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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB3

Z-value: 0.64

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.7 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB3hg19_v2_chr11_-_62521614_62521660-0.082.4e-01Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_149688655 23.86 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr3_-_149688502 22.90 ENST00000481767.1
ENST00000475518.1
PFN2
profilin 2
chr3_-_149688896 20.02 ENST00000239940.7
PFN2
profilin 2
chr4_+_166300084 13.60 ENST00000402744.4
CPE
carboxypeptidase E
chr16_-_19896220 13.53 ENST00000562469.1
ENST00000300571.2
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr21_-_48024986 13.09 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chrX_+_134166333 9.86 ENST00000257013.7
FAM127A
family with sequence similarity 127, member A
chr6_+_30850697 9.39 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_+_123100620 7.69 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr19_-_19006890 7.56 ENST00000247005.6
GDF1
growth differentiation factor 1
chr19_-_19006920 7.19 ENST00000429504.2
ENST00000427170.2
CERS1
ceramide synthase 1
chr4_-_5894777 6.48 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr1_-_32801825 6.48 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr4_-_73935409 4.67 ENST00000507544.2
ENST00000295890.4
COX18
COX18 cytochrome C oxidase assembly factor
chr5_+_138609441 4.65 ENST00000509990.1
ENST00000506147.1
ENST00000512107.1
MATR3
matrin 3
chr3_-_39322728 4.56 ENST00000541347.1
ENST00000412814.1
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr5_+_75378997 3.52 ENST00000502798.2
SV2C
synaptic vesicle glycoprotein 2C
chr16_+_24266874 3.45 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr11_+_64692143 3.10 ENST00000164133.2
ENST00000532850.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr9_+_74526384 3.03 ENST00000334731.2
ENST00000377031.3
C9orf85
chromosome 9 open reading frame 85
chr1_+_159141397 2.87 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr5_+_76506706 2.84 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B
phosphodiesterase 8B
chr5_-_82969405 2.71 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr17_-_56595196 2.54 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4
myotubularin related protein 4
chr11_+_73661364 2.44 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr17_+_72983674 2.36 ENST00000337231.5
CDR2L
cerebellar degeneration-related protein 2-like
chr7_+_16793160 2.17 ENST00000262067.4
TSPAN13
tetraspanin 13
chr18_-_33709268 1.93 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr6_+_12958137 1.81 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr11_-_130786400 1.76 ENST00000265909.4
SNX19
sorting nexin 19
chr8_-_42623924 1.74 ENST00000276410.2
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr5_+_170288856 1.55 ENST00000523189.1
RANBP17
RAN binding protein 17
chr14_-_92414055 1.37 ENST00000342058.4
FBLN5
fibulin 5
chr8_-_42623747 1.28 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr5_+_74807886 1.25 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr16_-_2185899 1.24 ENST00000262304.4
ENST00000423118.1
PKD1
polycystic kidney disease 1 (autosomal dominant)
chr5_-_94417339 1.06 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr6_-_31939734 0.96 ENST00000375356.3
DXO
decapping exoribonuclease
chr19_-_40023450 0.95 ENST00000326282.4
EID2B
EP300 interacting inhibitor of differentiation 2B
chr3_+_98250743 0.95 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chr4_-_15939963 0.95 ENST00000259988.2
FGFBP1
fibroblast growth factor binding protein 1
chr7_+_134576151 0.94 ENST00000393118.2
CALD1
caldesmon 1
chr3_-_49131473 0.94 ENST00000430979.1
ENST00000357496.2
ENST00000437939.1
QRICH1
glutamine-rich 1
chr17_+_7531281 0.92 ENST00000575729.1
ENST00000340624.5
SHBG
sex hormone-binding globulin
chrX_+_70364667 0.91 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr8_+_42196000 0.88 ENST00000518925.1
ENST00000538005.1
POLB
polymerase (DNA directed), beta
chr5_+_115177178 0.87 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr1_-_111148969 0.83 ENST00000316361.4
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr20_+_62289640 0.82 ENST00000508582.2
ENST00000360203.5
ENST00000356810.4
RTEL1
regulator of telomere elongation helicase 1
chr7_+_134576317 0.82 ENST00000424922.1
ENST00000495522.1
CALD1
caldesmon 1
chr7_-_127225620 0.80 ENST00000321407.2
GCC1
GRIP and coiled-coil domain containing 1
chr6_-_31940065 0.79 ENST00000375349.3
ENST00000337523.5
DXO
decapping exoribonuclease
chr9_+_72002837 0.76 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr3_-_49131788 0.59 ENST00000395443.2
ENST00000411682.1
QRICH1
glutamine-rich 1
chr3_+_139062838 0.54 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr7_-_38403077 0.54 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr14_-_92413727 0.52 ENST00000267620.10
FBLN5
fibulin 5
chr2_-_154335300 0.50 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr14_-_92413353 0.37 ENST00000556154.1
FBLN5
fibulin 5
chr21_+_45209394 0.37 ENST00000497547.1
RRP1
ribosomal RNA processing 1
chr10_+_99332198 0.37 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr11_+_82783097 0.32 ENST00000501011.2
ENST00000527627.1
ENST00000526795.1
ENST00000533528.1
ENST00000533708.1
ENST00000534499.1
RAB30-AS1
RAB30 antisense RNA 1 (head to head)
chr1_+_12040238 0.32 ENST00000444836.1
ENST00000235329.5
MFN2
mitofusin 2
chr19_+_47852538 0.29 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr6_+_123100853 0.26 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr1_-_236046872 0.21 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr19_-_55549624 0.20 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr1_+_210001309 0.20 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr20_+_54987168 0.19 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr1_+_28285973 0.16 ENST00000373884.5
XKR8
XK, Kell blood group complex subunit-related family, member 8
chr20_+_54987305 0.13 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr8_+_22424551 0.12 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr5_-_74807418 0.09 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr5_-_115177247 0.06 ENST00000500945.2
ATG12
autophagy related 12

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 66.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
2.7 13.6 GO:0030070 insulin processing(GO:0030070)
2.2 6.5 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
1.8 7.2 GO:0071492 cellular response to UV-A(GO:0071492)
1.5 4.6 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
1.5 13.1 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
1.0 9.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.8 13.5 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.8 3.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.6 1.8 GO:1990502 dense core granule maturation(GO:1990502)
0.3 7.9 GO:0060134 prepulse inhibition(GO:0060134)
0.3 1.2 GO:0072237 metanephric proximal tubule development(GO:0072237)
0.3 0.9 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.3 0.8 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.2 4.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 0.9 GO:0060024 rhythmic synaptic transmission(GO:0060024) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.2 2.0 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.2 3.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 2.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 0.7 GO:0021633 optic nerve structural organization(GO:0021633)
0.2 0.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 7.6 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 1.8 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 3.0 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 2.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 2.4 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 2.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.8 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.8 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.3 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.4 GO:2000291 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 1.8 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 66.8 GO:0043195 terminal bouton(GO:0043195)
0.2 2.3 GO:0071953 elastic fiber(GO:0071953)
0.2 5.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 4.7 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 3.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 3.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.8 GO:0030478 actin cap(GO:0030478)
0.1 3.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 17.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 1.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 12.6 GO:0001726 ruffle(GO:0001726)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.2 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 15.4 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 9.4 GO:0043235 receptor complex(GO:0043235)
0.0 2.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.8 GO:0030496 midbody(GO:0030496)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 5.2 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.3 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.5 4.6 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
1.5 66.8 GO:0003785 actin monomer binding(GO:0003785)
1.2 7.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.0 14.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 13.1 GO:0048156 tau protein binding(GO:0048156)
0.6 1.8 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.3 6.5 GO:0031005 filamin binding(GO:0031005)
0.2 2.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 3.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 13.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.9 GO:0005497 androgen binding(GO:0005497)
0.1 7.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 5.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 3.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 66.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 13.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 21.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 66.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.5 13.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 13.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.3 2.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 7.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 6.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 3.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 3.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 4.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 2.8 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis