl-oligosaccharide glucosidase
chr1_+_26737292 0.65 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr11_+_63870660 0.63 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr15_+_67418047 0.63 ENST00000540846.2
SMAD3
SMAD family member 3
chr20_+_57875658 0.62 ENST00000371025.3
EDN3
endothelin 3
chr9_+_87283430 0.60 ENST00000376214.1
ENST00000376213.1
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr15_-_43559055 0.58 ENST00000220420.5
ENST00000349114.4
TGM5
transglutaminase 5
chr3_-_114035026 0.55 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr11_-_101454658 0.53 ENST00000344327.3
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr15_+_55611128 0.53 ENST00000164305.5
ENST00000539642.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr5_+_140792614 0.52 ENST00000398610.2
PCDHGA10
protocadherin gamma subfamily A, 10
chr5_-_149324306 0.52 ENST00000255266.5
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr15_-_74501360 0.51 ENST00000323940.5
STRA6
stimulated by retinoic acid 6
chr4_-_100009856 0.51 ENST00000296412.8
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr1_-_217262933 0.49 ENST00000359162.2
ESRRG
estrogen-related receptor gamma
chr7_+_120969045 0.49 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr2_+_89923550 0.46 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr3_-_111314230 0.42 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr8_+_24241789 0.42 ENST00000256412.4
ENST00000538205.1
ADAMDEC1
ADAM-like, decysin 1
chr12_+_2162447 0.42 ENST00000335762.5
ENST00000399655.1
CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr2_+_113885138 0.41 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr5_+_132009675 0.40 ENST00000231449.2
ENST00000350025.2
IL4
interleukin 4
chrX_-_154563889 0.39 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr1_+_26737253 0.39 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr3_+_124303539 0.38 ENST00000428018.2
KALRN
kalirin, RhoGEF kinase
chr1_-_92951607 0.35 ENST00000427103.1
GFI1
growth factor independent 1 transcription repressor
chr7_+_97361218 0.29 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr19_+_7584088 0.28 ENST00000394341.2
ZNF358
zinc finger protein 358
chr7_+_95115210 0.28 ENST00000428113.1
ENST00000325885.5
ASB4
ankyrin repeat and SOCS box containing 4
chr10_-_7829909 0.26 ENST00000379562.4
ENST00000543003.1
ENST00000535925.1
KIN
KIN, antigenic determinant of recA protein homolog (mouse)
chr5_+_118690466 0.23 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_-_74501310 0.23 ENST00000423167.2
ENST00000432245.2
STRA6
stimulated by retinoic acid 6
chrX_+_150151752 0.22 ENST00000325307.7
HMGB3
high mobility group box 3
chr8_+_24241969 0.22 ENST00000522298.1
ADAMDEC1
ADAM-like, decysin 1
chr7_+_90225796 0.21 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr2_+_90139056 0.18 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr19_+_50936142 0.14 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr12_-_53893227 0.09 ENST00000547488.1
MAP3K12
mitogen-activated protein kinase kinase kinase 12
chr21_-_34185989 0.09 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr10_+_98064085 0.09 ENST00000419175.1
ENST00000371174.2
DNTT
DNA nucleotidylexotransferase
chr10_-_71332994 0.01 ENST00000242462.4
NEUROG3
neurogenin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
4.5 18.2 GO:0097325 melanocyte proliferation(GO:0097325)
3.2 9.7 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.8 11.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
2.6 20.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.5 31.9 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
2.2 6.5 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
1.2 3.7 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.9 10.9 GO:0001778 plasma membrane repair(GO:0001778)
0.9 4.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.8 7.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.6 2.2 GO:0035962 response to interleukin-13(GO:0035962)
0.5 1.6 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.5 3.1 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.5 3.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.5 1.4 GO:0060974 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.5 7.0 GO:0032060 bleb assembly(GO:0032060)
0.4 2.0 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 1.0 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.3 3.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 1.0 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.3 5.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 2.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.3 2.0 GO:0048241 epinephrine transport(GO:0048241)
0.3 5.3 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.2 1.2 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.2 1.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.2 3.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.8 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.2 8.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.2 1.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 2.9 GO:0045475 locomotor rhythm(GO:0045475)
0.2 0.5 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.2 4.9 GO:0030728 ovulation(GO:0030728)
0.2 0.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.5 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408) oxidative stress-induced premature senescence(GO:0090403)
0.2 3.6 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.2 1.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.2 1.4 GO:0070166 enamel mineralization(GO:0070166)
0.2 7.4 GO:0043171 peptide catabolic process(GO:0043171)
0.2 6.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.6 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.7 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 0.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.6 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.6 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.1 0.4 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 2.1 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 0.4 GO:2000317 T-helper 1 cell lineage commitment(GO:0002296) cellular response to mercury ion(GO:0071288) negative regulation of complement-dependent cytotoxicity(GO:1903660) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 1.3 GO:0070307 lens fiber cell development(GO:0070307)
0.1 4.0 GO:0030199 collagen fibril organization(GO:0030199)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.0 GO:0046548 retinal rod cell development(GO:0046548)
0.1 1.9 GO:1901881 positive regulation of protein depolymerization(GO:1901881)
0.1 2.0 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 2.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.8 GO:2000020 positive regulation of male gonad development(GO:2000020)
0.1 4.5 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0098912 calcium-mediated signaling using extracellular calcium source(GO:0035585) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.1 1.5 GO:0097237 cellular response to toxic substance(GO:0097237)
0.1 1.0 GO:0030252 growth hormone secretion(GO:0030252)
0.1 4.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.4 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 2.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 8.5 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.4 GO:0060315 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 3.2 GO:0032392 DNA geometric change(GO:0032392)
0.0 2.6 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.0 0.5 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 1.6 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 2.9 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.7 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.1 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.8 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.6 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.5 GO:0030449 regulation of complement activation(GO:0030449)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 31.9 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.7 20.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.7 18.2 GO:0071438 invadopodium membrane(GO:0071438)
0.3 7.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 9.9 GO:0043218 compact myelin(GO:0043218)
0.3 1.0 GO:0035838 growing cell tip(GO:0035838)
0.2 1.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 11.2 GO:0005581 collagen trimer(GO:0005581)
0.1 2.3 GO:0097225 sperm midpiece(GO:0097225)
0.1 8.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 6.2 GO:0016235 aggresome(GO:0016235)
0.1 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 10.9 GO:0005901 caveola(GO:0005901)
0.1 1.1 GO:0060077 inhibitory synapse(GO:0060077)
0.1 9.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 10.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.5 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 4.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 5.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 4.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.4 GO:0030315 T-tubule(GO:0030315)
0.0 15.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.9 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 7.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 36.8 GO:0005615 extracellular space(GO:0005615)
0.0 1.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.5 GO:0055037 recycling endosome(GO:0055037)
0.0 1.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.5 7.4 GO:0050436 microfibril binding(GO:0050436)
1.5 20.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.4 5.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.8 18.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 2.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.5 2.0 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.5 3.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.4 3.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 2.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.4 1.4 GO:0061714 folic acid receptor activity(GO:0061714)
0.3 1.0 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.3 1.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 5.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 7.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 6.2 GO:0031005 filamin binding(GO:0031005)
0.3 8.1 GO:0005521 lamin binding(GO:0005521)
0.2 1.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 0.4 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.2 1.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 3.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 4.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 11.8 GO:0005518 collagen binding(GO:0005518)
0.1 1.9 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 18.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.6 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 1.2 GO:0031433 telethonin binding(GO:0031433)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.6 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 2.0 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 9.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 2.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0015926 glucosidase activity(GO:0015926)
0.1 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 3.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.0 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 0.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.1 GO:0019894 kinesin binding(GO:0019894)
0.0 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.7 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.9 GO:0019838 growth factor binding(GO:0019838)
0.0 6.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 6.9 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 6.5 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.6 NABA COLLAGENS Genes encoding collagen proteins
0.3 3.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 19.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 9.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 3.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 6.5 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 7.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 6.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 3.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 10.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 25.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.8 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 3.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.8 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 1.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 0.5 PID EPO PATHWAY EPO signaling pathway
0.1 1.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 11.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.2 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID CD40 PATHWAY CD40/CD40L signaling
0.0 4.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 8.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 41.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 3.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 2.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 3.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 5.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 8.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 5.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 2.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 1.1 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.0 1.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects